Alloimmunization and clinical profile of sickle cell disease patients from Salvador-Brazil.

Detalhes bibliográficos
Autor(a) principal: Zanette, Angela Maria Dias
Data de Publicação: 2010
Outros Autores: Gonçalves, Marilda de Souza, Schettini, Laíse Vilasboas, Aguiar, Lais Magalhães, Bahia, Regina Célia Santos, Nogueira, Luciana Araujo Vasconcelos, Brandão, Cláudio José de Freitas, Azevedo, Ana Claudia Neves de, Aragao, Luciana Ramos de, Arruda, Sérgio Marcos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9043
Resumo: Hematology and Hemotherapy Center of Bahia. Salvador, BA, Brasil
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spelling Zanette, Angela Maria DiasGonçalves, Marilda de SouzaSchettini, Laíse VilasboasAguiar, Lais MagalhãesBahia, Regina Célia SantosNogueira, Luciana Araujo VasconcelosBrandão, Cláudio José de FreitasAzevedo, Ana Claudia Neves deAragao, Luciana Ramos deArruda, Sérgio Marcos2014-12-04T14:30:30Z2014-12-04T14:30:30Z2010ZANETTE, A. M. D. et al. Alloimmunization and clinical profile of sickle cell disease patients from Salvador-Brazil. Ethnicity & Disease, v. 20, n. 2, p. 136-141, 2010.1049-510Xhttps://www.arca.fiocruz.br/handle/icict/9043engInternational Society on Hypertension in BlacksAlloimmunization and clinical profile of sickle cell disease patients from Salvador-Brazil.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHematology and Hemotherapy Center of Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilMedicine School. Bahia Foundation for Science Development. Salvador, BA, BrasilMedicine School. Bahia Foundation for Science Development. Salvador, BA, BrasilHematology and Hemotherapy Center of Bahia. Salvador, BA, BrasilHematology and Hemotherapy Center of Bahia. Salvador, BA, BrasilHematology and Hemotherapy Center of Bahia. Salvador, BA, BrasilHematology and Hemotherapy Center of Bahia. Salvador, BA, BrasilHematology and Hemotherapy Center of Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilSickle cell disease (SCD) is an important public health issue in Bahia, Brazil. Erythrocyte transfusions may reduce morbidity of SCD, however, they are associated with numerous risks. Among other risk categories, alloimmunization to red cell antigens may result from transfusions. The aim of this study was to compare the clinical profile of transfused adult SCD patients with and without alloantibodies. The study included 108 patients (105 homozygous SS and three with hemoglobinopathy SC), followed in the Outpatient Unit of the Hematology and Hemotherapy Center of Bahia. A retrospective review of clinical records of adult SCD patients who received at least three red blood cell transfusions from 2004 to 2007 was performed. Transfusion units were phenotypically matched for ABH-D and C,c,E,e, and K antigens. Alloimmunization developed in 56 patients (53 SS and three SC). The most prevalent alloantibodies were anti-E, anti-K, and anti-C (39.3%, 21.4%, and 16.1%, respectively). Age, sex and positive antiglobulin test displayed statistically significant differences. Prevalence of clinical complications such as leg ulcers, stroke, and others did not show differences between groups. In conclusion, alloimmunization did not significantly modify the clinical outcomes of SCD patients from Bahia, Brazil.Sickle Cell DiseaseHemoglobinopathyAlloimmunizationRed Cell TransfusionAnemia Falciforme/terapiaTransfusão de Eritrócitos/efeitos adversosIsoanticorposAdolescenteAdultoAnemia Falciforme/complicaçõesBrasil/epidemiologiaTeste de CoombsEstudos TransversaisFemininoHumanosÚlcera da Perna/complicaçõesMasculinoMeia-IdadeAmbulatório Hospitalar/estatística & dados numéricosPrevalênciaEstudos RetrospectivosAcidente Vascular Cerebral/complicaçõesAdulto Joveminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9043/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALZanette AMD Aloimunization...pdfZanette AMD Aloimunization...pdfapplication/pdf209906https://www.arca.fiocruz.br/bitstream/icict/9043/2/Zanette%20AMD%20Aloimunization...pdf92d1c7423fb57fcea1446a062313e63cMD52TEXTZanette AMD Aloimunization...pdf.txtZanette AMD Aloimunization...pdf.txtExtracted texttext/plain31169https://www.arca.fiocruz.br/bitstream/icict/9043/3/Zanette%20AMD%20Aloimunization...pdf.txt41edf4e5d069de9bfd59c52d84a5d677MD53icict/90432023-03-15 14:33:10.969oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:10Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Alloimmunization and clinical profile of sickle cell disease patients from Salvador-Brazil.
title Alloimmunization and clinical profile of sickle cell disease patients from Salvador-Brazil.
spellingShingle Alloimmunization and clinical profile of sickle cell disease patients from Salvador-Brazil.
Zanette, Angela Maria Dias
Sickle Cell Disease
Hemoglobinopathy
Alloimmunization
Red Cell Transfusion
Anemia Falciforme/terapia
Transfusão de Eritrócitos/efeitos adversos
Isoanticorpos
Adolescente
Adulto
Anemia Falciforme/complicações
Brasil/epidemiologia
Teste de Coombs
Estudos Transversais
Feminino
Humanos
Úlcera da Perna/complicações
Masculino
Meia-Idade
Ambulatório Hospitalar/estatística & dados numéricos
Prevalência
Estudos Retrospectivos
Acidente Vascular Cerebral/complicações
Adulto Jovem
title_short Alloimmunization and clinical profile of sickle cell disease patients from Salvador-Brazil.
title_full Alloimmunization and clinical profile of sickle cell disease patients from Salvador-Brazil.
title_fullStr Alloimmunization and clinical profile of sickle cell disease patients from Salvador-Brazil.
title_full_unstemmed Alloimmunization and clinical profile of sickle cell disease patients from Salvador-Brazil.
title_sort Alloimmunization and clinical profile of sickle cell disease patients from Salvador-Brazil.
author Zanette, Angela Maria Dias
author_facet Zanette, Angela Maria Dias
Gonçalves, Marilda de Souza
Schettini, Laíse Vilasboas
Aguiar, Lais Magalhães
Bahia, Regina Célia Santos
Nogueira, Luciana Araujo Vasconcelos
Brandão, Cláudio José de Freitas
Azevedo, Ana Claudia Neves de
Aragao, Luciana Ramos de
Arruda, Sérgio Marcos
author_role author
author2 Gonçalves, Marilda de Souza
Schettini, Laíse Vilasboas
Aguiar, Lais Magalhães
Bahia, Regina Célia Santos
Nogueira, Luciana Araujo Vasconcelos
Brandão, Cláudio José de Freitas
Azevedo, Ana Claudia Neves de
Aragao, Luciana Ramos de
Arruda, Sérgio Marcos
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Zanette, Angela Maria Dias
Gonçalves, Marilda de Souza
Schettini, Laíse Vilasboas
Aguiar, Lais Magalhães
Bahia, Regina Célia Santos
Nogueira, Luciana Araujo Vasconcelos
Brandão, Cláudio José de Freitas
Azevedo, Ana Claudia Neves de
Aragao, Luciana Ramos de
Arruda, Sérgio Marcos
dc.subject.en.pt_BR.fl_str_mv Sickle Cell Disease
Hemoglobinopathy
Alloimmunization
Red Cell Transfusion
topic Sickle Cell Disease
Hemoglobinopathy
Alloimmunization
Red Cell Transfusion
Anemia Falciforme/terapia
Transfusão de Eritrócitos/efeitos adversos
Isoanticorpos
Adolescente
Adulto
Anemia Falciforme/complicações
Brasil/epidemiologia
Teste de Coombs
Estudos Transversais
Feminino
Humanos
Úlcera da Perna/complicações
Masculino
Meia-Idade
Ambulatório Hospitalar/estatística & dados numéricos
Prevalência
Estudos Retrospectivos
Acidente Vascular Cerebral/complicações
Adulto Jovem
dc.subject.decs.pt_BR.fl_str_mv Anemia Falciforme/terapia
Transfusão de Eritrócitos/efeitos adversos
Isoanticorpos
Adolescente
Adulto
Anemia Falciforme/complicações
Brasil/epidemiologia
Teste de Coombs
Estudos Transversais
Feminino
Humanos
Úlcera da Perna/complicações
Masculino
Meia-Idade
Ambulatório Hospitalar/estatística & dados numéricos
Prevalência
Estudos Retrospectivos
Acidente Vascular Cerebral/complicações
Adulto Jovem
description Hematology and Hemotherapy Center of Bahia. Salvador, BA, Brasil
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2014-12-04T14:30:30Z
dc.date.available.fl_str_mv 2014-12-04T14:30:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ZANETTE, A. M. D. et al. Alloimmunization and clinical profile of sickle cell disease patients from Salvador-Brazil. Ethnicity & Disease, v. 20, n. 2, p. 136-141, 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9043
dc.identifier.issn.none.fl_str_mv 1049-510X
identifier_str_mv ZANETTE, A. M. D. et al. Alloimmunization and clinical profile of sickle cell disease patients from Salvador-Brazil. Ethnicity & Disease, v. 20, n. 2, p. 136-141, 2010.
1049-510X
url https://www.arca.fiocruz.br/handle/icict/9043
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv International Society on Hypertension in Blacks
publisher.none.fl_str_mv International Society on Hypertension in Blacks
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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