HIV-1 Antiretroviral Drug Resistance Mutations in Treatment Naïve and Experienced Panamanian Subjects: Impact on National Use of EFV-Based Schemes
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/40802 |
Resumo: | Gorgas Memorial Institute for Health Studies. Direction of Research and Technological Development. Panama City, Panama / Department of Biotechnology, Acharya Nagarjuna University, Guntur City, India / University of Panama. Department of Genetics and Molecular Biology, School of Biology. Panama City, Panama / Institute for Scientific Research and High Technology Services of Panama. Panama City, Panama. |
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Mendoza, YaxelisMewa, Juan CastilloMartinez, Alexander A.Zaldivar, YamitzelSosa, NéstorArteaga, GriseldaArmién, BlasBautista, Christian T.Garcia-Morales, ClaudiaTapia-Tejo, DanielaÁvila-Rios, SantiagoReyes-Terán, GustavoBello, GonzaloPascale, Juan M.2020-04-16T14:24:11Z2020-04-16T14:24:11Z2016MENDOZA, Yaxelis et al. HIV-1 Antiretroviral Drug Resistance Mutations in Treatment Naïve and Experienced Panamanian Subjects: Impact on National Use of EFV-Based Schemes. Plos One, v. 11, n. 4, e015317, 19p, Apr. 20161932-6203https://www.arca.fiocruz.br/handle/icict/40802:10.1371/journal. pone.0154317engPublic Library of ScienceHIV-1Resistência às drogas anti-retroviraisPanamáUso de esquemas baseados em EFVHIV-1Antiretroviral Drug ResistancePanamaNational Use of EFV-Based SchemesHIV-1 Antiretroviral Drug Resistance Mutations in Treatment Naïve and Experienced Panamanian Subjects: Impact on National Use of EFV-Based Schemesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleGorgas Memorial Institute for Health Studies. Direction of Research and Technological Development. Panama City, Panama / Department of Biotechnology, Acharya Nagarjuna University, Guntur City, India / University of Panama. Department of Genetics and Molecular Biology, School of Biology. Panama City, Panama / Institute for Scientific Research and High Technology Services of Panama. Panama City, Panama.Gorgas Memorial Institute for Health Studies. Direction of Research and Technological Development. Panama City, Panama.Gorgas Memorial Institute for Health Studies. Direction of Research and Technological Development. Panama City, Panama / Department of Biotechnology, Acharya Nagarjuna University, Guntur City, India / Institute for Scientific Research and High Technology Services of Panama. Panama City, Panama.Gorgas Memorial Institute for Health Studies. Direction of Research and Technological Development. Panama City, Panama.Gorgas Memorial Institute for Health Studies. Direction of Research and Technological Development. Panama City, Panama.University of Panama. Department of Microbiology, School of Medicine. Panama City, Panama.Gorgas Memorial Institute for Health Studies. Direction of Research and Technological Development. Panama City, Panama / Universidad Interamericana de Panamá. Facultad de Ciencias de la Salud. Panama City, Panama.Gorgas Memorial Institute for Health Studies. Direction of Research and Technological Development. Panama City, Panama.Instituto Nacional de Enfermedades Respiratorias. Centro de Investigación en Enfermedades Infecciosas. Mexico City, Mexico.Instituto Nacional de Enfermedades Respiratorias. Centro de Investigación en Enfermedades Infecciosas. Mexico City, Mexico.Instituto Nacional de Enfermedades Respiratorias. Centro de Investigación en Enfermedades Infecciosas. Mexico City, Mexico.Instituto Nacional de Enfermedades Respiratorias. Centro de Investigación en Enfermedades Infecciosas. Mexico City, Mexico.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Gorgas Memorial Institute for Health Studies. Direction of Research and Technological Development. Panama City, Panama / University of Panama. School of Medicine. Departamento of Microbiology. Panama City, Panama.The use of antiretroviral therapy in HIV infected subjects prevents AIDS-related illness and delayed occurrence of death. In Panama, rollout of ART started in 1999 and national coverage has reached 62.8% since then. The objective of this study was to determine the level and patterns of acquired drug resistance mutations of clinical relevance (ADR-CRM) and surveillance drug resistance mutations (SDRMs) from 717 HIV-1 pol gene sequences obtained from 467 ARV drug-experienced and 250 ARV drug-naïve HIV-1 subtypes B infected subjects during 2007–2013, respectively. The overall prevalence of SDRM and of ADR-CRM during the study period was 9.2% and 87.6%, respectively. The majority of subjects with ADR-CRM had a pattern of mutations that confer resistance to at least two classes of ARV inhibitors. The non-nucleoside reverse transcriptase inhibitor (NNRTI) mutations K103N and P225H were more prevalent in both ARV drug-naïve and ARV drugexperienced subjects. The nucleoside reverse transcriptase inhibitor (NRTI) mutation M184V was more frequent in ARV drug-experienced individuals, while T215YFrev and M41L were more frequent in ARV drug-naïve subjects. Prevalence of mutations associated to protease inhibitors (PI) was lower than 4.1% in both types of subjects. Therefore, there is a high level of resistance (>73%) to Efavirenz/Nevirapine, Lamivudine and Azidothymidine in ARV drug-experienced subjects, and an intermediate to high level of resistance (5–10%) to Efavirenz/Nevirapine in ARV drug-naïve subjects. During the study period, we observed an increasing trend in the prevalence of ADR-CRM in subjects under first-line schemes, but not significant changes in the prevalence of SDRM. These results reinforce the paramount importance of a national surveillance system of ADR-CRM and SDRM for national management policies of subjects living with HIV.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40802/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGBello_YMendoza_etal_IOC_2016.pdfGBello_YMendoza_etal_IOC_2016.pdfapplication/pdf3009122https://www.arca.fiocruz.br/bitstream/icict/40802/2/GBello_YMendoza_etal_IOC_2016.pdf9ac1aecdba0a8337eef8acb1440348dbMD52TEXTGBello_YMendoza_etal_IOC_2016.pdf.txtGBello_YMendoza_etal_IOC_2016.pdf.txtExtracted texttext/plain56484https://www.arca.fiocruz.br/bitstream/icict/40802/3/GBello_YMendoza_etal_IOC_2016.pdf.txt3f10be012f18831b2570659bf5ccb36aMD53icict/408022020-04-17 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| dc.title.pt_BR.fl_str_mv |
HIV-1 Antiretroviral Drug Resistance Mutations in Treatment Naïve and Experienced Panamanian Subjects: Impact on National Use of EFV-Based Schemes |
| title |
HIV-1 Antiretroviral Drug Resistance Mutations in Treatment Naïve and Experienced Panamanian Subjects: Impact on National Use of EFV-Based Schemes |
| spellingShingle |
HIV-1 Antiretroviral Drug Resistance Mutations in Treatment Naïve and Experienced Panamanian Subjects: Impact on National Use of EFV-Based Schemes Mendoza, Yaxelis HIV-1 Resistência às drogas anti-retrovirais Panamá Uso de esquemas baseados em EFV HIV-1 Antiretroviral Drug Resistance Panama National Use of EFV-Based Schemes |
| title_short |
HIV-1 Antiretroviral Drug Resistance Mutations in Treatment Naïve and Experienced Panamanian Subjects: Impact on National Use of EFV-Based Schemes |
| title_full |
HIV-1 Antiretroviral Drug Resistance Mutations in Treatment Naïve and Experienced Panamanian Subjects: Impact on National Use of EFV-Based Schemes |
| title_fullStr |
HIV-1 Antiretroviral Drug Resistance Mutations in Treatment Naïve and Experienced Panamanian Subjects: Impact on National Use of EFV-Based Schemes |
| title_full_unstemmed |
HIV-1 Antiretroviral Drug Resistance Mutations in Treatment Naïve and Experienced Panamanian Subjects: Impact on National Use of EFV-Based Schemes |
| title_sort |
HIV-1 Antiretroviral Drug Resistance Mutations in Treatment Naïve and Experienced Panamanian Subjects: Impact on National Use of EFV-Based Schemes |
| author |
Mendoza, Yaxelis |
| author_facet |
Mendoza, Yaxelis Mewa, Juan Castillo Martinez, Alexander A. Zaldivar, Yamitzel Sosa, Néstor Arteaga, Griselda Armién, Blas Bautista, Christian T. Garcia-Morales, Claudia Tapia-Tejo, Daniela Ávila-Rios, Santiago Reyes-Terán, Gustavo Bello, Gonzalo Pascale, Juan M. |
| author_role |
author |
| author2 |
Mewa, Juan Castillo Martinez, Alexander A. Zaldivar, Yamitzel Sosa, Néstor Arteaga, Griselda Armién, Blas Bautista, Christian T. Garcia-Morales, Claudia Tapia-Tejo, Daniela Ávila-Rios, Santiago Reyes-Terán, Gustavo Bello, Gonzalo Pascale, Juan M. |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Mendoza, Yaxelis Mewa, Juan Castillo Martinez, Alexander A. Zaldivar, Yamitzel Sosa, Néstor Arteaga, Griselda Armién, Blas Bautista, Christian T. Garcia-Morales, Claudia Tapia-Tejo, Daniela Ávila-Rios, Santiago Reyes-Terán, Gustavo Bello, Gonzalo Pascale, Juan M. |
| dc.subject.other.pt_BR.fl_str_mv |
HIV-1 Resistência às drogas anti-retrovirais Panamá Uso de esquemas baseados em EFV |
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HIV-1 Resistência às drogas anti-retrovirais Panamá Uso de esquemas baseados em EFV HIV-1 Antiretroviral Drug Resistance Panama National Use of EFV-Based Schemes |
| dc.subject.en.pt_BR.fl_str_mv |
HIV-1 Antiretroviral Drug Resistance Panama National Use of EFV-Based Schemes |
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Gorgas Memorial Institute for Health Studies. Direction of Research and Technological Development. Panama City, Panama / Department of Biotechnology, Acharya Nagarjuna University, Guntur City, India / University of Panama. Department of Genetics and Molecular Biology, School of Biology. Panama City, Panama / Institute for Scientific Research and High Technology Services of Panama. Panama City, Panama. |
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2016 |
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2016 |
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2020-04-16T14:24:11Z |
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2020-04-16T14:24:11Z |
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MENDOZA, Yaxelis et al. HIV-1 Antiretroviral Drug Resistance Mutations in Treatment Naïve and Experienced Panamanian Subjects: Impact on National Use of EFV-Based Schemes. Plos One, v. 11, n. 4, e015317, 19p, Apr. 2016 |
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https://www.arca.fiocruz.br/handle/icict/40802 |
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1932-6203 |
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:10.1371/journal. pone.0154317 |
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MENDOZA, Yaxelis et al. HIV-1 Antiretroviral Drug Resistance Mutations in Treatment Naïve and Experienced Panamanian Subjects: Impact on National Use of EFV-Based Schemes. Plos One, v. 11, n. 4, e015317, 19p, Apr. 2016 1932-6203 :10.1371/journal. pone.0154317 |
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