Human Immunodeficiency Virus Type 1 (HIV-1) Subtype B Epidemic in Panama Is Mainly Driven by Dissemination of Country-Specific Clades

Detalhes bibliográficos
Autor(a) principal: Mendoza, Yaxelis
Data de Publicação: 2014
Outros Autores: Martinez, Alexander A., Mewa, Juan Castillo, González, Claudia, García-Morales, Claudia, Avila-Rios, Santiago, Reyes-Terán, Gustavo, Armién, Blas, Pascale, Juan M., Bello, Gonzalo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9917
Resumo: The project was supported in part by the Department of Genomics and Proteomics (ICGES) and the Ministry of Health (Panama) and Project PAN-6011 from the International Atomic Energy Agency (IAEA). YM was funded by a fellowship from Instituto para la Formacio´n de Recursos Humanos (IFARHU) and Secretarı´a Nacional de Ciencia y Tecnologı´a (SENACYT).The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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spelling Mendoza, YaxelisMartinez, Alexander A.Mewa, Juan CastilloGonzález, ClaudiaGarcía-Morales, ClaudiaAvila-Rios, SantiagoReyes-Terán, GustavoArmién, BlasPascale, Juan M.Bello, Gonzalo2015-04-08T14:09:57Z2015-04-08T14:09:57Z2014MENDOZA Y, MARTÍNEZ AA, CASTILLO Mewa J, GONZÉLEZ C, GARCÍA-MORALES C, et al. (2014) Human Immunodeficiency Virus Type 1 (HIV-1) Subtype B Epidemic in Panama Is Mainly Driven by Dissemination of Country-Specific Clades. PLoS ONE , v.9, n.4, 13p, Apr. 2014.https://www.arca.fiocruz.br/handle/icict/9917The project was supported in part by the Department of Genomics and Proteomics (ICGES) and the Ministry of Health (Panama) and Project PAN-6011 from the International Atomic Energy Agency (IAEA). YM was funded by a fellowship from Instituto para la Formacio´n de Recursos Humanos (IFARHU) and Secretarı´a Nacional de Ciencia y Tecnologı´a (SENACYT).The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Gorgas Memorial Institute for Health Studies. Department of Genomics and Proteomics. Panama City, Panama /Acharya Nagarjuna University. Department of Biotechnology. Guntur City, Andhra Pradesh, India / University of Panama. Department of Genetics and Molecular Biology. Panama, Panama / INDICASAT-AIP. City of Knowledge. Clayton, Panama, Panama.Gorgas Memorial Institute for Health Studies. Department of Genomics and Proteomics. Panama City, Panama /Acharya Nagarjuna University. Department of Biotechnology. Guntur City, Andhra Pradesh, India / INDICASAT-AIP. City of Knowledge. Clayton, Panama, Panama.Gorgas Memorial Institute for Health Studies. Department of Genomics and Proteomics. Panama City, Panama .Gorgas Memorial Institute for Health Studies. Department of Genomics and Proteomics. Panama City, Panama.Instituto Nacional de Enfermedades Respiratorias. Centro de Investigación en Enfermedades Infecciosas. Mexico City, Mexico.Instituto Nacional de Enfermedades Respiratorias. Centro de Investigación en Enfermedades Infecciosas. Mexico City, Mexico.Instituto Nacional de Enfermedades Respiratorias. Centro de Investigacio´n en Enfermedades Infecciosas. Mexico City, Mexico.Gorgas Memorial Institute for Health Studies. Department of Emerging and Zoonotic Infectious Diseases. Panama City, Panama.Gorgas Memorial Institute for Health Studies. Department of Genomics and Proteomics. Panama City, Panama /Acharya Nagarjuna University. Department of Biotechnology. Guntur City, Andhra Pradesh, India / University of Panama. Department of Genetics and Molecular Biology. Panama, Panama / INDICASAT-AIP. City of Knowledge. Clayton, Panama, Panama.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.The Human immunodeficiency virus type-1 (HIV-1) subtype B is the most predominant clade in Central America; but information about the evolutionary history of this virus in this geographic region is scarce. In this study, we reconstructed the spatiotemporal and population dynamics of the HIV-1 subtype B epidemic in Panama. A total of 761 HIV-1 subtype B pol sequences obtained in Panama between 2004 and 2013 were combined with subtype B pol sequences from the Americas and Europe. Maximum Likelihood phylogenetic analyses revealed that HIV-1 subtype B infections in Panama derived from the dissemination of multiple founder viruses. Most Panamanian subtype B viruses (94.5%) belong to the pandemic viral strain proposed as originated in the US, whereas others (5.5%) were intermixed among non-pandemic Caribbean strains. The bulk (76.6%) of subtype B sequences from Panama grouped within 12 country-specific clades that were not detected in other Central American countries. Bayesian coalescent-based analyses suggest that most Panamanian clades probably originated between the early 1970s and the early 1980s. The root location of major Panamanian clades was traced to the most densely populated districts of Panama province. Major Panamanian clades appear to have experienced one or two periods of exponential growth of variable duration between the 1970s and the 2000s, with median growth rates from 0.2 to 0.4 year21. Thus, the HIV-1 subtype B epidemic in Panama is driven by the expansion of local viral strains that were introduced from the Caribbean and other American countries at an early stage of the AIDS pandemic.engPlos OneHIVPanamaAmérica CentralInfecções por HIVDoenças Sexualmente TransmissíveisHIV-1HIVHuman Immunodeficiency Virus Type 1 (HIV-1) Subtype B Epidemic in Panama Is Mainly Driven by Dissemination of Country-Specific Cladesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/9917/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALgonzalo_belloetal_IOC_2014.pdfapplication/pdf2790140https://www.arca.fiocruz.br/bitstream/icict/9917/2/gonzalo_belloetal_IOC_2014.pdf48526443150d646a08bb5e7c34b6d70cMD52TEXTgonzalo_belloetal_IOC_2014.pdf.txtgonzalo_belloetal_IOC_2014.pdf.txtExtracted texttext/plain54123https://www.arca.fiocruz.br/bitstream/icict/9917/3/gonzalo_belloetal_IOC_2014.pdf.txt263990ade4a5052d927b2560ea392307MD53icict/99172022-06-24 13:08:45.132oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:08:45Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Human Immunodeficiency Virus Type 1 (HIV-1) Subtype B Epidemic in Panama Is Mainly Driven by Dissemination of Country-Specific Clades
title Human Immunodeficiency Virus Type 1 (HIV-1) Subtype B Epidemic in Panama Is Mainly Driven by Dissemination of Country-Specific Clades
spellingShingle Human Immunodeficiency Virus Type 1 (HIV-1) Subtype B Epidemic in Panama Is Mainly Driven by Dissemination of Country-Specific Clades
Mendoza, Yaxelis
HIV
Panama
América Central
Infecções por HIV
Doenças Sexualmente Transmissíveis
HIV-1
HIV
title_short Human Immunodeficiency Virus Type 1 (HIV-1) Subtype B Epidemic in Panama Is Mainly Driven by Dissemination of Country-Specific Clades
title_full Human Immunodeficiency Virus Type 1 (HIV-1) Subtype B Epidemic in Panama Is Mainly Driven by Dissemination of Country-Specific Clades
title_fullStr Human Immunodeficiency Virus Type 1 (HIV-1) Subtype B Epidemic in Panama Is Mainly Driven by Dissemination of Country-Specific Clades
title_full_unstemmed Human Immunodeficiency Virus Type 1 (HIV-1) Subtype B Epidemic in Panama Is Mainly Driven by Dissemination of Country-Specific Clades
title_sort Human Immunodeficiency Virus Type 1 (HIV-1) Subtype B Epidemic in Panama Is Mainly Driven by Dissemination of Country-Specific Clades
author Mendoza, Yaxelis
author_facet Mendoza, Yaxelis
Martinez, Alexander A.
Mewa, Juan Castillo
González, Claudia
García-Morales, Claudia
Avila-Rios, Santiago
Reyes-Terán, Gustavo
Armién, Blas
Pascale, Juan M.
Bello, Gonzalo
author_role author
author2 Martinez, Alexander A.
Mewa, Juan Castillo
González, Claudia
García-Morales, Claudia
Avila-Rios, Santiago
Reyes-Terán, Gustavo
Armién, Blas
Pascale, Juan M.
Bello, Gonzalo
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mendoza, Yaxelis
Martinez, Alexander A.
Mewa, Juan Castillo
González, Claudia
García-Morales, Claudia
Avila-Rios, Santiago
Reyes-Terán, Gustavo
Armién, Blas
Pascale, Juan M.
Bello, Gonzalo
dc.subject.other.pt_BR.fl_str_mv HIV
Panama
América Central
Infecções por HIV
topic HIV
Panama
América Central
Infecções por HIV
Doenças Sexualmente Transmissíveis
HIV-1
HIV
dc.subject.decs.pt_BR.fl_str_mv Doenças Sexualmente Transmissíveis
HIV-1
HIV
description The project was supported in part by the Department of Genomics and Proteomics (ICGES) and the Ministry of Health (Panama) and Project PAN-6011 from the International Atomic Energy Agency (IAEA). YM was funded by a fellowship from Instituto para la Formacio´n de Recursos Humanos (IFARHU) and Secretarı´a Nacional de Ciencia y Tecnologı´a (SENACYT).The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-04-08T14:09:57Z
dc.date.available.fl_str_mv 2015-04-08T14:09:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv MENDOZA Y, MARTÍNEZ AA, CASTILLO Mewa J, GONZÉLEZ C, GARCÍA-MORALES C, et al. (2014) Human Immunodeficiency Virus Type 1 (HIV-1) Subtype B Epidemic in Panama Is Mainly Driven by Dissemination of Country-Specific Clades. PLoS ONE , v.9, n.4, 13p, Apr. 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9917
identifier_str_mv MENDOZA Y, MARTÍNEZ AA, CASTILLO Mewa J, GONZÉLEZ C, GARCÍA-MORALES C, et al. (2014) Human Immunodeficiency Virus Type 1 (HIV-1) Subtype B Epidemic in Panama Is Mainly Driven by Dissemination of Country-Specific Clades. PLoS ONE , v.9, n.4, 13p, Apr. 2014.
url https://www.arca.fiocruz.br/handle/icict/9917
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language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Plos One
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dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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