Plasmodium vivax circumsporozoite genotypes: a limited variation or new subspecies with major biological consequences?
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/5893 |
Resumo: | Universidade Estadual Paulista Júlio Mesquita Filho. Departamento de Biologia, São José do Rio Preto, SP, Brazil |
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Neiras, Wanessa Cristina de SouzaMelo, Luciane Moreno StortiCassiano, Gustavo CapattiCouto, Vanja Suely Calvosa D’AlmeidaCouto, Alvaro Augusto Ribeiro D'AlmeidaSoares, Irene da SilvaCarvalho, Luzia Helena deCunha, Maristela G.Póvoa, Marinete MarinsHerrera, SocratesHerrera, Myriam A.Rossit, Andrea Regina BaptistaCarareto, Claudia Marcia AparecidaMachado, Ricardo Luiz Dantas2012-11-28T12:44:40Z2012-11-28T12:44:40Z2010SOUZA NEIRAS, Wanessa C, et al. Pelsaeasrcmh odium vivax circumsporozoite genotypes: a limited variation or new subspecies with major biological consequences? Malaria Journal 2010, 9:1781475-2875https://www.arca.fiocruz.br/handle/icict/5893engPlasmodium vivax circumsporozoite genotypes: a limited variation or new subspecies with major biological consequences?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Estadual Paulista Júlio Mesquita Filho. Departamento de Biologia, São José do Rio Preto, SP, BrazilUniversidade Estadual Paulista Júlio Mesquita Filho. Departamento de Biologia, São José do Rio Preto, SP, BrazilUniversidade Estadual Paulista Júlio Mesquita Filho. Departamento de Biologia, São José do Rio Preto, SP, BrazilFaculdade SEAMA, Macapá, AP, Brazil,Faculdade SEAMA, Macapá, AP, Brazil,Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Análises Clínicas e Toxicológicas. São Paulo, SP, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil,Universidade Federal do Pará. Instituto de Ciências Biológicas. Belém, PA, Brazil,Instituto Evandro Chagas. MS/SVS. Ananindeua, PA Brazil,Universidade Del Valle. Instituto de Imunologia. Cali, ColômbiaUniversidade Del Valle. Instituto de Imunologia. Cali, ColômbiaFaculdade de Medicina de São José do Rio Preto. Centro de Investigação de Microrganismos. Departamento de Doenças Dermatológicas, Infecciosas e Parasitárias. São Paulo, SP, BrazilUniversidade Estadual Paulista Júlio Mesquita Filho. Departamento de Biologia, São José do Rio Preto, SP, BrazilFaculdade de Medicina de São José do Rio Preto. Centro de Investigação de Microrganismos. Departamento de Doenças Dermatológicas, Infecciosas e Parasitárias. São Paulo, SP, BrazilBackground: Plasmodium vivax circumsporozoite variants have been identified in several geographical areas. The real implication of the genetic variation in this region of the P. vivax genome has been questioned for a long time. Although previous studies have observed significant association between VK210 and the Duffy blood group, we present here that evidences of this variation are limited to the CSP central portion. Methods: The phylogenetic analyses were accomplished starting from the amplification of conserved domains of 18 SSU RNAr and Cyt B. The antibodies responses against the CSP peptides, MSP-1, AMA-1 and DBP were detected by ELISA, in plasma samples of individuals infected with two P. vivax CS genotypes: VK210 and P. vivax-like. Results: These analyses of the two markers demonstrate high similarity among the P. vivax CS genotypes and surprisingly showed diversity equal to zero between VK210 and P. vivax-like, positioning these CS genotypes in the same clade. A high frequency IgG antibody against the N- and C-terminal regions of the P. vivax CSP was found as compared to the immune response to the R- and V- repetitive regions (p = 0.0005, Fisher's Exact test). This difference was more pronounced when the P. vivax-like variant was present in the infection (p = 0.003, Fisher's Exact test). A high frequency of antibody response against MSP-1 and AMA-1 peptides was observed for all P. vivax CS genotypes in comparison to the same frequency for DBP. Conclusions: This results target that the differences among the P. vivax CS variants are restrict to the central repeated region of the protein, mostly nucleotide variation with important serological consequences.Plasmodium vivaxinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINAL119.2010.pdf119.2010.pdfapplication/pdf996199https://www.arca.fiocruz.br/bitstream/icict/5893/1/119.2010.pdf9083a09051da6c2f8c0223ae75897080MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5893/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXT119.2010.pdf.txt119.2010.pdf.txtExtracted texttext/plain35215https://www.arca.fiocruz.br/bitstream/icict/5893/5/119.2010.pdf.txtbc2641f7411a84598733b43bf7ecafd7MD55THUMBNAIL119.2010.pdf.jpg119.2010.pdf.jpgGenerated Thumbnailimage/jpeg2241https://www.arca.fiocruz.br/bitstream/icict/5893/4/119.2010.pdf.jpg2986956c82dbd1bc7dc7da9c1984e5e4MD54icict/58932018-05-18 08:26:58.73oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-05-18T11:26:58Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Plasmodium vivax circumsporozoite genotypes: a limited variation or new subspecies with major biological consequences? |
title |
Plasmodium vivax circumsporozoite genotypes: a limited variation or new subspecies with major biological consequences? |
spellingShingle |
Plasmodium vivax circumsporozoite genotypes: a limited variation or new subspecies with major biological consequences? Neiras, Wanessa Cristina de Souza Plasmodium vivax |
title_short |
Plasmodium vivax circumsporozoite genotypes: a limited variation or new subspecies with major biological consequences? |
title_full |
Plasmodium vivax circumsporozoite genotypes: a limited variation or new subspecies with major biological consequences? |
title_fullStr |
Plasmodium vivax circumsporozoite genotypes: a limited variation or new subspecies with major biological consequences? |
title_full_unstemmed |
Plasmodium vivax circumsporozoite genotypes: a limited variation or new subspecies with major biological consequences? |
title_sort |
Plasmodium vivax circumsporozoite genotypes: a limited variation or new subspecies with major biological consequences? |
author |
Neiras, Wanessa Cristina de Souza |
author_facet |
Neiras, Wanessa Cristina de Souza Melo, Luciane Moreno Storti Cassiano, Gustavo Capatti Couto, Vanja Suely Calvosa D’Almeida Couto, Alvaro Augusto Ribeiro D'Almeida Soares, Irene da Silva Carvalho, Luzia Helena de Cunha, Maristela G. Póvoa, Marinete Marins Herrera, Socrates Herrera, Myriam A. Rossit, Andrea Regina Baptista Carareto, Claudia Marcia Aparecida Machado, Ricardo Luiz Dantas |
author_role |
author |
author2 |
Melo, Luciane Moreno Storti Cassiano, Gustavo Capatti Couto, Vanja Suely Calvosa D’Almeida Couto, Alvaro Augusto Ribeiro D'Almeida Soares, Irene da Silva Carvalho, Luzia Helena de Cunha, Maristela G. Póvoa, Marinete Marins Herrera, Socrates Herrera, Myriam A. Rossit, Andrea Regina Baptista Carareto, Claudia Marcia Aparecida Machado, Ricardo Luiz Dantas |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Neiras, Wanessa Cristina de Souza Melo, Luciane Moreno Storti Cassiano, Gustavo Capatti Couto, Vanja Suely Calvosa D’Almeida Couto, Alvaro Augusto Ribeiro D'Almeida Soares, Irene da Silva Carvalho, Luzia Helena de Cunha, Maristela G. Póvoa, Marinete Marins Herrera, Socrates Herrera, Myriam A. Rossit, Andrea Regina Baptista Carareto, Claudia Marcia Aparecida Machado, Ricardo Luiz Dantas |
dc.subject.en.pt_BR.fl_str_mv |
Plasmodium vivax |
topic |
Plasmodium vivax |
description |
Universidade Estadual Paulista Júlio Mesquita Filho. Departamento de Biologia, São José do Rio Preto, SP, Brazil |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010 |
dc.date.accessioned.fl_str_mv |
2012-11-28T12:44:40Z |
dc.date.available.fl_str_mv |
2012-11-28T12:44:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SOUZA NEIRAS, Wanessa C, et al. Pelsaeasrcmh odium vivax circumsporozoite genotypes: a limited variation or new subspecies with major biological consequences? Malaria Journal 2010, 9:178 |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/5893 |
dc.identifier.issn.none.fl_str_mv |
1475-2875 |
identifier_str_mv |
SOUZA NEIRAS, Wanessa C, et al. Pelsaeasrcmh odium vivax circumsporozoite genotypes: a limited variation or new subspecies with major biological consequences? Malaria Journal 2010, 9:178 1475-2875 |
url |
https://www.arca.fiocruz.br/handle/icict/5893 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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