Differential pulse voltammetric studies on Lamivudine: an antiretroviral drug

Detalhes bibliográficos
Autor(a) principal: Leandro, Katia Christina
Data de Publicação: 2013
Outros Autores: Moreira, Josino Costa, Farias, Pércio Augusto Mardini
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13968
http://dx.doi.org/10.4236/ajac.2013.46A007
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Departamento de Química. Rio de Janeiro, RJ, Brasil.
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spelling Leandro, Katia ChristinaMoreira, Josino CostaFarias, Pércio Augusto Mardini2016-04-26T11:58:24Z2016-04-26T11:58:24Z2013LEANDRO, K. C.; MOREIRA, J. C.; FARIAS, P. A. M. Differential pulse voltammetric studies on Lamivudine: an antiretroviral drug. Am. J. Anal. Chem., v. 4, n. 6A, p. 47-51, 2013.2156-8251https://www.arca.fiocruz.br/handle/icict/13968http://dx.doi.org/10.4236/ajac.2013.46A007engScientific Research PublishingLamivudinaHIVDrogas anti-retroviraisVoltametriaLamivudine DeterminationHIVAntiretroviral DrugsVoltammetric AnalysisLamivudinaFármacos Anti-HIVInibidores da Transcriptase ReversaHIVAntirretroviraisDifferential pulse voltammetric studies on Lamivudine: an antiretroviral druginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Departamento de Química. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Rio de Janeiro, RJ, Brasil.Pontifícia Universidade Católica do Rio de Janeiro. Departamento de Química. Rio de Janeiro, RJ, Brasil.Lamivudine (also known as 3TC) is a dideoxynucleoside analogue, which undergoes intracellular phosphorylation in the putative active metabolite, lamivudine triphosphate. Lamivudine triphosphate prevents HIV replication by competitively inhibiting viral reverse transcriptase. Lamivudine has been extensively used in the treatment of HIV patients owing to its antiretroviral activity. For the determination of lamivudine in pharmaceuticals, an analytical methodology using voltammetry was developed. Lamivudine was reduced at a hanging mercury drop electrode (HMDE) at –1.16 V vs Ag/AgCl at pH 2.0. The influence of electroanalytical parameters such as scan rate (20 mV·s–1), amplitude (50 mV), nature of the support electrolyte (Clark-Lubs), and pH (2.0) on the voltammetric signal was optimized. Under these op- timized conditions, the method had been validated using pharmaceutical formulations. The lamivudine peak current varied linearly with its concentration from 1.15 to 10.40 mg·L–1, detection and determination limits of 0.46 and 1.0 mg·L–1, respectively, and recovery of 95.15% with a relative standard deviation of 1.10%.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13968/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAm_J_Anal_Chem_4_47-51.pdfAm_J_Anal_Chem_4_47-51.pdfapplication/pdf276269https://www.arca.fiocruz.br/bitstream/icict/13968/2/Am_J_Anal_Chem_4_47-51.pdfb92481cadd9d205dde86a200a2d06dd6MD52TEXTAm_J_Anal_Chem_4_47-51.pdf.txtAm_J_Anal_Chem_4_47-51.pdf.txtExtracted texttext/plain22747https://www.arca.fiocruz.br/bitstream/icict/13968/3/Am_J_Anal_Chem_4_47-51.pdf.txt02e4407a43c4cafb4e478dc1b0800e3fMD53icict/139682018-04-02 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dc.title.en.fl_str_mv Differential pulse voltammetric studies on Lamivudine: an antiretroviral drug
title Differential pulse voltammetric studies on Lamivudine: an antiretroviral drug
spellingShingle Differential pulse voltammetric studies on Lamivudine: an antiretroviral drug
Leandro, Katia Christina
Lamivudina
HIV
Drogas anti-retrovirais
Voltametria
Lamivudine Determination
HIV
Antiretroviral Drugs
Voltammetric Analysis
Lamivudina
Fármacos Anti-HIV
Inibidores da Transcriptase Reversa
HIV
Antirretrovirais
title_short Differential pulse voltammetric studies on Lamivudine: an antiretroviral drug
title_full Differential pulse voltammetric studies on Lamivudine: an antiretroviral drug
title_fullStr Differential pulse voltammetric studies on Lamivudine: an antiretroviral drug
title_full_unstemmed Differential pulse voltammetric studies on Lamivudine: an antiretroviral drug
title_sort Differential pulse voltammetric studies on Lamivudine: an antiretroviral drug
author Leandro, Katia Christina
author_facet Leandro, Katia Christina
Moreira, Josino Costa
Farias, Pércio Augusto Mardini
author_role author
author2 Moreira, Josino Costa
Farias, Pércio Augusto Mardini
author2_role author
author
dc.contributor.author.fl_str_mv Leandro, Katia Christina
Moreira, Josino Costa
Farias, Pércio Augusto Mardini
dc.subject.other.pt_BR.fl_str_mv Lamivudina
HIV
Drogas anti-retrovirais
Voltametria
topic Lamivudina
HIV
Drogas anti-retrovirais
Voltametria
Lamivudine Determination
HIV
Antiretroviral Drugs
Voltammetric Analysis
Lamivudina
Fármacos Anti-HIV
Inibidores da Transcriptase Reversa
HIV
Antirretrovirais
dc.subject.en.en.fl_str_mv Lamivudine Determination
HIV
Antiretroviral Drugs
Voltammetric Analysis
dc.subject.decs.pt_BR.fl_str_mv Lamivudina
Fármacos Anti-HIV
Inibidores da Transcriptase Reversa
HIV
Antirretrovirais
description Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Departamento de Química. Rio de Janeiro, RJ, Brasil.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2016-04-26T11:58:24Z
dc.date.available.fl_str_mv 2016-04-26T11:58:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LEANDRO, K. C.; MOREIRA, J. C.; FARIAS, P. A. M. Differential pulse voltammetric studies on Lamivudine: an antiretroviral drug. Am. J. Anal. Chem., v. 4, n. 6A, p. 47-51, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13968
dc.identifier.issn.none.fl_str_mv 2156-8251
dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.4236/ajac.2013.46A007
identifier_str_mv LEANDRO, K. C.; MOREIRA, J. C.; FARIAS, P. A. M. Differential pulse voltammetric studies on Lamivudine: an antiretroviral drug. Am. J. Anal. Chem., v. 4, n. 6A, p. 47-51, 2013.
2156-8251
url https://www.arca.fiocruz.br/handle/icict/13968
http://dx.doi.org/10.4236/ajac.2013.46A007
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Scientific Research Publishing
publisher.none.fl_str_mv Scientific Research Publishing
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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