In vitro activity of Schinus terebinthifolius extract and fractions against Sporothrix brasiliensis

Detalhes bibliográficos
Autor(a) principal: Almeida-Silva, Fernando
Data de Publicação: 2022
Outros Autores: Bernardes-Engemann, Andrea Reis, Bérenger, Ana Luiza Rangel, Silva, Vagner Pereira da, Figueiredo, Maria Raquel, Freitas, Dayvison Francis Saraiva
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/55688
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.
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spelling Almeida-Silva, FernandoBernardes-Engemann, Andrea ReisBérenger, Ana Luiza RangelSilva, Vagner Pereira daFigueiredo, Maria RaquelFreitas, Dayvison Francis Saraiva2022-11-17T18:30:28Z2022-11-17T18:30:28Z2022ALMEIDA-SILVA, Fernando et al. In vitro activity of Schinus terebinthifolius extract and fractions against Sporothrix brasiliensis. Memorias do Instituto Oswaldo Cruz, v. 117, p. 1-5, 2022.0074-0276https://www.arca.fiocruz.br/handle/icict/5568810.1590/0074-02760220063engScieloIn vitro activity of Schinus terebinthifolius extract and fractions against Sporothrix brasiliensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Laboratório de Química de Produtos Naturais. TecBio/LDFito. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Laboratório de Química de Produtos Naturais. TecBio/LDFito. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Laboratório de Química de Produtos Naturais. TecBio/LDFito. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil.Background: Sporothrix brasiliensis is the causative agent of zoonotic cases of sporotrichosis in Brazil and is associated with atypical and severe presentations in cats, dogs, and humans. Sporotrichosis treatment is usually time- and cost-consuming, sometimes with poor response and host toxicity. Schinus terebinthifolius has proven efficacy against bacteria and fungi of clinical interest. Objective: To determine the in vitro activity of S. terebinthifolius against S. brasiliensis. Methods: Five S. brasiliensis isolates and three reference strains were subjected to a hydroethanol extract derived from the leaves of S. terebinthifolius and its fractions. The minimal inhibitory concentration (MIC) was determined using the broth microdilution method according to the M38-A2 CLSI guidelines. Also, the fungicidal/fungistatic activity of the extract and fractions was studied. Findings: The crude extract of S. terebinthifolius inhibited the growth of S. brasiliensis (MIC: 0.5-1.0 µg/mL), while the partitioned extracts dichloromethane, ethyl acetate, and butanol demonstrated growth inhibition at 8 µg/mL due to a fungistatic activity. Main conclusions: Due to its in vitro efficacy against S. brasiliensis and its known pharmacological safety, S. terebinthifolius is a candidate to be tested using in vivo models of sporotrichosis.Sporothrix brasiliensisSporotrichosisAntifungal agentsFungal drug sensitivity testsSchinus terebinthifoliusinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/55688/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALIn_Fernando_Silva_etal_INI_2022.pdfIn_Fernando_Silva_etal_INI_2022.pdfapplication/pdf974007https://www.arca.fiocruz.br/bitstream/icict/55688/2/In_Fernando_Silva_etal_INI_2022.pdfaf832b0db6e952bc2af8215056eebd30MD52icict/556882022-11-17 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dc.title.en_US.fl_str_mv In vitro activity of Schinus terebinthifolius extract and fractions against Sporothrix brasiliensis
title In vitro activity of Schinus terebinthifolius extract and fractions against Sporothrix brasiliensis
spellingShingle In vitro activity of Schinus terebinthifolius extract and fractions against Sporothrix brasiliensis
Almeida-Silva, Fernando
Sporothrix brasiliensis
Sporotrichosis
Antifungal agents
Fungal drug sensitivity tests
Schinus terebinthifolius
title_short In vitro activity of Schinus terebinthifolius extract and fractions against Sporothrix brasiliensis
title_full In vitro activity of Schinus terebinthifolius extract and fractions against Sporothrix brasiliensis
title_fullStr In vitro activity of Schinus terebinthifolius extract and fractions against Sporothrix brasiliensis
title_full_unstemmed In vitro activity of Schinus terebinthifolius extract and fractions against Sporothrix brasiliensis
title_sort In vitro activity of Schinus terebinthifolius extract and fractions against Sporothrix brasiliensis
author Almeida-Silva, Fernando
author_facet Almeida-Silva, Fernando
Bernardes-Engemann, Andrea Reis
Bérenger, Ana Luiza Rangel
Silva, Vagner Pereira da
Figueiredo, Maria Raquel
Freitas, Dayvison Francis Saraiva
author_role author
author2 Bernardes-Engemann, Andrea Reis
Bérenger, Ana Luiza Rangel
Silva, Vagner Pereira da
Figueiredo, Maria Raquel
Freitas, Dayvison Francis Saraiva
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Almeida-Silva, Fernando
Bernardes-Engemann, Andrea Reis
Bérenger, Ana Luiza Rangel
Silva, Vagner Pereira da
Figueiredo, Maria Raquel
Freitas, Dayvison Francis Saraiva
dc.subject.en.en_US.fl_str_mv Sporothrix brasiliensis
Sporotrichosis
Antifungal agents
Fungal drug sensitivity tests
Schinus terebinthifolius
topic Sporothrix brasiliensis
Sporotrichosis
Antifungal agents
Fungal drug sensitivity tests
Schinus terebinthifolius
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-11-17T18:30:28Z
dc.date.available.fl_str_mv 2022-11-17T18:30:28Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALMEIDA-SILVA, Fernando et al. In vitro activity of Schinus terebinthifolius extract and fractions against Sporothrix brasiliensis. Memorias do Instituto Oswaldo Cruz, v. 117, p. 1-5, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/55688
dc.identifier.issn.en_US.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/0074-02760220063
identifier_str_mv ALMEIDA-SILVA, Fernando et al. In vitro activity of Schinus terebinthifolius extract and fractions against Sporothrix brasiliensis. Memorias do Instituto Oswaldo Cruz, v. 117, p. 1-5, 2022.
0074-0276
10.1590/0074-02760220063
url https://www.arca.fiocruz.br/handle/icict/55688
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Scielo
publisher.none.fl_str_mv Scielo
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/55688/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/55688/2/In_Fernando_Silva_etal_INI_2022.pdf
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