In vitro susceptibility of antifungal drugs against Sporothrix brasiliensis recovered from cats with sporotrichosis in Brazil

Detalhes bibliográficos
Autor(a) principal: Brilhante, Raimunda Sâmia Nogueira
Data de Publicação: 2016
Outros Autores: Rodrigues, Anderson Messias, Sidrim, José Júlio Costa, Rocha, Marcos Fábio Gadelha, Pereira, Sandro Antonio, Gremião, Isabella Dib Ferreira, Schubach, Tânia Maria Pacheco, Camargo, Zoilo Pires de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32567
Resumo: 2020-04-15
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spelling Brilhante, Raimunda Sâmia NogueiraRodrigues, Anderson MessiasSidrim, José Júlio CostaRocha, Marcos Fábio GadelhaPereira, Sandro AntonioGremião, Isabella Dib FerreiraSchubach, Tânia Maria PachecoCamargo, Zoilo Pires de2019-04-18T00:49:05Z2019-04-18T00:49:05Z2016BRILHANTE, Raimunda Sâmia Nogueira et al. In vitro susceptibility of antifungal drugs against Sporothrix brasiliensis recovered from cats with sporotrichosis in Brazil. Medical Mycology, v. 54, p. 275-279, 2016.1369-3786https://www.arca.fiocruz.br/handle/icict/3256710.1093/mmy/myv0391460-2709engOxford University PressIn vitro susceptibility of antifungal drugs against Sporothrix brasiliensis recovered from cats with sporotrichosis in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-04-15Federal University of Ceará. Specialized Medical Mycology Center. Postgraduate Program in Medical Microbiology. Fortaleza, CE, Brazil.Federal University of São Paulo. Department of Microbiology, Immunology and Parasitology. Cellular Biology Division. São Paulo, SP, Brazil.Federal University of Ceará. Specialized Medical Mycology Center. Postgraduate Program in Medical Microbiology. Fortaleza, CE, Brazil.Federal University of Ceará. Specialized Medical Mycology Center. Postgraduate Program in Medical Microbiology. Fortaleza, CE, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Federal University of São Paulo. Department of Microbiology, Immunology and Parasitology. Cellular Biology Division. São Paulo, SP, Brazil.Sporotrichosis is an important subcutaneous mycosis of humans and animals. Classically, the disease is acquired upon traumatic inoculation of Sporothrix propagules from contaminated soil and plant debris. In addition, the direct horizontal transmission of Sporothrix among animals and the resulting zoonotic infection in humans highlight an alternative and efficient rout of transmission through biting and scratching. Sporothrix brasiliensis is the most virulent species of the Sporothrix schenckii complex and is responsible for the long-lasting outbreak of feline sporotrichosis in Brazil. However, antifungal susceptibility data of animal-borne isolates is scarce. Therefore, this study evaluated the in vitro activity of amphotericin B, caspofungin, itraconazole, voriconazole, fluconazole, and ketoconazole against animal-borne isolates of S. brasiliensis. The susceptibility tests were performed through broth microdilution (M38-A2). The results show the relevant activity of itraconazole, amphotericin B, and ketoconazole against S. brasiliensis, with the following MIC ranges: 0.125-2, 0.125-4 and 0.0312-2 μg/ml, respectively. Caspofungin was moderately effective, displaying higher variation in MIC values (0.25-64 μg/ml). Voriconazole (2-64 μg/ml) and fluconazole (62.5-500 μg/ml) showed low activity against S. brasiliensis strains. This study contributed to the characterization of the in vitro antifungal susceptibility of strains of S. brasiliensis recovered from cats with sporotrichosis, which have recently been considered the main source of human infections.Sporothrix brasiliensisCatsAntifungal susceptibilitySporotrichosisSporothrix schenckii complexinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/32567/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Brilhante_Raimunda_etal_INI_2016.pdfve_Brilhante_Raimunda_etal_INI_2016.pdfapplication/pdf351785https://www.arca.fiocruz.br/bitstream/icict/32567/2/ve_Brilhante_Raimunda_etal_INI_2016.pdf6c82d10e08edbfd82bfd6abff0ace5a1MD52TEXTve_Brilhante_Raimunda_etal_INI_2016.pdf.txtve_Brilhante_Raimunda_etal_INI_2016.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv In vitro susceptibility of antifungal drugs against Sporothrix brasiliensis recovered from cats with sporotrichosis in Brazil
title In vitro susceptibility of antifungal drugs against Sporothrix brasiliensis recovered from cats with sporotrichosis in Brazil
spellingShingle In vitro susceptibility of antifungal drugs against Sporothrix brasiliensis recovered from cats with sporotrichosis in Brazil
Brilhante, Raimunda Sâmia Nogueira
Sporothrix brasiliensis
Cats
Antifungal susceptibility
Sporotrichosis
Sporothrix schenckii complex
title_short In vitro susceptibility of antifungal drugs against Sporothrix brasiliensis recovered from cats with sporotrichosis in Brazil
title_full In vitro susceptibility of antifungal drugs against Sporothrix brasiliensis recovered from cats with sporotrichosis in Brazil
title_fullStr In vitro susceptibility of antifungal drugs against Sporothrix brasiliensis recovered from cats with sporotrichosis in Brazil
title_full_unstemmed In vitro susceptibility of antifungal drugs against Sporothrix brasiliensis recovered from cats with sporotrichosis in Brazil
title_sort In vitro susceptibility of antifungal drugs against Sporothrix brasiliensis recovered from cats with sporotrichosis in Brazil
author Brilhante, Raimunda Sâmia Nogueira
author_facet Brilhante, Raimunda Sâmia Nogueira
Rodrigues, Anderson Messias
Sidrim, José Júlio Costa
Rocha, Marcos Fábio Gadelha
Pereira, Sandro Antonio
Gremião, Isabella Dib Ferreira
Schubach, Tânia Maria Pacheco
Camargo, Zoilo Pires de
author_role author
author2 Rodrigues, Anderson Messias
Sidrim, José Júlio Costa
Rocha, Marcos Fábio Gadelha
Pereira, Sandro Antonio
Gremião, Isabella Dib Ferreira
Schubach, Tânia Maria Pacheco
Camargo, Zoilo Pires de
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Brilhante, Raimunda Sâmia Nogueira
Rodrigues, Anderson Messias
Sidrim, José Júlio Costa
Rocha, Marcos Fábio Gadelha
Pereira, Sandro Antonio
Gremião, Isabella Dib Ferreira
Schubach, Tânia Maria Pacheco
Camargo, Zoilo Pires de
dc.subject.en.pt_BR.fl_str_mv Sporothrix brasiliensis
Cats
Antifungal susceptibility
Sporotrichosis
Sporothrix schenckii complex
topic Sporothrix brasiliensis
Cats
Antifungal susceptibility
Sporotrichosis
Sporothrix schenckii complex
description 2020-04-15
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2019-04-18T00:49:05Z
dc.date.available.fl_str_mv 2019-04-18T00:49:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BRILHANTE, Raimunda Sâmia Nogueira et al. In vitro susceptibility of antifungal drugs against Sporothrix brasiliensis recovered from cats with sporotrichosis in Brazil. Medical Mycology, v. 54, p. 275-279, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32567
dc.identifier.issn.pt_BR.fl_str_mv 1369-3786
dc.identifier.doi.none.fl_str_mv 10.1093/mmy/myv039
dc.identifier.eissn.none.fl_str_mv 1460-2709
identifier_str_mv BRILHANTE, Raimunda Sâmia Nogueira et al. In vitro susceptibility of antifungal drugs against Sporothrix brasiliensis recovered from cats with sporotrichosis in Brazil. Medical Mycology, v. 54, p. 275-279, 2016.
1369-3786
10.1093/mmy/myv039
1460-2709
url https://www.arca.fiocruz.br/handle/icict/32567
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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