The role of NLRP3 inflammasome activation in the epithelial to mesenchymal transition process during the fibrosis

Detalhes bibliográficos
Autor(a) principal: Alyaseer, Amani Abraheem Alsadiq
Data de Publicação: 2020
Outros Autores: Lima, Murilo Henrique Saturnino de, Braga, Tarcio Teodoro
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/42490
Resumo: Universidade Federal do Paraná. Departamento de Patologia. Curitiba, PR, Brasil.
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spelling Alyaseer, Amani Abraheem AlsadiqLima, Murilo Henrique Saturnino deBraga, Tarcio Teodoro2020-07-31T16:51:58Z2020-07-31T16:51:58Z2020ALYASEER, Amani Abraheem Alsadiq et al. The role of NLRP3 inflammasome activation in the epithelial to mesenchymal transition process during the fibrosis. Frontiers in Immunology, v. 11, n. 883, p. 1-14, 2020.1664-3224https://www.arca.fiocruz.br/handle/icict/4249010.3389/fimmu.2020.008831664-3224porFrontiers MediaNLRP3TGF-BFibrosisNLR Family, Pyrin Domain-Containing 3 ProteinInflammasomesTransforming Growth Factor beta3Proteína con Dominio Pirina 3 de la Familia NLRInflamasomasFactor de Crecimiento Transformador beta3FibroseProteína 3 que Contém Domínio de Pirina da Família NLRInflamassomosFator de Crescimento Transformador beta3The role of NLRP3 inflammasome activation in the epithelial to mesenchymal transition process during the fibrosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Paraná. Departamento de Patologia. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Patologia. Curitiba, PR, Brasil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Patologia. Curitiba, PR, Brasil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Fibrosis is considered a complex form of tissue damage commonly present in the end stage of many diseases. It is also related to a high percentage of death, whose predominant characteristics are an excessive and abnormal deposition of fibroblasts and myofibroblasts -derived extracellular matrix (ECM) components. Epithelial-to-mesenchymal transition (EMT), a process in which epithelial cells gradually change to mesenchymal ones, is a major contributor in the pathogenesis of fibrosis. The key mediator of EMT is a multifunctional cytokine called transforming growth factor-β (TGF-β) that acts as the main inducer of the ECM assembly and remodeling through the phosphorylation of Smad2/3, which ultimately forms a complex with Smad4 and translocates into the nucleus. On the other hand, the bone morphogenic protein-7 (BMP-7), a member of the TGF family, reverses EMT by directly counteracting TGF-β induced Smad-dependent cell signaling. NLRP3 (NACHT, LRR, and PYD domains-containing protein 3), in turn, acts as cytosolic sensors of microbial and self-derived molecules and forms an immune complex called inflammasome in the context of inflammatory commitments. NLRP3 inflammasome assembly is triggered by extracellular ATP, reactive oxygen species (ROS), potassium efflux, calcium misbalance, and lysosome disruption. Due to its involvement in multiple diseases, NLRP3 has become one of the most studied pattern-recognition receptors (PRRs). Nevertheless, the role of NLRP3 in fibrosis development has not been completely elucidated. In this review, we described the relation of the previously mentioned fibrosis pathway with the NLRP3 inflammasome complex formation, especially EMT-related pathways. For now, it is suggested that the EMT happens independently from the oligomerization of the whole inflammasome complex, requiring just the presence of the NLRP3 receptor and the ASC protein to trigger the EMT events, and we will present different pieces of research that give controversial point of views.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/42490/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALfimmu-11-008ok.pdffimmu-11-008ok.pdfapplication/pdf794928https://www.arca.fiocruz.br/bitstream/icict/42490/2/fimmu-11-008ok.pdf8b49d84b9783776bece438536a286b1fMD52TEXTfimmu-11-008ok.pdf.txtfimmu-11-008ok.pdf.txtExtracted texttext/plain89567https://www.arca.fiocruz.br/bitstream/icict/42490/3/fimmu-11-008ok.pdf.txt7f24e3e527d0cb2da727f58a9cd88798MD53icict/424902020-09-06 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dc.title.pt_BR.fl_str_mv The role of NLRP3 inflammasome activation in the epithelial to mesenchymal transition process during the fibrosis
title The role of NLRP3 inflammasome activation in the epithelial to mesenchymal transition process during the fibrosis
spellingShingle The role of NLRP3 inflammasome activation in the epithelial to mesenchymal transition process during the fibrosis
Alyaseer, Amani Abraheem Alsadiq
NLRP3
TGF-B
Fibrosis
NLR Family, Pyrin Domain-Containing 3 Protein
Inflammasomes
Transforming Growth Factor beta3
Proteína con Dominio Pirina 3 de la Familia NLR
Inflamasomas
Factor de Crecimiento Transformador beta3
Fibrose
Proteína 3 que Contém Domínio de Pirina da Família NLR
Inflamassomos
Fator de Crescimento Transformador beta3
title_short The role of NLRP3 inflammasome activation in the epithelial to mesenchymal transition process during the fibrosis
title_full The role of NLRP3 inflammasome activation in the epithelial to mesenchymal transition process during the fibrosis
title_fullStr The role of NLRP3 inflammasome activation in the epithelial to mesenchymal transition process during the fibrosis
title_full_unstemmed The role of NLRP3 inflammasome activation in the epithelial to mesenchymal transition process during the fibrosis
title_sort The role of NLRP3 inflammasome activation in the epithelial to mesenchymal transition process during the fibrosis
author Alyaseer, Amani Abraheem Alsadiq
author_facet Alyaseer, Amani Abraheem Alsadiq
Lima, Murilo Henrique Saturnino de
Braga, Tarcio Teodoro
author_role author
author2 Lima, Murilo Henrique Saturnino de
Braga, Tarcio Teodoro
author2_role author
author
dc.contributor.author.fl_str_mv Alyaseer, Amani Abraheem Alsadiq
Lima, Murilo Henrique Saturnino de
Braga, Tarcio Teodoro
dc.subject.other.pt_BR.fl_str_mv NLRP3
TGF-B
topic NLRP3
TGF-B
Fibrosis
NLR Family, Pyrin Domain-Containing 3 Protein
Inflammasomes
Transforming Growth Factor beta3
Proteína con Dominio Pirina 3 de la Familia NLR
Inflamasomas
Factor de Crecimiento Transformador beta3
Fibrose
Proteína 3 que Contém Domínio de Pirina da Família NLR
Inflamassomos
Fator de Crescimento Transformador beta3
dc.subject.en.pt_BR.fl_str_mv Fibrosis
NLR Family, Pyrin Domain-Containing 3 Protein
Inflammasomes
Transforming Growth Factor beta3
dc.subject.es.pt_BR.fl_str_mv Proteína con Dominio Pirina 3 de la Familia NLR
Inflamasomas
Factor de Crecimiento Transformador beta3
dc.subject.decs.pt_BR.fl_str_mv Fibrose
Proteína 3 que Contém Domínio de Pirina da Família NLR
Inflamassomos
Fator de Crescimento Transformador beta3
description Universidade Federal do Paraná. Departamento de Patologia. Curitiba, PR, Brasil.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-07-31T16:51:58Z
dc.date.available.fl_str_mv 2020-07-31T16:51:58Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALYASEER, Amani Abraheem Alsadiq et al. The role of NLRP3 inflammasome activation in the epithelial to mesenchymal transition process during the fibrosis. Frontiers in Immunology, v. 11, n. 883, p. 1-14, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/42490
dc.identifier.issn.pt_BR.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2020.00883
dc.identifier.eissn.none.fl_str_mv 1664-3224
identifier_str_mv ALYASEER, Amani Abraheem Alsadiq et al. The role of NLRP3 inflammasome activation in the epithelial to mesenchymal transition process during the fibrosis. Frontiers in Immunology, v. 11, n. 883, p. 1-14, 2020.
1664-3224
10.3389/fimmu.2020.00883
url https://www.arca.fiocruz.br/handle/icict/42490
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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