Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/2791 |
Resumo: | Agradecimentos a Dra. Aldina Barral, Dr. Manoel Barral Netto, Dr. MC José Ribeiro, e Ryan Jochim pela revisão crítica deste manuscrito; Ao Dr. Robert Gwadz pelo apoio contínuo; a Sheila Dreher pela construção de DNA dos plasmídeos; Edivaldo Passos pela assistência técnica, e Nancy Shulman pela assistência editorial. |
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Gomes, Regis Bernardo BrandimTeixeira, Clarissa RomeroTeixeira, Maria JâniaOliveira, FabianoMenezes, Maria JoséSilva, ClaireOliveira, Camila Indiani deMiranda, José CarlosElnaiem, Dia-Eldin AKamhawi, ShadenValenzuela, Jesus GBrodskyn, Claudia Ida2011-08-10T13:01:31Z2011-08-10T13:01:31Z2008GOMES, R. et al. Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model. Proceedings of the National Academy of Sciences of the United States of America, v.105, n.22, p.7845-7850, jun. 2008.0027-8424https://www.arca.fiocruz.br/handle/icict/2791Agradecimentos a Dra. Aldina Barral, Dr. Manoel Barral Netto, Dr. MC José Ribeiro, e Ryan Jochim pela revisão crítica deste manuscrito; Ao Dr. Robert Gwadz pelo apoio contínuo; a Sheila Dreher pela construção de DNA dos plasmídeos; Edivaldo Passos pela assistência técnica, e Nancy Shulman pela assistência editorial.Estudo financiado pela Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPQ) e Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes) e em parte pela Divisão de Pesquisa do Instituto Nacional de Alergia e Doenças Infecciosas e dos Institutos Nacionais da Saúde.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Vector Molecular Biology Unit. National Institutes of Health. Twinbrook Parkway, Rockville, MD, USAFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Vector Molecular Biology Unit. National Institutes of Health. Twinbrook Parkway, Rockville, MD, USAFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Vector Molecular Biology Unit. National Institutes of Health. Twinbrook Parkway, Rockville, MD, USAFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilNational Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Vector Molecular Biology Unit. National Institutes of Health. Twinbrook Parkway, Rockville, MD, USANational Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Vector Molecular Biology Unit. National Institutes of Health. Twinbrook Parkway, Rockville, MD, USANational Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Vector Molecular Biology Unit. National Institutes of Health. Twinbrook Parkway, Rockville, MD, USA /Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Instituto de Investigação em Imunologia. Salvador, BA, BrasilVisceral leishmaniasis (VL) is a fatal disease for humans, and no vaccine is currently available. Sand fly salivary proteins have been associated with protection against cutaneous leishmaniasis. To test whether vector salivary proteins can protect against VL, a hamster model was developed involving intradermal inoculation in the ears of 100,000 Leishmania infantum chagasi parasites together with Lutzomyia longipalpis saliva to mimic natural transmission by sand flies. Hamsters developed classical signs of VL rapidly, culminating in a fatal outcome 5–6 months postinfection. Saliva had no effect on the course of infection in this model. Immunization with 16 DNA plasmids coding for salivary proteins of Lu. longipalpis resulted in the identification of LJM19, a novel 11-kDa protein, that protected hamsters against the fatal outcome of VL. LJM19-immunized hamsters maintained a low parasite load that correlated with an overall high IFN- /TGF- ratio and inducible NOS expression in the spleen and liver up to 5 months postinfection. Importantly, a delayed-type hypersensitivity response with high expression of IFN- was also noted in the skin of LJM19-immunized hamsters 48 h after exposure to uninfected sand fly bites. Induction of IFN- at the site of bite could partly explain the protection observed in the viscera of LJM19-immunized hamsters through direct parasite killing and/or priming of anti-Leishmania immunity. We have shown that immunity to a defined salivary protein (LJM19) confers powerful protection against the fatal outcome of a parasitic disease, which reinforces the concept of using components of arthropod saliva in vaccine strategies against vector-borne diseases.engNational Academy of SciencesImunidade AntisalivaLeishmaniaVetor de VacinasAntisaliva ImmunityLeishmaniaSand fly salivaVector-based VaccineAnimaisCricetinaeModelos Animais de DoençasHumanosImunidadeMordeduras e Picadas de InsetosProteínas de InsetosInsetos VetoresInterferon gamaVacinas contra LeishmanioseLeishmaniose VisceralPlasmídeosPsychodidaeProteínas e Peptídeos SalivaresVacinaçãoImmunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster modelinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALGomes_Teixeira_Oliveira_etal.pdfGomes_Teixeira_Oliveira_etal.pdfapplication/pdf699305https://www.arca.fiocruz.br/bitstream/icict/2791/1/Gomes_Teixeira_Oliveira_etal.pdfd753576b000f1975543b95270446226cMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/2791/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTGomes_Teixeira_Oliveira_etal.pdf.txtGomes_Teixeira_Oliveira_etal.pdf.txtExtracted texttext/plain42152https://www.arca.fiocruz.br/bitstream/icict/2791/5/Gomes_Teixeira_Oliveira_etal.pdf.txt75591518e638d1e67897b71b82414998MD55THUMBNAILGomes_Teixeira_Oliveira_etal.pdf.jpgGomes_Teixeira_Oliveira_etal.pdf.jpgGenerated Thumbnailimage/jpeg2568https://www.arca.fiocruz.br/bitstream/icict/2791/4/Gomes_Teixeira_Oliveira_etal.pdf.jpgf2ad5ab0dd82b0a71d30ce558b4783d6MD54icict/27912023-03-15 14:33:18.301oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:18Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model |
title |
Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model |
spellingShingle |
Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model Gomes, Regis Bernardo Brandim Imunidade Antisaliva Leishmania Vetor de Vacinas Antisaliva Immunity Leishmania Sand fly saliva Vector-based Vaccine Animais Cricetinae Modelos Animais de Doenças Humanos Imunidade Mordeduras e Picadas de Insetos Proteínas de Insetos Insetos Vetores Interferon gama Vacinas contra Leishmaniose Leishmaniose Visceral Plasmídeos Psychodidae Proteínas e Peptídeos Salivares Vacinação |
title_short |
Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model |
title_full |
Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model |
title_fullStr |
Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model |
title_full_unstemmed |
Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model |
title_sort |
Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model |
author |
Gomes, Regis Bernardo Brandim |
author_facet |
Gomes, Regis Bernardo Brandim Teixeira, Clarissa Romero Teixeira, Maria Jânia Oliveira, Fabiano Menezes, Maria José Silva, Claire Oliveira, Camila Indiani de Miranda, José Carlos Elnaiem, Dia-Eldin A Kamhawi, Shaden Valenzuela, Jesus G Brodskyn, Claudia Ida |
author_role |
author |
author2 |
Teixeira, Clarissa Romero Teixeira, Maria Jânia Oliveira, Fabiano Menezes, Maria José Silva, Claire Oliveira, Camila Indiani de Miranda, José Carlos Elnaiem, Dia-Eldin A Kamhawi, Shaden Valenzuela, Jesus G Brodskyn, Claudia Ida |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Gomes, Regis Bernardo Brandim Teixeira, Clarissa Romero Teixeira, Maria Jânia Oliveira, Fabiano Menezes, Maria José Silva, Claire Oliveira, Camila Indiani de Miranda, José Carlos Elnaiem, Dia-Eldin A Kamhawi, Shaden Valenzuela, Jesus G Brodskyn, Claudia Ida |
dc.subject.other.pt_BR.fl_str_mv |
Imunidade Antisaliva Leishmania Vetor de Vacinas |
topic |
Imunidade Antisaliva Leishmania Vetor de Vacinas Antisaliva Immunity Leishmania Sand fly saliva Vector-based Vaccine Animais Cricetinae Modelos Animais de Doenças Humanos Imunidade Mordeduras e Picadas de Insetos Proteínas de Insetos Insetos Vetores Interferon gama Vacinas contra Leishmaniose Leishmaniose Visceral Plasmídeos Psychodidae Proteínas e Peptídeos Salivares Vacinação |
dc.subject.en.pt_BR.fl_str_mv |
Antisaliva Immunity Leishmania Sand fly saliva Vector-based Vaccine |
dc.subject.decs.pt_BR.fl_str_mv |
Animais Cricetinae Modelos Animais de Doenças Humanos Imunidade Mordeduras e Picadas de Insetos Proteínas de Insetos Insetos Vetores Interferon gama Vacinas contra Leishmaniose Leishmaniose Visceral Plasmídeos Psychodidae Proteínas e Peptídeos Salivares Vacinação |
description |
Agradecimentos a Dra. Aldina Barral, Dr. Manoel Barral Netto, Dr. MC José Ribeiro, e Ryan Jochim pela revisão crítica deste manuscrito; Ao Dr. Robert Gwadz pelo apoio contínuo; a Sheila Dreher pela construção de DNA dos plasmídeos; Edivaldo Passos pela assistência técnica, e Nancy Shulman pela assistência editorial. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008 |
dc.date.accessioned.fl_str_mv |
2011-08-10T13:01:31Z |
dc.date.available.fl_str_mv |
2011-08-10T13:01:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GOMES, R. et al. Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model. Proceedings of the National Academy of Sciences of the United States of America, v.105, n.22, p.7845-7850, jun. 2008. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/2791 |
dc.identifier.issn.none.fl_str_mv |
0027-8424 |
identifier_str_mv |
GOMES, R. et al. Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of visceral leishmaniasis in a hamster model. Proceedings of the National Academy of Sciences of the United States of America, v.105, n.22, p.7845-7850, jun. 2008. 0027-8424 |
url |
https://www.arca.fiocruz.br/handle/icict/2791 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
National Academy of Sciences |
publisher.none.fl_str_mv |
National Academy of Sciences |
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FIOCRUZ |
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