A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in non human primates.

Detalhes bibliográficos
Autor(a) principal: Oliveira, Fabiano
Data de Publicação: 2015
Outros Autores: Rowton, Edgar, Aslan, Hamide, Gomes, Regis Bernardo Brandim, Castrovinci, Philip A, Alvarenga, Patricia Hessab, Abdeladhim, Maha, Teixeira, Clarissa, Meneses, Claudio, Kleeman, Lindsey T, Costa, Anderson Guimarães Baptista, Rowland, Tobin E, Gilmore, Dana C, Doumbia, Seydou, Reed, Steven G, Lawyer, Philip G, Andersen, John F, Kamhawi, Shaden, Valenzuela, Jesus G
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11200
Resumo: National Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USA
id CRUZ_e23681de4809aa630a0bb0727c7dd7ee
oai_identifier_str oai:www.arca.fiocruz.br:icict/11200
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Oliveira, FabianoRowton, EdgarAslan, HamideGomes, Regis Bernardo BrandimCastrovinci, Philip AAlvarenga, Patricia HessabAbdeladhim, MahaTeixeira, ClarissaMeneses, ClaudioKleeman, Lindsey TCosta, Anderson Guimarães BaptistaRowland, Tobin EGilmore, Dana CDoumbia, SeydouReed, Steven GLawyer, Philip GAndersen, John FKamhawi, ShadenValenzuela, Jesus G2015-07-09T18:35:46Z2015-07-09T18:35:46Z2015OLIVEIRA, F. et al. A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in non human primates. Science Translational Medicine, v. 7, n. 290, p. 290ra90, 2015.1946-6242https://www.arca.fiocruz.br/handle/icict/1120010.1126/scitranslmed.aaa3043engAmerican Association for the Advancement of ScienceLeishmanioseVacinasImunidade celularProteinas salivaresSalivaFlebótomosAnimalLeishmaniose CutâneaLeishmaniose humanaMacacos rhesusA sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in non human primates.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNational Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USAWalter Read Army Institute of Research. Department of Entomology. Silver Spring, MD, USANational Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USANational Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USA / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilNational Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USAUniversidade Federal do Rio de Janeiro. Instituto de Bioquimica Medica. Laboratório de Bioquímica e Resposta ao Estresse. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Rio de Janeiro, RJ, BrasilNational Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USANational Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USA / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilNational Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USANational Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USANational Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USAWalter Read Army Institute of Research. Department of Entomology. Silver Spring, MD, USANational Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USAUniversity of Bamaco. Faculty of Medicine, Pharmacy and Odontostomatology. Bamako, MaliInfection Disease Research Institute. Seattle, WA, USANational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Diyarbakir, TurkeyWalter Read Army Institute of Research. Department of Entomology. Silver Spring, MD, USANational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Diyarbakir, TurkeyNational Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USANational Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USACurrently, there are no commercially available human vaccines against leishmaniasis. In rodents, cellular immunity to salivary proteins of sand fly vectors is associated to protection against leishmaniasis, making them worthy targets for further exploration as vaccines. We demonstrate that nonhuman primates (NHP) exposed to Phlebotomus duboscqi uninfected sand fly bites or immunized with salivary protein PdSP15 are protected against cutaneous leishmaniasis initiated by infected bites. Uninfected sand fly-exposed and 7 of 10 PdSP15-immunized rhesus macaques displayed a significant reduction in disease and parasite burden compared to controls. Protection correlated to the early appearance of Leishmania-specific CD4(+)IFN-γ(+) lymphocytes, suggesting that immunity to saliva or PdSP15 augments the host immune response to the parasites while maintaining minimal pathology. Notably, the 30% unprotected PdSP15-immunized NHP developed neither immunity to PdSP15 nor an accelerated Leishmania-specific immunity. Sera and peripheral blood mononuclear cells from individuals naturally exposed to P. duboscqi bites recognized PdSP15, demonstrating its immunogenicity in humans. PdSP15 sequence and structure show no homology to mammalian proteins, further demonstrating its potential as a component of a vaccine for human leishmaniasis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/11200/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALOliveira F A sandy fly salivary....pdfOliveira F A sandy fly salivary....pdfapplication/pdf1236375https://www.arca.fiocruz.br/bitstream/icict/11200/2/Oliveira%20F%20A%20sandy%20fly%20salivary....pdf321923fe6fa6d90b760b2d9640dfd6f4MD52TEXTOliveira F A sandy fly salivary....pdf.txtOliveira F A sandy fly salivary....pdf.txtExtracted texttext/plain79065https://www.arca.fiocruz.br/bitstream/icict/11200/3/Oliveira%20F%20A%20sandy%20fly%20salivary....pdf.txt7be5c799df845f3762936e94f2dcdabdMD53icict/112002023-03-15 14:33:07.495oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:07Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in non human primates.
title A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in non human primates.
spellingShingle A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in non human primates.
Oliveira, Fabiano
Leishmaniose
Vacinas
Imunidade celular
Proteinas salivares
Saliva
Flebótomos
Animal
Leishmaniose Cutânea
Leishmaniose humana
Macacos rhesus
title_short A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in non human primates.
title_full A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in non human primates.
title_fullStr A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in non human primates.
title_full_unstemmed A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in non human primates.
title_sort A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in non human primates.
author Oliveira, Fabiano
author_facet Oliveira, Fabiano
Rowton, Edgar
Aslan, Hamide
Gomes, Regis Bernardo Brandim
Castrovinci, Philip A
Alvarenga, Patricia Hessab
Abdeladhim, Maha
Teixeira, Clarissa
Meneses, Claudio
Kleeman, Lindsey T
Costa, Anderson Guimarães Baptista
Rowland, Tobin E
Gilmore, Dana C
Doumbia, Seydou
Reed, Steven G
Lawyer, Philip G
Andersen, John F
Kamhawi, Shaden
Valenzuela, Jesus G
author_role author
author2 Rowton, Edgar
Aslan, Hamide
Gomes, Regis Bernardo Brandim
Castrovinci, Philip A
Alvarenga, Patricia Hessab
Abdeladhim, Maha
Teixeira, Clarissa
Meneses, Claudio
Kleeman, Lindsey T
Costa, Anderson Guimarães Baptista
Rowland, Tobin E
Gilmore, Dana C
Doumbia, Seydou
Reed, Steven G
Lawyer, Philip G
Andersen, John F
Kamhawi, Shaden
Valenzuela, Jesus G
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Fabiano
Rowton, Edgar
Aslan, Hamide
Gomes, Regis Bernardo Brandim
Castrovinci, Philip A
Alvarenga, Patricia Hessab
Abdeladhim, Maha
Teixeira, Clarissa
Meneses, Claudio
Kleeman, Lindsey T
Costa, Anderson Guimarães Baptista
Rowland, Tobin E
Gilmore, Dana C
Doumbia, Seydou
Reed, Steven G
Lawyer, Philip G
Andersen, John F
Kamhawi, Shaden
Valenzuela, Jesus G
dc.subject.other.pt_BR.fl_str_mv Leishmaniose
Vacinas
Imunidade celular
Proteinas salivares
Saliva
Flebótomos
Animal
Leishmaniose Cutânea
Leishmaniose humana
Macacos rhesus
topic Leishmaniose
Vacinas
Imunidade celular
Proteinas salivares
Saliva
Flebótomos
Animal
Leishmaniose Cutânea
Leishmaniose humana
Macacos rhesus
description National Institutes of Allergy and Infectious Disease. Laboratory of Malaria and Vector. Vector Molecular Biology Section. Rockville, MD, USA
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-07-09T18:35:46Z
dc.date.available.fl_str_mv 2015-07-09T18:35:46Z
dc.date.issued.fl_str_mv 2015
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, F. et al. A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in non human primates. Science Translational Medicine, v. 7, n. 290, p. 290ra90, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11200
dc.identifier.issn.none.fl_str_mv 1946-6242
dc.identifier.doi.none.fl_str_mv 10.1126/scitranslmed.aaa3043
identifier_str_mv OLIVEIRA, F. et al. A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in non human primates. Science Translational Medicine, v. 7, n. 290, p. 290ra90, 2015.
1946-6242
10.1126/scitranslmed.aaa3043
url https://www.arca.fiocruz.br/handle/icict/11200
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Association for the Advancement of Science
publisher.none.fl_str_mv American Association for the Advancement of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/11200/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/11200/2/Oliveira%20F%20A%20sandy%20fly%20salivary....pdf
https://www.arca.fiocruz.br/bitstream/icict/11200/3/Oliveira%20F%20A%20sandy%20fly%20salivary....pdf.txt
bitstream.checksum.fl_str_mv 8b4c200b4e10021c5683c6ccaba07169
321923fe6fa6d90b760b2d9640dfd6f4
7be5c799df845f3762936e94f2dcdabd
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324642279063552

Registros relacionados