Correlation of antifungal susceptibility and molecular type within the Cryptococcus neoformans/C. gattii species complex

Detalhes bibliográficos
Autor(a) principal: Trilles, Luciana
Data de Publicação: 2012
Outros Autores: Meyer, Wieland, Wanke, Bodo, Guarro, Josep, Lazéra, Marcia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/37104
Resumo: 2020-11-18
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spelling Trilles, LucianaMeyer, WielandWanke, BodoGuarro, JosepLazéra, Marcia2019-11-18T12:37:59Z2019-11-18T12:37:59Z2012TRILLES, Luciana et al. Correlation of antifungal susceptibility and molecular type within the Cryptococcus neoformans/C. gattii species complex. Medical Mycology, v. 50, p. 328-332, Apr. 2012.1369-3786https://www.arca.fiocruz.br/handle/icict/3710410.3109/13693786.2011.6021261460-2709engOxford University PressCorrelation of antifungal susceptibility and molecular type within the Cryptococcus neoformans/C. gattii species complexinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-11-18Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.University of Sydney. Sydney Medical School. Westmead Hospital. Westmead Millennium Institute. Molecular Mycology Research Laboratory. Sydney, NSW, Australia / University of Sydney. Sydney Institute of Emerging Infectious Diseases and Biosecurity. Sydney, NSW, Australia.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universitat Rovira i Virgili. Instituto de Investigación Sanitaria Pere Virgili. Facultat de Medicina i Ciencies de la Salut. Reus, Spain.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Members of the Cryptococcus neoformans/C. gattii species complex are grouped into eight molecular types, differing in their epidemiology, disease severity and geographic range. Recent in vitro antifungal susceptibility studies of isolates of the complex revealed contradictory results. The objective of the present study was to assess if this variation is random or correlates with different molecular types by testing the in vitro antifungal susceptibility of 18 C. neoformans (VNI), 11 C. gattii (VGI) and 38 C. gattii (VGII) strains from Brazil to eight antifungal drugs using the CLSI microdilution method. We herein report that the molecular type VGII is the least susceptible genotype, followed by VGI and VNI. This indicates a clear correlation between antifungal susceptibilities and genotypes of the causative cryptococcosis agents, emphasizing the importance of determining the molecular type as part of the clinical diagnostic process to enable an informed decision as to the most appropriate antifungal treatment.Cryptococcus neoformansCryptococcus gattiiMolecular typesAntifungal susceptibilityinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/37104/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Trilles_Luciana_etal_INI_2012.pdfve_Trilles_Luciana_etal_INI_2012.pdfapplication/pdf124079https://www.arca.fiocruz.br/bitstream/icict/37104/2/ve_Trilles_Luciana_etal_INI_2012.pdf9ead7e1ef4488d38bc7fafa6a3f399ebMD52TEXTve_Trilles_Luciana_etal_INI_2012.pdf.txtve_Trilles_Luciana_etal_INI_2012.pdf.txtExtracted texttext/plain24436https://www.arca.fiocruz.br/bitstream/icict/37104/3/ve_Trilles_Luciana_etal_INI_2012.pdf.txt3bc7b20ff0a1aeb23d8fcfea18ff7183MD53icict/371042021-03-24 16:32:39.275oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:39Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Correlation of antifungal susceptibility and molecular type within the Cryptococcus neoformans/C. gattii species complex
title Correlation of antifungal susceptibility and molecular type within the Cryptococcus neoformans/C. gattii species complex
spellingShingle Correlation of antifungal susceptibility and molecular type within the Cryptococcus neoformans/C. gattii species complex
Trilles, Luciana
Cryptococcus neoformans
Cryptococcus gattii
Molecular types
Antifungal susceptibility
title_short Correlation of antifungal susceptibility and molecular type within the Cryptococcus neoformans/C. gattii species complex
title_full Correlation of antifungal susceptibility and molecular type within the Cryptococcus neoformans/C. gattii species complex
title_fullStr Correlation of antifungal susceptibility and molecular type within the Cryptococcus neoformans/C. gattii species complex
title_full_unstemmed Correlation of antifungal susceptibility and molecular type within the Cryptococcus neoformans/C. gattii species complex
title_sort Correlation of antifungal susceptibility and molecular type within the Cryptococcus neoformans/C. gattii species complex
author Trilles, Luciana
author_facet Trilles, Luciana
Meyer, Wieland
Wanke, Bodo
Guarro, Josep
Lazéra, Marcia
author_role author
author2 Meyer, Wieland
Wanke, Bodo
Guarro, Josep
Lazéra, Marcia
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Trilles, Luciana
Meyer, Wieland
Wanke, Bodo
Guarro, Josep
Lazéra, Marcia
dc.subject.en.pt_BR.fl_str_mv Cryptococcus neoformans
Cryptococcus gattii
Molecular types
Antifungal susceptibility
topic Cryptococcus neoformans
Cryptococcus gattii
Molecular types
Antifungal susceptibility
description 2020-11-18
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2019-11-18T12:37:59Z
dc.date.available.fl_str_mv 2019-11-18T12:37:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TRILLES, Luciana et al. Correlation of antifungal susceptibility and molecular type within the Cryptococcus neoformans/C. gattii species complex. Medical Mycology, v. 50, p. 328-332, Apr. 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/37104
dc.identifier.issn.pt_BR.fl_str_mv 1369-3786
dc.identifier.doi.none.fl_str_mv 10.3109/13693786.2011.602126
dc.identifier.eissn.none.fl_str_mv 1460-2709
identifier_str_mv TRILLES, Luciana et al. Correlation of antifungal susceptibility and molecular type within the Cryptococcus neoformans/C. gattii species complex. Medical Mycology, v. 50, p. 328-332, Apr. 2012.
1369-3786
10.3109/13693786.2011.602126
1460-2709
url https://www.arca.fiocruz.br/handle/icict/37104
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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