Schistosomiasis mansoni and viral B hepatitis in woodchucks.

Detalhes bibliográficos
Autor(a) principal: Andrade, Zilton de Araújo
Data de Publicação: 2001
Outros Autores: Berthillon, Pascale, Paraná, Raymundo, Grimaud, Jean Alexis, Trépo, Christian
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5626
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Andrade, Zilton de AraújoBerthillon, PascaleParaná, RaymundoGrimaud, Jean AlexisTrépo, Christian2012-10-02T21:11:57Z2012-10-02T21:11:57Z2001ANDRADE, Z.A. et al. Schistosomiasis mansoni and viral B hepatitis in woodchucks. Journal of Hepatology, v. 34, n. 1, p. 134-9, jan. 2001.0168-8278S0168-8278(00)00068-4https://www.arca.fiocruz.br/handle/icict/5626engSchistosomiasis mansoni and viral B hepatitis in woodchucks.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasill'Institut National de la Santé et de la Recherche Médicale. Lyon, FranceUniversity of Bahia. Faculty of Medicine. Salvador, BA, Brasill'Institut National de la Santé et de la Recherche Médicale. Lyon, Francel'Institut National de la Santé et de la Recherche Médicale. Lyon, FranceBACKGROUND/AIMS: An interaction between human schistosomiasis and viral hepatitis B has often been suggested, but never established. The experimental investigation has been hampered by the lack of a suitable model. Only woodchucks are susceptible to both Schistosoma mansoni and a B-like hepatitis virus (WHV) infections. This study explores the relevance of this unique model regarding hepatitis/schistosomiasis interactions. METHODS: Woodchucks (Marmota monax and Marmota marmota) were infected with: (a), S. mansoni; (b), WHV; or (c), both S. mansoni and WHV. RESULTS: Following the experimental parasitic infection of woodchucks, with or without WHV, schistosomiasis presented a peculiar and severe course in early infection, involving mostly the intestines. Subsequently, the intestinal and hepatic lesions underwent considerable modulation and the periovular granulomas decreased in size and number, while the parasitic infection tended to self-cure within the 9 months following infection. Nine woodchucks inoculated with the hepatitis virus alone presented with several degrees of acute and chronic hepatitis, with one of them dying of hepatocarcinoma 1 year after inoculation. Four woodchucks with concomitant viral and schistosome infections presented with a simple additive pattern of lesions, without any evidence of modification or aggravation of either one of the two infections. Similarly, no significant impact of schistosomiasis on WHV serum markers could be seen. CONCLUSIONS: Schistosomiasis and viral hepatitis in woodchucks run parallel courses, with neither apparent special histological features derived from the association of the two conditions, nor modulation of WHV replication. Schistosomiasis itself, however, was observed to run a peculiar course in the woodchuck. The present data are important for consideration in further experiments exploring the interplay between schistosomiasis and viral hepatitis induced liver damage in this unique experimental hostViral B hepatitisSchistosomiasis mansoniWoodchucksVírus da Hepatite B da MarmotaHepatite B/patologiaEsquistossomose mansoni/patologiaAnimaisDNA Viral/análiseModelos Animais de DoençasSuscetibilidade a DoençasFemininoHepatite B/etiologiaFígado/patologiaMasculinoMarmotaEsquistossomose mansoni/virologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade ZA Schistosomiasis mansoni ....pdfAndrade ZA Schistosomiasis mansoni ....pdfapplication/pdf453947https://www.arca.fiocruz.br/bitstream/icict/5626/1/Andrade%20ZA%20Schistosomiasis%20mansoni%20....pdfcd321b681184a0d06941591cedca82abMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5626/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTAndrade ZA Schistosomiasis mansoni ....pdf.txtAndrade ZA Schistosomiasis mansoni ....pdf.txtExtracted texttext/plain25123https://www.arca.fiocruz.br/bitstream/icict/5626/5/Andrade%20ZA%20Schistosomiasis%20mansoni%20....pdf.txt743601cb3d7680f1cd9286490ed3f875MD55THUMBNAILAndrade ZA Schistosomiasis mansoni ....pdf.jpgAndrade ZA Schistosomiasis mansoni ....pdf.jpgGenerated Thumbnailimage/jpeg2393https://www.arca.fiocruz.br/bitstream/icict/5626/4/Andrade%20ZA%20Schistosomiasis%20mansoni%20....pdf.jpg77bda38b3c3400754c594cefaf24091bMD54icict/56262023-03-15 14:33:13.673oai:www.arca.fiocruz.br:icict/5626TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGFzc2luYXIgZSBlbnRyZWdhciBlc3RhIGxpY2Vuw6dhLCBvL2EgU3IuL1NyYS4gKGF1dG9yIG91IGRldGVudG9yIGRvcyBkaXJlaXRvcyBkbyBhdXRvcik6CgpBbyBjb25jb3JkYXIgZSBhY2VpdGFyIGVzdGEgbGljZW7Dp2Egdm9jw6ogKGF1dG9yIG91IGRldGVudG9yIGRvcyBkaXJlaXRvcyBhdXRvcmFpcyk6CgphKSBEZWNsYXJhIHF1ZSBjb25oZWNlIGEgcG9sw610aWNhIGRlIGNvcHlyaWdodCBkYSBlZGl0b3JhIGRvIHNldSBkb2N1bWVudG8uCgpiKSBEZWNsYXJhIHF1ZSBjb25oZWNlIGUgYWNlaXRhIGFzIERpcmV0cml6ZXMgcGFyYSBvIFJlcG9zaXTDs3JpbyBJbnN0aXR1Y2lvbmFsIGRhIEZ1bmRhw6fDo28gT3N3YWxkbyBDcnV6IChGSU9DUlVaKS4KCmMpIENvbmNlZGUgw6AgRklPQ1JVWiBvIGRpcmVpdG8gbsOjby1leGNsdXNpdm8gZGUgYXJxdWl2YXIsIHJlcHJvZHV6aXIsIGNvbnZlcnRlciAoY29tbyBkZWZpbmlkbyBhIHNlZ3VpciksIGNvbXVuaWNhcgogCmUvb3UgZGlzdHJpYnVpciBubyBSZXBvc2l0w7NyaW8gZGEgRklPQ1JVWiwgbyBkb2N1bWVudG8gZW50cmVndWUgKGluY2x1aW5kbyBvIHJlc3Vtby9hYnN0cmFjdCkgZW0gZm9ybWF0byBkaWdpdGFsIG91IAoKcG9yIHF1YWxxdWVyIG91dHJvIG1laW8uCgpkKSBEZWNsYXJhIHF1ZSBhdXRvcml6YSBhIEZJT0NSVVogYSBhcnF1aXZhciBtYWlzIGRlIHVtYSBjw7NwaWEgZGVzdGUgZG9jdW1lbnRvIGUgY29udmVydMOqLWxvLCBzZW0gYWx0ZXJhciBvIHNldSBjb250ZcO6ZG8sIAoKcGFyYSBxdWFscXVlciBmb3JtYXRvIGRlIGFycXVpdm8sIG1laW8gb3Ugc3Vwb3J0ZSwgcGFyYSBlZmVpdG9zIGRlIHNlZ3VyYW7Dp2EsIHByZXNlcnZhw6fDo28gKGJhY2t1cCkgZSBhY2Vzc28uCgplKSBEZWNsYXJhIHF1ZSBvIGRvY3VtZW50byBzdWJtZXRpZG8gw6kgbyBzZXUgdHJhYmFsaG8gb3JpZ2luYWwsIGUgcXVlIGRldMOpbSBvIGRpcmVpdG8gZGUgY29uY2VkZXIgYSB0ZXJjZWlyb3Mgb3MgZGlyZWl0b3MgCgpjb250aWRvcyBuZXN0YSBsaWNlbsOnYS4gRGVjbGFyYSB0YW1iw6ltIHF1ZSBhIGVudHJlZ2EgZG8gZG9jdW1lbnRvIG7Do28gaW5mcmluZ2Ugb3MgZGlyZWl0b3MgZGUgcXVhbHF1ZXIgb3V0cmEgcGVzc29hIG91IGVudGlkYWRlLgoKZikgRGVjbGFyYSBxdWUsIG5vIGNhc28gZG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyBjb250ZXIgbWF0ZXJpYWwgZG8gcXVhbCBuw6NvIGRldMOpbSBvcyBkaXJlaXRvcyBkZSBhdXRvciwgb2J0ZXZlIGEgYXV0b3JpemHDp8OjbyAKCmlycmVzdHJpdGEgZG8gcmVzcGVjdGl2byBkZXRlbnRvciBkZXNzZXMgZGlyZWl0b3MsIHBhcmEgY2VkZXIgYSBGSU9DUlVaIG9zIGRpcmVpdG9zIHJlcXVlcmlkb3MgcG9yIGVzdGEgTGljZW7Dp2EgZSBhdXRvcml6YXIgYSAKCnV0aWxpesOhLWxvcyBsZWdhbG1lbnRlLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGVzc2UgbWF0ZXJpYWwgY3Vqb3MgZGlyZWl0b3Mgc8OjbyBkZSB0ZXJjZWlyb3MgZXN0w6EgY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyAKCm5vIHRleHRvIG91IGNvbnRlw7pkbyBkbyBkb2N1bWVudG8gZW50cmVndWUuCgpnKSBTRSBPIERPQ1VNRU5UTyBFTlRSRUdVRSDDiSBCQVNFQURPIEVNIFRSQUJBTEhPIEZJTkFOQ0lBRE8gT1UgQVBPSUFETyBQT1IgT1VUUkEgSU5TVElUVUnDh8ODTyBRVUUgTsODTyBBIEZJT0NSVVosIERFQ0xBUkEgUVVFIENVTVBSSVUgCgpRVUFJU1FVRVIgT0JSSUdBw4fDlUVTIEVYSUdJREFTIFBFTE8gUkVTUEVDVElWTyBDT05UUkFUTyBPVSBBQ09SRE8uIEEgRklPQ1JVWiBpZGVudGlmaWNhcsOhIGNsYXJhbWVudGUgbyhzKSBub21lKHMpIGRvKHMpIGF1dG9yKGVzKSBkb3MgCgpkaXJlaXRvcyBkbyBkb2N1bWVudG8gZW50cmVndWUgZSBuw6NvIGZhcsOhIHF1YWxxdWVyIGFsdGVyYcOnw6NvLCBwYXJhIGFsw6ltIGRvIHByZXZpc3RvIG5hIGFsw61uZWEgYykuCg==Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:13Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Schistosomiasis mansoni and viral B hepatitis in woodchucks.
title Schistosomiasis mansoni and viral B hepatitis in woodchucks.
spellingShingle Schistosomiasis mansoni and viral B hepatitis in woodchucks.
Andrade, Zilton de Araújo
Viral B hepatitis
Schistosomiasis mansoni
Woodchucks
Vírus da Hepatite B da Marmota
Hepatite B/patologia
Esquistossomose mansoni/patologia
Animais
DNA Viral/análise
Modelos Animais de Doenças
Suscetibilidade a Doenças
Feminino
Hepatite B/etiologia
Fígado/patologia
Masculino
Marmota
Esquistossomose mansoni/virologia
title_short Schistosomiasis mansoni and viral B hepatitis in woodchucks.
title_full Schistosomiasis mansoni and viral B hepatitis in woodchucks.
title_fullStr Schistosomiasis mansoni and viral B hepatitis in woodchucks.
title_full_unstemmed Schistosomiasis mansoni and viral B hepatitis in woodchucks.
title_sort Schistosomiasis mansoni and viral B hepatitis in woodchucks.
author Andrade, Zilton de Araújo
author_facet Andrade, Zilton de Araújo
Berthillon, Pascale
Paraná, Raymundo
Grimaud, Jean Alexis
Trépo, Christian
author_role author
author2 Berthillon, Pascale
Paraná, Raymundo
Grimaud, Jean Alexis
Trépo, Christian
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Zilton de Araújo
Berthillon, Pascale
Paraná, Raymundo
Grimaud, Jean Alexis
Trépo, Christian
dc.subject.en.pt_BR.fl_str_mv Viral B hepatitis
Schistosomiasis mansoni
Woodchucks
topic Viral B hepatitis
Schistosomiasis mansoni
Woodchucks
Vírus da Hepatite B da Marmota
Hepatite B/patologia
Esquistossomose mansoni/patologia
Animais
DNA Viral/análise
Modelos Animais de Doenças
Suscetibilidade a Doenças
Feminino
Hepatite B/etiologia
Fígado/patologia
Masculino
Marmota
Esquistossomose mansoni/virologia
dc.subject.decs.pt_BR.fl_str_mv Vírus da Hepatite B da Marmota
Hepatite B/patologia
Esquistossomose mansoni/patologia
Animais
DNA Viral/análise
Modelos Animais de Doenças
Suscetibilidade a Doenças
Feminino
Hepatite B/etiologia
Fígado/patologia
Masculino
Marmota
Esquistossomose mansoni/virologia
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2012-10-02T21:11:57Z
dc.date.available.fl_str_mv 2012-10-02T21:11:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv ANDRADE, Z.A. et al. Schistosomiasis mansoni and viral B hepatitis in woodchucks. Journal of Hepatology, v. 34, n. 1, p. 134-9, jan. 2001.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5626
dc.identifier.issn.none.fl_str_mv 0168-8278
dc.identifier.other.none.fl_str_mv S0168-8278(00)00068-4
identifier_str_mv ANDRADE, Z.A. et al. Schistosomiasis mansoni and viral B hepatitis in woodchucks. Journal of Hepatology, v. 34, n. 1, p. 134-9, jan. 2001.
0168-8278
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url https://www.arca.fiocruz.br/handle/icict/5626
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