Schistosomiasis mansoni and viral B hepatitis in woodchucks

Detalhes bibliográficos
Autor(a) principal: Andrade, Zilton de Araújo
Data de Publicação: 2001
Outros Autores: Berthillon, Pascale, Paraná, Raymundo, Grimaud, Jean Alexis, Trepo, Christian
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7772
Resumo: Texto completo: acesso restrito. p.134–139
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spelling Andrade, Zilton de AraújoBerthillon, PascaleParaná, RaymundoGrimaud, Jean AlexisTrepo, ChristianAndrade, Zilton de AraújoBerthillon, PascaleParaná, RaymundoGrimaud, Jean AlexisTrepo, Christian2013-01-07T16:00:02Z20010168-8278http://www.repositorio.ufba.br/ri/handle/ri/7772v. 34, n. 1Texto completo: acesso restrito. p.134–139Background/Aims: An interaction between human schistosomiasis and viral hepatitis B has often been suggested, but never established. The experimental investigation has been hampered by the lack of a suitable model. Only woodchucks are susceptible to both Schistosoma mansoni and a B-like hepatitis virus (WHV) infections. This study explores the relevance of this unique model regarding hepatitis/schistosomiasis interactions. Methods: Woodchucks (Marmota monax and Marmota marmota) were infected with: (a), S. mansoni; (b), WHV; or (c), both S. mansoni and WHV. Results: Following the experimental parasitic infection of woodchucks, with or without WHV, schistosomiasis presented a peculiar and severe course in early infection, involving mostly the intestines. Subsequently, the intestinal and hepatic lesions underwent considerable modulation and the periovular granulomas decreased in size and number, while the parasitic infection tended to self-cure within the 9 months following infection. Nine woodchucks inoculated with the hepatitis virus alone presented with several degrees of acute and chronic hepatitis, with one of them dying of hepatocarcinoma 1 year after inoculation. Four woodchucks with concomitant viral and schistosome infections presented with a simple additive pattern of lesions, without any evidence of modification or aggravation of either one of the two infections. Similarly, no significant impact of schistosomiasis on WHV serum markers could be seen. Conclusions: Schistosomiasis and viral hepatitis in woodchucks run parallel courses, with neither apparent special histological features derived from the association of the two conditions, nor modulation of WHV replication. Schistosomiasis itself, however, was observed to run a peculiar course in the woodchuck. The present data are important for consideration in further experiments exploring the interplay between schistosomiasis and viral hepatitis induced liver damage in this unique experimental host.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2013-01-07T16:00:02Z No. of bitstreams: 1 Andrade.pdf: 453947 bytes, checksum: cd321b681184a0d06941591cedca82ab (MD5)Made available in DSpace on 2013-01-07T16:00:02Z (GMT). No. of bitstreams: 1 Andrade.pdf: 453947 bytes, checksum: cd321b681184a0d06941591cedca82ab (MD5) Previous issue date: 2001http://dx.doi.org/10.1016/S0168-8278(00)00068-4reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAViral B hepatitisSchistosomiasis mansoniWoodchucksSchistosomiasis mansoni and viral B hepatitis in woodchucksJournal of Hepatologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALAndrade.pdfAndrade.pdfapplication/pdf453947https://repositorio.ufba.br/bitstream/ri/7772/1/Andrade.pdfcd321b681184a0d06941591cedca82abMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7772/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTAndrade.pdf.txtAndrade.pdf.txtExtracted texttext/plain25082https://repositorio.ufba.br/bitstream/ri/7772/3/Andrade.pdf.txtca4820c3d590ad0f83193f2c5d1096f6MD53ri/77722022-07-05 14:04:04.485oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:04:04Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Schistosomiasis mansoni and viral B hepatitis in woodchucks
dc.title.alternative.pt_BR.fl_str_mv Journal of Hepatology
title Schistosomiasis mansoni and viral B hepatitis in woodchucks
spellingShingle Schistosomiasis mansoni and viral B hepatitis in woodchucks
Andrade, Zilton de Araújo
Viral B hepatitis
Schistosomiasis mansoni
Woodchucks
title_short Schistosomiasis mansoni and viral B hepatitis in woodchucks
title_full Schistosomiasis mansoni and viral B hepatitis in woodchucks
title_fullStr Schistosomiasis mansoni and viral B hepatitis in woodchucks
title_full_unstemmed Schistosomiasis mansoni and viral B hepatitis in woodchucks
title_sort Schistosomiasis mansoni and viral B hepatitis in woodchucks
author Andrade, Zilton de Araújo
author_facet Andrade, Zilton de Araújo
Berthillon, Pascale
Paraná, Raymundo
Grimaud, Jean Alexis
Trepo, Christian
author_role author
author2 Berthillon, Pascale
Paraná, Raymundo
Grimaud, Jean Alexis
Trepo, Christian
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Zilton de Araújo
Berthillon, Pascale
Paraná, Raymundo
Grimaud, Jean Alexis
Trepo, Christian
Andrade, Zilton de Araújo
Berthillon, Pascale
Paraná, Raymundo
Grimaud, Jean Alexis
Trepo, Christian
dc.subject.por.fl_str_mv Viral B hepatitis
Schistosomiasis mansoni
Woodchucks
topic Viral B hepatitis
Schistosomiasis mansoni
Woodchucks
description Texto completo: acesso restrito. p.134–139
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2013-01-07T16:00:02Z
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dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7772
dc.identifier.issn.none.fl_str_mv 0168-8278
dc.identifier.number.pt_BR.fl_str_mv v. 34, n. 1
identifier_str_mv 0168-8278
v. 34, n. 1
url http://www.repositorio.ufba.br/ri/handle/ri/7772
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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