Reply to "CSF Cytokine Profiles Do Not Reliably Delineate Encephalopathy and Inflammation in Neuro-COVID"

Detalhes bibliográficos
Autor(a) principal: Espíndola, Otávio M.
Data de Publicação: 2021
Outros Autores: Gomes, Yago C. P., Lima, Marco Antonio S. D., Leite, Ana Claudia C. B., Araujo, Abelardo Q. C., Silva, Marcus Tulius T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50514
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
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spelling Espíndola, Otávio M.Gomes, Yago C. P.Lima, Marco Antonio S. D.Leite, Ana Claudia C. B.Araujo, Abelardo Q. C.Silva, Marcus Tulius T.2021-12-21T23:51:04Z2021-12-21T23:51:04Z2021ESPÍNDOLA, Otávio M. et al. Reply to "CSF Cytokine Profiles Do Not Reliably Delineate Encephalopathy and Inflammation in Neuro-COVID". Annals of Neurology, v. 90, n. 4, p. 1-2, 2021.0364-5134https://www.arca.fiocruz.br/handle/icict/5051410.1002/ana.26193engWileyReply to "CSF Cytokine Profiles Do Not Reliably Delineate Encephalopathy and Inflammation in Neuro-COVID"info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Serviço de Neurologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto Deolindo Couto de Neurologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Serviço de Neurologia do Complexo Hospitalar de Niterói. Niterói, RJ, Brasil.Patients presented diverse cerebrospinal fluid (CSF) profiles regarding markers of neuroinflammation and neurodegeneration, and biochemical and cellular findings, even among patients with the same neurological condition. The same applied to inflammatory cytokines. On average, CSF and serum cytokine patterns were distinct, which underscored the chronology of events triggering neurological manifestations. CSF elevation of cytokines in inflammatory neurological diseases (IND) did not reflect a respective increase in serum. Conversely, encephalopathy was associated with higher serum interleukin 6, C-X-C motif chemokine ligand 8 (CXCL8), and transforming growth factor β1 levels, but cytokines in the CSF did not differ from controls in most cases.COVID-19Cerebrospinal fluidNeuroinflammationNeurodegenerationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/50514/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALCSF_Otavio_Espindola_etal_INI_2021.pdfCSF_Otavio_Espindola_etal_INI_2021.pdfapplication/pdf85882https://www.arca.fiocruz.br/bitstream/icict/50514/2/CSF_Otavio_Espindola_etal_INI_2021.pdffe30da7197cea0dfe0712dc98843fc2dMD52icict/505142023-02-25 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dc.title.pt_BR.fl_str_mv Reply to "CSF Cytokine Profiles Do Not Reliably Delineate Encephalopathy and Inflammation in Neuro-COVID"
title Reply to "CSF Cytokine Profiles Do Not Reliably Delineate Encephalopathy and Inflammation in Neuro-COVID"
spellingShingle Reply to "CSF Cytokine Profiles Do Not Reliably Delineate Encephalopathy and Inflammation in Neuro-COVID"
Espíndola, Otávio M.
COVID-19
Cerebrospinal fluid
Neuroinflammation
Neurodegeneration
title_short Reply to "CSF Cytokine Profiles Do Not Reliably Delineate Encephalopathy and Inflammation in Neuro-COVID"
title_full Reply to "CSF Cytokine Profiles Do Not Reliably Delineate Encephalopathy and Inflammation in Neuro-COVID"
title_fullStr Reply to "CSF Cytokine Profiles Do Not Reliably Delineate Encephalopathy and Inflammation in Neuro-COVID"
title_full_unstemmed Reply to "CSF Cytokine Profiles Do Not Reliably Delineate Encephalopathy and Inflammation in Neuro-COVID"
title_sort Reply to "CSF Cytokine Profiles Do Not Reliably Delineate Encephalopathy and Inflammation in Neuro-COVID"
author Espíndola, Otávio M.
author_facet Espíndola, Otávio M.
Gomes, Yago C. P.
Lima, Marco Antonio S. D.
Leite, Ana Claudia C. B.
Araujo, Abelardo Q. C.
Silva, Marcus Tulius T.
author_role author
author2 Gomes, Yago C. P.
Lima, Marco Antonio S. D.
Leite, Ana Claudia C. B.
Araujo, Abelardo Q. C.
Silva, Marcus Tulius T.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Espíndola, Otávio M.
Gomes, Yago C. P.
Lima, Marco Antonio S. D.
Leite, Ana Claudia C. B.
Araujo, Abelardo Q. C.
Silva, Marcus Tulius T.
dc.subject.en.pt_BR.fl_str_mv COVID-19
Cerebrospinal fluid
Neuroinflammation
Neurodegeneration
topic COVID-19
Cerebrospinal fluid
Neuroinflammation
Neurodegeneration
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-12-21T23:51:04Z
dc.date.available.fl_str_mv 2021-12-21T23:51:04Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ESPÍNDOLA, Otávio M. et al. Reply to "CSF Cytokine Profiles Do Not Reliably Delineate Encephalopathy and Inflammation in Neuro-COVID". Annals of Neurology, v. 90, n. 4, p. 1-2, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50514
dc.identifier.issn.pt_BR.fl_str_mv 0364-5134
dc.identifier.doi.none.fl_str_mv 10.1002/ana.26193
identifier_str_mv ESPÍNDOLA, Otávio M. et al. Reply to "CSF Cytokine Profiles Do Not Reliably Delineate Encephalopathy and Inflammation in Neuro-COVID". Annals of Neurology, v. 90, n. 4, p. 1-2, 2021.
0364-5134
10.1002/ana.26193
url https://www.arca.fiocruz.br/handle/icict/50514
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50514/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50514/2/CSF_Otavio_Espindola_etal_INI_2021.pdf
bitstream.checksum.fl_str_mv 586c046dcfeef936e32f0323bb9a47c0
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MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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