Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases

Detalhes bibliográficos
Autor(a) principal: Lagente, Vincent
Data de Publicação: 2005
Outros Autores: Martin-Chouly, Corinne, Boichot, Elisabeth, Martins, Marco A., Silva, Patrica M. R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/37742
Resumo: Université de Rennes. Faculté de Pharmacie. Rennes, France.
id CRUZ_54387d69b3f0ed8f8d6695828423d45e
oai_identifier_str oai:www.arca.fiocruz.br:icict/37742
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Lagente, VincentMartin-Chouly, CorinneBoichot, ElisabethMartins, Marco A.Silva, Patrica M. R.2019-12-10T13:20:09Z2019-12-10T13:20:09Z2005LAGENTE, Vincent et al. Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, Suppl. 1, p. 131-136, 2005.0074-0206https://www.arca.fiocruz.br/handle/icict/3774210.1590/s0074-027620050009000231678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzTipo de fosfodiesterase 4InflamaçãoDoenças das vias aéreasPhosphodiesterase type4InflammationAirway diseasesSelective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversité de Rennes. Faculté de Pharmacie. Rennes, France.Université de Rennes. Faculté de Pharmacie. Rennes, France.Université de Rennes. Faculté de Pharmacie. Rennes, France.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Phosphodiesterases (PDEs) are responsible for the breakdown of intracellular cyclic nucleotides, from which PDE4 are the major cyclic AMP metabolizing isoenzymes found in inflammatory and immune cells. This generated greatest interest on PDE4 as a potential target to treat lung inflammatory diseases. For example, cigarette smoke-induced neutrophilia in BAL was dose and time dependently reduced by cilomilast. Beside the undesired side effects associated with the first generation of PDE4 inhibitors, the second generation of selective inhibitors such as cilomilast and roflumilast showed clinical efficacy in asthma and chronic obstructive pulmonary diseases trials, thus re-enhancing the interest on these classes of compounds. However, the ability of PDE4 inhibitors to prevent or modulate the airway remodelling remains relatively unexplored. We demonstrated that selective PDE4 inhibitor RP 73-401 reduced matrix metalloproteinase (MMP)-9 activity and TGF-beta1 release during LPS-induced lung injury in mice and that CI-1044 inhibited the production of MMP-1 and MMP-2 from human lung fibroblasts stimulated by pro-inflammatory cytokines. Since inflammatory diseases of the bronchial airways are associated with destruction of normal tissue structure, our data suggest a therapeutic benefit for PDE4 inhibitors in tissue remodelling associated with chronic lung diseases.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/37742/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPatriciaMRSilva_MarcoAMartins_etal_IOC_2005.pdfPatriciaMRSilva_MarcoAMartins_etal_IOC_2005.pdfapplication/pdf37877https://www.arca.fiocruz.br/bitstream/icict/37742/2/PatriciaMRSilva_MarcoAMartins_etal_IOC_2005.pdf34193efa72a0db960588c0cdfcfafd86MD52TEXTPatriciaMRSilva_MarcoAMartins_etal_IOC_2005.pdf.txtPatriciaMRSilva_MarcoAMartins_etal_IOC_2005.pdf.txtExtracted texttext/plain31588https://www.arca.fiocruz.br/bitstream/icict/37742/3/PatriciaMRSilva_MarcoAMartins_etal_IOC_2005.pdf.txt3de3b219d5f150dca2b870fde346dd52MD53icict/377422019-12-11 02:10:23.69oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-12-11T05:10:23Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases
title Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases
spellingShingle Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases
Lagente, Vincent
Tipo de fosfodiesterase 4
Inflamação
Doenças das vias aéreas
Phosphodiesterase type4
Inflammation
Airway diseases
title_short Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases
title_full Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases
title_fullStr Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases
title_full_unstemmed Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases
title_sort Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases
author Lagente, Vincent
author_facet Lagente, Vincent
Martin-Chouly, Corinne
Boichot, Elisabeth
Martins, Marco A.
Silva, Patrica M. R.
author_role author
author2 Martin-Chouly, Corinne
Boichot, Elisabeth
Martins, Marco A.
Silva, Patrica M. R.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Lagente, Vincent
Martin-Chouly, Corinne
Boichot, Elisabeth
Martins, Marco A.
Silva, Patrica M. R.
dc.subject.other.pt_BR.fl_str_mv Tipo de fosfodiesterase 4
Inflamação
Doenças das vias aéreas
topic Tipo de fosfodiesterase 4
Inflamação
Doenças das vias aéreas
Phosphodiesterase type4
Inflammation
Airway diseases
dc.subject.en.pt_BR.fl_str_mv Phosphodiesterase type4
Inflammation
Airway diseases
description Université de Rennes. Faculté de Pharmacie. Rennes, France.
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2019-12-10T13:20:09Z
dc.date.available.fl_str_mv 2019-12-10T13:20:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LAGENTE, Vincent et al. Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, Suppl. 1, p. 131-136, 2005.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/37742
dc.identifier.issn.pt_BR.fl_str_mv 0074-0206
dc.identifier.doi.none.fl_str_mv 10.1590/s0074-02762005000900023
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv LAGENTE, Vincent et al. Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, Suppl. 1, p. 131-136, 2005.
0074-0206
10.1590/s0074-02762005000900023
1678-8060
url https://www.arca.fiocruz.br/handle/icict/37742
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/37742/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/37742/2/PatriciaMRSilva_MarcoAMartins_etal_IOC_2005.pdf
https://www.arca.fiocruz.br/bitstream/icict/37742/3/PatriciaMRSilva_MarcoAMartins_etal_IOC_2005.pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
34193efa72a0db960588c0cdfcfafd86
3de3b219d5f150dca2b870fde346dd52
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324767380471808

Registros relacionados