An Immunomics Approach to Schistosome Antigen Discovery: Antibody Signatures of Naturally Resistant and Chronically Infected Individuals from Endemic Areas
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/50569 |
Resumo: | Centre for Biodiscovery and Molecular Development of Therapeutics. Australian Institute of Tropical Health and Medicine. Queensland Tropical Health Alliance Laboratory. James Cook University. Cairns, Queensland, Australia/ Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Manaus, AM, Brasil/ Fundação Oswaldo Cruz. Centro de Pesquisas René RachouBelo Horizonte, MG, Brazil |
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Jangola, Soraya Torres GazeDriguez, PatrickPearson, Mark S.Mendes, TiagoDoolan, Denise L.Trieu, AngelaMcManus, Donald P.Gobert, Geoffrey N.Periago, Maria VictoriaOliveira, Rodrigo Correa deCardoso, Fernanda C.Oliveira, Guilherme Corrêa deNakajima, RieJasinskas, AlHung, ChrisLiang, LiPablo, JozelynBethony, Jeffrey MichaelFelgner, Philip L.Loukas, Alex2021-12-29T18:03:44Z2021-12-29T18:03:44Z2014JANGOLA, Soraya Torres Gaze et al. An Immunomics Approach to Schistosome Antigen Discovery: Antibody Signatures of Naturally Resistant and Chronically Infected Individuals from Endemic Areas. PLoS Pathog., v. 10, n. 3, p. e1004033, 2014. doi: 10.1371/journal.ppat.10040331553-7366https://www.arca.fiocruz.br/handle/icict/5056910.1371/journal.ppat.1004033engPublic Library of ScienceEsquistossomoseáreas endemicasAn Immunomics Approach to Schistosome Antigen Discovery: Antibody Signatures of Naturally Resistant and Chronically Infected Individuals from Endemic Areasinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCentre for Biodiscovery and Molecular Development of Therapeutics. Australian Institute of Tropical Health and Medicine. Queensland Tropical Health Alliance Laboratory. James Cook University. Cairns, Queensland, Australia/ Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Manaus, AM, Brasil/ Fundação Oswaldo Cruz. Centro de Pesquisas René RachouBelo Horizonte, MG, BrazilQIMR Berghofer Medical Research Institute. Brisbane, Queensland, AustraliaCentre for Biodiscovery and Molecular Development of Therapeutics. Australian Institute of Tropical Health and Medicine. Queensland Tropical Health Alliance Laboratory. James Cook University. Cairns, Queensland, AustraliaFederal University of Minas Gerais. Belo Horizonte, MG, BrazilQIMR Berghofer Medical Research Institute. Brisbane, Queensland, AustraliaQIMR Berghofer Medical Research Institute, Brisbane, Queensland, AustraliaQIMR Berghofer Medical Research Institute. Brisbane, Queensland, AustraliaQIMR Berghofer Medical Research Institute. Brisbane, Queensland, AustraliaInstituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Manaus, AM, Brasil/ Fundação Oswaldo Cruz. Centro de Pesquisas René RachouBelo Horizonte, MG, BrazilInstituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Manaus, AM, Brasil/ Fundação Oswaldo Cruz. Centro de Pesquisas René RachouBelo Horizonte, MG, BrazilQIMR Berghofer Medical Research Institute, Brisbane. Queensland, Australia/ Institute for Molecular Biosciences. The University of Queensland. St Lucia, Queensland, AustraliaInstituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Manaus, AM, Brasil/ Fundação Oswaldo Cruz. Centro de Pesquisas René RachouBelo Horizonte, MG, BrazilUniversity of California Irvine, Irvine, California, United States of AmericaUniversity of California Irvine. Irvine, California, United States of AmericaUniversity of California Irvine. Irvine, California, United States of AmericaUniversity of California Irvine,.Irvine, California, United States of AmericaUniversity of California Irvine. Irvine, California, United States of AmericaGeorge Washington University. Washington, D.C., United States of AmericaUniversity of California Irvine, Irvine, California, United States of AmericaCentre for Biodiscovery and Molecular Development of Therapeutics. Australian Institute of Tropical Health and Medicine. Queensland Tropical Health /Alliance Laboratory. James Cook University, Cairns. Queensland, AustraliaSchistosomiasis is a neglected tropical disease that is responsible for almost 300,000 deaths annually. Mass drug administration (MDA) is used worldwide for the control of schistosomiasis, but chemotherapy fails to prevent reinfection with schistosomes, so MDA alone is not sufficient to eliminate the disease, and a prophylactic vaccine is required. Herein, we take advantage of recent advances in systems biology and longitudinal studies in schistosomiasis endemic areas in Brazil to pilot an immunomics approach to the discovery of schistosomiasis vaccine antigens. We selected mostly surface-derived proteins, produced them using an in vitro rapid translation system and then printed them to generate the first protein microarray for a multi-cellular pathogen. Using well-established Brazilian cohorts of putatively resistant (PR) and chronically infected (CI) individuals stratified by the intensity of their S. mansoni infection, we probed arrays for IgG subclass and IgE responses to these antigens to detect antibody signatures that were reflective of protective vs. non-protective immune responses. Moreover, probing for IgE responses allowed us to identify antigens that might induce potentially deleterious hypersensitivity responses if used as subunit vaccines in endemic populations. Using multi-dimensional cluster analysis we showed that PR individuals mounted a distinct and robust IgG1 response to a small set of newly discovered and well-characterized surface (tegument) antigens in contrast to CI individuals who mounted strong IgE and IgG4 responses to many antigens. Herein, we show the utility of a vaccinomics approach that profiles antibody responses of resistant individuals in a high-throughput multiplex approach for the identification of several potentially protective and safe schistosomiasis vaccine antigensinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/50569/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALAn Immunomics Approach to Schistosome Antigen.pdfAn Immunomics Approach to Schistosome Antigen.pdfapplication/pdf1664160https://www.arca.fiocruz.br/bitstream/icict/50569/2/An%20Immunomics%20Approach%20to%20Schistosome%20Antigen.pdf9c517dc05ca63355eac6ae035bb5ea23MD52icict/505692021-12-29 15:03:44.242oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-12-29T18:03:44Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
An Immunomics Approach to Schistosome Antigen Discovery: Antibody Signatures of Naturally Resistant and Chronically Infected Individuals from Endemic Areas |
| title |
An Immunomics Approach to Schistosome Antigen Discovery: Antibody Signatures of Naturally Resistant and Chronically Infected Individuals from Endemic Areas |
| spellingShingle |
An Immunomics Approach to Schistosome Antigen Discovery: Antibody Signatures of Naturally Resistant and Chronically Infected Individuals from Endemic Areas Jangola, Soraya Torres Gaze Esquistossomose áreas endemicas |
| title_short |
An Immunomics Approach to Schistosome Antigen Discovery: Antibody Signatures of Naturally Resistant and Chronically Infected Individuals from Endemic Areas |
| title_full |
An Immunomics Approach to Schistosome Antigen Discovery: Antibody Signatures of Naturally Resistant and Chronically Infected Individuals from Endemic Areas |
| title_fullStr |
An Immunomics Approach to Schistosome Antigen Discovery: Antibody Signatures of Naturally Resistant and Chronically Infected Individuals from Endemic Areas |
| title_full_unstemmed |
An Immunomics Approach to Schistosome Antigen Discovery: Antibody Signatures of Naturally Resistant and Chronically Infected Individuals from Endemic Areas |
| title_sort |
An Immunomics Approach to Schistosome Antigen Discovery: Antibody Signatures of Naturally Resistant and Chronically Infected Individuals from Endemic Areas |
| author |
Jangola, Soraya Torres Gaze |
| author_facet |
Jangola, Soraya Torres Gaze Driguez, Patrick Pearson, Mark S. Mendes, Tiago Doolan, Denise L. Trieu, Angela McManus, Donald P. Gobert, Geoffrey N. Periago, Maria Victoria Oliveira, Rodrigo Correa de Cardoso, Fernanda C. Oliveira, Guilherme Corrêa de Nakajima, Rie Jasinskas, Al Hung, Chris Liang, Li Pablo, Jozelyn Bethony, Jeffrey Michael Felgner, Philip L. Loukas, Alex |
| author_role |
author |
| author2 |
Driguez, Patrick Pearson, Mark S. Mendes, Tiago Doolan, Denise L. Trieu, Angela McManus, Donald P. Gobert, Geoffrey N. Periago, Maria Victoria Oliveira, Rodrigo Correa de Cardoso, Fernanda C. Oliveira, Guilherme Corrêa de Nakajima, Rie Jasinskas, Al Hung, Chris Liang, Li Pablo, Jozelyn Bethony, Jeffrey Michael Felgner, Philip L. Loukas, Alex |
| author2_role |
author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Jangola, Soraya Torres Gaze Driguez, Patrick Pearson, Mark S. Mendes, Tiago Doolan, Denise L. Trieu, Angela McManus, Donald P. Gobert, Geoffrey N. Periago, Maria Victoria Oliveira, Rodrigo Correa de Cardoso, Fernanda C. Oliveira, Guilherme Corrêa de Nakajima, Rie Jasinskas, Al Hung, Chris Liang, Li Pablo, Jozelyn Bethony, Jeffrey Michael Felgner, Philip L. Loukas, Alex |
| dc.subject.other.pt_BR.fl_str_mv |
Esquistossomose áreas endemicas |
| topic |
Esquistossomose áreas endemicas |
| description |
Centre for Biodiscovery and Molecular Development of Therapeutics. Australian Institute of Tropical Health and Medicine. Queensland Tropical Health Alliance Laboratory. James Cook University. Cairns, Queensland, Australia/ Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Manaus, AM, Brasil/ Fundação Oswaldo Cruz. Centro de Pesquisas René RachouBelo Horizonte, MG, Brazil |
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2014 |
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2014 |
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2021-12-29T18:03:44Z |
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2021-12-29T18:03:44Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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JANGOLA, Soraya Torres Gaze et al. An Immunomics Approach to Schistosome Antigen Discovery: Antibody Signatures of Naturally Resistant and Chronically Infected Individuals from Endemic Areas. PLoS Pathog., v. 10, n. 3, p. e1004033, 2014. doi: 10.1371/journal.ppat.1004033 |
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https://www.arca.fiocruz.br/handle/icict/50569 |
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1553-7366 |
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10.1371/journal.ppat.1004033 |
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JANGOLA, Soraya Torres Gaze et al. An Immunomics Approach to Schistosome Antigen Discovery: Antibody Signatures of Naturally Resistant and Chronically Infected Individuals from Endemic Areas. PLoS Pathog., v. 10, n. 3, p. e1004033, 2014. doi: 10.1371/journal.ppat.1004033 1553-7366 10.1371/journal.ppat.1004033 |
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Public Library of Science |
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