Severe Sporotrichosis Treated with Amphotericin B: A 20-Year Cohort Study in an Endemic Area of Zoonotic Transmission

Fichman, Vivian; Freitas, Dayvison Francis Saraiva; Valle, Antonio Carlos Francesconi do; Souza, Rogerio Valls de; Curi, André Luiz Land; Valete-Rosalino, Cláudia Maria; Macedo, Priscila Marques de; Varon, Andréa Gina; Figueiredo-Carvalho, Maria Helena Galdino; Almeida-Silva, Fernando; Zancopé-Oliveira, Rosely Maria; Oliveira, Raquel de Vasconcelos Carvalhaes; Almeida-Paes, Rodrigo; Gutierrez-Galhardo, Maria Clara

Severe Sporotrichosis Treated with Amphotericin B: A 20-Year Cohort Study in an Endemic Area of Zoonotic Transmission

Detalhes bibliográficos
Autor(a) principal:	Fichman, Vivian
Data de Publicação:	2022
Outros Autores:	Freitas, Dayvison Francis Saraiva, Valle, Antonio Carlos Francesconi do, Souza, Rogerio Valls de, Curi, André Luiz Land, Valete-Rosalino, Cláudia Maria, Macedo, Priscila Marques de, Varon, Andréa Gina, Figueiredo-Carvalho, Maria Helena Galdino, Almeida-Silva, Fernando, Zancopé-Oliveira, Rosely Maria, Oliveira, Raquel de Vasconcelos Carvalhaes, Almeida-Paes, Rodrigo, Gutierrez-Galhardo, Maria Clara
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/53633
Resumo:	Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil.

Metadados do item

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network_acronym_str	CRUZ
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spelling	Fichman, VivianFreitas, Dayvison Francis SaraivaValle, Antonio Carlos Francesconi doSouza, Rogerio Valls deCuri, André Luiz LandValete-Rosalino, Cláudia MariaMacedo, Priscila Marques deVaron, Andréa GinaFigueiredo-Carvalho, Maria Helena GaldinoAlmeida-Silva, FernandoZancopé-Oliveira, Rosely MariaOliveira, Raquel de Vasconcelos CarvalhaesAlmeida-Paes, RodrigoGutierrez-Galhardo, Maria Clara2022-07-04T23:47:22Z2022-07-04T23:47:22Z2022FICHMAN, Vivian et al. Severe Sporotrichosis Treated with Amphotericin B: A 20-Year Cohort Study in an Endemic Area of Zoonotic Transmission. Journal of Fungi, v. 8, n. 5, p. 1-12, 2022.2309-608Xhttps://www.arca.fiocruz.br/handle/icict/5363310.3390/jof8050469engMDPISevere Sporotrichosis Treated with Amphotericin B: A 20-Year Cohort Study in an Endemic Area of Zoonotic Transmissioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Serviço Médico. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Oftalmologia Infecciosa. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica e Vigilância em Leishmaniose. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Serviço Médico. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Epidemiologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil.Although rare, disseminated sporotrichosis is increasing in several countries. Despite its limiting toxic potential, amphotericin B is the only intravenous antifungal available to treat severe sporotrichosis. We aimed to describe the effectiveness and safety of amphotericin B treatment for severe sporotrichosis. Clinical records of patients with disseminated sporotrichosis at a reference center were reviewed. This study included 73 patients. Most (53.4%) were men and non-white. HIV coinfection was the main comorbidity (52.1%). Most reported contact with cats (76.7%). Sporothrix brasiliensis was the causative species. Affected sites were skin (98.6%), osteoarticular system (64.4%), upper airway (42.5%), central nervous system (20.5%), eyes (12.3%), and lungs (8.2%). Median doses of amphotericin B used were 750 mg and 4500 mg for deoxycholate and lipid complex formulations, respectively. Amphotericin B discontinuation occurred in 20.5% due to adverse events, mainly azotemia. The outcomes included cure (52.1%), death due to sporotrichosis (21.9%), death due to other causes (9.6%), and loss to follow-up (8.2%). Survival analysis showed an association between cure and the absence of bone, upper airway, and central nervous system involvement. Amphotericin B is the first-choice treatment for disseminated sporotrichosis; however, the severity of systemic dissemination might predict its response. Favorable clinical results depend on prompt diagnosis, investigation of fungal dissemination, and early therapy initiation.Sporothrix brasiliensisAdverse eventsZoonoticinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/53633/1/license.txt73c2438d9038594f05d706f987b602c3MD51ORIGINALSevere_Vivian_Fichman_etal_INI_2022.pdfSevere_Vivian_Fichman_etal_INI_2022.pdfapplication/pdf773677https://www.arca.fiocruz.br/bitstream/icict/53633/2/Severe_Vivian_Fichman_etal_INI_2022.pdf6742df96f2046d9ec3e11e508915301aMD52icict/536332022-12-02 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dc.title.pt_BR.fl_str_mv	Severe Sporotrichosis Treated with Amphotericin B: A 20-Year Cohort Study in an Endemic Area of Zoonotic Transmission
title	Severe Sporotrichosis Treated with Amphotericin B: A 20-Year Cohort Study in an Endemic Area of Zoonotic Transmission
spellingShingle	Severe Sporotrichosis Treated with Amphotericin B: A 20-Year Cohort Study in an Endemic Area of Zoonotic Transmission Fichman, Vivian Sporothrix brasiliensis Adverse events Zoonotic
title_short	Severe Sporotrichosis Treated with Amphotericin B: A 20-Year Cohort Study in an Endemic Area of Zoonotic Transmission
title_full	Severe Sporotrichosis Treated with Amphotericin B: A 20-Year Cohort Study in an Endemic Area of Zoonotic Transmission
title_fullStr	Severe Sporotrichosis Treated with Amphotericin B: A 20-Year Cohort Study in an Endemic Area of Zoonotic Transmission
title_full_unstemmed	Severe Sporotrichosis Treated with Amphotericin B: A 20-Year Cohort Study in an Endemic Area of Zoonotic Transmission
title_sort	Severe Sporotrichosis Treated with Amphotericin B: A 20-Year Cohort Study in an Endemic Area of Zoonotic Transmission
author	Fichman, Vivian
author_facet	Fichman, Vivian Freitas, Dayvison Francis Saraiva Valle, Antonio Carlos Francesconi do Souza, Rogerio Valls de Curi, André Luiz Land Valete-Rosalino, Cláudia Maria Macedo, Priscila Marques de Varon, Andréa Gina Figueiredo-Carvalho, Maria Helena Galdino Almeida-Silva, Fernando Zancopé-Oliveira, Rosely Maria Oliveira, Raquel de Vasconcelos Carvalhaes Almeida-Paes, Rodrigo Gutierrez-Galhardo, Maria Clara
author_role	author
author2	Freitas, Dayvison Francis Saraiva Valle, Antonio Carlos Francesconi do Souza, Rogerio Valls de Curi, André Luiz Land Valete-Rosalino, Cláudia Maria Macedo, Priscila Marques de Varon, Andréa Gina Figueiredo-Carvalho, Maria Helena Galdino Almeida-Silva, Fernando Zancopé-Oliveira, Rosely Maria Oliveira, Raquel de Vasconcelos Carvalhaes Almeida-Paes, Rodrigo Gutierrez-Galhardo, Maria Clara
author2_role	author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Fichman, Vivian Freitas, Dayvison Francis Saraiva Valle, Antonio Carlos Francesconi do Souza, Rogerio Valls de Curi, André Luiz Land Valete-Rosalino, Cláudia Maria Macedo, Priscila Marques de Varon, Andréa Gina Figueiredo-Carvalho, Maria Helena Galdino Almeida-Silva, Fernando Zancopé-Oliveira, Rosely Maria Oliveira, Raquel de Vasconcelos Carvalhaes Almeida-Paes, Rodrigo Gutierrez-Galhardo, Maria Clara
dc.subject.en.pt_BR.fl_str_mv	Sporothrix brasiliensis Adverse events Zoonotic
topic	Sporothrix brasiliensis Adverse events Zoonotic
description	Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil.
publishDate	2022
dc.date.accessioned.fl_str_mv	2022-07-04T23:47:22Z
dc.date.available.fl_str_mv	2022-07-04T23:47:22Z
dc.date.issued.fl_str_mv	2022
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	FICHMAN, Vivian et al. Severe Sporotrichosis Treated with Amphotericin B: A 20-Year Cohort Study in an Endemic Area of Zoonotic Transmission. Journal of Fungi, v. 8, n. 5, p. 1-12, 2022.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/53633
dc.identifier.issn.pt_BR.fl_str_mv	2309-608X
dc.identifier.doi.none.fl_str_mv	10.3390/jof8050469
identifier_str_mv	FICHMAN, Vivian et al. Severe Sporotrichosis Treated with Amphotericin B: A 20-Year Cohort Study in an Endemic Area of Zoonotic Transmission. Journal of Fungi, v. 8, n. 5, p. 1-12, 2022. 2309-608X 10.3390/jof8050469
url	https://www.arca.fiocruz.br/handle/icict/53633
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	MDPI
publisher.none.fl_str_mv	MDPI
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/53633/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/53633/2/Severe_Vivian_Fichman_etal_INI_2022.pdf
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bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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Severe Sporotrichosis Treated with Amphotericin B: A 20-Year Cohort Study in an Endemic Area of Zoonotic Transmission

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