Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study

Detalhes bibliográficos
Autor(a) principal: Fichman, Vivian
Data de Publicação: 2022
Outros Autores: Mota-Damasceno, Caroline Graça, Procópio-Azevedo, Anna Carolina, Almeida-Silva, Fernando, Macedo, Priscila Marques de, Medeiros, Denise Machado, Astacio, Guis Saint-Martin, Zancopé-Oliveira, Rosely Maria, Almeida-Paes, Rodrigo, Freitas, Dayvison Francis Saraiva, Gutierrez-Galhardo, Maria Clara
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57155
Resumo: Institutional Review Board Statement: This study was approved by the Research Ethics Committee of Instituto Nacional de Infectologia Evandro Chagas (INI/FIOCRUZ), RJ, Brazil (appreciation number 08097112.3.0000.5262). Adult patients diagnosed with sporotrichosis based on fungal isolation from pulmonary specimens were included in the study.
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spelling Fichman, VivianMota-Damasceno, Caroline GraçaProcópio-Azevedo, Anna CarolinaAlmeida-Silva, FernandoMacedo, Priscila Marques deMedeiros, Denise MachadoAstacio, Guis Saint-MartinZancopé-Oliveira, Rosely MariaAlmeida-Paes, RodrigoFreitas, Dayvison Francis SaraivaGutierrez-Galhardo, Maria Clara2023-02-28T02:55:39Z2023-02-28T02:55:39Z2022FICHMAN, Vivian et al. Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study. Journal of Fungi, v. 8, p. 1-11, May 2022.2309-608Xhttps://www.arca.fiocruz.br/handle/icict/5715510.3390/jof8050536Institutional Review Board Statement: This study was approved by the Research Ethics Committee of Instituto Nacional de Infectologia Evandro Chagas (INI/FIOCRUZ), RJ, Brazil (appreciation number 08097112.3.0000.5262). Adult patients diagnosed with sporotrichosis based on fungal isolation from pulmonary specimens were included in the study.This research was supported in part by Conselho Nacional de Desenvolvimento Científico e Tecnológico [CNPq 302796/2017-7] and the Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) [E-26/202.527/2019]. C.G.M.-D. received funding from FAPERJ, grant no. E26/201.866/2017.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research in Infectious Dermatology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research in Infectious Dermatology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Mycology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Mycology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research in Infectious Dermatology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Medical Service. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Image Service. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Mycology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Mycology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research in Infectious Dermatology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research in Infectious Dermatology. Rio de Janeiro, RJ, Brazil.Pulmonary sporotrichosis is a rare condition. It can present as a primary pulmonary disease, resulting from direct Sporothrix species (spp). conidia inhalation, or as part of multifocal sporotrichosis with multiple organ involvement, mainly in immunocompromised patients. This study aimed to describe the sociodemographic and epidemiological characteristics and clinical course of patients with positive cultures for Sporothrix spp. from pulmonary specimens (sputum and/or bronchoalveolar lavage) at a reference center in an area hyperendemic for zoonotic sporotrichosis. The clinical records of these patients were reviewed. Fourteen patients were included, and Sporothrix brasiliensis was identified in all cases. Disseminated sporotrichosis was the clinical presentation in 92.9% of cases, and primary pulmonary sporotrichosis accounted for 7.1%. Comorbidities included human immunodeficiency virus infection (78.6%), alcoholism (71.4%), and chronic obstructive pulmonary disease (14.3%). Treatment with amphotericin B followed by itraconazole was the preferred regimen and was prescribed in 92.9% of cases. Sporotrichosis-related death occurred in 42.9% while 35.7% of patients were cured. In five cases there was a probable contamination from upper airway lesions. Despite the significant increase in sporotrichosis cases, pulmonary sporotrichosis remains rare. The treatment of disseminated sporotrichosis is typically difficult. Prompt diagnosis and identification of all affected organs are crucial for better prognosis.engMDPIPulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePulmonary sporotrichosisSporothrix brasiliensisZoonotic transmissionAIDSinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57155/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFichman_Vivian_etal_INI_2022.pdfFichman_Vivian_etal_INI_2022.pdfapplication/pdf1897019https://www.arca.fiocruz.br/bitstream/icict/57155/2/Fichman_Vivian_etal_INI_2022.pdfd3648da612c51dfcfbc4c2c02f381e84MD52icict/571552023-02-27 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dc.title.en_US.fl_str_mv Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study
title Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study
spellingShingle Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study
Fichman, Vivian
Pulmonary sporotrichosis
Sporothrix brasiliensis
Zoonotic transmission
AIDS
title_short Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study
title_full Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study
title_fullStr Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study
title_full_unstemmed Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study
title_sort Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study
author Fichman, Vivian
author_facet Fichman, Vivian
Mota-Damasceno, Caroline Graça
Procópio-Azevedo, Anna Carolina
Almeida-Silva, Fernando
Macedo, Priscila Marques de
Medeiros, Denise Machado
Astacio, Guis Saint-Martin
Zancopé-Oliveira, Rosely Maria
Almeida-Paes, Rodrigo
Freitas, Dayvison Francis Saraiva
Gutierrez-Galhardo, Maria Clara
author_role author
author2 Mota-Damasceno, Caroline Graça
Procópio-Azevedo, Anna Carolina
Almeida-Silva, Fernando
Macedo, Priscila Marques de
Medeiros, Denise Machado
Astacio, Guis Saint-Martin
Zancopé-Oliveira, Rosely Maria
Almeida-Paes, Rodrigo
Freitas, Dayvison Francis Saraiva
Gutierrez-Galhardo, Maria Clara
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fichman, Vivian
Mota-Damasceno, Caroline Graça
Procópio-Azevedo, Anna Carolina
Almeida-Silva, Fernando
Macedo, Priscila Marques de
Medeiros, Denise Machado
Astacio, Guis Saint-Martin
Zancopé-Oliveira, Rosely Maria
Almeida-Paes, Rodrigo
Freitas, Dayvison Francis Saraiva
Gutierrez-Galhardo, Maria Clara
dc.subject.en.en_US.fl_str_mv Pulmonary sporotrichosis
Sporothrix brasiliensis
Zoonotic transmission
AIDS
topic Pulmonary sporotrichosis
Sporothrix brasiliensis
Zoonotic transmission
AIDS
description Institutional Review Board Statement: This study was approved by the Research Ethics Committee of Instituto Nacional de Infectologia Evandro Chagas (INI/FIOCRUZ), RJ, Brazil (appreciation number 08097112.3.0000.5262). Adult patients diagnosed with sporotrichosis based on fungal isolation from pulmonary specimens were included in the study.
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-02-28T02:55:39Z
dc.date.available.fl_str_mv 2023-02-28T02:55:39Z
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dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv FICHMAN, Vivian et al. Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study. Journal of Fungi, v. 8, p. 1-11, May 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57155
dc.identifier.issn.en_US.fl_str_mv 2309-608X
dc.identifier.doi.none.fl_str_mv 10.3390/jof8050536
identifier_str_mv FICHMAN, Vivian et al. Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study. Journal of Fungi, v. 8, p. 1-11, May 2022.
2309-608X
10.3390/jof8050536
url https://www.arca.fiocruz.br/handle/icict/57155
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv MDPI
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