Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/57155 |
Resumo: | Institutional Review Board Statement: This study was approved by the Research Ethics Committee of Instituto Nacional de Infectologia Evandro Chagas (INI/FIOCRUZ), RJ, Brazil (appreciation number 08097112.3.0000.5262). Adult patients diagnosed with sporotrichosis based on fungal isolation from pulmonary specimens were included in the study. |
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Fichman, VivianMota-Damasceno, Caroline GraçaProcópio-Azevedo, Anna CarolinaAlmeida-Silva, FernandoMacedo, Priscila Marques deMedeiros, Denise MachadoAstacio, Guis Saint-MartinZancopé-Oliveira, Rosely MariaAlmeida-Paes, RodrigoFreitas, Dayvison Francis SaraivaGutierrez-Galhardo, Maria Clara2023-02-28T02:55:39Z2023-02-28T02:55:39Z2022FICHMAN, Vivian et al. Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study. Journal of Fungi, v. 8, p. 1-11, May 2022.2309-608Xhttps://www.arca.fiocruz.br/handle/icict/5715510.3390/jof8050536Institutional Review Board Statement: This study was approved by the Research Ethics Committee of Instituto Nacional de Infectologia Evandro Chagas (INI/FIOCRUZ), RJ, Brazil (appreciation number 08097112.3.0000.5262). Adult patients diagnosed with sporotrichosis based on fungal isolation from pulmonary specimens were included in the study.This research was supported in part by Conselho Nacional de Desenvolvimento Científico e Tecnológico [CNPq 302796/2017-7] and the Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) [E-26/202.527/2019]. C.G.M.-D. received funding from FAPERJ, grant no. E26/201.866/2017.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research in Infectious Dermatology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research in Infectious Dermatology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Mycology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Mycology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research in Infectious Dermatology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Medical Service. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Image Service. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Mycology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Mycology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research in Infectious Dermatology. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Laboratory of Clinical Research in Infectious Dermatology. Rio de Janeiro, RJ, Brazil.Pulmonary sporotrichosis is a rare condition. It can present as a primary pulmonary disease, resulting from direct Sporothrix species (spp). conidia inhalation, or as part of multifocal sporotrichosis with multiple organ involvement, mainly in immunocompromised patients. This study aimed to describe the sociodemographic and epidemiological characteristics and clinical course of patients with positive cultures for Sporothrix spp. from pulmonary specimens (sputum and/or bronchoalveolar lavage) at a reference center in an area hyperendemic for zoonotic sporotrichosis. The clinical records of these patients were reviewed. Fourteen patients were included, and Sporothrix brasiliensis was identified in all cases. Disseminated sporotrichosis was the clinical presentation in 92.9% of cases, and primary pulmonary sporotrichosis accounted for 7.1%. Comorbidities included human immunodeficiency virus infection (78.6%), alcoholism (71.4%), and chronic obstructive pulmonary disease (14.3%). Treatment with amphotericin B followed by itraconazole was the preferred regimen and was prescribed in 92.9% of cases. Sporotrichosis-related death occurred in 42.9% while 35.7% of patients were cured. In five cases there was a probable contamination from upper airway lesions. Despite the significant increase in sporotrichosis cases, pulmonary sporotrichosis remains rare. The treatment of disseminated sporotrichosis is typically difficult. Prompt diagnosis and identification of all affected organs are crucial for better prognosis.engMDPIPulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePulmonary sporotrichosisSporothrix brasiliensisZoonotic transmissionAIDSinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57155/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFichman_Vivian_etal_INI_2022.pdfFichman_Vivian_etal_INI_2022.pdfapplication/pdf1897019https://www.arca.fiocruz.br/bitstream/icict/57155/2/Fichman_Vivian_etal_INI_2022.pdfd3648da612c51dfcfbc4c2c02f381e84MD52icict/571552023-02-27 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dc.title.en_US.fl_str_mv |
Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study |
title |
Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study |
spellingShingle |
Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study Fichman, Vivian Pulmonary sporotrichosis Sporothrix brasiliensis Zoonotic transmission AIDS |
title_short |
Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study |
title_full |
Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study |
title_fullStr |
Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study |
title_full_unstemmed |
Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study |
title_sort |
Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study |
author |
Fichman, Vivian |
author_facet |
Fichman, Vivian Mota-Damasceno, Caroline Graça Procópio-Azevedo, Anna Carolina Almeida-Silva, Fernando Macedo, Priscila Marques de Medeiros, Denise Machado Astacio, Guis Saint-Martin Zancopé-Oliveira, Rosely Maria Almeida-Paes, Rodrigo Freitas, Dayvison Francis Saraiva Gutierrez-Galhardo, Maria Clara |
author_role |
author |
author2 |
Mota-Damasceno, Caroline Graça Procópio-Azevedo, Anna Carolina Almeida-Silva, Fernando Macedo, Priscila Marques de Medeiros, Denise Machado Astacio, Guis Saint-Martin Zancopé-Oliveira, Rosely Maria Almeida-Paes, Rodrigo Freitas, Dayvison Francis Saraiva Gutierrez-Galhardo, Maria Clara |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Fichman, Vivian Mota-Damasceno, Caroline Graça Procópio-Azevedo, Anna Carolina Almeida-Silva, Fernando Macedo, Priscila Marques de Medeiros, Denise Machado Astacio, Guis Saint-Martin Zancopé-Oliveira, Rosely Maria Almeida-Paes, Rodrigo Freitas, Dayvison Francis Saraiva Gutierrez-Galhardo, Maria Clara |
dc.subject.en.en_US.fl_str_mv |
Pulmonary sporotrichosis Sporothrix brasiliensis Zoonotic transmission AIDS |
topic |
Pulmonary sporotrichosis Sporothrix brasiliensis Zoonotic transmission AIDS |
description |
Institutional Review Board Statement: This study was approved by the Research Ethics Committee of Instituto Nacional de Infectologia Evandro Chagas (INI/FIOCRUZ), RJ, Brazil (appreciation number 08097112.3.0000.5262). Adult patients diagnosed with sporotrichosis based on fungal isolation from pulmonary specimens were included in the study. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022 |
dc.date.accessioned.fl_str_mv |
2023-02-28T02:55:39Z |
dc.date.available.fl_str_mv |
2023-02-28T02:55:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FICHMAN, Vivian et al. Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study. Journal of Fungi, v. 8, p. 1-11, May 2022. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/57155 |
dc.identifier.issn.en_US.fl_str_mv |
2309-608X |
dc.identifier.doi.none.fl_str_mv |
10.3390/jof8050536 |
identifier_str_mv |
FICHMAN, Vivian et al. Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study. Journal of Fungi, v. 8, p. 1-11, May 2022. 2309-608X 10.3390/jof8050536 |
url |
https://www.arca.fiocruz.br/handle/icict/57155 |
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eng |
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eng |
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openAccess |
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MDPI |
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MDPI |
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