Antibactarial and larvicide activity of the ethanolic extract of Azadirachta indica. Juss (Meliaceae)
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/46381 |
Resumo: | Ribeiro Filho, Jaime. “Documento protegido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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Almeida, Ray Silva deAraújo, Ana Carolina Justino deFreitas, Priscilla RamosFerreira, Vitória AssunçãoLeite, Pedro Ivo PalacioTintino, Saulo RelisonTintino, Cicera Datiane de Morais OliveiraCoutinho, Henrique Douglas MeloRibeiro Filho, JaimeCosta, Raíra Justino Oliveira2021-03-19T14:40:34Z2021-03-19T14:40:34Z2021ALMEIDA, Ray Silva de at al. Antibactarial and larvicide activity of the ethanolic extract of Azadirachta indica. Juss (Meliaceae). Revista Interfaces,v. 9, n. 1, 2021.2317-434Xhttps://www.arca.fiocruz.br/handle/icict/4638110.16891/2317 434X.v9.e1.a2021.pp823 832Ribeiro Filho, Jaime. “Documento protegido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Regional University of Cariri and the Laboratory of Microbiology and Molecular BiologyUniversidade Regional do Cariri. Crato, CE, Brasil.Universidade Regional do Cariri. Crato, CE, Brasil.Universidade Regional do Cariri. Crato, CE, Brasil.Universidade Regional do Cariri. Crato, CE, Brasil.Universidade Regional do Cariri. Crato, CE, Brasil.Universidade Regional do Cariri. Crato, CE, Brasil.Universidade Regional do Cariri. Crato, CE, Brasil.Universidade Regional do Cariri. Crato, CE, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Universidade Regional do Cariri. Crato, CE, Brasil.Azadirachta indica, popularly known as "Indian neem" is a species widely used in folk medicine due to its antimicrobial properties. The present study aimed to evaluate the antimicrobial properties and analyze the cytotoxicity of the ethanolic extract of the Azadirachta indica plant (AiEE) against larvae of the Aedes aegypti mosquito. A preliminary phytochemical analysis by Thin-Layer Chromatography was used to determine the presence of secondary metabolites. The larvicidal activity was evaluated at 30 min, 1h, 2h, 4h, 8h, 16h and 24h, observing the larval mortality before different extract concentrations. The antibacterial activity of the extract against multiresistant strains of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa in the presence or absence of antibiotics was analyzed using the broth microdilution method. The qualitative phytochemical analysis revealed the presence of coumarins, phenols, terpenes and triterpenes. AiEE displayed a concentration-dependent larvicidal activity although no clinically relevant antibacterial activity was observed, the extract potentiated the activity of conventional antibiotics. Our results suggest that AiEE has bioactive constituents with the potential to be explored in research aimed at combating dengue and antibiotic resistance.engDesconhecidoAedes aegyptiAzadirachtaResistência bacterianaAtividade larvicidaAedes aegyptiAzadirachta indicaBacterial resistanceLarvicidal activityAntibactarial and larvicide activity of the ethanolic extract of Azadirachta indica. Juss (Meliaceae)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/46381/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAlmeida Ray Silva Antibacterial....pdfAlmeida Ray Silva Antibacterial....pdfapplication/pdf422841https://www.arca.fiocruz.br/bitstream/icict/46381/2/Almeida%20Ray%20Silva%20Antibacterial....pdf935627ba5a4226929692f54ef74b629fMD52TEXTAlmeida Ray Silva Antibacterial....pdf.txtAlmeida Ray Silva Antibacterial....pdf.txtExtracted texttext/plain35572https://www.arca.fiocruz.br/bitstream/icict/46381/3/Almeida%20Ray%20Silva%20Antibacterial....pdf.txteacdda8445d5c0d0f1aa66248c4d20a7MD53icict/463812023-03-15 14:34:31.869oai:www.arca.fiocruz.br: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ório 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| dc.title.pt_BR.fl_str_mv |
Antibactarial and larvicide activity of the ethanolic extract of Azadirachta indica. Juss (Meliaceae) |
| title |
Antibactarial and larvicide activity of the ethanolic extract of Azadirachta indica. Juss (Meliaceae) |
| spellingShingle |
Antibactarial and larvicide activity of the ethanolic extract of Azadirachta indica. Juss (Meliaceae) Almeida, Ray Silva de Aedes aegypti Azadirachta Resistência bacteriana Atividade larvicida Aedes aegypti Azadirachta indica Bacterial resistance Larvicidal activity |
| title_short |
Antibactarial and larvicide activity of the ethanolic extract of Azadirachta indica. Juss (Meliaceae) |
| title_full |
Antibactarial and larvicide activity of the ethanolic extract of Azadirachta indica. Juss (Meliaceae) |
| title_fullStr |
Antibactarial and larvicide activity of the ethanolic extract of Azadirachta indica. Juss (Meliaceae) |
| title_full_unstemmed |
Antibactarial and larvicide activity of the ethanolic extract of Azadirachta indica. Juss (Meliaceae) |
| title_sort |
Antibactarial and larvicide activity of the ethanolic extract of Azadirachta indica. Juss (Meliaceae) |
| author |
Almeida, Ray Silva de |
| author_facet |
Almeida, Ray Silva de Araújo, Ana Carolina Justino de Freitas, Priscilla Ramos Ferreira, Vitória Assunção Leite, Pedro Ivo Palacio Tintino, Saulo Relison Tintino, Cicera Datiane de Morais Oliveira Coutinho, Henrique Douglas Melo Ribeiro Filho, Jaime Costa, Raíra Justino Oliveira |
| author_role |
author |
| author2 |
Araújo, Ana Carolina Justino de Freitas, Priscilla Ramos Ferreira, Vitória Assunção Leite, Pedro Ivo Palacio Tintino, Saulo Relison Tintino, Cicera Datiane de Morais Oliveira Coutinho, Henrique Douglas Melo Ribeiro Filho, Jaime Costa, Raíra Justino Oliveira |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Almeida, Ray Silva de Araújo, Ana Carolina Justino de Freitas, Priscilla Ramos Ferreira, Vitória Assunção Leite, Pedro Ivo Palacio Tintino, Saulo Relison Tintino, Cicera Datiane de Morais Oliveira Coutinho, Henrique Douglas Melo Ribeiro Filho, Jaime Costa, Raíra Justino Oliveira |
| dc.subject.other.pt_BR.fl_str_mv |
Aedes aegypti Azadirachta Resistência bacteriana Atividade larvicida |
| topic |
Aedes aegypti Azadirachta Resistência bacteriana Atividade larvicida Aedes aegypti Azadirachta indica Bacterial resistance Larvicidal activity |
| dc.subject.en.pt_BR.fl_str_mv |
Aedes aegypti Azadirachta indica Bacterial resistance Larvicidal activity |
| description |
Ribeiro Filho, Jaime. “Documento protegido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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2021 |
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2021-03-19T14:40:34Z |
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2021-03-19T14:40:34Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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ALMEIDA, Ray Silva de at al. Antibactarial and larvicide activity of the ethanolic extract of Azadirachta indica. Juss (Meliaceae). Revista Interfaces,v. 9, n. 1, 2021. |
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https://www.arca.fiocruz.br/handle/icict/46381 |
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2317-434X |
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10.16891/2317 434X.v9.e1.a2021.pp823 832 |
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ALMEIDA, Ray Silva de at al. Antibactarial and larvicide activity of the ethanolic extract of Azadirachta indica. Juss (Meliaceae). Revista Interfaces,v. 9, n. 1, 2021. 2317-434X 10.16891/2317 434X.v9.e1.a2021.pp823 832 |
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