Inflammasome genetic variants are associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes

Detalhes bibliográficos
Autor(a) principal: Sá, Nathalia Beatriz Ramos de
Data de Publicação: 2022
Outros Autores: Souza, Nara Cristina Silva de, Neira-Goulart, Milena, Ribeiro-Alves, Marcelo, Silva, Tatiana Pereira da, Pilotto, Jose Henrique, Rolla, Valeria Cavalcanti, Giacoia-Gripp, Carmem B. W., Pinto, Luzia Maria de Oliveira, Scott-Algara, Daniel, Morgado, Mariza Gonçalves, Teixeira, Sylvia Lopes Maia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/55639
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
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spelling Sá, Nathalia Beatriz Ramos deSouza, Nara Cristina Silva deNeira-Goulart, MilenaRibeiro-Alves, MarceloSilva, Tatiana Pereira daPilotto, Jose HenriqueRolla, Valeria CavalcantiGiacoia-Gripp, Carmem B. W.Pinto, Luzia Maria de OliveiraScott-Algara, DanielMorgado, Mariza GonçalvesTeixeira, Sylvia Lopes Maia2022-11-16T17:36:00Z2022-11-16T17:36:00Z2022SÁ, Nathalia Beatriz Ramos et al. Inflammasome genetic variants are associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes. Frontiers in Cellular and Infection Microbiology, v. 12, p. 1-14, 2022.2235-2988https://www.arca.fiocruz.br/handle/icict/5563910.3389/fcimb.2022.962059engFrontiers MediaInflammasome genetic variants are associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil / Hospital Geral de Nova Iguaçu . Nova Iguaçu. RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobactérias. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Institut Pasteur. Unité de Biologie Cellulaire des Lymphocytes. Paris, France.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Background: Tuberculosis (TB) and AIDS are the leading causes of infectious diseases death worldwide. Here, we investigated the relationship between from single nucleotide polymorphisms (SNPs) of the NLRP3, CARD8, AIM2, CASP-1, IFI16, and IL-1β inflammasome genes, as well as the profiles of secreted proinflammatory cytokines (e.g., IL-1β, IL-18, IL-33, and IL-6) with the TB clinical profiles, TB-HIV coinfection, and IRIS onset. Methods: The individuals were divided into four groups: TB-HIV group (n=88; 11 of them with IRIS), HIV-1 group (n=20), TB group (n=24) and healthy volunteers (HC) group (n=10), and were followed up at INI/FIOCRUZ and HGNI (Rio de Janeiro/Brazil) from 2006 to 2016. Real-time PCR was used to determine the genotypes of the Single Nucleotide Polymorphism (SNPs), and ELISA was used to measure the plasma cytokine levels. Unconditional logistic regression models were used to perform risk estimations. Results: A higher risk for extrapulmonary TB was associated with the TT genotype (aOR=6.76; P=0.026) in the NLRP3 rs4612666 Single Nucleotide Polymorphism (SNP) and the C-C-T-G-C haplotype (aOR=4.99; P= 0.017) in the NLRP3 variants. This same Single Nucleotide Polymorphism (SNP) was associated with lower risk against extrapulmonary TB when the carrier allele C (aOR=0.15; P=0.021) was present. Among those with HIV-1 infections, a higher risk for TB onset was associated with the GA genotype (aOR=5.5; P=0.044) in the IL1-β rs1143634 Single Nucleotide Polymorphism (SNP). In contrast, lower risk against TB onset was associated with the A-G haplotype (aOR=0.17; P= 0.026) in the CARD8 variants. Higher IL-6 and IL-33 levels were observed in individuals with TB. A higher risk for IRIS onset was associated with CD8 counts ≤ 500 cells/mm3 (aOR=12.32; P=0.010), the presence of extrapulmonary TB (aOR=6.6; P=0.038), and the CT genotype (aOR=61.06; P=0.026) or carrier allele T (aOR=61.06; P=0.026) in the AIM2 rs2276405 Single Nucleotide Polymorphism (SNP), whereas lower risk against IRIS onset was associated with the AT genotype (aOR=0.02; P=0.033) or carrier allele T (aOR=0.02; P=0.029) in the CARD8 rs2043211 Single Nucleotide Polymorphism (SNP) and the T-G haplotype (aOR=0.07; P= 0.033) in the CARD8 variants. No other significant associations were observed. Conclusions: Our results depict the involvement of genetic polymorphisms of crucial innate immunity genes and proinflammatory cytokines in the clinical outcomes related to TB-HIV coinfection.HIV-1TB-HIV/IRISInflammasome Single Nucleotide Polymorphism (SNP)Proinflammatory cytokinesTuberculosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/55639/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALInflammasome_Marcelo_Alves_etal_INI_2022.pdfInflammasome_Marcelo_Alves_etal_INI_2022.pdfapplication/pdf1824174https://www.arca.fiocruz.br/bitstream/icict/55639/2/Inflammasome_Marcelo_Alves_etal_INI_2022.pdf89e6b2851546ce0d7467c0350644701bMD52icict/556392023-09-14 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dc.title.en_US.fl_str_mv Inflammasome genetic variants are associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes
title Inflammasome genetic variants are associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes
spellingShingle Inflammasome genetic variants are associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes
Sá, Nathalia Beatriz Ramos de
HIV-1
TB-HIV/IRIS
Inflammasome Single Nucleotide Polymorphism (SNP)
Proinflammatory cytokines
Tuberculosis
title_short Inflammasome genetic variants are associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes
title_full Inflammasome genetic variants are associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes
title_fullStr Inflammasome genetic variants are associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes
title_full_unstemmed Inflammasome genetic variants are associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes
title_sort Inflammasome genetic variants are associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes
author Sá, Nathalia Beatriz Ramos de
author_facet Sá, Nathalia Beatriz Ramos de
Souza, Nara Cristina Silva de
Neira-Goulart, Milena
Ribeiro-Alves, Marcelo
Silva, Tatiana Pereira da
Pilotto, Jose Henrique
Rolla, Valeria Cavalcanti
Giacoia-Gripp, Carmem B. W.
Pinto, Luzia Maria de Oliveira
Scott-Algara, Daniel
Morgado, Mariza Gonçalves
Teixeira, Sylvia Lopes Maia
author_role author
author2 Souza, Nara Cristina Silva de
Neira-Goulart, Milena
Ribeiro-Alves, Marcelo
Silva, Tatiana Pereira da
Pilotto, Jose Henrique
Rolla, Valeria Cavalcanti
Giacoia-Gripp, Carmem B. W.
Pinto, Luzia Maria de Oliveira
Scott-Algara, Daniel
Morgado, Mariza Gonçalves
Teixeira, Sylvia Lopes Maia
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sá, Nathalia Beatriz Ramos de
Souza, Nara Cristina Silva de
Neira-Goulart, Milena
Ribeiro-Alves, Marcelo
Silva, Tatiana Pereira da
Pilotto, Jose Henrique
Rolla, Valeria Cavalcanti
Giacoia-Gripp, Carmem B. W.
Pinto, Luzia Maria de Oliveira
Scott-Algara, Daniel
Morgado, Mariza Gonçalves
Teixeira, Sylvia Lopes Maia
dc.subject.en.en_US.fl_str_mv HIV-1
TB-HIV/IRIS
Inflammasome Single Nucleotide Polymorphism (SNP)
Proinflammatory cytokines
Tuberculosis
topic HIV-1
TB-HIV/IRIS
Inflammasome Single Nucleotide Polymorphism (SNP)
Proinflammatory cytokines
Tuberculosis
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-11-16T17:36:00Z
dc.date.available.fl_str_mv 2022-11-16T17:36:00Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SÁ, Nathalia Beatriz Ramos et al. Inflammasome genetic variants are associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes. Frontiers in Cellular and Infection Microbiology, v. 12, p. 1-14, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/55639
dc.identifier.issn.en_US.fl_str_mv 2235-2988
dc.identifier.doi.none.fl_str_mv 10.3389/fcimb.2022.962059
identifier_str_mv SÁ, Nathalia Beatriz Ramos et al. Inflammasome genetic variants are associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes. Frontiers in Cellular and Infection Microbiology, v. 12, p. 1-14, 2022.
2235-2988
10.3389/fcimb.2022.962059
url https://www.arca.fiocruz.br/handle/icict/55639
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/55639/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/55639/2/Inflammasome_Marcelo_Alves_etal_INI_2022.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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