Tuberculosis-immune reconstitution inflammatory syndrome in HIV: from pathogenesis to prediction

Detalhes bibliográficos
Autor(a) principal: Gopalan, Narendran
Data de Publicação: 2014
Outros Autores: Andrade, Bruno de Bezerril, Swaminathan, Soumya
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/25841
Resumo: Andrade, Bruno Bezerril. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Gopalan, NarendranAndrade, Bruno de BezerrilSwaminathan, Soumya2018-04-13T18:42:12Z2018-04-13T18:42:12Z2014GOPALAN, N.; ANDRADE, B. B.; SWAMINATHAN, S. Tuberculosis-immune reconstitution inflammatory syndrome in HIV: from pathogenesis to prediction. Expert Review of Clinical Immunology, v. 10, n. 5, p. 631-645, 2014.1744-666Xhttps://www.arca.fiocruz.br/handle/icict/2584110.1586/1744666X.2014.892828Andrade, Bruno Bezerril. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.National Institute for Research in Tuberculosis. Mayor Sathyamoorthy. Road. Chetpet, Chennai, IndiaNational Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Immunology Section. Bethesda, MD, USANational Institute for Research in Tuberculosis. Mayor Sathyamoorthy. Road. Chetpet, Chennai, IndiaTuberculosis-immune reconstitution inflammatory syndrome (TB-IRIS) is an exaggerated, dysregulated immune response against dead or viable antigens of Mycobacterium tuberculosis that frequently occurs after initiation of antiretroviral therapy despite an effective suppression of HIV viremia. Scientific advances in IRIS pathogenesis have led researchers and clinicians to postulate risk factors that could possibly predict this syndrome, in an attempt to reduce the incidence and the severity of IRIS, with appropriate anti-inflammatory therapy. This review is a summary of the available literature on pathogenic mechanisms involved from the macro to the micro level, the clinical spectrum, available predictors and the scope of these biomarkers to function as specific therapeutic targets, that could effectively modulate or ameliorate this syndrome in future.engTaylor & FrancisBiomarcadores para IRISHIVIRISTuberculoseMycobacterium tuberculosisARTBiomarkers for IRISHAARTHIVIRISParadoxical reactionTBTuberculosis-immune reconstitution inflammatory syndrome in HIV: from pathogenesis to predictioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25841/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGopalan N Tuberculosis-immmune....pdfGopalan N 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dc.title.pt_BR.fl_str_mv Tuberculosis-immune reconstitution inflammatory syndrome in HIV: from pathogenesis to prediction
title Tuberculosis-immune reconstitution inflammatory syndrome in HIV: from pathogenesis to prediction
spellingShingle Tuberculosis-immune reconstitution inflammatory syndrome in HIV: from pathogenesis to prediction
Gopalan, Narendran
Biomarcadores para IRIS
HIV
IRIS
Tuberculose
Mycobacterium tuberculosis
ART
Biomarkers for IRIS
HAART
HIV
IRIS
Paradoxical reaction
TB
title_short Tuberculosis-immune reconstitution inflammatory syndrome in HIV: from pathogenesis to prediction
title_full Tuberculosis-immune reconstitution inflammatory syndrome in HIV: from pathogenesis to prediction
title_fullStr Tuberculosis-immune reconstitution inflammatory syndrome in HIV: from pathogenesis to prediction
title_full_unstemmed Tuberculosis-immune reconstitution inflammatory syndrome in HIV: from pathogenesis to prediction
title_sort Tuberculosis-immune reconstitution inflammatory syndrome in HIV: from pathogenesis to prediction
author Gopalan, Narendran
author_facet Gopalan, Narendran
Andrade, Bruno de Bezerril
Swaminathan, Soumya
author_role author
author2 Andrade, Bruno de Bezerril
Swaminathan, Soumya
author2_role author
author
dc.contributor.author.fl_str_mv Gopalan, Narendran
Andrade, Bruno de Bezerril
Swaminathan, Soumya
dc.subject.other.pt_BR.fl_str_mv Biomarcadores para IRIS
HIV
IRIS
Tuberculose
Mycobacterium tuberculosis
topic Biomarcadores para IRIS
HIV
IRIS
Tuberculose
Mycobacterium tuberculosis
ART
Biomarkers for IRIS
HAART
HIV
IRIS
Paradoxical reaction
TB
dc.subject.en.pt_BR.fl_str_mv ART
Biomarkers for IRIS
HAART
HIV
IRIS
Paradoxical reaction
TB
description Andrade, Bruno Bezerril. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2018-04-13T18:42:12Z
dc.date.available.fl_str_mv 2018-04-13T18:42:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GOPALAN, N.; ANDRADE, B. B.; SWAMINATHAN, S. Tuberculosis-immune reconstitution inflammatory syndrome in HIV: from pathogenesis to prediction. Expert Review of Clinical Immunology, v. 10, n. 5, p. 631-645, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/25841
dc.identifier.issn.pt_BR.fl_str_mv 1744-666X
dc.identifier.doi.none.fl_str_mv 10.1586/1744666X.2014.892828
identifier_str_mv GOPALAN, N.; ANDRADE, B. B.; SWAMINATHAN, S. Tuberculosis-immune reconstitution inflammatory syndrome in HIV: from pathogenesis to prediction. Expert Review of Clinical Immunology, v. 10, n. 5, p. 631-645, 2014.
1744-666X
10.1586/1744666X.2014.892828
url https://www.arca.fiocruz.br/handle/icict/25841
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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