Association of ApoEpolymorphisms with prevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS)

Detalhes bibliográficos
Autor(a) principal: Fuzikawa, Alberto Kazuo
Data de Publicação: 2008
Outros Autores: Peixoto, Sérgio William Viana, Taufer, Maristela, Moriguchi, Emílio Hideyuki, Costa, Maria Fernanda Lima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/6648
Resumo: CNPq
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spelling Fuzikawa, Alberto KazuoPeixoto, Sérgio William VianaTaufer, MaristelaMoriguchi, Emílio HideyukiCosta, Maria Fernanda Lima2013-07-04T17:24:49Z2013-07-04T17:24:49Z2008FUZIKAWA, Alberto Kazuo et al. Association of ApoEpolymorphisms withprevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS). ApoEpolymorphism and hypertension in the elderly. Brazilian Journal of Medical and Biological Research, n. 41, p. 89-94, 2008.0100-879Xhttps://www.arca.fiocruz.br/handle/icict/6648CNPqFundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Núcleo de Estudos em Saúde Pública e Envelhecimento. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Núcleo de Estudos em Saúde Pública e Envelhecimento. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil.CMIC Brasil Pesquisas Clínicas. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Porto Alegre, RS, Brasil / Universidade do Vale dos Sinos. Porto Alegre, RS, Brasil / Hospital Moinhos de Vento de Porto Alegre. Porto Alegre, RS, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Núcleo de Estudos em Saúde Pública e Envelhecimento. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil.Apolipoprotein E (ApoE) polymorphism influences lipid metabolism, but its association with arterial hypertension is controver-sial. The objective of this study was to examine the association between ApoEpolymorphism and prevalent hypertension in a large unselected population of older adults. Participants from the baseline of the Bambuí Health Aging Study whose ApoE genes had been genotyped were selected for this study (N = 1406, aged 60-95 years). These subjects represented 80.7% of the total elderly residents in Bambuí city, MG, Brazil. Hypertension was defined as a systolic blood pressure ≥140 mmHg and/or a diastolic blood pressure ≥90 mmHg, or the use of anti-hypertensive medication. The exposure variable was the ApoEgenotype as follows: ε3 carriers, ε3ε3; ε2 carriers, ε2ε2 or ε2ε3, and ε4 carriers, ε3ε4 or ε4ε4. Potential confounding variables were age, gender, traditional cardiovascular risk factors, uric acid, and creatinine levels. The prevalence of hypertension was 61.3%. Compared with the ε3 homozygotes, neither the ε2 nor the ε4 carrier status was associated with hypertension (adjusted prevalence ratios = 0.94, 95%CI = 0.83-1.07 and 0.98, 0.89-1.07, respectively). On the other hand, the ε2 allele carriers had lower LDL cholesterol levels (P < 0.001) and the ε4 carriers had higher LDL cholesterol levels (P = 0.036). This study provides epidemiologic evidence that the ApoEgenotype is not associated with prevalent hypertension in old age.engAssociation of ApoEpolymorphisms with prevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleApolipoprotein EHypertensionLow-density lipoprotein cholesterolTriglyceridesLipid metabolisminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINAL58. FUZIKAWA AK, PEIXOTO SV.pdf58. FUZIKAWA AK, PEIXOTO SV.pdfapplication/pdf459268https://www.arca.fiocruz.br/bitstream/icict/6648/1/58.%20FUZIKAWA%20AK%2c%20PEIXOTO%20SV.pdf57ac6a69ea1cd4684c2f6e2da88e4c39MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/6648/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXT58. FUZIKAWA AK, PEIXOTO SV.pdf.txt58. 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dc.title.pt_BR.fl_str_mv Association of ApoEpolymorphisms with prevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS)
title Association of ApoEpolymorphisms with prevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS)
spellingShingle Association of ApoEpolymorphisms with prevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS)
Fuzikawa, Alberto Kazuo
Apolipoprotein E
Hypertension
Low-density lipoprotein cholesterol
Triglycerides
Lipid metabolism
title_short Association of ApoEpolymorphisms with prevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS)
title_full Association of ApoEpolymorphisms with prevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS)
title_fullStr Association of ApoEpolymorphisms with prevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS)
title_full_unstemmed Association of ApoEpolymorphisms with prevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS)
title_sort Association of ApoEpolymorphisms with prevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS)
author Fuzikawa, Alberto Kazuo
author_facet Fuzikawa, Alberto Kazuo
Peixoto, Sérgio William Viana
Taufer, Maristela
Moriguchi, Emílio Hideyuki
Costa, Maria Fernanda Lima
author_role author
author2 Peixoto, Sérgio William Viana
Taufer, Maristela
Moriguchi, Emílio Hideyuki
Costa, Maria Fernanda Lima
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Fuzikawa, Alberto Kazuo
Peixoto, Sérgio William Viana
Taufer, Maristela
Moriguchi, Emílio Hideyuki
Costa, Maria Fernanda Lima
dc.subject.en.pt_BR.fl_str_mv Apolipoprotein E
Hypertension
Low-density lipoprotein cholesterol
Triglycerides
Lipid metabolism
topic Apolipoprotein E
Hypertension
Low-density lipoprotein cholesterol
Triglycerides
Lipid metabolism
description CNPq
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2013-07-04T17:24:49Z
dc.date.available.fl_str_mv 2013-07-04T17:24:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv FUZIKAWA, Alberto Kazuo et al. Association of ApoEpolymorphisms withprevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS). ApoEpolymorphism and hypertension in the elderly. Brazilian Journal of Medical and Biological Research, n. 41, p. 89-94, 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/6648
dc.identifier.issn.none.fl_str_mv 0100-879X
identifier_str_mv FUZIKAWA, Alberto Kazuo et al. Association of ApoEpolymorphisms withprevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS). ApoEpolymorphism and hypertension in the elderly. Brazilian Journal of Medical and Biological Research, n. 41, p. 89-94, 2008.
0100-879X
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