Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25002 |
Resumo: | National Institutes of Health (Grant U01 AI088650-06) |
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Costa, Rúbia Suely SantanaCarvalho, Lucas Pedreira deBritto, Taís Menezes Cerqueira Campos deMagalhães, Andréa SPassos, Sara TimoteoSchriefer, AlbertSilva, Juliana ALago, EdnaldoPaixão, Camilla SantosMachado, Paulo Roberto LimaScott, PhillipCarvalho Filho, Edgar Marcelino2018-02-28T17:51:42Z2018-02-28T17:51:42Z2018COSTA, R. S. S. et al. Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy. The Journal of Infectious Diseases, v. 217, p. 840–850, 2018.0022-1899https://www.arca.fiocruz.br/handle/icict/2500210.1093/infdis/jix627National Institutes of Health (Grant U01 AI088650-06)Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / University of Pennsylvania. School of Veterinary Medicine. Department Pathobiology. Philadelphia, PAUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, BrasilUniversity of Pennsylvania. School of Veterinary Medicine. Department Pathobiology. Philadelphia, PAUniversidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, BrasilEarly cutaneous leishmaniasis (ECL) is characterized by a nonulcerated papular lesion and illness duration less than 30 days. Approximately 4 weeks later, the cutaneous leishmaniasis (CL) ulcers appear. We were surprised to find that failure after antimony therapy (Sb5) is higher in ECL than CL. We hypothesize that the inflammatory response in ECL patients may increase during Sb5 therapy, which leads to treatment failure. Methods. A cohort of 44 ECL patients infected by Leishmania braziliensis was established to evaluate the response to Sb5 and to compare immunologic responses in ECL patients with CL and healthy subjects. Results. A hierarchical clustering based on cytokine levels showed a weak positive correlation between proinflammatory cytokine levels and those patients that failed Sb5 treatment. Although Sb5 therapy decreased interferon-γ and tumor necrosis factor levels in CL patients, we were surprised to find that an increase in these cytokines was observed in ECL patients. Moreover, interleukin (IL)-10 was less able to down-modulate immune responses in ECL. Conclusions. The enhanced production of proinflammatory cytokines, due in part to the decreased ability of IL-10 to down-modulate immune response during therapy in ECL, promotes the development and persistence of leishmania ulcer despite antimony therapy.engUniversity of Chicago PressLeishmaniose cutânea precoceQuimiocinasLeishmaniose cutâneaLeishmania braziliensisCitocinasEarly cutaneous leishmaniasisChemokinesCutaneous leishmaniasisLeishmania braziliensisCytokinesEarly Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25002/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCosta RS Early Cutaneous Leishmaniasis Patients Infected....pdfCosta RS Early Cutaneous Leishmaniasis Patients Infected....pdfapplication/pdf1578790https://www.arca.fiocruz.br/bitstream/icict/25002/2/Costa%20RS%20Early%20Cutaneous%20Leishmaniasis%20Patients%20Infected....pdfebe3b7a6ad798d68d377b1aafe5d1de2MD52TEXTCosta RS Early Cutaneous Leishmaniasis Patients Infected....pdf.txtCosta RS Early Cutaneous Leishmaniasis Patients Infected....pdf.txtExtracted texttext/plain46136https://www.arca.fiocruz.br/bitstream/icict/25002/3/Costa%20RS%20Early%20Cutaneous%20Leishmaniasis%20Patients%20Infected....pdf.txte624a190de26d59e3336f82ac513c677MD53icict/250022023-03-15 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dc.title.pt_BR.fl_str_mv |
Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy |
title |
Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy |
spellingShingle |
Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy Costa, Rúbia Suely Santana Leishmaniose cutânea precoce Quimiocinas Leishmaniose cutânea Leishmania braziliensis Citocinas Early cutaneous leishmaniasis Chemokines Cutaneous leishmaniasis Leishmania braziliensis Cytokines |
title_short |
Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy |
title_full |
Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy |
title_fullStr |
Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy |
title_full_unstemmed |
Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy |
title_sort |
Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy |
author |
Costa, Rúbia Suely Santana |
author_facet |
Costa, Rúbia Suely Santana Carvalho, Lucas Pedreira de Britto, Taís Menezes Cerqueira Campos de Magalhães, Andréa S Passos, Sara Timoteo Schriefer, Albert Silva, Juliana A Lago, Ednaldo Paixão, Camilla Santos Machado, Paulo Roberto Lima Scott, Phillip Carvalho Filho, Edgar Marcelino |
author_role |
author |
author2 |
Carvalho, Lucas Pedreira de Britto, Taís Menezes Cerqueira Campos de Magalhães, Andréa S Passos, Sara Timoteo Schriefer, Albert Silva, Juliana A Lago, Ednaldo Paixão, Camilla Santos Machado, Paulo Roberto Lima Scott, Phillip Carvalho Filho, Edgar Marcelino |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Costa, Rúbia Suely Santana Carvalho, Lucas Pedreira de Britto, Taís Menezes Cerqueira Campos de Magalhães, Andréa S Passos, Sara Timoteo Schriefer, Albert Silva, Juliana A Lago, Ednaldo Paixão, Camilla Santos Machado, Paulo Roberto Lima Scott, Phillip Carvalho Filho, Edgar Marcelino |
dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose cutânea precoce Quimiocinas Leishmaniose cutânea Leishmania braziliensis Citocinas |
topic |
Leishmaniose cutânea precoce Quimiocinas Leishmaniose cutânea Leishmania braziliensis Citocinas Early cutaneous leishmaniasis Chemokines Cutaneous leishmaniasis Leishmania braziliensis Cytokines |
dc.subject.en.pt_BR.fl_str_mv |
Early cutaneous leishmaniasis Chemokines Cutaneous leishmaniasis Leishmania braziliensis Cytokines |
description |
National Institutes of Health (Grant U01 AI088650-06) |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-02-28T17:51:42Z |
dc.date.available.fl_str_mv |
2018-02-28T17:51:42Z |
dc.date.issued.fl_str_mv |
2018 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
COSTA, R. S. S. et al. Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy. The Journal of Infectious Diseases, v. 217, p. 840–850, 2018. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/25002 |
dc.identifier.issn.pt_BR.fl_str_mv |
0022-1899 |
dc.identifier.doi.none.fl_str_mv |
10.1093/infdis/jix627 |
identifier_str_mv |
COSTA, R. S. S. et al. Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy. The Journal of Infectious Diseases, v. 217, p. 840–850, 2018. 0022-1899 10.1093/infdis/jix627 |
url |
https://www.arca.fiocruz.br/handle/icict/25002 |
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eng |
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University of Chicago Press |
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University of Chicago Press |
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