Polymorphism in the IL-1B promoter is associated with IgG antibody response to circumsporozoite protein repeats of Plasmodium vivax
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1093/trstmh/traa055 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45480 |
Resumo: | Universidade do Estado de São Paulo. Programa de Graduação em Biociências. Sçao José do Rio Preto, SP, Brasil. |
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Capobianco, Marcela PetroliniCassiano, Gustavo CapattiStorti-Melo, Luciane MorenoPimenta, Tamirys SimãoRodrigues, Ana Paula DrummondArruda, José Eduardo GomesPinto, Marcia RibeiroBaptista, Andrea Regina de SouzaPratt-Riccio, Lilian RoseDomingos, Cláudia Regina BoniniFerreira, Joseli de OliveiraMachado, Ricardo Luiz Dantas2020-12-31T14:03:54Z2020-12-31T14:03:54Z2020CAPOBIANCO, Marcela Petrolini et al. Polymorphism in the IL-1B promoter is associated with IgG antibody response to circumsporozoite protein repeats of Plasmodium vivax. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 114, p. 858-865, Aug. 2020.0035-9203https://www.arca.fiocruz.br/handle/icict/4548010.1093/trstmh/traa0551878-3503engOxford AcademicPlasmodium vivaxPolimorfismo GenéticoCitocinasProteína CircunsporozoítaAnticorposGoianésia do ParáPlasmodium vivaxCircumsporozoite proteinPolymorphismIgG antibodyBrazilAntibodyPolymorphism in the IL-1B promoter is associated with IgG antibody response to circumsporozoite protein repeats of Plasmodium vivaxinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade do Estado de São Paulo. Programa de Graduação em Biociências. Sçao José do Rio Preto, SP, Brasil.Lisboa University. Tropical Medicine and Hygiene Institut. Global Health and Tropical Medicine. Lisboa, Portugal.Universidade Federal de Sergipe. Departamento de Biologia. Aracaju, SE, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Laboratório de Imunogenética em Malária. Ananindeua, PA, Brasil.Ministério da Saúde. Instituto Evandro Chagas. Laboratório de Microscopia Eletrônica. Ananindeua, PA, Brasil.Universidade Federal Fluminense. Centro de Investigação de Microorganismos. Niterói, RJ, Brasil.Universidade Federal Fluminense. Centro de Investigação de Microorganismos. Niterói, RJ, Brasil.Universidade Federal Fluminense. Centro de Investigação de Microorganismos. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Universidade do Estado de São Paulo. Programa de Graduação em Biociências. Sçao José do Rio Preto, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado de São Paulo. Programa de Graduação em Biociências. Sçao José do Rio Preto, SP, Brasil / Universidade Federal Fluminense. Centro de Investigação de Microorganismos. Niterói, RJ, Brasil.BACKGROUND: It is well established that infection by Plasmodium vivax is a result of host-parasite interactions. In the present study, association with the IL1/IL2 cytokine profiles, anticircumsporozoite protein antibody levels and parasitic loads was evaluated in individuals naturally infected with P. vivax in an endemic area of the Brazilian Amazon. METHODS: Molecular diagnosis of P. vivax and variants was performed using the PCR-RFLP method and IL1B -511C>T, IL2 -330T>G and IL2+114T>G polymorphisms were identified using PCR-RFLP and allele-specific PCR. IL-1β and IL-2 cytokine levels were detected by flow cytometry and circumsporozoite protein (CSP) antibodies were measured by ELISA. RESULTS: Three variants of P. vivax CSP were identified and VK247 was found to be the most frequent. However, the prevalence and magnitude of IgG antibodies were higher for the VK210 variant. Furthermore, the antibody response to the CSP variants was not associated with the presence of the variant in the infection. Significant differences were observed between the single nucleotide polymorphism (SNP) -511T>C in the IL1B gene and levels of antibodies to the VK247 and P. vivax-like variants, but there were no associations between SNPs in IL1 and IL2 genes and their plasma products. CONCLUSIONS: Individuals with the rs16944 CC genotype in the IL1β gene have higher antibody levels to the CSP of P. vivax of VK247 and P. vivax-like variants.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45480/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALClaudiaDomigos_JoseliFerreira_etal_IOC_2020.pdfClaudiaDomigos_JoseliFerreira_etal_IOC_2020.pdfapplication/pdf743259https://www.arca.fiocruz.br/bitstream/icict/45480/2/ClaudiaDomigos_JoseliFerreira_etal_IOC_2020.pdfa5bd432f97a2b927884fed24871a3d8fMD52TEXTClaudiaDomigos_JoseliFerreira_etal_IOC_2020.pdf.txtClaudiaDomigos_JoseliFerreira_etal_IOC_2020.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Polymorphism in the IL-1B promoter is associated with IgG antibody response to circumsporozoite protein repeats of Plasmodium vivax |
| title |
Polymorphism in the IL-1B promoter is associated with IgG antibody response to circumsporozoite protein repeats of Plasmodium vivax |
| spellingShingle |
Polymorphism in the IL-1B promoter is associated with IgG antibody response to circumsporozoite protein repeats of Plasmodium vivax Capobianco, Marcela Petrolini Plasmodium vivax Polimorfismo Genético Citocinas Proteína Circunsporozoíta Anticorpos Goianésia do Pará Plasmodium vivax Circumsporozoite protein Polymorphism IgG antibody Brazil Antibody |
| title_short |
Polymorphism in the IL-1B promoter is associated with IgG antibody response to circumsporozoite protein repeats of Plasmodium vivax |
| title_full |
Polymorphism in the IL-1B promoter is associated with IgG antibody response to circumsporozoite protein repeats of Plasmodium vivax |
| title_fullStr |
Polymorphism in the IL-1B promoter is associated with IgG antibody response to circumsporozoite protein repeats of Plasmodium vivax |
| title_full_unstemmed |
Polymorphism in the IL-1B promoter is associated with IgG antibody response to circumsporozoite protein repeats of Plasmodium vivax |
| title_sort |
Polymorphism in the IL-1B promoter is associated with IgG antibody response to circumsporozoite protein repeats of Plasmodium vivax |
| author |
Capobianco, Marcela Petrolini |
| author_facet |
Capobianco, Marcela Petrolini Cassiano, Gustavo Capatti Storti-Melo, Luciane Moreno Pimenta, Tamirys Simão Rodrigues, Ana Paula Drummond Arruda, José Eduardo Gomes Pinto, Marcia Ribeiro Baptista, Andrea Regina de Souza Pratt-Riccio, Lilian Rose Domingos, Cláudia Regina Bonini Ferreira, Joseli de Oliveira Machado, Ricardo Luiz Dantas |
| author_role |
author |
| author2 |
Cassiano, Gustavo Capatti Storti-Melo, Luciane Moreno Pimenta, Tamirys Simão Rodrigues, Ana Paula Drummond Arruda, José Eduardo Gomes Pinto, Marcia Ribeiro Baptista, Andrea Regina de Souza Pratt-Riccio, Lilian Rose Domingos, Cláudia Regina Bonini Ferreira, Joseli de Oliveira Machado, Ricardo Luiz Dantas |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Capobianco, Marcela Petrolini Cassiano, Gustavo Capatti Storti-Melo, Luciane Moreno Pimenta, Tamirys Simão Rodrigues, Ana Paula Drummond Arruda, José Eduardo Gomes Pinto, Marcia Ribeiro Baptista, Andrea Regina de Souza Pratt-Riccio, Lilian Rose Domingos, Cláudia Regina Bonini Ferreira, Joseli de Oliveira Machado, Ricardo Luiz Dantas |
| dc.subject.other.pt_BR.fl_str_mv |
Plasmodium vivax Polimorfismo Genético Citocinas Proteína Circunsporozoíta Anticorpos Goianésia do Pará |
| topic |
Plasmodium vivax Polimorfismo Genético Citocinas Proteína Circunsporozoíta Anticorpos Goianésia do Pará Plasmodium vivax Circumsporozoite protein Polymorphism IgG antibody Brazil Antibody |
| dc.subject.en.pt_BR.fl_str_mv |
Plasmodium vivax Circumsporozoite protein Polymorphism IgG antibody Brazil Antibody |
| description |
Universidade do Estado de São Paulo. Programa de Graduação em Biociências. Sçao José do Rio Preto, SP, Brasil. |
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2020 |
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2020-12-31T14:03:54Z |
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2020-12-31T14:03:54Z |
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2020 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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CAPOBIANCO, Marcela Petrolini et al. Polymorphism in the IL-1B promoter is associated with IgG antibody response to circumsporozoite protein repeats of Plasmodium vivax. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 114, p. 858-865, Aug. 2020. |
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https://www.arca.fiocruz.br/handle/icict/45480 |
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0035-9203 |
| dc.identifier.doi.none.fl_str_mv |
10.1093/trstmh/traa055 |
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1878-3503 |
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CAPOBIANCO, Marcela Petrolini et al. Polymorphism in the IL-1B promoter is associated with IgG antibody response to circumsporozoite protein repeats of Plasmodium vivax. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 114, p. 858-865, Aug. 2020. 0035-9203 10.1093/trstmh/traa055 1878-3503 |
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Oxford Academic |
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Oxford Academic |
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