Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45648 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. |
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Soares, Isabel FerreiraCamacho, César LópezSilva, Rodrigo Nunes Rodrigues daMatos, Ada da SilvaBaptista, Barbara de OliveiraTotino, Paulo Renato RivasSouza, Rodrigo Medeiros deHarrison, KateGimenez, Alba MarinaFreitas, Elisângela Oliveira deKim, Young ChanFerreira, Joseli OliveiraDaniel‑Ribeiro, Cláudio TadeuReyes‑Sandova, ArturoPratt‑Riccio, Lilian RoseLima Junior, Josué da Costa2021-01-11T19:20:45Z2021-01-11T19:20:45Z2020SOARES, Isabel Ferreira et al. Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon. Scientifc Reports, v. 10, 14020, 14p, 2020.https://www.arca.fiocruz.br/handle/icict/45648/10.1038/s41598-020-70893-32045-2322engNature ResearchPlasmodium RecombinanteSuperfície circunsporozoíta vivaxProteína alélicaAnticorpoAmazônia brasileiraRecombinant PlasmodiumVivax circumsporozoite surfaceProtein allelicAntibodyBrazilian AmazonRecombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazoninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Nuffield Department of Medicine, The Jenner Institute, The Henry Wellcome Building for Molecular Physiology. University of Oxford, Oxford, UK.Fundação Oswaldo Cruz. Instituto de Tecnologia de Imunobiológicos. Laboratório de Tecnologia em Anticorpos Monoclonais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Universidade Federal do Acre. Centro de Pesquisa em Doenças Infecciosas. Centro Multidisciplinar, Campus Floresta. Rio Branco, AC, Brasil.Nuffield Department of Medicine, The Jenner Institute, The Henry Wellcome Building for Molecular Physiology. University of Oxford, Oxford, UK.Nuffield Department of Medicine, The Jenner Institute, The Henry Wellcome Building for Molecular Physiology. University of Oxford, Oxford, UK.Nuffield Department of Medicine, The Jenner Institute, The Henry Wellcome Building for Molecular Physiology. University of Oxford, Oxford, UK.Nuffield Department of Medicine, The Jenner Institute, The Henry Wellcome Building for Molecular Physiology. University of Oxford, Oxford, UK.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil / Centro de Pesquisa, Diagnóstico e Tratamento em Malária. Rio de Janeiro, RJ, Brasil.Nuffield Department of Medicine, The Jenner Institute, The Henry Wellcome Building for Molecular Physiology. University of Oxford, Oxford, UK.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Circumsporozoite protein (CSP) variants of P. vivax, besides having variations in the protein repetitive portion, can differ from each other in aspects such as geographical distribution, intensity of transmission, vectorial competence and immune response. Such aspects must be considered to P. vivax vaccine development. Therefore, we evaluated the immunogenicity of novel recombinant proteins corresponding to each of the three P. vivax allelic variants (VK210, VK247 and P. vivax-like) and of the C-terminal region (shared by all PvCSP variants) in naturally malaria-exposed populations of Brazilian Amazon. Our results demonstrated that PvCSP-VK210 was the major target of humoral immune response in studied population, presenting higher frequency and magnitude of IgG response. The IgG subclass profile showed a prevalence of cytophilic antibodies (IgG1 and IgG3), that seem to have an essential role in protective immune response. Differently of PvCSP allelic variants, antibodies elicited against C-terminal region of protein did not correlate with epidemiological parameters, bringing additional evidence that humoral response against this protein region is not essential to protective immunity. Taken together, these findings increase the knowledge on serological response to distinct PvCSP allelic variants and may contribute to the development of a global and effective P. vivax vaccine.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45648/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJoseliOFerreira_etal_IOC_2020.pdfJoseliOFerreira_etal_IOC_2020.pdfapplication/pdf1819381https://www.arca.fiocruz.br/bitstream/icict/45648/2/JoseliOFerreira_etal_IOC_2020.pdfa7168d294048bdcf3ed7193ab379eafaMD52TEXTJoseliOFerreira_etal_IOC_2020.pdf.txtJoseliOFerreira_etal_IOC_2020.pdf.txtExtracted texttext/plain66651https://www.arca.fiocruz.br/bitstream/icict/45648/3/JoseliOFerreira_etal_IOC_2020.pdf.txtd235e3d29e619a69a0a28bf08bf9b87fMD53icict/456482022-06-24 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| dc.title.pt_BR.fl_str_mv |
Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon |
| title |
Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon |
| spellingShingle |
Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon Soares, Isabel Ferreira Plasmodium Recombinante Superfície circunsporozoíta vivax Proteína alélica Anticorpo Amazônia brasileira Recombinant Plasmodium Vivax circumsporozoite surface Protein allelic Antibody Brazilian Amazon |
| title_short |
Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon |
| title_full |
Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon |
| title_fullStr |
Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon |
| title_full_unstemmed |
Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon |
| title_sort |
Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon |
| author |
Soares, Isabel Ferreira |
| author_facet |
Soares, Isabel Ferreira Camacho, César López Silva, Rodrigo Nunes Rodrigues da Matos, Ada da Silva Baptista, Barbara de Oliveira Totino, Paulo Renato Rivas Souza, Rodrigo Medeiros de Harrison, Kate Gimenez, Alba Marina Freitas, Elisângela Oliveira de Kim, Young Chan Ferreira, Joseli Oliveira Daniel‑Ribeiro, Cláudio Tadeu Reyes‑Sandova, Arturo Pratt‑Riccio, Lilian Rose Lima Junior, Josué da Costa |
| author_role |
author |
| author2 |
Camacho, César López Silva, Rodrigo Nunes Rodrigues da Matos, Ada da Silva Baptista, Barbara de Oliveira Totino, Paulo Renato Rivas Souza, Rodrigo Medeiros de Harrison, Kate Gimenez, Alba Marina Freitas, Elisângela Oliveira de Kim, Young Chan Ferreira, Joseli Oliveira Daniel‑Ribeiro, Cláudio Tadeu Reyes‑Sandova, Arturo Pratt‑Riccio, Lilian Rose Lima Junior, Josué da Costa |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Soares, Isabel Ferreira Camacho, César López Silva, Rodrigo Nunes Rodrigues da Matos, Ada da Silva Baptista, Barbara de Oliveira Totino, Paulo Renato Rivas Souza, Rodrigo Medeiros de Harrison, Kate Gimenez, Alba Marina Freitas, Elisângela Oliveira de Kim, Young Chan Ferreira, Joseli Oliveira Daniel‑Ribeiro, Cláudio Tadeu Reyes‑Sandova, Arturo Pratt‑Riccio, Lilian Rose Lima Junior, Josué da Costa |
| dc.subject.other.pt_BR.fl_str_mv |
Plasmodium Recombinante Superfície circunsporozoíta vivax Proteína alélica Anticorpo Amazônia brasileira |
| topic |
Plasmodium Recombinante Superfície circunsporozoíta vivax Proteína alélica Anticorpo Amazônia brasileira Recombinant Plasmodium Vivax circumsporozoite surface Protein allelic Antibody Brazilian Amazon |
| dc.subject.en.pt_BR.fl_str_mv |
Recombinant Plasmodium Vivax circumsporozoite surface Protein allelic Antibody Brazilian Amazon |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. |
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2020 |
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2020 |
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2021-01-11T19:20:45Z |
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2021-01-11T19:20:45Z |
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info:eu-repo/semantics/publishedVersion |
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SOARES, Isabel Ferreira et al. Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon. Scientifc Reports, v. 10, 14020, 14p, 2020. |
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2045-2322 |
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SOARES, Isabel Ferreira et al. Recombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon. Scientifc Reports, v. 10, 14020, 14p, 2020. /10.1038/s41598-020-70893-3 2045-2322 |
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Nature Research |
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Nature Research |
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