A single dose of inactivated hepatitis A vaccine promotes HAV-specific memory cellular response similar to that induced by a natural infection

Detalhes bibliográficos
Autor(a) principal: Melgaço, Juliana Gil
Data de Publicação: 2015
Outros Autores: Morgado, Lucas Nóbrega, Santiago, Marta Almeida, Oliveira, Jaqueline Mendes de, Lewis-Ximenez, Lia Laura, Hasselmann, Bárbara, Cruz, Oswaldo Gonçalves, Pinto, Marcelo Alves, Vitral, Claudia Lamarca
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12738
Resumo: Universidade Federal Fluminense. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.
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spelling Melgaço, Juliana GilMorgado, Lucas NóbregaSantiago, Marta AlmeidaOliveira, Jaqueline Mendes deLewis-Ximenez, Lia LauraHasselmann, BárbaraCruz, Oswaldo GonçalvesPinto, Marcelo AlvesVitral, Claudia Lamarca2016-02-16T16:13:41Z2016-02-16T16:13:41Z2015MELGAÇO, Juliana Gil et al. A single dose of inactivated hepatitis A vaccine promotes HAV-specific memory cellular response similar to that induced by a natural infection. Vaccine, v. 33, n. 32, p. 3813-3820, July 2015.0264-410Xhttps://www.arca.fiocruz.br/handle/icict/1273810.1016/j.vaccine.2015.06.099engElsevierHepatite AVacinasDose ÚnicaHepatitis A vaccineSingle doseCentral memory cellsEffector memory cellsCellular responseA single dose of inactivated hepatitis A vaccine promotes HAV-specific memory cellular response similar to that induced by a natural infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal Fluminense. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos. Laboratório de Tecnologia Diagnóstica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Ambulatório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Ambulatório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil.Based on current studies on the effects of single dose vaccines on antibody production, Latin American countries have adopted a single dose vaccine program. However, no data are available on the activation of cellular response to a single dose of hepatitis A. Our study investigated the functional reactivity of the memory cell phenotype after hepatitis A virus (HAV) stimulation through administration of the first or second dose of HAV vaccine and compared the response to that of a baseline group to an initial natural infection. Proliferation assays showed that the first vaccine dose induced HAV-specific cellular response; this response was similar to that induced by a second dose or an initial natural infection. Thus, from the first dose to the second dose, increase in the frequencies of classical memory B cells, TCD8 cells, and central memory TCD4 and TCD8 cells were observed. Regarding cytokine production, increased IL-6, IL-10, TNF, and IFN levels were observed after vaccination. Our findings suggest that a single dose of HAV vaccine promotes HAV-specific memory cell response similar to that induced by a natural infection. The HAV-specific T cell immunity induced by primary vaccination persisted independently of the protective plasma antibody level. In addition, our results suggest that a single dose immunization system could serve as an alternative strategy for the prevention of hepatitis A in developing countries.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALlia_ximenez_etal_IOC_2015.pdflia_ximenez_etal_IOC_2015.pdfapplication/pdf1130672https://www.arca.fiocruz.br/bitstream/icict/12738/2/lia_ximenez_etal_IOC_2015.pdf99ca2327c3aee33314e3763f002fb051MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12738/3/license.txt5a560609d32a3863062d77ff32785d58MD53TEXTlia_ximenez_etal_IOC_2015.pdf.txtlia_ximenez_etal_IOC_2015.pdf.txtExtracted texttext/plain45027https://www.arca.fiocruz.br/bitstream/icict/12738/4/lia_ximenez_etal_IOC_2015.pdf.txt097f88f09498f403681c64d2b34db20aMD54icict/127382019-06-23 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dc.title.pt_BR.fl_str_mv A single dose of inactivated hepatitis A vaccine promotes HAV-specific memory cellular response similar to that induced by a natural infection
title A single dose of inactivated hepatitis A vaccine promotes HAV-specific memory cellular response similar to that induced by a natural infection
spellingShingle A single dose of inactivated hepatitis A vaccine promotes HAV-specific memory cellular response similar to that induced by a natural infection
Melgaço, Juliana Gil
Hepatite A
Vacinas
Dose Única
Hepatitis A vaccine
Single dose
Central memory cells
Effector memory cells
Cellular response
title_short A single dose of inactivated hepatitis A vaccine promotes HAV-specific memory cellular response similar to that induced by a natural infection
title_full A single dose of inactivated hepatitis A vaccine promotes HAV-specific memory cellular response similar to that induced by a natural infection
title_fullStr A single dose of inactivated hepatitis A vaccine promotes HAV-specific memory cellular response similar to that induced by a natural infection
title_full_unstemmed A single dose of inactivated hepatitis A vaccine promotes HAV-specific memory cellular response similar to that induced by a natural infection
title_sort A single dose of inactivated hepatitis A vaccine promotes HAV-specific memory cellular response similar to that induced by a natural infection
author Melgaço, Juliana Gil
author_facet Melgaço, Juliana Gil
Morgado, Lucas Nóbrega
Santiago, Marta Almeida
Oliveira, Jaqueline Mendes de
Lewis-Ximenez, Lia Laura
Hasselmann, Bárbara
Cruz, Oswaldo Gonçalves
Pinto, Marcelo Alves
Vitral, Claudia Lamarca
author_role author
author2 Morgado, Lucas Nóbrega
Santiago, Marta Almeida
Oliveira, Jaqueline Mendes de
Lewis-Ximenez, Lia Laura
Hasselmann, Bárbara
Cruz, Oswaldo Gonçalves
Pinto, Marcelo Alves
Vitral, Claudia Lamarca
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Melgaço, Juliana Gil
Morgado, Lucas Nóbrega
Santiago, Marta Almeida
Oliveira, Jaqueline Mendes de
Lewis-Ximenez, Lia Laura
Hasselmann, Bárbara
Cruz, Oswaldo Gonçalves
Pinto, Marcelo Alves
Vitral, Claudia Lamarca
dc.subject.other.pt_BR.fl_str_mv Hepatite A
Vacinas
Dose Única
topic Hepatite A
Vacinas
Dose Única
Hepatitis A vaccine
Single dose
Central memory cells
Effector memory cells
Cellular response
dc.subject.en.pt_BR.fl_str_mv Hepatitis A vaccine
Single dose
Central memory cells
Effector memory cells
Cellular response
description Universidade Federal Fluminense. Departamento de Microbiologia e Parasitologia. Niterói, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Desenvolvimento Tecnológico em Virologia. Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-02-16T16:13:41Z
dc.date.available.fl_str_mv 2016-02-16T16:13:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MELGAÇO, Juliana Gil et al. A single dose of inactivated hepatitis A vaccine promotes HAV-specific memory cellular response similar to that induced by a natural infection. Vaccine, v. 33, n. 32, p. 3813-3820, July 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12738
dc.identifier.issn.none.fl_str_mv 0264-410X
dc.identifier.doi.none.fl_str_mv 10.1016/j.vaccine.2015.06.099
identifier_str_mv MELGAÇO, Juliana Gil et al. A single dose of inactivated hepatitis A vaccine promotes HAV-specific memory cellular response similar to that induced by a natural infection. Vaccine, v. 33, n. 32, p. 3813-3820, July 2015.
0264-410X
10.1016/j.vaccine.2015.06.099
url https://www.arca.fiocruz.br/handle/icict/12738
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/12738/2/lia_ximenez_etal_IOC_2015.pdf
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