Population‑based surveillance for congenital zika virus syndrome: a latent class analysis of recorded cases from 2015–2018
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/56348 |
Resumo: | Secretaria de Vigilância Sanitária, Ministério da Saúde do Brasil. Wellcome Trust |
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Paixao, Enny S.Rodrigues, Laura C.Costa, Maria da Conceição N.Sauer, Rita de Cassia Oliveira de CarvalhoOliveira, Wanderson K.Cardim, Luciana L.Faccini, Lavinia SchulerAndrade, Roberto F. S.Rodrigues, Moreno S.Brickley, Elizabeth B.Veiga, Rafael V.Costa, Larissa C.Carmo, Eduardo H.Smeeth, LiamBarreto, Mauricio L.Teixeira, Maria Gloria2023-01-06T14:03:58Z2023-01-06T14:03:58Z2022PAIXAO, Enny S. et al. Population‑based surveillance for congenital zika virus syndrome: a latent class analysis of recorded cases from 2015–2018. BMC Pregnancy and Childbirth, v. 22, n. 530, p. 1-10, 2022.1471-2393https://www.arca.fiocruz.br/handle/icict/5634810.1186/s12884-022-04860-3Secretaria de Vigilância Sanitária, Ministério da Saúde do Brasil. Wellcome TrustLondon School of Hygiene and Tropical Medicine. Keppel St, London, UK / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil.London School of Hygiene and Tropical Medicine. Keppel St, London, UK / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Secretaria de Estado da Saúde da Bahia. Centro Regional de Saúde Leste. Santo Antônio de Jesus, BA, Brasil.Ministério da Defesa Hospital das Armadas Forces. Diretoria Técnica de Ensino e Pesquisa. Brasília, DF, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil.Universidade Federal do Rio Grande do Sul. Genética Departamento. Porto Alegre, RS, Brasil / Serviço de Genética Médica, Hospital de Clínicas do Porto Alegre. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil.London School of Hygiene and Tropical Medicine. Keppel St, London, UK.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil.London School of Hygiene and Tropical Medicine. Keppel St, London, UK.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Objective: This study aims to describe clinical findings and determine the medium-term survival of congenital zika syndrome (CZS) suspected cases. Methods: A retrospective cohort study using routine register-based linked data. It included all suspected cases of CZS born in Brazil from January 1, 2015, to December 31, 2018, and followed up from birth until death, 36 months, or December 31, 2018, whichever came first. Latent class analysis was used to cluster unconfirmed cases into classes with similar combinations of anthropometry at birth, imaging findings, maternally reported rash, region, and year of birth. Kaplan–Meier curves were plotted, and Cox proportional hazards models were fitted to determine mortality up to 36 months. Results: We followed 11,850 suspected cases of CZS, of which 28.3% were confirmed, 9.3% inconclusive and 62.4% unconfirmed. Confirmed cases had almost two times higher mortality when compared with unconfirmed cases. Among unconfirmed cases, we identified three distinct clusters with different mortality trajectories. The highest mortality risk was observed in those with abnormal imaging findings compatible with congenital infections (HR = 12.6; IC95%8.8–18.0) and other abnormalities (HR = 11.6; IC95%8.6–15.6) compared with those with normal imaging findings. The risk was high in those with severe microcephaly (HR = 8.2; IC95%6.4–10.6) and macrocephaly (HR = 6.6; IC95%4.5–9.7) compared with normal head size. Conclusion: Abnormal imaging and head circumference appear to be the main drivers of the increased mortality among suspected cases of CZS. We suggest identifying children who are more likely to die and have a greater need to optimise interventions and resource allocation regardless of the final diagnoses.engBMCSíndrome congênita do zikaMortalidadeMicrocefaliaAchados de imagemCongenital Zika syndromeMortalityMicrocephalyImaging findingsInfecção por Zika virusMortalidadeMicrocefaliaPopulation‑based surveillance for congenital zika virus syndrome: a latent class analysis of recorded cases from 2015–2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALPaixão E.S. Population-based surveillance.pdfPaixão E.S. Population-based surveillance.pdfapplication/pdf1284904https://www.arca.fiocruz.br/bitstream/icict/56348/2/Paix%c3%a3o%20E.S.%20Population-based%20surveillance.pdf40d77de92bcb08232fe5a62ed46ce6d6MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56348/1/license.txt5a560609d32a3863062d77ff32785d58MD51icict/563482023-03-15 14:32:49.981oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:49Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Population‑based surveillance for congenital zika virus syndrome: a latent class analysis of recorded cases from 2015–2018 |
| title |
Population‑based surveillance for congenital zika virus syndrome: a latent class analysis of recorded cases from 2015–2018 |
| spellingShingle |
Population‑based surveillance for congenital zika virus syndrome: a latent class analysis of recorded cases from 2015–2018 Paixao, Enny S. Síndrome congênita do zika Mortalidade Microcefalia Achados de imagem Congenital Zika syndrome Mortality Microcephaly Imaging findings Infecção por Zika virus Mortalidade Microcefalia |
| title_short |
Population‑based surveillance for congenital zika virus syndrome: a latent class analysis of recorded cases from 2015–2018 |
| title_full |
Population‑based surveillance for congenital zika virus syndrome: a latent class analysis of recorded cases from 2015–2018 |
| title_fullStr |
Population‑based surveillance for congenital zika virus syndrome: a latent class analysis of recorded cases from 2015–2018 |
| title_full_unstemmed |
Population‑based surveillance for congenital zika virus syndrome: a latent class analysis of recorded cases from 2015–2018 |
| title_sort |
Population‑based surveillance for congenital zika virus syndrome: a latent class analysis of recorded cases from 2015–2018 |
| author |
Paixao, Enny S. |
| author_facet |
Paixao, Enny S. Rodrigues, Laura C. Costa, Maria da Conceição N. Sauer, Rita de Cassia Oliveira de Carvalho Oliveira, Wanderson K. Cardim, Luciana L. Faccini, Lavinia Schuler Andrade, Roberto F. S. Rodrigues, Moreno S. Brickley, Elizabeth B. Veiga, Rafael V. Costa, Larissa C. Carmo, Eduardo H. Smeeth, Liam Barreto, Mauricio L. Teixeira, Maria Gloria |
| author_role |
author |
| author2 |
Rodrigues, Laura C. Costa, Maria da Conceição N. Sauer, Rita de Cassia Oliveira de Carvalho Oliveira, Wanderson K. Cardim, Luciana L. Faccini, Lavinia Schuler Andrade, Roberto F. S. Rodrigues, Moreno S. Brickley, Elizabeth B. Veiga, Rafael V. Costa, Larissa C. Carmo, Eduardo H. Smeeth, Liam Barreto, Mauricio L. Teixeira, Maria Gloria |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Paixao, Enny S. Rodrigues, Laura C. Costa, Maria da Conceição N. Sauer, Rita de Cassia Oliveira de Carvalho Oliveira, Wanderson K. Cardim, Luciana L. Faccini, Lavinia Schuler Andrade, Roberto F. S. Rodrigues, Moreno S. Brickley, Elizabeth B. Veiga, Rafael V. Costa, Larissa C. Carmo, Eduardo H. Smeeth, Liam Barreto, Mauricio L. Teixeira, Maria Gloria |
| dc.subject.other.en_US.fl_str_mv |
Síndrome congênita do zika Mortalidade Microcefalia Achados de imagem |
| topic |
Síndrome congênita do zika Mortalidade Microcefalia Achados de imagem Congenital Zika syndrome Mortality Microcephaly Imaging findings Infecção por Zika virus Mortalidade Microcefalia |
| dc.subject.en.en_US.fl_str_mv |
Congenital Zika syndrome Mortality Microcephaly Imaging findings |
| dc.subject.decs.en_US.fl_str_mv |
Infecção por Zika virus Mortalidade Microcefalia |
| description |
Secretaria de Vigilância Sanitária, Ministério da Saúde do Brasil. Wellcome Trust |
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2022 |
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2022 |
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2023-01-06T14:03:58Z |
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2023-01-06T14:03:58Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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PAIXAO, Enny S. et al. Population‑based surveillance for congenital zika virus syndrome: a latent class analysis of recorded cases from 2015–2018. BMC Pregnancy and Childbirth, v. 22, n. 530, p. 1-10, 2022. |
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https://www.arca.fiocruz.br/handle/icict/56348 |
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1471-2393 |
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10.1186/s12884-022-04860-3 |
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PAIXAO, Enny S. et al. Population‑based surveillance for congenital zika virus syndrome: a latent class analysis of recorded cases from 2015–2018. BMC Pregnancy and Childbirth, v. 22, n. 530, p. 1-10, 2022. 1471-2393 10.1186/s12884-022-04860-3 |
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