Population-based surveillance for congenital zika virus syndrome : a latent class analysis of recorded cases from 2015–2018

Detalhes bibliográficos
Autor(a) principal: Paixão, Enny Santos da
Data de Publicação: 2022
Outros Autores: Rodrigues, Laura Cunha, Costa, Maria da Conceição Nascimento, Carvalho-Sauer, Rita de Cassia Oliveira, Oliveira, Wanderson Kleber de, Cardim, Luciana Lobato, Faccini, Lavinia Schuler, Andrade, Roberto Fernandes Silva, Rodrigues, Moreno Magalhães de Souza, Brickley, Elizabeth B., Veiga, Rafael Valente, Costa, Larissa Catharina, Carmo, Eduardo Hage, Smeeth, Liam, Barreto, Mauricio Lima, Teixeira, Maria Gloria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/267053
Resumo: Abstract Objective: This study aims to describe clinical fndings and determine the medium-term survival of congenital zika syndrome (CZS) suspected cases. Methods: A retrospective cohort study using routine register-based linked data. It included all suspected cases of CZS born in Brazil from January 1, 2015, to December 31, 2018, and followed up from birth until death, 36 months, or December 31, 2018, whichever came frst. Latent class analysis was used to cluster unconfrmed cases into classes with similar combinations of anthropometry at birth, imaging fndings, maternally reported rash, region, and year of birth. Kaplan–Meier curves were plotted, and Cox proportional hazards models were ftted to determine mortality up to 36 months Results: We followed 11,850 suspected cases of CZS, of which 28.3% were confrmed, 9.3% inconclusive and 62.4% unconfrmed. Confrmed cases had almost two times higher mortality when compared with unconfrmed cases. Among unconfrmed cases, we identifed three distinct clusters with diferent mortality trajectories. The highest mor‑ tality risk was observed in those with abnormal imaging fndings compatible with congenital infections (HR=12.6; IC95%8.8–18.0) and other abnormalities (HR=11.6; IC95%8.6–15.6) compared with those with normal imaging fndings. The risk was high in those with severe microcephaly (HR=8.2; IC95%6.4–10.6) and macrocephaly (HR=6.6; IC95%4.5–9.7) compared with normal head size. Conclusion: Abnormal imaging and head circumference appear to be the main drivers of the increased mortality among suspected cases of CZS. We suggest identifying children who are more likely to die and have a greater need to optimise interventions and resource allocation regardless of the fnal diagnoses.
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spelling Paixão, Enny Santos daRodrigues, Laura CunhaCosta, Maria da Conceição NascimentoCarvalho-Sauer, Rita de Cassia OliveiraOliveira, Wanderson Kleber deCardim, Luciana LobatoFaccini, Lavinia SchulerAndrade, Roberto Fernandes SilvaRodrigues, Moreno Magalhães de SouzaBrickley, Elizabeth B.Veiga, Rafael ValenteCosta, Larissa CatharinaCarmo, Eduardo HageSmeeth, LiamBarreto, Mauricio LimaTeixeira, Maria Gloria2023-11-11T03:26:08Z20221471-2393http://hdl.handle.net/10183/267053001153714Abstract Objective: This study aims to describe clinical fndings and determine the medium-term survival of congenital zika syndrome (CZS) suspected cases. Methods: A retrospective cohort study using routine register-based linked data. It included all suspected cases of CZS born in Brazil from January 1, 2015, to December 31, 2018, and followed up from birth until death, 36 months, or December 31, 2018, whichever came frst. Latent class analysis was used to cluster unconfrmed cases into classes with similar combinations of anthropometry at birth, imaging fndings, maternally reported rash, region, and year of birth. Kaplan–Meier curves were plotted, and Cox proportional hazards models were ftted to determine mortality up to 36 months Results: We followed 11,850 suspected cases of CZS, of which 28.3% were confrmed, 9.3% inconclusive and 62.4% unconfrmed. Confrmed cases had almost two times higher mortality when compared with unconfrmed cases. Among unconfrmed cases, we identifed three distinct clusters with diferent mortality trajectories. The highest mor‑ tality risk was observed in those with abnormal imaging fndings compatible with congenital infections (HR=12.6; IC95%8.8–18.0) and other abnormalities (HR=11.6; IC95%8.6–15.6) compared with those with normal imaging fndings. The risk was high in those with severe microcephaly (HR=8.2; IC95%6.4–10.6) and macrocephaly (HR=6.6; IC95%4.5–9.7) compared with normal head size. Conclusion: Abnormal imaging and head circumference appear to be the main drivers of the increased mortality among suspected cases of CZS. We suggest identifying children who are more likely to die and have a greater need to optimise interventions and resource allocation regardless of the fnal diagnoses.application/pdfengBMC pregnancy and childbirth. United Kingdom. Vol. 22 (2022), e530, 10 p.Zika virusInfecção por Zika virusMortalidadeCongenital zika syndromeImaging findingsPopulation-based surveillance for congenital zika virus syndrome : a latent class analysis of recorded cases from 2015–2018Estrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001153714.pdf.txt001153714.pdf.txtExtracted Texttext/plain0http://www.lume.ufrgs.br/bitstream/10183/267053/2/001153714.pdf.txtd41d8cd98f00b204e9800998ecf8427eMD52ORIGINAL001153714.pdfTexto completo (inglês)application/pdf3326974http://www.lume.ufrgs.br/bitstream/10183/267053/1/001153714.pdfa6d353864d24ad262b3f4b8befbdc4e7MD5110183/2670532024-09-21 06:42:40.789089oai:www.lume.ufrgs.br:10183/267053Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2024-09-21T09:42:40Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Population-based surveillance for congenital zika virus syndrome : a latent class analysis of recorded cases from 2015–2018
title Population-based surveillance for congenital zika virus syndrome : a latent class analysis of recorded cases from 2015–2018
spellingShingle Population-based surveillance for congenital zika virus syndrome : a latent class analysis of recorded cases from 2015–2018
Paixão, Enny Santos da
Zika virus
Infecção por Zika virus
Mortalidade
Congenital zika syndrome
Imaging findings
title_short Population-based surveillance for congenital zika virus syndrome : a latent class analysis of recorded cases from 2015–2018
title_full Population-based surveillance for congenital zika virus syndrome : a latent class analysis of recorded cases from 2015–2018
title_fullStr Population-based surveillance for congenital zika virus syndrome : a latent class analysis of recorded cases from 2015–2018
title_full_unstemmed Population-based surveillance for congenital zika virus syndrome : a latent class analysis of recorded cases from 2015–2018
title_sort Population-based surveillance for congenital zika virus syndrome : a latent class analysis of recorded cases from 2015–2018
author Paixão, Enny Santos da
author_facet Paixão, Enny Santos da
Rodrigues, Laura Cunha
Costa, Maria da Conceição Nascimento
Carvalho-Sauer, Rita de Cassia Oliveira
Oliveira, Wanderson Kleber de
Cardim, Luciana Lobato
Faccini, Lavinia Schuler
Andrade, Roberto Fernandes Silva
Rodrigues, Moreno Magalhães de Souza
Brickley, Elizabeth B.
Veiga, Rafael Valente
Costa, Larissa Catharina
Carmo, Eduardo Hage
Smeeth, Liam
Barreto, Mauricio Lima
Teixeira, Maria Gloria
author_role author
author2 Rodrigues, Laura Cunha
Costa, Maria da Conceição Nascimento
Carvalho-Sauer, Rita de Cassia Oliveira
Oliveira, Wanderson Kleber de
Cardim, Luciana Lobato
Faccini, Lavinia Schuler
Andrade, Roberto Fernandes Silva
Rodrigues, Moreno Magalhães de Souza
Brickley, Elizabeth B.
Veiga, Rafael Valente
Costa, Larissa Catharina
Carmo, Eduardo Hage
Smeeth, Liam
Barreto, Mauricio Lima
Teixeira, Maria Gloria
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Paixão, Enny Santos da
Rodrigues, Laura Cunha
Costa, Maria da Conceição Nascimento
Carvalho-Sauer, Rita de Cassia Oliveira
Oliveira, Wanderson Kleber de
Cardim, Luciana Lobato
Faccini, Lavinia Schuler
Andrade, Roberto Fernandes Silva
Rodrigues, Moreno Magalhães de Souza
Brickley, Elizabeth B.
Veiga, Rafael Valente
Costa, Larissa Catharina
Carmo, Eduardo Hage
Smeeth, Liam
Barreto, Mauricio Lima
Teixeira, Maria Gloria
dc.subject.por.fl_str_mv Zika virus
Infecção por Zika virus
Mortalidade
topic Zika virus
Infecção por Zika virus
Mortalidade
Congenital zika syndrome
Imaging findings
dc.subject.eng.fl_str_mv Congenital zika syndrome
Imaging findings
description Abstract Objective: This study aims to describe clinical fndings and determine the medium-term survival of congenital zika syndrome (CZS) suspected cases. Methods: A retrospective cohort study using routine register-based linked data. It included all suspected cases of CZS born in Brazil from January 1, 2015, to December 31, 2018, and followed up from birth until death, 36 months, or December 31, 2018, whichever came frst. Latent class analysis was used to cluster unconfrmed cases into classes with similar combinations of anthropometry at birth, imaging fndings, maternally reported rash, region, and year of birth. Kaplan–Meier curves were plotted, and Cox proportional hazards models were ftted to determine mortality up to 36 months Results: We followed 11,850 suspected cases of CZS, of which 28.3% were confrmed, 9.3% inconclusive and 62.4% unconfrmed. Confrmed cases had almost two times higher mortality when compared with unconfrmed cases. Among unconfrmed cases, we identifed three distinct clusters with diferent mortality trajectories. The highest mor‑ tality risk was observed in those with abnormal imaging fndings compatible with congenital infections (HR=12.6; IC95%8.8–18.0) and other abnormalities (HR=11.6; IC95%8.6–15.6) compared with those with normal imaging fndings. The risk was high in those with severe microcephaly (HR=8.2; IC95%6.4–10.6) and macrocephaly (HR=6.6; IC95%4.5–9.7) compared with normal head size. Conclusion: Abnormal imaging and head circumference appear to be the main drivers of the increased mortality among suspected cases of CZS. We suggest identifying children who are more likely to die and have a greater need to optimise interventions and resource allocation regardless of the fnal diagnoses.
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-11-11T03:26:08Z
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dc.relation.ispartof.pt_BR.fl_str_mv BMC pregnancy and childbirth. United Kingdom. Vol. 22 (2022), e530, 10 p.
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