Tissue Damage in Human Cutaneous Leishmaniasis: Correlations Between Inflammatory Cells and Molecule Expression

Detalhes bibliográficos
Autor(a) principal: Saldanha, Maíra Garcia
Data de Publicação: 2020
Outros Autores: Pagliari, Carla, Queiroz, Adriano, Machado, Paulo Roberto Lima, Carvalho, Lucas, Scott, Phillip, Carvalho, Edgar Marcelino de, Arruda, Sérgio Marcos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/44372
Resumo: National Institutes of Health (grant AI088650) and Conselho Nacional de Pesquisa Instituto Nacional de Ciência e Tecnologia—Doenças Tropicais (project no. 573839/2008-5). The funders had no role in study design, data collection or analysis, the decision to publish, or manuscript preparation.
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spelling Saldanha, Maíra GarciaPagliari, CarlaQueiroz, AdrianoMachado, Paulo Roberto LimaCarvalho, LucasScott, PhillipCarvalho, Edgar Marcelino deArruda, Sérgio Marcos2020-11-11T12:14:58Z2020-11-11T12:14:58Z2020SALDANHA, Maíra Garcia et al. Tissue Damage in Human Cutaneous Leishmaniasis: Correlations Between Inflammatory Cells and Molecule Expression. Frontiers in Cellular and Infection Microbiology, 2020.2235-2988https://www.arca.fiocruz.br/handle/icict/4437210.3389/fcimb.2020.00355National Institutes of Health (grant AI088650) and Conselho Nacional de Pesquisa Instituto Nacional de Ciência e Tecnologia—Doenças Tropicais (project no. 573839/2008-5). The funders had no role in study design, data collection or analysis, the decision to publish, or manuscript preparation.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade São Paulo. Faculdade de Medicina. Departamento de Patologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.University of Pennsylvania. School of Veterinary Medicine. Department of Pathobiology. Philadelphia, PA, United States.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Estadual da Bahia. Departamento de Ciências de Vida. Salvador, BA, Brasil.Cutaneous leishmaniasis (CL) is caused by the bite of the infected sand fly, which inoculates parasites of Leishmania spp and triggers an immune response. An exacerbated cutaneous inflammatory response is crucial for controlling parasite burden but can also promote tissue damage. This study aimed to characterize the populations of natural killer (NK), CD57+, CD4+, and CD8+ T cells, CD20+ B cells, as well as CD68+ macrophages, in biopsies of ulcerated CL lesions, and quantify the production of perforin+, grazyme B+, interleukin 1 beta (IL-1b+) and Tumor Necrosis Factor (TNF-a+ cells). We then correlated these parameters with necrosis, inflammation and the number of amastigotes. CD4+ T cells were positively correlated to the extent of inflammation, B cells and IL-1b+ were associated with the extent of necrosis, CD68+ macrophages and perforin were correlated with the number of amastigotes, and CD57+ NK cells was correlated to CD68+ macrophages and amastigotes. In sum, the finding suggests that the production of cytotoxic granules and cytokines by inflammatory cells contributes to tissue damage in CL lesionengFrontiers MediaLeishmaniose CutâneaInflamaçãoNecroseAmastigotasTecidosCutaneous LeishmaniasisInflammatory cellsNecrosisAmastigotesTissue damageTissue Damage in Human Cutaneous Leishmaniasis: Correlations Between Inflammatory Cells and Molecule Expressioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/44372/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALSaldanha, Maíra Garcia. Tissue....pdfSaldanha, Maíra Garcia. 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dc.title.pt_BR.fl_str_mv Tissue Damage in Human Cutaneous Leishmaniasis: Correlations Between Inflammatory Cells and Molecule Expression
title Tissue Damage in Human Cutaneous Leishmaniasis: Correlations Between Inflammatory Cells and Molecule Expression
spellingShingle Tissue Damage in Human Cutaneous Leishmaniasis: Correlations Between Inflammatory Cells and Molecule Expression
Saldanha, Maíra Garcia
Leishmaniose Cutânea
Inflamação
Necrose
Amastigotas
Tecidos
Cutaneous Leishmaniasis
Inflammatory cells
Necrosis
Amastigotes
Tissue damage
title_short Tissue Damage in Human Cutaneous Leishmaniasis: Correlations Between Inflammatory Cells and Molecule Expression
title_full Tissue Damage in Human Cutaneous Leishmaniasis: Correlations Between Inflammatory Cells and Molecule Expression
title_fullStr Tissue Damage in Human Cutaneous Leishmaniasis: Correlations Between Inflammatory Cells and Molecule Expression
title_full_unstemmed Tissue Damage in Human Cutaneous Leishmaniasis: Correlations Between Inflammatory Cells and Molecule Expression
title_sort Tissue Damage in Human Cutaneous Leishmaniasis: Correlations Between Inflammatory Cells and Molecule Expression
author Saldanha, Maíra Garcia
author_facet Saldanha, Maíra Garcia
Pagliari, Carla
Queiroz, Adriano
Machado, Paulo Roberto Lima
Carvalho, Lucas
Scott, Phillip
Carvalho, Edgar Marcelino de
Arruda, Sérgio Marcos
author_role author
author2 Pagliari, Carla
Queiroz, Adriano
Machado, Paulo Roberto Lima
Carvalho, Lucas
Scott, Phillip
Carvalho, Edgar Marcelino de
Arruda, Sérgio Marcos
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Saldanha, Maíra Garcia
Pagliari, Carla
Queiroz, Adriano
Machado, Paulo Roberto Lima
Carvalho, Lucas
Scott, Phillip
Carvalho, Edgar Marcelino de
Arruda, Sérgio Marcos
dc.subject.other.pt_BR.fl_str_mv Leishmaniose Cutânea
Inflamação
Necrose
Amastigotas
Tecidos
topic Leishmaniose Cutânea
Inflamação
Necrose
Amastigotas
Tecidos
Cutaneous Leishmaniasis
Inflammatory cells
Necrosis
Amastigotes
Tissue damage
dc.subject.en.pt_BR.fl_str_mv Cutaneous Leishmaniasis
Inflammatory cells
Necrosis
Amastigotes
Tissue damage
description National Institutes of Health (grant AI088650) and Conselho Nacional de Pesquisa Instituto Nacional de Ciência e Tecnologia—Doenças Tropicais (project no. 573839/2008-5). The funders had no role in study design, data collection or analysis, the decision to publish, or manuscript preparation.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-11-11T12:14:58Z
dc.date.available.fl_str_mv 2020-11-11T12:14:58Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SALDANHA, Maíra Garcia et al. Tissue Damage in Human Cutaneous Leishmaniasis: Correlations Between Inflammatory Cells and Molecule Expression. Frontiers in Cellular and Infection Microbiology, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/44372
dc.identifier.issn.pt_BR.fl_str_mv 2235-2988
dc.identifier.doi.none.fl_str_mv 10.3389/fcimb.2020.00355
identifier_str_mv SALDANHA, Maíra Garcia et al. Tissue Damage in Human Cutaneous Leishmaniasis: Correlations Between Inflammatory Cells and Molecule Expression. Frontiers in Cellular and Infection Microbiology, 2020.
2235-2988
10.3389/fcimb.2020.00355
url https://www.arca.fiocruz.br/handle/icict/44372
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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