Molecular bioprospecting of plant extracts: experience report of the BIOPROS/UFV group in the search for antitumor compounds

Detalhes bibliográficos
Autor(a) principal: Almeida, Alisson Andrade
Data de Publicação: 2022
Outros Autores: Leite, João Paulo Viana, Simão, Marcos Vinícius Ribeiro de Castro, Rody, Hugo Rody Vianna
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51658
Resumo: Universidade Federal de Viçosa. Centro de Ciências Biológicas e da Saúde. Departamento de Bioquímica e Biologia Molecular. Viçosa, MG, Brasil.
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spelling Almeida, Alisson AndradeLeite, João Paulo VianaSimão, Marcos Vinícius Ribeiro de CastroRody, Hugo Rody Vianna2022-03-09T16:52:43Z2022-03-09T16:52:43Z2022ALMEIDA, Alisson Andrade et al. Molecular bioprospecting of plant extracts: experience report of the BIOPROS/UFV group in the search for antitumor compounds. Revista Fitos, v. 16, Supl. 2, p. 238-246, Mar. 2022.1808-9569https://www.arca.fiocruz.br/handle/icict/5165810.32712/2446-4775.2022.12852446-4775engFundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Centro de Inovação em Biodiversidade e SaúdeMolecular bioprospecting of plant extracts: experience report of the BIOPROS/UFV group in the search for antitumor compoundsBioprospecção molecular de extratos vegetais: relato de experiência do grupo BIOPROS / UFV na busca de compostos antitumoraisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Viçosa. Centro de Ciências Biológicas e da Saúde. Departamento de Bioquímica e Biologia Molecular. Viçosa, MG, Brasil.Universidade Federal de Viçosa. Centro de Ciências Biológicas e da Saúde. Departamento de Bioquímica e Biologia Molecular. Viçosa, MG, Brasil.Instituto Federal de Educação, Ciência e Tecnologia do Amazonas. Eirunepé, AM, Brasil.Universidade de São Paulo. Escola Superior de Agricultura “Luiz de Queiroz". Piracicaba, SP, Brasil.This manuscript discusses the experience of the research group BIOPROS (Molecular Bioprospecting in the Sustainable Use of Biodiversity) from the Federal University of Viçosa in the field of bioprospecting. We describe our experience on the search for antitumor compounds from the collection of extracts of native tree species from the Atlantic Forest biome. Presenting an interdisciplinary approach, integrating knowledge of forestry engineering, bioinformatics and natural products chemistry, the bioprospecting research of the BIOPROS group has innovated in the generation of pharmacochemical knowledge of native species of the Atlantic Forest. For the composition of the extract library a total of 220 plant species distributed in 57 botanical families and 140 genera were identified. 196 extracts from 49 plant species were produced; all of them evaluated for cytotoxic activity. By showing the process of obtaining a promising antitumor activity withanolides compounds from Athenaea velutina, a species hitherto little known to science, this manuscript shows our sequence of methodological steps used to unravel bioactive natural products from fragments of Atlantic Forest. The research follows the premises of the Convention on Biological Diversity, regarding the creation of strategies for the sustainable use of biodiversity.Extract libraryPharmaceutical bioprospectingAtlantic forestCytotoxic activityAthenaea velutinaWithanolidesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/51658/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALa_a_et_all.pdfapplication/pdf708520https://www.arca.fiocruz.br/bitstream/icict/51658/2/a_a_et_all.pdf88095d70210a338462cf5f0ab1e1db3bMD52icict/516582022-12-12 10:58:22.542oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-12-12T13:58:22Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Molecular bioprospecting of plant extracts: experience report of the BIOPROS/UFV group in the search for antitumor compounds
dc.title.alternative.pt_BR.fl_str_mv Bioprospecção molecular de extratos vegetais: relato de experiência do grupo BIOPROS / UFV na busca de compostos antitumorais
title Molecular bioprospecting of plant extracts: experience report of the BIOPROS/UFV group in the search for antitumor compounds
spellingShingle Molecular bioprospecting of plant extracts: experience report of the BIOPROS/UFV group in the search for antitumor compounds
Almeida, Alisson Andrade
Extract library
Pharmaceutical bioprospecting
Atlantic forest
Cytotoxic activity
Athenaea velutina
Withanolides
title_short Molecular bioprospecting of plant extracts: experience report of the BIOPROS/UFV group in the search for antitumor compounds
title_full Molecular bioprospecting of plant extracts: experience report of the BIOPROS/UFV group in the search for antitumor compounds
title_fullStr Molecular bioprospecting of plant extracts: experience report of the BIOPROS/UFV group in the search for antitumor compounds
title_full_unstemmed Molecular bioprospecting of plant extracts: experience report of the BIOPROS/UFV group in the search for antitumor compounds
title_sort Molecular bioprospecting of plant extracts: experience report of the BIOPROS/UFV group in the search for antitumor compounds
author Almeida, Alisson Andrade
author_facet Almeida, Alisson Andrade
Leite, João Paulo Viana
Simão, Marcos Vinícius Ribeiro de Castro
Rody, Hugo Rody Vianna
author_role author
author2 Leite, João Paulo Viana
Simão, Marcos Vinícius Ribeiro de Castro
Rody, Hugo Rody Vianna
author2_role author
author
author
dc.contributor.author.fl_str_mv Almeida, Alisson Andrade
Leite, João Paulo Viana
Simão, Marcos Vinícius Ribeiro de Castro
Rody, Hugo Rody Vianna
dc.subject.en.en_US.fl_str_mv Extract library
Pharmaceutical bioprospecting
Atlantic forest
Cytotoxic activity
Athenaea velutina
Withanolides
topic Extract library
Pharmaceutical bioprospecting
Atlantic forest
Cytotoxic activity
Athenaea velutina
Withanolides
description Universidade Federal de Viçosa. Centro de Ciências Biológicas e da Saúde. Departamento de Bioquímica e Biologia Molecular. Viçosa, MG, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-03-09T16:52:43Z
dc.date.available.fl_str_mv 2022-03-09T16:52:43Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALMEIDA, Alisson Andrade et al. Molecular bioprospecting of plant extracts: experience report of the BIOPROS/UFV group in the search for antitumor compounds. Revista Fitos, v. 16, Supl. 2, p. 238-246, Mar. 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51658
dc.identifier.issn.none.fl_str_mv 1808-9569
dc.identifier.doi.none.fl_str_mv 10.32712/2446-4775.2022.1285
dc.identifier.eissn.none.fl_str_mv 2446-4775
identifier_str_mv ALMEIDA, Alisson Andrade et al. Molecular bioprospecting of plant extracts: experience report of the BIOPROS/UFV group in the search for antitumor compounds. Revista Fitos, v. 16, Supl. 2, p. 238-246, Mar. 2022.
1808-9569
10.32712/2446-4775.2022.1285
2446-4775
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Centro de Inovação em Biodiversidade e Saúde
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Centro de Inovação em Biodiversidade e Saúde
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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