Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1038/s41591-018-0275-4 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/41658 |
Resumo: | O artigo encontra-se disponível em acesso aberto no site da Editora. |
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Lourenco, Mychael V.Frozza, Rudimar L.Freitas, Guilherme B. deZhang, HongKincheski, Grasielle C.Ribeiro, Felipe C.Gonçalves, Rafaella A.Clarke, Julia R.Beckman, DanielleStaniszewski, AgnieszkaBerman, HannaGuerra, Lorena A.Forny-Germano, LetíciaMeier, ShelbyWilcock, Donna M.Souza, Jorge M. deAlves-Leon, SonizaPrado, Vania F.Prado, Marco A. M.Abisambra, Jose F.Tovar-Moll, FernandaMattos, PauloArancio, OttavioFerreira, Sergio T.De Felice, Fernanda G.2020-06-15T19:36:38Z2020-06-15T19:36:38Z2019LOURENCO, Mychael V. et al. Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models. Nature Medicine, v. 25, p. 165-175, Jan. 2019.1078-8956https://www.arca.fiocruz.br/handle/icict/4165810.1038/s41591-018-0275-41546-170XO artigo encontra-se disponível em acesso aberto no site da Editora.2022-01-01Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil / Taub Institute for Research on Alzheimer’s Disease and the Aging Brain. Columbia University. New York, NY, USA.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil / Centre for Neuroscience Studies. Queen’s University. Kingston, Ontario, Canada.Taub Institute for Research on Alzheimer’s Disease and the Aging Brain.Columbia University. New York, NY, USA.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Centre for Neuroscience Studies. Queen’s University. Kingston, Ontario, Canada.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Escola de Farmácia. Rio de Janeiro, RJ, Brasil. .Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Taub Institute for Research on Alzheimer’s Disease and the Aging Brain. Columbia University. New York, NY, USA..Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.Sanders-Brown Center on Aging. University of Kentucky. Lexington, KY, USA.Sanders-Brown Center on Aging. University of Kentucky. Lexington, KY, USA.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Neurocirurgia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Neurologia/Programa de Epilepsia. Rio de Janeiro, RJ, Brasil.Robarts Research Institute. University of Western Ontario. London, Ontario, Canada / Department of Physiology and Pharmacology. University of Western Ontario. London, Ontario, Canada / Department of Anatomy & Cell Biology. University of Western Ontario, London, Ontario, Canada.Robarts Research Institute. University of Western Ontario. London, Ontario, Canada / Department of Physiology and Pharmacology. University of Western Ontario. London, Ontario, Canada / Department of Anatomy & Cell Biology. University of Western Ontario, London, Ontario, Canada.Sanders-Brown Center on Aging. University of Kentucky. Lexington, KY, USA.Instituto D´Or para Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Rio de Janeiro, RJ, Brasil.Instituto D´Or para Pesquisa e Educação. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Psiquiatria. Rio de Janeiro, RJ, Brasil..Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, USA / Universidade Federal do Rio de Janeiro. Escola de Farmácia. Rio de janeiro, RJ, Brasil / Columbia University. Department of Medicine. New York, NY, USAUniversidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil / Centre for Neuroscience Studies. Queen’s University. Kingston, Ontario, Canada / Department of Psychiatry, Queen’s University. Kingston, Ontario, Canada.Defective brain hormonal signaling has been associated with Alzheimer's disease (AD), a disorder characterized by synapse and memory failure. Irisin is an exercise-induced myokine released on cleavage of the membrane-bound precursor protein fibronectin type III domain-containing protein 5 (FNDC5), also expressed in the hippocampus. Here we show that FNDC5/irisin levels are reduced in AD hippocampi and cerebrospinal fluid, and in experimental AD models. Knockdown of brain FNDC5/irisin impairs long-term potentiation and novel object recognition memory in mice. Conversely, boosting brain levels of FNDC5/irisin rescues synaptic plasticity and memory in AD mouse models. Peripheral overexpression of FNDC5/irisin rescues memory impairment, whereas blockade of either peripheral or brain FNDC5/irisin attenuates the neuroprotective actions of physical exercise on synaptic plasticity and memory in AD mice. By showing that FNDC5/irisin is an important mediator of the beneficial effects of exercise in AD models, our findings place FNDC5/irisin as a novel agent capable of opposing synapse failure and memory impairment in AD.engNature ResearchResgates FNDC5IrisinaPlasticidade sinápticDefeitos de memóriModelos de AlzheimerAlzheimer’s modelsSynaptic plasticityMemory defectsIrisin rescuesExercise-linked FNDC5Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's modelsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/41658/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRudimarFrozza_etal_IOC_2019.pdf.pdfRudimarFrozza_etal_IOC_2019.pdf.pdfapplication/pdf15815399https://www.arca.fiocruz.br/bitstream/icict/41658/2/RudimarFrozza_etal_IOC_2019.pdf.pdf2d6aee701ff1c82f9dc66c9b0cfa12b5MD52TEXTRudimarFrozza_etal_IOC_2019.pdf.pdf.txtRudimarFrozza_etal_IOC_2019.pdf.pdf.txtExtracted texttext/plain119573https://www.arca.fiocruz.br/bitstream/icict/41658/3/RudimarFrozza_etal_IOC_2019.pdf.pdf.txtd5f7a2890806fe7ecaabef32bfb0a510MD53icict/416582021-02-10 19:39:45.039oai:www.arca.fiocruz.br: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ório 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| dc.title.pt_BR.fl_str_mv |
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models |
| title |
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models |
| spellingShingle |
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models Lourenco, Mychael V. Resgates FNDC5 Irisina Plasticidade sináptic Defeitos de memóri Modelos de Alzheimer Alzheimer’s models Synaptic plasticity Memory defects Irisin rescues Exercise-linked FNDC5 |
| title_short |
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models |
| title_full |
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models |
| title_fullStr |
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models |
| title_full_unstemmed |
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models |
| title_sort |
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models |
| author |
Lourenco, Mychael V. |
| author_facet |
Lourenco, Mychael V. Frozza, Rudimar L. Freitas, Guilherme B. de Zhang, Hong Kincheski, Grasielle C. Ribeiro, Felipe C. Gonçalves, Rafaella A. Clarke, Julia R. Beckman, Danielle Staniszewski, Agnieszka Berman, Hanna Guerra, Lorena A. Forny-Germano, Letícia Meier, Shelby Wilcock, Donna M. Souza, Jorge M. de Alves-Leon, Soniza Prado, Vania F. Prado, Marco A. M. Abisambra, Jose F. Tovar-Moll, Fernanda Mattos, Paulo Arancio, Ottavio Ferreira, Sergio T. De Felice, Fernanda G. |
| author_role |
author |
| author2 |
Frozza, Rudimar L. Freitas, Guilherme B. de Zhang, Hong Kincheski, Grasielle C. Ribeiro, Felipe C. Gonçalves, Rafaella A. Clarke, Julia R. Beckman, Danielle Staniszewski, Agnieszka Berman, Hanna Guerra, Lorena A. Forny-Germano, Letícia Meier, Shelby Wilcock, Donna M. Souza, Jorge M. de Alves-Leon, Soniza Prado, Vania F. Prado, Marco A. M. Abisambra, Jose F. Tovar-Moll, Fernanda Mattos, Paulo Arancio, Ottavio Ferreira, Sergio T. De Felice, Fernanda G. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Lourenco, Mychael V. Frozza, Rudimar L. Freitas, Guilherme B. de Zhang, Hong Kincheski, Grasielle C. Ribeiro, Felipe C. Gonçalves, Rafaella A. Clarke, Julia R. Beckman, Danielle Staniszewski, Agnieszka Berman, Hanna Guerra, Lorena A. Forny-Germano, Letícia Meier, Shelby Wilcock, Donna M. Souza, Jorge M. de Alves-Leon, Soniza Prado, Vania F. Prado, Marco A. M. Abisambra, Jose F. Tovar-Moll, Fernanda Mattos, Paulo Arancio, Ottavio Ferreira, Sergio T. De Felice, Fernanda G. |
| dc.subject.other.pt_BR.fl_str_mv |
Resgates FNDC5 Irisina Plasticidade sináptic Defeitos de memóri Modelos de Alzheimer |
| topic |
Resgates FNDC5 Irisina Plasticidade sináptic Defeitos de memóri Modelos de Alzheimer Alzheimer’s models Synaptic plasticity Memory defects Irisin rescues Exercise-linked FNDC5 |
| dc.subject.en.pt_BR.fl_str_mv |
Alzheimer’s models Synaptic plasticity Memory defects Irisin rescues Exercise-linked FNDC5 |
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O artigo encontra-se disponível em acesso aberto no site da Editora. |
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2019 |
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2019 |
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2020-06-15T19:36:38Z |
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2020-06-15T19:36:38Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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LOURENCO, Mychael V. et al. Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models. Nature Medicine, v. 25, p. 165-175, Jan. 2019. |
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https://www.arca.fiocruz.br/handle/icict/41658 |
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1078-8956 |
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10.1038/s41591-018-0275-4 |
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1546-170X |
| identifier_str_mv |
LOURENCO, Mychael V. et al. Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models. Nature Medicine, v. 25, p. 165-175, Jan. 2019. 1078-8956 10.1038/s41591-018-0275-4 1546-170X |
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https://www.arca.fiocruz.br/handle/icict/41658 |
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eng |
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eng |
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Nature Research |
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Nature Research |
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