Plasma heme oxygenase-1 levels distinguish latent or successfully treated human tuberculosis from active disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/24743 |
Resumo: | Andrade, Bruno Bezerril. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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Andrade, Bruno de BezerrilPavan Kumar, NathellaMayer-Barber, Katrin DBarber, Daniel LSridhar, RathinamRekha, Vaithilingam V BanuJawahar, Mohideen SNutman, Thomas BSher, AlanBabu, Subash2018-02-06T16:41:32Z2018-02-06T16:41:32Z2013ANDRADE, B. B. et al. Plasma heme oxygenase-1 levels distinguish latent or successfully treated human tuberculosis from active disease. Plos One, v. 8, n. 5, p. e62618, 2013.1932-6203https://www.arca.fiocruz.br/handle/icict/2474310.1371/journal.pone.0062618Andrade, Bruno Bezerril. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthNational Institutes of Health. Laboratory of Parasitic Diseases. Bethesda, Maryland, United States of AmericaNational Institutes of Health. International Center for Excellence in Research. Chennai, IndiaNational Institutes of Health. Laboratory of Parasitic Diseases. Bethesda, Maryland, United States of AmericaNational Institutes of Health. Laboratory of Parasitic Diseases. Bethesda, Maryland, United States of AmericaGovernment Stanley Medical Hospital., Chennai, IndiaNational Institute for Research in Tuberculosis. Chennai, IndiaNational Institute for Research in Tuberculosis. Chennai, IndiaNational Institutes of Health. Laboratory of Parasitic Diseases. Bethesda, Maryland, United States of AmericaNational Institutes of Health. Laboratory of Parasitic Diseases. Bethesda, Maryland, United States of AmericaNational Institutes of Health. Laboratory of Parasitic Diseases. Bethesda, Maryland, United States of America / National Institutes of Health. International Center for Excellence in Research. Chennai, India / National Cancer Institute. Science Applications International Corporation. Frederick, Maryland, United States of AmericaTuberculosis (TB) is associated with oxidative stress and the induction of host anti-oxidants to counteract this response. Heme oxygenase-1 (HO-1) is a critical promoter of cytoprotection in diverse disease models including mycobacterial infection. Nevertheless, the pattern of expression of HO-1 in human tuberculosis has not been studied. Here, we examine expression of HO-1 in M. tuberculosis-exposed and -infected individuals and test its ability to distinguish active from latent and successfully treated TB cases. In addition, we assess correlations between plasma levels of HO-1 and cytokines closely associated with the immunopathogenesis of TB. Methods: Cross-sectional and longitudinal analyses of levels of HO-1, acute phase proteins and pro-inflammatory cytokines were performed in plasma samples from individuals with active pulmonary, extra-pulmonary or latent TB infection and healthy controls as part of a prospective cohort study in South India. Results: Systemic levels of HO-1 were dramatically increased in individuals with active pulmonary and extra-pulmonary tuberculosis and particularly those with bilateral lung lesions and elevated bacillary loads in sputum. HO-1 levels effectively discriminated active from latent tuberculosis with higher predictive values than either C-reactive protein or serum amyloid protein. Moreover, there was a marked reduction in HO-1 levels in active TB cases following anti-tuberculous therapy but not in those who failed treatment. Pulmonary TB patients displaying the highest concentrations of HO-1 in plasma exhibited significantly elevated plasma levels of interleukin (IL)-10, interferon (IFN)-c and IL-17 and diminished levels of tumor necrosis factor (TNF)-a. Conclusion: These findings establish HO-1 levels as a potentially useful parameter for distinguishing active from latent or treated pulmonary tuberculosis, that is superior in this respect to the measurement of other acute inflammatory proteinsengPublic Library of ScienceTuberculose PulmonarHeme Oxigenase-1Tuberculose LatenteAgentes antituberculososHumanosAdolescenteTuberculosis, PulmonaryHeme Oxygenase-1Latent TuberculosisAntitubercular AgentsHumansAdolescentPlasma heme oxygenase-1 levels distinguish latent or successfully treated human tuberculosis from active diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24743/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAndade BB Plasma Heme Oxygenase-1 Levels 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| dc.title.pt_BR.fl_str_mv |
Plasma heme oxygenase-1 levels distinguish latent or successfully treated human tuberculosis from active disease |
| title |
Plasma heme oxygenase-1 levels distinguish latent or successfully treated human tuberculosis from active disease |
| spellingShingle |
Plasma heme oxygenase-1 levels distinguish latent or successfully treated human tuberculosis from active disease Andrade, Bruno de Bezerril Tuberculose Pulmonar Heme Oxigenase-1 Tuberculose Latente Agentes antituberculosos Humanos Adolescente Tuberculosis, Pulmonary Heme Oxygenase-1 Latent Tuberculosis Antitubercular Agents Humans Adolescent |
| title_short |
Plasma heme oxygenase-1 levels distinguish latent or successfully treated human tuberculosis from active disease |
| title_full |
Plasma heme oxygenase-1 levels distinguish latent or successfully treated human tuberculosis from active disease |
| title_fullStr |
Plasma heme oxygenase-1 levels distinguish latent or successfully treated human tuberculosis from active disease |
| title_full_unstemmed |
Plasma heme oxygenase-1 levels distinguish latent or successfully treated human tuberculosis from active disease |
| title_sort |
Plasma heme oxygenase-1 levels distinguish latent or successfully treated human tuberculosis from active disease |
| author |
Andrade, Bruno de Bezerril |
| author_facet |
Andrade, Bruno de Bezerril Pavan Kumar, Nathella Mayer-Barber, Katrin D Barber, Daniel L Sridhar, Rathinam Rekha, Vaithilingam V Banu Jawahar, Mohideen S Nutman, Thomas B Sher, Alan Babu, Subash |
| author_role |
author |
| author2 |
Pavan Kumar, Nathella Mayer-Barber, Katrin D Barber, Daniel L Sridhar, Rathinam Rekha, Vaithilingam V Banu Jawahar, Mohideen S Nutman, Thomas B Sher, Alan Babu, Subash |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Andrade, Bruno de Bezerril Pavan Kumar, Nathella Mayer-Barber, Katrin D Barber, Daniel L Sridhar, Rathinam Rekha, Vaithilingam V Banu Jawahar, Mohideen S Nutman, Thomas B Sher, Alan Babu, Subash |
| dc.subject.other.pt_BR.fl_str_mv |
Tuberculose Pulmonar Heme Oxigenase-1 Tuberculose Latente Agentes antituberculosos Humanos Adolescente |
| topic |
Tuberculose Pulmonar Heme Oxigenase-1 Tuberculose Latente Agentes antituberculosos Humanos Adolescente Tuberculosis, Pulmonary Heme Oxygenase-1 Latent Tuberculosis Antitubercular Agents Humans Adolescent |
| dc.subject.en.pt_BR.fl_str_mv |
Tuberculosis, Pulmonary Heme Oxygenase-1 Latent Tuberculosis Antitubercular Agents Humans Adolescent |
| description |
Andrade, Bruno Bezerril. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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2013 |
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2013 |
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2018-02-06T16:41:32Z |
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2018-02-06T16:41:32Z |
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ANDRADE, B. B. et al. Plasma heme oxygenase-1 levels distinguish latent or successfully treated human tuberculosis from active disease. Plos One, v. 8, n. 5, p. e62618, 2013. |
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https://www.arca.fiocruz.br/handle/icict/24743 |
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1932-6203 |
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10.1371/journal.pone.0062618 |
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ANDRADE, B. B. et al. Plasma heme oxygenase-1 levels distinguish latent or successfully treated human tuberculosis from active disease. Plos One, v. 8, n. 5, p. e62618, 2013. 1932-6203 10.1371/journal.pone.0062618 |
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