Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis

Detalhes bibliográficos
Autor(a) principal: Andrade, Bruno de Bezerril
Data de Publicação: 2015
Outros Autores: Pavan Kumar, Nathella, Amaral, Eduardo Pinheiro, Riteau, Nicolas, Mayer-Barber, Katrin D, Tosh, Kevin W, Maier, Nolan, Conceição, Elisabete Lopes, Kubler, Andre, Sridhar, Rathinam, Banurekha, Vaithilingam V, Jawahar, Mohideen S, Bessa, Theolis Costa Barbosa, Manganiello, Vincent C, Moss, Joel, Fontana, Joseph R, Marciano, Beatriz E, Sampaio, Elizabeth P, Olivier, Kenneth N, Holland, Steven M, Jackson, Sharon H, Moayeri, Mahtab, Leppla, Stephen, Sereti, Irini, Barber, Daniel L, Nutman, Thomas B, Babu, Subash, Sher, Alan
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20169
Resumo: Andrade, Bruno de Bezerril; Bessa, Theolis Costa Barbosa. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Unidade de Medicina Investigativa. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil *Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; †Unidade de Medicina Investigativa, Laborato´rio Integrado de Microbiologia e Imunorregulação, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador 40296-710, Brazil; ‡National Institutes of Health, International Center for Excellence in Research, Chennai 600031, India; xNational Institute for Research in Tuberculosis, Chennai 600031, India; {Microbial Pathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; ‖Department of Medicine, Imperial College London, London SW7 2AZ, United Kingdom; #Government Stanley Medical Hospital, Chennai 600001, India; **Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; ††Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; ‡‡Division of Intramural Research, National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD 20892; xxClinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; {{T-Lymphocyte Biology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; ‖‖Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
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spelling Andrade, Bruno de BezerrilPavan Kumar, NathellaAmaral, Eduardo PinheiroRiteau, NicolasMayer-Barber, Katrin DTosh, Kevin WMaier, NolanConceição, Elisabete LopesKubler, AndreSridhar, RathinamBanurekha, Vaithilingam VJawahar, Mohideen SBessa, Theolis Costa BarbosaManganiello, Vincent CMoss, JoelFontana, Joseph RMarciano, Beatriz ESampaio, Elizabeth POlivier, Kenneth NHolland, Steven MJackson, Sharon HMoayeri, MahtabLeppla, StephenSereti, IriniBarber, Daniel LNutman, Thomas BBabu, SubashSher, Alan2017-07-21T17:57:14Z2017-07-21T17:57:14Z2015ANDRADE, B. B. et al. Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis. The Journal of Immunology, v. 195, n. 6, p. 2763–2773, 2015.0022-1767https://www.arca.fiocruz.br/handle/icict/2016910.4049/jimmunol.1500942Andrade, Bruno de Bezerril; Bessa, Theolis Costa Barbosa. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Unidade de Medicina Investigativa. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil *Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; †Unidade de Medicina Investigativa, Laborato´rio Integrado de Microbiologia e Imunorregulação, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador 40296-710, Brazil; ‡National Institutes of Health, International Center for Excellence in Research, Chennai 600031, India; xNational Institute for Research in Tuberculosis, Chennai 600031, India; {Microbial Pathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; ‖Department of Medicine, Imperial College London, London SW7 2AZ, United Kingdom; #Government Stanley Medical Hospital, Chennai 600001, India; **Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; ††Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; ‡‡Division of Intramural Research, National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD 20892; xxClinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; {{T-Lymphocyte Biology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; ‖‖Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health. J.M., V.C.M., and J.R.F. were supported by the National Heart, Lung, and Blood Institute Intramural Research Program. The Brazilian study was funded by Fundação de Amparo à Pesquisa do Estado da Bahia and Conselho Nacional de Desenvolvimento Cientı´fico e Tecnológico, Brazil (Grant 028/2010).Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Unidade de Medicina Investigativa. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Unidade de Medicina Investigativa. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, BrasilMúltipla – ver em NotasPulmonary tuberculosis (TB) is characterized by oxidative stress and lung tissue destruction by matrix metalloproteinases (MMPs). The interplay between these distinct pathological processes and the implications for TB diagnosis and disease staging are poorly understood. Heme oxygenase-1 (HO-1) levels were previously shown to distinguish active from latent TB, as well as successfully treated Mycobacterium tuberculosis infection. MMP-1 expression is also associated with active TB. In this study, we measured plasma levels of these two important biomarkers in distinct TB cohorts from India and Brazil. Patients with active TB expressed either very high levels of HO-1 and low levels of MMP-1 or the converse. Moreover, TB patients with either high HO-1 or MMP-1 levels displayed distinct clinical presentations, as well as plasma inflammatory marker profiles. In contrast, in an exploratory North American study, inversely correlated expression of HO-1 and MMP-1 was not observed in patients with other nontuberculous lung diseases. To assess possible regulatory interactions in the biosynthesis of these two enzymes at the cellular level, we studied the expression of HO-1 and MMP-1 in M. tuberculosis-infected human and murine macrophages. We found that infection of macrophages with live virulent M. tuberculosis is required for robust induction of high levels of HO-1 but not MMP-1. In addition, we observed that CO, a product of M. tuberculosis-induced HO-1 activity, inhibits MMP-1 expression by suppressing c-Jun/AP-1 activation. These findings reveal a mechanistic link between oxidative stress and tissue remodeling that may find applicability in the clinical staging of TB patients.engAmerican Association of ImmunologistsTuberculose, PulmonarMatrix Metalloproteinase 1Heme Oxygenase-1Mycobacterium tuberculosisMacrófagosBiomarcadoresHumanosAdultoTuberculosis, PulmonaryMatrix Metalloproteinase 1Heme Oxygenase-1Mycobacterium tuberculosisMacrophagesBiomarkersHumansAdultOxidative StressEstresse oxidativoHeme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20169/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAndrade BB Heme oxygenase-1 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dc.title.pt_BR.fl_str_mv Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis
title Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis
spellingShingle Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis
Andrade, Bruno de Bezerril
Tuberculose, Pulmonar
Matrix Metalloproteinase 1
Heme Oxygenase-1
Mycobacterium tuberculosis
Macrófagos
Biomarcadores
Humanos
Adulto
Tuberculosis, Pulmonary
Matrix Metalloproteinase 1
Heme Oxygenase-1
Mycobacterium tuberculosis
Macrophages
Biomarkers
Humans
Adult
Oxidative Stress
Estresse oxidativo
title_short Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis
title_full Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis
title_fullStr Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis
title_full_unstemmed Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis
title_sort Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis
author Andrade, Bruno de Bezerril
author_facet Andrade, Bruno de Bezerril
Pavan Kumar, Nathella
Amaral, Eduardo Pinheiro
Riteau, Nicolas
Mayer-Barber, Katrin D
Tosh, Kevin W
Maier, Nolan
Conceição, Elisabete Lopes
Kubler, Andre
Sridhar, Rathinam
Banurekha, Vaithilingam V
Jawahar, Mohideen S
Bessa, Theolis Costa Barbosa
Manganiello, Vincent C
Moss, Joel
Fontana, Joseph R
Marciano, Beatriz E
Sampaio, Elizabeth P
Olivier, Kenneth N
Holland, Steven M
Jackson, Sharon H
Moayeri, Mahtab
Leppla, Stephen
Sereti, Irini
Barber, Daniel L
Nutman, Thomas B
Babu, Subash
Sher, Alan
author_role author
author2 Pavan Kumar, Nathella
Amaral, Eduardo Pinheiro
Riteau, Nicolas
Mayer-Barber, Katrin D
Tosh, Kevin W
Maier, Nolan
Conceição, Elisabete Lopes
Kubler, Andre
Sridhar, Rathinam
Banurekha, Vaithilingam V
Jawahar, Mohideen S
Bessa, Theolis Costa Barbosa
Manganiello, Vincent C
Moss, Joel
Fontana, Joseph R
Marciano, Beatriz E
Sampaio, Elizabeth P
Olivier, Kenneth N
Holland, Steven M
Jackson, Sharon H
Moayeri, Mahtab
Leppla, Stephen
Sereti, Irini
Barber, Daniel L
Nutman, Thomas B
Babu, Subash
Sher, Alan
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Bruno de Bezerril
Pavan Kumar, Nathella
Amaral, Eduardo Pinheiro
Riteau, Nicolas
Mayer-Barber, Katrin D
Tosh, Kevin W
Maier, Nolan
Conceição, Elisabete Lopes
Kubler, Andre
Sridhar, Rathinam
Banurekha, Vaithilingam V
Jawahar, Mohideen S
Bessa, Theolis Costa Barbosa
Manganiello, Vincent C
Moss, Joel
Fontana, Joseph R
Marciano, Beatriz E
Sampaio, Elizabeth P
Olivier, Kenneth N
Holland, Steven M
Jackson, Sharon H
Moayeri, Mahtab
Leppla, Stephen
Sereti, Irini
Barber, Daniel L
Nutman, Thomas B
Babu, Subash
Sher, Alan
dc.subject.other.pt_BR.fl_str_mv Tuberculose, Pulmonar
Matrix Metalloproteinase 1
Heme Oxygenase-1
Mycobacterium tuberculosis
Macrófagos
Biomarcadores
Humanos
Adulto
topic Tuberculose, Pulmonar
Matrix Metalloproteinase 1
Heme Oxygenase-1
Mycobacterium tuberculosis
Macrófagos
Biomarcadores
Humanos
Adulto
Tuberculosis, Pulmonary
Matrix Metalloproteinase 1
Heme Oxygenase-1
Mycobacterium tuberculosis
Macrophages
Biomarkers
Humans
Adult
Oxidative Stress
Estresse oxidativo
dc.subject.en.pt_BR.fl_str_mv Tuberculosis, Pulmonary
Matrix Metalloproteinase 1
Heme Oxygenase-1
Mycobacterium tuberculosis
Macrophages
Biomarkers
Humans
Adult
Oxidative Stress
Estresse oxidativo
description Andrade, Bruno de Bezerril; Bessa, Theolis Costa Barbosa. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Unidade de Medicina Investigativa. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil *Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; †Unidade de Medicina Investigativa, Laborato´rio Integrado de Microbiologia e Imunorregulação, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador 40296-710, Brazil; ‡National Institutes of Health, International Center for Excellence in Research, Chennai 600031, India; xNational Institute for Research in Tuberculosis, Chennai 600031, India; {Microbial Pathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; ‖Department of Medicine, Imperial College London, London SW7 2AZ, United Kingdom; #Government Stanley Medical Hospital, Chennai 600001, India; **Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; ††Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; ‡‡Division of Intramural Research, National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD 20892; xxClinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; {{T-Lymphocyte Biology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; ‖‖Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2017-07-21T17:57:14Z
dc.date.available.fl_str_mv 2017-07-21T17:57:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, B. B. et al. Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis. The Journal of Immunology, v. 195, n. 6, p. 2763–2773, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20169
dc.identifier.issn.pt_BR.fl_str_mv 0022-1767
dc.identifier.doi.none.fl_str_mv 10.4049/jimmunol.1500942
identifier_str_mv ANDRADE, B. B. et al. Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis. The Journal of Immunology, v. 195, n. 6, p. 2763–2773, 2015.
0022-1767
10.4049/jimmunol.1500942
url https://www.arca.fiocruz.br/handle/icict/20169
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Association of Immunologists
publisher.none.fl_str_mv American Association of Immunologists
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repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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