Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20169 |
Resumo: | Andrade, Bruno de Bezerril; Bessa, Theolis Costa Barbosa. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Unidade de Medicina Investigativa. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil *Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; †Unidade de Medicina Investigativa, Laborato´rio Integrado de Microbiologia e Imunorregulação, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador 40296-710, Brazil; ‡National Institutes of Health, International Center for Excellence in Research, Chennai 600031, India; xNational Institute for Research in Tuberculosis, Chennai 600031, India; {Microbial Pathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; ‖Department of Medicine, Imperial College London, London SW7 2AZ, United Kingdom; #Government Stanley Medical Hospital, Chennai 600001, India; **Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; ††Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; ‡‡Division of Intramural Research, National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD 20892; xxClinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; {{T-Lymphocyte Biology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; ‖‖Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 |
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Andrade, Bruno de BezerrilPavan Kumar, NathellaAmaral, Eduardo PinheiroRiteau, NicolasMayer-Barber, Katrin DTosh, Kevin WMaier, NolanConceição, Elisabete LopesKubler, AndreSridhar, RathinamBanurekha, Vaithilingam VJawahar, Mohideen SBessa, Theolis Costa BarbosaManganiello, Vincent CMoss, JoelFontana, Joseph RMarciano, Beatriz ESampaio, Elizabeth POlivier, Kenneth NHolland, Steven MJackson, Sharon HMoayeri, MahtabLeppla, StephenSereti, IriniBarber, Daniel LNutman, Thomas BBabu, SubashSher, Alan2017-07-21T17:57:14Z2017-07-21T17:57:14Z2015ANDRADE, B. B. et al. Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis. The Journal of Immunology, v. 195, n. 6, p. 2763–2773, 2015.0022-1767https://www.arca.fiocruz.br/handle/icict/2016910.4049/jimmunol.1500942Andrade, Bruno de Bezerril; Bessa, Theolis Costa Barbosa. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Unidade de Medicina Investigativa. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil *Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; †Unidade de Medicina Investigativa, Laborato´rio Integrado de Microbiologia e Imunorregulação, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador 40296-710, Brazil; ‡National Institutes of Health, International Center for Excellence in Research, Chennai 600031, India; xNational Institute for Research in Tuberculosis, Chennai 600031, India; {Microbial Pathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; ‖Department of Medicine, Imperial College London, London SW7 2AZ, United Kingdom; #Government Stanley Medical Hospital, Chennai 600001, India; **Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; ††Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; ‡‡Division of Intramural Research, National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD 20892; xxClinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; {{T-Lymphocyte Biology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; ‖‖Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health. J.M., V.C.M., and J.R.F. were supported by the National Heart, Lung, and Blood Institute Intramural Research Program. The Brazilian study was funded by Fundação de Amparo à Pesquisa do Estado da Bahia and Conselho Nacional de Desenvolvimento Cientı´fico e Tecnológico, Brazil (Grant 028/2010).Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Unidade de Medicina Investigativa. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Unidade de Medicina Investigativa. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, BrasilMúltipla – ver em NotasPulmonary tuberculosis (TB) is characterized by oxidative stress and lung tissue destruction by matrix metalloproteinases (MMPs). The interplay between these distinct pathological processes and the implications for TB diagnosis and disease staging are poorly understood. Heme oxygenase-1 (HO-1) levels were previously shown to distinguish active from latent TB, as well as successfully treated Mycobacterium tuberculosis infection. MMP-1 expression is also associated with active TB. In this study, we measured plasma levels of these two important biomarkers in distinct TB cohorts from India and Brazil. Patients with active TB expressed either very high levels of HO-1 and low levels of MMP-1 or the converse. Moreover, TB patients with either high HO-1 or MMP-1 levels displayed distinct clinical presentations, as well as plasma inflammatory marker profiles. In contrast, in an exploratory North American study, inversely correlated expression of HO-1 and MMP-1 was not observed in patients with other nontuberculous lung diseases. To assess possible regulatory interactions in the biosynthesis of these two enzymes at the cellular level, we studied the expression of HO-1 and MMP-1 in M. tuberculosis-infected human and murine macrophages. We found that infection of macrophages with live virulent M. tuberculosis is required for robust induction of high levels of HO-1 but not MMP-1. In addition, we observed that CO, a product of M. tuberculosis-induced HO-1 activity, inhibits MMP-1 expression by suppressing c-Jun/AP-1 activation. These findings reveal a mechanistic link between oxidative stress and tissue remodeling that may find applicability in the clinical staging of TB patients.engAmerican Association of ImmunologistsTuberculose, PulmonarMatrix Metalloproteinase 1Heme Oxygenase-1Mycobacterium tuberculosisMacrófagosBiomarcadoresHumanosAdultoTuberculosis, PulmonaryMatrix Metalloproteinase 1Heme Oxygenase-1Mycobacterium tuberculosisMacrophagesBiomarkersHumansAdultOxidative StressEstresse oxidativoHeme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20169/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAndrade BB Heme oxygenase-1 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dc.title.pt_BR.fl_str_mv |
Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis |
title |
Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis |
spellingShingle |
Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis Andrade, Bruno de Bezerril Tuberculose, Pulmonar Matrix Metalloproteinase 1 Heme Oxygenase-1 Mycobacterium tuberculosis Macrófagos Biomarcadores Humanos Adulto Tuberculosis, Pulmonary Matrix Metalloproteinase 1 Heme Oxygenase-1 Mycobacterium tuberculosis Macrophages Biomarkers Humans Adult Oxidative Stress Estresse oxidativo |
title_short |
Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis |
title_full |
Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis |
title_fullStr |
Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis |
title_full_unstemmed |
Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis |
title_sort |
Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis |
author |
Andrade, Bruno de Bezerril |
author_facet |
Andrade, Bruno de Bezerril Pavan Kumar, Nathella Amaral, Eduardo Pinheiro Riteau, Nicolas Mayer-Barber, Katrin D Tosh, Kevin W Maier, Nolan Conceição, Elisabete Lopes Kubler, Andre Sridhar, Rathinam Banurekha, Vaithilingam V Jawahar, Mohideen S Bessa, Theolis Costa Barbosa Manganiello, Vincent C Moss, Joel Fontana, Joseph R Marciano, Beatriz E Sampaio, Elizabeth P Olivier, Kenneth N Holland, Steven M Jackson, Sharon H Moayeri, Mahtab Leppla, Stephen Sereti, Irini Barber, Daniel L Nutman, Thomas B Babu, Subash Sher, Alan |
author_role |
author |
author2 |
Pavan Kumar, Nathella Amaral, Eduardo Pinheiro Riteau, Nicolas Mayer-Barber, Katrin D Tosh, Kevin W Maier, Nolan Conceição, Elisabete Lopes Kubler, Andre Sridhar, Rathinam Banurekha, Vaithilingam V Jawahar, Mohideen S Bessa, Theolis Costa Barbosa Manganiello, Vincent C Moss, Joel Fontana, Joseph R Marciano, Beatriz E Sampaio, Elizabeth P Olivier, Kenneth N Holland, Steven M Jackson, Sharon H Moayeri, Mahtab Leppla, Stephen Sereti, Irini Barber, Daniel L Nutman, Thomas B Babu, Subash Sher, Alan |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Andrade, Bruno de Bezerril Pavan Kumar, Nathella Amaral, Eduardo Pinheiro Riteau, Nicolas Mayer-Barber, Katrin D Tosh, Kevin W Maier, Nolan Conceição, Elisabete Lopes Kubler, Andre Sridhar, Rathinam Banurekha, Vaithilingam V Jawahar, Mohideen S Bessa, Theolis Costa Barbosa Manganiello, Vincent C Moss, Joel Fontana, Joseph R Marciano, Beatriz E Sampaio, Elizabeth P Olivier, Kenneth N Holland, Steven M Jackson, Sharon H Moayeri, Mahtab Leppla, Stephen Sereti, Irini Barber, Daniel L Nutman, Thomas B Babu, Subash Sher, Alan |
dc.subject.other.pt_BR.fl_str_mv |
Tuberculose, Pulmonar Matrix Metalloproteinase 1 Heme Oxygenase-1 Mycobacterium tuberculosis Macrófagos Biomarcadores Humanos Adulto |
topic |
Tuberculose, Pulmonar Matrix Metalloproteinase 1 Heme Oxygenase-1 Mycobacterium tuberculosis Macrófagos Biomarcadores Humanos Adulto Tuberculosis, Pulmonary Matrix Metalloproteinase 1 Heme Oxygenase-1 Mycobacterium tuberculosis Macrophages Biomarkers Humans Adult Oxidative Stress Estresse oxidativo |
dc.subject.en.pt_BR.fl_str_mv |
Tuberculosis, Pulmonary Matrix Metalloproteinase 1 Heme Oxygenase-1 Mycobacterium tuberculosis Macrophages Biomarkers Humans Adult Oxidative Stress Estresse oxidativo |
description |
Andrade, Bruno de Bezerril; Bessa, Theolis Costa Barbosa. Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Unidade de Medicina Investigativa. Laboratório Integrado de Microbiologia e Imunorregulação. Salvador, BA, Brasil *Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; †Unidade de Medicina Investigativa, Laborato´rio Integrado de Microbiologia e Imunorregulação, Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador 40296-710, Brazil; ‡National Institutes of Health, International Center for Excellence in Research, Chennai 600031, India; xNational Institute for Research in Tuberculosis, Chennai 600031, India; {Microbial Pathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; ‖Department of Medicine, Imperial College London, London SW7 2AZ, United Kingdom; #Government Stanley Medical Hospital, Chennai 600001, India; **Cardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; ††Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; ‡‡Division of Intramural Research, National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD 20892; xxClinical and Molecular Retrovirology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; {{T-Lymphocyte Biology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; ‖‖Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2017-07-21T17:57:14Z |
dc.date.available.fl_str_mv |
2017-07-21T17:57:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ANDRADE, B. B. et al. Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis. The Journal of Immunology, v. 195, n. 6, p. 2763–2773, 2015. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/20169 |
dc.identifier.issn.pt_BR.fl_str_mv |
0022-1767 |
dc.identifier.doi.none.fl_str_mv |
10.4049/jimmunol.1500942 |
identifier_str_mv |
ANDRADE, B. B. et al. Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis. The Journal of Immunology, v. 195, n. 6, p. 2763–2773, 2015. 0022-1767 10.4049/jimmunol.1500942 |
url |
https://www.arca.fiocruz.br/handle/icict/20169 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
American Association of Immunologists |
publisher.none.fl_str_mv |
American Association of Immunologists |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
collection |
Repositório Institucional da FIOCRUZ (ARCA) |
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5a560609d32a3863062d77ff32785d58 060069be6b5ca6497c330534a63ac8a0 30676d43d325554b9ef8d018a37be1b0 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
_version_ |
1813009154554462208 |