Should covid-19 be branded to viral thrombotic fever ?

Detalhes bibliográficos
Autor(a) principal: Costa Filho, Rubens Carmo
Data de Publicação: 2020
Outros Autores: Faria Neto, Hugo Caire Castro, Mengel, José, Machado, Marcelo Pelajo, Martins, Marco Aurélio, Leite, Érica Távora, Mendonça Filho, Hugo Tanus, Souza, Tatiana de Arruda Campos Brasil de, Bentacor, Gonzalo Bello, Leite, José Paulo Gagliardi
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/52065
Resumo: Hospital Pró-Cardíaco, Américas Serviços Médicos. United-Health Group. Rio de Janeiro, RJ, Brasil.
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spelling Costa Filho, Rubens CarmoFaria Neto, Hugo Caire CastroMengel, JoséMachado, Marcelo PelajoMartins, Marco AurélioLeite, Érica TávoraMendonça Filho, Hugo TanusSouza, Tatiana de Arruda Campos Brasil deBentacor, Gonzalo BelloLeite, José Paulo Gagliardi2022-04-06T18:09:30Z2022-04-06T18:09:30Z2020COSTA FILHO, Rubens Carmo et al. Should COVID-19 be branded to viral thrombotic fever?. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 116, e200552, p. 1 - 8, 2021.0074-0206https://www.arca.fiocruz.br/handle/icict/520651678-8060porFundação Oswaldo Cruz. Instituto Oswaldo Cruz.COVID-19SARS-CoV-2EndotélioSARS CoV MproInflamaçãoCoagulaçãoHipercoagulabilidadeTromboseEndotheliumCOVID-19SARS-CoV-2SARS CoV MproInflammationCoagulationHypercoagulabilityThrombosisShould covid-19 be branded to viral thrombotic fever ?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital Pró-Cardíaco, Américas Serviços Médicos. United-Health Group. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz.Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / Centro Universitário Arthur Sá Earp Neto. Faculdade de Medicina de Petrópolis. Petrópolis, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Câncer. Rio de Janeiro, RJ, Brasil.Políticas de Saúde do United-Health Group. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica Estrutural e Computacional. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.Coronaviruses can cause a diverse array of clinical manifestations, from fever with symptoms of the common cold to highly lethal severe acute respiratory syndrome (SARS) and middle east respiratory syndrome (MERS). SARS-CoV-2, the coronavirus discovered in Hubei province, China, at the end of 2019, became known worldwide for causing coronavirus disease 2019 (COVID-19). Over one year’s time period, the scientific community has produced a large bulk of knowledge about this disease and countless reports about its immune-pathological aspects. This knowledge, including data obtained in postmortem studies, points unequivocally to a hypercoagulability state. However, the name COVID-19 tells us very little about the true meaning of the disease. Our proposal is more comprehensive; it intends to frame COVID-19 in more clinical terminology, making an analogy to viral haemorrhagic fever (VHF). Thus, we found irrefutable evidence in the current literature that COVID-19 is the first viral disease that can be branded as a viral thrombotic fever. This manuscript points out that SARS-CoV-2 goes far beyond pneumonia or SARS. COVID-19 infections promote remarkable interactions among the endothelium, coagulation, and immune response, building up a background capable of promoting a “thrombotic storm,” much more than a “cytokine storm.” The importance of a viral protease called main protease (Mpro) is highlighted as a critical component for its replication in the host cell. A deeper analysis of this protease and its importance on the coagulation system is also discussed for the first time, mainly because of its similarity with the thrombin and factor Xa molecules, as recently pointed out by structural comparison crystallographic structures.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83076https://www.arca.fiocruz.br/bitstream/icict/52065/1/license.txta9b18b0d08b7fede5ff41a7d140be961MD51ORIGINALShould COVID-19 be branded to viral thrombotic fever?.pdfShould COVID-19 be branded to viral thrombotic fever?.pdfapplication/pdf2153373https://www.arca.fiocruz.br/bitstream/icict/52065/2/Should%20COVID-19%20be%20branded%20to%20viral%20thrombotic%20fever%3f.pdf4ed31b39a092a2922e5f23ca6cfb7a0aMD52icict/520652022-04-06 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dc.title.pt_BR.fl_str_mv Should covid-19 be branded to viral thrombotic fever ?
title Should covid-19 be branded to viral thrombotic fever ?
spellingShingle Should covid-19 be branded to viral thrombotic fever ?
Costa Filho, Rubens Carmo
COVID-19
SARS-CoV-2
Endotélio
SARS CoV Mpro
Inflamação
Coagulação
Hipercoagulabilidade
Trombose
Endothelium
COVID-19
SARS-CoV-2
SARS CoV Mpro
Inflammation
Coagulation
Hypercoagulability
Thrombosis
title_short Should covid-19 be branded to viral thrombotic fever ?
title_full Should covid-19 be branded to viral thrombotic fever ?
title_fullStr Should covid-19 be branded to viral thrombotic fever ?
title_full_unstemmed Should covid-19 be branded to viral thrombotic fever ?
title_sort Should covid-19 be branded to viral thrombotic fever ?
author Costa Filho, Rubens Carmo
author_facet Costa Filho, Rubens Carmo
Faria Neto, Hugo Caire Castro
Mengel, José
Machado, Marcelo Pelajo
Martins, Marco Aurélio
Leite, Érica Távora
Mendonça Filho, Hugo Tanus
Souza, Tatiana de Arruda Campos Brasil de
Bentacor, Gonzalo Bello
Leite, José Paulo Gagliardi
author_role author
author2 Faria Neto, Hugo Caire Castro
Mengel, José
Machado, Marcelo Pelajo
Martins, Marco Aurélio
Leite, Érica Távora
Mendonça Filho, Hugo Tanus
Souza, Tatiana de Arruda Campos Brasil de
Bentacor, Gonzalo Bello
Leite, José Paulo Gagliardi
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Costa Filho, Rubens Carmo
Faria Neto, Hugo Caire Castro
Mengel, José
Machado, Marcelo Pelajo
Martins, Marco Aurélio
Leite, Érica Távora
Mendonça Filho, Hugo Tanus
Souza, Tatiana de Arruda Campos Brasil de
Bentacor, Gonzalo Bello
Leite, José Paulo Gagliardi
dc.subject.other.pt_BR.fl_str_mv COVID-19
SARS-CoV-2
Endotélio
SARS CoV Mpro
Inflamação
Coagulação
Hipercoagulabilidade
Trombose
topic COVID-19
SARS-CoV-2
Endotélio
SARS CoV Mpro
Inflamação
Coagulação
Hipercoagulabilidade
Trombose
Endothelium
COVID-19
SARS-CoV-2
SARS CoV Mpro
Inflammation
Coagulation
Hypercoagulability
Thrombosis
dc.subject.en.pt_BR.fl_str_mv Endothelium
COVID-19
SARS-CoV-2
SARS CoV Mpro
Inflammation
Coagulation
Hypercoagulability
Thrombosis
description Hospital Pró-Cardíaco, Américas Serviços Médicos. United-Health Group. Rio de Janeiro, RJ, Brasil.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2022-04-06T18:09:30Z
dc.date.available.fl_str_mv 2022-04-06T18:09:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COSTA FILHO, Rubens Carmo et al. Should COVID-19 be branded to viral thrombotic fever?. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 116, e200552, p. 1 - 8, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/52065
dc.identifier.issn.pt_BR.fl_str_mv 0074-0206
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv COSTA FILHO, Rubens Carmo et al. Should COVID-19 be branded to viral thrombotic fever?. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 116, e200552, p. 1 - 8, 2021.
0074-0206
1678-8060
url https://www.arca.fiocruz.br/handle/icict/52065
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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