Should COVID-19 be branded to viral thrombotic fever?
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/47732 |
Resumo: | Hospital Pró-Cardíaco. Founder and coordinator of Department of Critical Care. Americas Medical Services. United Health Group. Rio de Janeiro, RJ, Brasil. |
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Costa-Filho, Rubens CarmoCastro-Faria Neto, Hugo CaireMengel, JoséPelajo-Machado, MarceloMartins, Marco AurélioLeite, Érica TávoraMendonça-Filho, Hugo TannusSouza, Tatiana de Arruda Campos Brasil deBentacor, Gonzalo BelloLeite, José Paulo Gagliardi2021-06-16T19:01:30Z2021-06-16T19:01:30Z2021COSTA-FILHO, Rubens Carmo et al. Should COVID-19 be branded to viral thrombotic fever? Mem Inst. Oswaldo Cruz, n. 116, p. 1–8, 2021.1678-8060https://www.arca.fiocruz.br/handle/icict/4773210.1590/0074-02760200552porFundação Oswaldo Cruz. Instituto Oswaldo CruzShould COVID-19 be branded to viral thrombotic fever?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital Pró-Cardíaco. Founder and coordinator of Department of Critical Care. Americas Medical Services. United Health Group. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / UNIFASE. Faculdade de Medicina. Petrópolis, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Instituto Nacional do Câncer. Rio de Janeiro, RJ, Brasil.Políticas de Saúde – UHG (UnitedHealth Group). BrasilFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica Estrutural e Computacional. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.Coronaviruses can cause a diverse array of clinical manifestations, from fever with symptoms of the common cold to highly lethal severe acute respiratory syndrome (SARS) and middle east respiratory syndrome (MERS). SARS-CoV-2, the coronavirus discovered in Hubei province, China, at the end of 2019, became known worldwide for causing coronavirus disease 2019 (COVID-19). Over one year’s time period, the scientific community has produced a large bulk of knowledge about this disease and countless reports about its immune-pathological aspects. This knowledge, including data obtained in postmortem studies, points unequivocally to a hypercoagulability state. However, the name COVID-19 tells us very little about the true meaning of the disease. Our proposal is more comprehensive; it intends to frame COVID-19 in more clinical terminology, making an analogy to viral haemorrhagic fever (VHF). Thus, we found irrefutable evidence in the current literature that COVID-19 is the first viral disease that can be branded as a viral thrombotic fever. This manuscript points out that SARS-CoV-2 goes far beyond pneumonia or SARS. COVID-19 infections promote remarkable interactions among the endothelium, coagulation, and immune response, building up a background capable of promoting a “thrombotic storm,” much more than a “cytokine storm.” The importance of a viral protease called main protease (Mpro) is highlighted as a critical component for its replication in the host cell. A deeper analysis of this protease and its importance on the coagulation system is also discussed for the first time, mainly because of its similarity with the thrombin and factor Xa molecules, as recently pointed out by structural comparison crystallographic structures.EndotheliumSARS CoV 2 InfectionCoronavirus 3C ProteasesInflammationBlood CoagulationThrombosisThrombelastographyEndotelioProteasas 3C de CoronavirusInflamaciónCoagulación SanguíneaTrombosisTromboelastografíaEndothéliumInflammationCoagulation sanguineThromboseThromboélastographieEndotélioCOVID-19SARS-CoV-2Proteína Mpro de CoronavírusInflamaçãoCoagulação SanguíneaTromboseTromboelastografiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Should COVID-19 be branded to viral thrombotic fever? |
title |
Should COVID-19 be branded to viral thrombotic fever? |
spellingShingle |
Should COVID-19 be branded to viral thrombotic fever? Costa-Filho, Rubens Carmo Endothelium SARS CoV 2 Infection Coronavirus 3C Proteases Inflammation Blood Coagulation Thrombosis Thrombelastography Endotelio Proteasas 3C de Coronavirus Inflamación Coagulación Sanguínea Trombosis Tromboelastografía Endothélium Inflammation Coagulation sanguine Thrombose Thromboélastographie Endotélio COVID-19 SARS-CoV-2 Proteína Mpro de Coronavírus Inflamação Coagulação Sanguínea Trombose Tromboelastografia |
title_short |
Should COVID-19 be branded to viral thrombotic fever? |
title_full |
Should COVID-19 be branded to viral thrombotic fever? |
title_fullStr |
Should COVID-19 be branded to viral thrombotic fever? |
title_full_unstemmed |
Should COVID-19 be branded to viral thrombotic fever? |
title_sort |
Should COVID-19 be branded to viral thrombotic fever? |
author |
Costa-Filho, Rubens Carmo |
author_facet |
Costa-Filho, Rubens Carmo Castro-Faria Neto, Hugo Caire Mengel, José Pelajo-Machado, Marcelo Martins, Marco Aurélio Leite, Érica Távora Mendonça-Filho, Hugo Tannus Souza, Tatiana de Arruda Campos Brasil de Bentacor, Gonzalo Bello Leite, José Paulo Gagliardi |
author_role |
author |
author2 |
Castro-Faria Neto, Hugo Caire Mengel, José Pelajo-Machado, Marcelo Martins, Marco Aurélio Leite, Érica Távora Mendonça-Filho, Hugo Tannus Souza, Tatiana de Arruda Campos Brasil de Bentacor, Gonzalo Bello Leite, José Paulo Gagliardi |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Costa-Filho, Rubens Carmo Castro-Faria Neto, Hugo Caire Mengel, José Pelajo-Machado, Marcelo Martins, Marco Aurélio Leite, Érica Távora Mendonça-Filho, Hugo Tannus Souza, Tatiana de Arruda Campos Brasil de Bentacor, Gonzalo Bello Leite, José Paulo Gagliardi |
dc.subject.en.pt_BR.fl_str_mv |
Endothelium SARS CoV 2 Infection Coronavirus 3C Proteases Inflammation Blood Coagulation Thrombosis Thrombelastography |
topic |
Endothelium SARS CoV 2 Infection Coronavirus 3C Proteases Inflammation Blood Coagulation Thrombosis Thrombelastography Endotelio Proteasas 3C de Coronavirus Inflamación Coagulación Sanguínea Trombosis Tromboelastografía Endothélium Inflammation Coagulation sanguine Thrombose Thromboélastographie Endotélio COVID-19 SARS-CoV-2 Proteína Mpro de Coronavírus Inflamação Coagulação Sanguínea Trombose Tromboelastografia |
dc.subject.es.pt_BR.fl_str_mv |
Endotelio Proteasas 3C de Coronavirus Inflamación Coagulación Sanguínea Trombosis Tromboelastografía |
dc.subject.fr.pt_BR.fl_str_mv |
Endothélium Inflammation Coagulation sanguine Thrombose Thromboélastographie |
dc.subject.decs.pt_BR.fl_str_mv |
Endotélio COVID-19 SARS-CoV-2 Proteína Mpro de Coronavírus Inflamação Coagulação Sanguínea Trombose Tromboelastografia |
description |
Hospital Pró-Cardíaco. Founder and coordinator of Department of Critical Care. Americas Medical Services. United Health Group. Rio de Janeiro, RJ, Brasil. |
publishDate |
2021 |
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2021-06-16T19:01:30Z |
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2021-06-16T19:01:30Z |
dc.date.issued.fl_str_mv |
2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
COSTA-FILHO, Rubens Carmo et al. Should COVID-19 be branded to viral thrombotic fever? Mem Inst. Oswaldo Cruz, n. 116, p. 1–8, 2021. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/47732 |
dc.identifier.issn.pt_BR.fl_str_mv |
1678-8060 |
dc.identifier.doi.none.fl_str_mv |
10.1590/0074-02760200552 |
identifier_str_mv |
COSTA-FILHO, Rubens Carmo et al. Should COVID-19 be branded to viral thrombotic fever? Mem Inst. Oswaldo Cruz, n. 116, p. 1–8, 2021. 1678-8060 10.1590/0074-02760200552 |
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