Should COVID-19 be branded to viral thrombotic fever?

Detalhes bibliográficos
Autor(a) principal: Costa-Filho, Rubens Carmo
Data de Publicação: 2021
Outros Autores: Castro-Faria Neto, Hugo Caire, Mengel, José, Pelajo-Machado, Marcelo, Martins, Marco Aurélio, Leite, Érica Távora, Mendonça-Filho, Hugo Tannus, Souza, Tatiana de Arruda Campos Brasil de, Bentacor, Gonzalo Bello, Leite, José Paulo Gagliardi
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/47732
Resumo: Hospital Pró-Cardíaco. Founder and coordinator of Department of Critical Care. Americas Medical Services. United Health Group. Rio de Janeiro, RJ, Brasil.
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spelling Costa-Filho, Rubens CarmoCastro-Faria Neto, Hugo CaireMengel, JoséPelajo-Machado, MarceloMartins, Marco AurélioLeite, Érica TávoraMendonça-Filho, Hugo TannusSouza, Tatiana de Arruda Campos Brasil deBentacor, Gonzalo BelloLeite, José Paulo Gagliardi2021-06-16T19:01:30Z2021-06-16T19:01:30Z2021COSTA-FILHO, Rubens Carmo et al. Should COVID-19 be branded to viral thrombotic fever? Mem Inst. Oswaldo Cruz, n. 116, p. 1–8, 2021.1678-8060https://www.arca.fiocruz.br/handle/icict/4773210.1590/0074-02760200552porFundação Oswaldo Cruz. Instituto Oswaldo CruzShould COVID-19 be branded to viral thrombotic fever?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital Pró-Cardíaco. Founder and coordinator of Department of Critical Care. Americas Medical Services. United Health Group. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil / UNIFASE. Faculdade de Medicina. Petrópolis, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil.Instituto Nacional do Câncer. Rio de Janeiro, RJ, Brasil.Políticas de Saúde – UHG (UnitedHealth Group). BrasilFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Proteômica Estrutural e Computacional. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS & Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratorio de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.Coronaviruses can cause a diverse array of clinical manifestations, from fever with symptoms of the common cold to highly lethal severe acute respiratory syndrome (SARS) and middle east respiratory syndrome (MERS). SARS-CoV-2, the coronavirus discovered in Hubei province, China, at the end of 2019, became known worldwide for causing coronavirus disease 2019 (COVID-19). Over one year’s time period, the scientific community has produced a large bulk of knowledge about this disease and countless reports about its immune-pathological aspects. This knowledge, including data obtained in postmortem studies, points unequivocally to a hypercoagulability state. However, the name COVID-19 tells us very little about the true meaning of the disease. Our proposal is more comprehensive; it intends to frame COVID-19 in more clinical terminology, making an analogy to viral haemorrhagic fever (VHF). Thus, we found irrefutable evidence in the current literature that COVID-19 is the first viral disease that can be branded as a viral thrombotic fever. This manuscript points out that SARS-CoV-2 goes far beyond pneumonia or SARS. COVID-19 infections promote remarkable interactions among the endothelium, coagulation, and immune response, building up a background capable of promoting a “thrombotic storm,” much more than a “cytokine storm.” The importance of a viral protease called main protease (Mpro) is highlighted as a critical component for its replication in the host cell. A deeper analysis of this protease and its importance on the coagulation system is also discussed for the first time, mainly because of its similarity with the thrombin and factor Xa molecules, as recently pointed out by structural comparison crystallographic structures.EndotheliumSARS CoV 2 InfectionCoronavirus 3C ProteasesInflammationBlood CoagulationThrombosisThrombelastographyEndotelioProteasas 3C de CoronavirusInflamaciónCoagulación SanguíneaTrombosisTromboelastografíaEndothéliumInflammationCoagulation sanguineThromboseThromboélastographieEndotélioCOVID-19SARS-CoV-2Proteína Mpro de CoronavírusInflamaçãoCoagulação SanguíneaTromboseTromboelastografiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Should COVID-19 be branded to viral thrombotic fever?
title Should COVID-19 be branded to viral thrombotic fever?
spellingShingle Should COVID-19 be branded to viral thrombotic fever?
Costa-Filho, Rubens Carmo
Endothelium
SARS CoV 2 Infection
Coronavirus 3C Proteases
Inflammation
Blood Coagulation
Thrombosis
Thrombelastography
Endotelio
Proteasas 3C de Coronavirus
Inflamación
Coagulación Sanguínea
Trombosis
Tromboelastografía
Endothélium
Inflammation
Coagulation sanguine
Thrombose
Thromboélastographie
Endotélio
COVID-19
SARS-CoV-2
Proteína Mpro de Coronavírus
Inflamação
Coagulação Sanguínea
Trombose
Tromboelastografia
title_short Should COVID-19 be branded to viral thrombotic fever?
title_full Should COVID-19 be branded to viral thrombotic fever?
title_fullStr Should COVID-19 be branded to viral thrombotic fever?
title_full_unstemmed Should COVID-19 be branded to viral thrombotic fever?
title_sort Should COVID-19 be branded to viral thrombotic fever?
author Costa-Filho, Rubens Carmo
author_facet Costa-Filho, Rubens Carmo
Castro-Faria Neto, Hugo Caire
Mengel, José
Pelajo-Machado, Marcelo
Martins, Marco Aurélio
Leite, Érica Távora
Mendonça-Filho, Hugo Tannus
Souza, Tatiana de Arruda Campos Brasil de
Bentacor, Gonzalo Bello
Leite, José Paulo Gagliardi
author_role author
author2 Castro-Faria Neto, Hugo Caire
Mengel, José
Pelajo-Machado, Marcelo
Martins, Marco Aurélio
Leite, Érica Távora
Mendonça-Filho, Hugo Tannus
Souza, Tatiana de Arruda Campos Brasil de
Bentacor, Gonzalo Bello
Leite, José Paulo Gagliardi
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Costa-Filho, Rubens Carmo
Castro-Faria Neto, Hugo Caire
Mengel, José
Pelajo-Machado, Marcelo
Martins, Marco Aurélio
Leite, Érica Távora
Mendonça-Filho, Hugo Tannus
Souza, Tatiana de Arruda Campos Brasil de
Bentacor, Gonzalo Bello
Leite, José Paulo Gagliardi
dc.subject.en.pt_BR.fl_str_mv Endothelium
SARS CoV 2 Infection
Coronavirus 3C Proteases
Inflammation
Blood Coagulation
Thrombosis
Thrombelastography
topic Endothelium
SARS CoV 2 Infection
Coronavirus 3C Proteases
Inflammation
Blood Coagulation
Thrombosis
Thrombelastography
Endotelio
Proteasas 3C de Coronavirus
Inflamación
Coagulación Sanguínea
Trombosis
Tromboelastografía
Endothélium
Inflammation
Coagulation sanguine
Thrombose
Thromboélastographie
Endotélio
COVID-19
SARS-CoV-2
Proteína Mpro de Coronavírus
Inflamação
Coagulação Sanguínea
Trombose
Tromboelastografia
dc.subject.es.pt_BR.fl_str_mv Endotelio
Proteasas 3C de Coronavirus
Inflamación
Coagulación Sanguínea
Trombosis
Tromboelastografía
dc.subject.fr.pt_BR.fl_str_mv Endothélium
Inflammation
Coagulation sanguine
Thrombose
Thromboélastographie
dc.subject.decs.pt_BR.fl_str_mv Endotélio
COVID-19
SARS-CoV-2
Proteína Mpro de Coronavírus
Inflamação
Coagulação Sanguínea
Trombose
Tromboelastografia
description Hospital Pró-Cardíaco. Founder and coordinator of Department of Critical Care. Americas Medical Services. United Health Group. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-06-16T19:01:30Z
dc.date.available.fl_str_mv 2021-06-16T19:01:30Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COSTA-FILHO, Rubens Carmo et al. Should COVID-19 be branded to viral thrombotic fever? Mem Inst. Oswaldo Cruz, n. 116, p. 1–8, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/47732
dc.identifier.issn.pt_BR.fl_str_mv 1678-8060
dc.identifier.doi.none.fl_str_mv 10.1590/0074-02760200552
identifier_str_mv COSTA-FILHO, Rubens Carmo et al. Should COVID-19 be branded to viral thrombotic fever? Mem Inst. Oswaldo Cruz, n. 116, p. 1–8, 2021.
1678-8060
10.1590/0074-02760200552
url https://www.arca.fiocruz.br/handle/icict/47732
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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collection Repositório Institucional da FIOCRUZ (ARCA)
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