Variants in proinflammatory genes IL1RL1, IL1B and IRF4 are associated with overweight in a pediatric Brazilian population

Detalhes bibliográficos
Autor(a) principal: Melo, Ana Paula Castro
Data de Publicação: 2022
Outros Autores: Teixeira, Helena Mariana Pitangueira, Coelho, Raisa Santos, Jesus, Talita dos Santos de, Queiroz, Gerson Almeida, ilva, Hatilla Dos Santos S., Almeida, Yasmim Cristina Ferreira de, Neves, Neuza Maria Alcantara, Matos, Sheila Maria Alvim de, D’innocenzo, Silvana, Silva, Rita De Cassia Ribeiro, Barreto, Maurício Lima, Costa, Ryan dos Santos, Pinto, Laise Cedraz, Figueiredo, Camila Alexandrina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/56156
Resumo: Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Social Change, Asthma and Allergy in Latin America (SCAALA ).
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spelling Melo, Ana Paula CastroTeixeira, Helena Mariana PitangueiraCoelho, Raisa SantosJesus, Talita dos Santos deQueiroz, Gerson Almeidailva, Hatilla Dos Santos S.Almeida, Yasmim Cristina Ferreira deNeves, Neuza Maria AlcantaraMatos, Sheila Maria Alvim deD’innocenzo, SilvanaSilva, Rita De Cassia RibeiroBarreto, Maurício LimaCosta, Ryan dos SantosPinto, Laise CedrazFigueiredo, Camila Alexandrina2022-12-22T13:07:06Z2022-12-22T13:07:06Z2022MELO, Ana Paula Castro et al. Variants in proinflammatory genes IL1RL1, IL1B and IRF4 are associated with overweight in a pediatric Brazilian population. Gene, v. 828, p. 1-10, 2022.0378-1119https://www.arca.fiocruz.br/handle/icict/5615610.1016/j.gene.2022.146478Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Social Change, Asthma and Allergy in Latin America (SCAALA ).Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Centro de Integração de Dados e Conhecimentos para a Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Escola de Nutrição. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Background: Obesity is a chronic complex disease with great prevalence for children all over the world. Characterized for low-grade inflammation associated with several comorbidities such as resistance and type 2 diabetes mellitus (T2DM). Objectives: To investigate whether genetic variants in IL10, IL1RL1, IL1B, IRF4, TNF, IL6, and IL33 genes are associated with being overweight in children. Methods: We performed the genotyping of 1004 children using Illumina 2.5 Human Omni bead chip, and association analysis on the genetic variants and the overweight through logistic regression adjusted for sex, age and components principal. Results: Of the seven genes analyzed, 16 SNVs significantly associated. Eleven variants in IL1RL1, two in IL1B and one in IRF4 genes increased overweight risk and two SNVs in IL1RL1 were associated with protection against overweight. The rs2287047-A was negatively associated (OR: 0.66, CI95%: 0.19–0.45) and had a reduced IL1RL1 expression in whole blood (p 0.033) in silico eQTL. The rs12203592-T, in IRF4, was positively associated with being overweight, and led to an increased gene expression in whole blood (p < 0.001) and adipose tissue (p <0.001). Conclusion: These results suggest that genetic variants in inflammatory genes may play an important role in the development of overweight in children.engElsevierOverweightExcesso de pesoVariantes genéticasGenes pró-inflamatóriosOverweightGenetic variantsProinflammatory genesVariants in proinflammatory genes IL1RL1, IL1B and IRF4 are associated with overweight in a pediatric Brazilian populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMelo, Ana Paula Castro - Variants in proinflammatory genes IL1RL1.pdfMelo, Ana Paula Castro - Variants in proinflammatory genes IL1RL1.pdfapplication/pdf3451522https://www.arca.fiocruz.br/bitstream/icict/56156/2/Melo%2c%20Ana%20Paula%20Castro%20%20-%20Variants%20in%20proinflammatory%20genes%20IL1RL1.pdffac2b0d1d67068f7fe248d73bc187514MD52LICENSElicense.txtlicense.txttext/plain; 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dc.title.en_US.fl_str_mv Variants in proinflammatory genes IL1RL1, IL1B and IRF4 are associated with overweight in a pediatric Brazilian population
title Variants in proinflammatory genes IL1RL1, IL1B and IRF4 are associated with overweight in a pediatric Brazilian population
spellingShingle Variants in proinflammatory genes IL1RL1, IL1B and IRF4 are associated with overweight in a pediatric Brazilian population
Melo, Ana Paula Castro
Overweight
Excesso de peso
Variantes genéticas
Genes pró-inflamatórios
Overweight
Genetic variants
Proinflammatory genes
title_short Variants in proinflammatory genes IL1RL1, IL1B and IRF4 are associated with overweight in a pediatric Brazilian population
title_full Variants in proinflammatory genes IL1RL1, IL1B and IRF4 are associated with overweight in a pediatric Brazilian population
title_fullStr Variants in proinflammatory genes IL1RL1, IL1B and IRF4 are associated with overweight in a pediatric Brazilian population
title_full_unstemmed Variants in proinflammatory genes IL1RL1, IL1B and IRF4 are associated with overweight in a pediatric Brazilian population
title_sort Variants in proinflammatory genes IL1RL1, IL1B and IRF4 are associated with overweight in a pediatric Brazilian population
author Melo, Ana Paula Castro
author_facet Melo, Ana Paula Castro
Teixeira, Helena Mariana Pitangueira
Coelho, Raisa Santos
Jesus, Talita dos Santos de
Queiroz, Gerson Almeida
ilva, Hatilla Dos Santos S.
Almeida, Yasmim Cristina Ferreira de
Neves, Neuza Maria Alcantara
Matos, Sheila Maria Alvim de
D’innocenzo, Silvana
Silva, Rita De Cassia Ribeiro
Barreto, Maurício Lima
Costa, Ryan dos Santos
Pinto, Laise Cedraz
Figueiredo, Camila Alexandrina
author_role author
author2 Teixeira, Helena Mariana Pitangueira
Coelho, Raisa Santos
Jesus, Talita dos Santos de
Queiroz, Gerson Almeida
ilva, Hatilla Dos Santos S.
Almeida, Yasmim Cristina Ferreira de
Neves, Neuza Maria Alcantara
Matos, Sheila Maria Alvim de
D’innocenzo, Silvana
Silva, Rita De Cassia Ribeiro
Barreto, Maurício Lima
Costa, Ryan dos Santos
Pinto, Laise Cedraz
Figueiredo, Camila Alexandrina
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Melo, Ana Paula Castro
Teixeira, Helena Mariana Pitangueira
Coelho, Raisa Santos
Jesus, Talita dos Santos de
Queiroz, Gerson Almeida
ilva, Hatilla Dos Santos S.
Almeida, Yasmim Cristina Ferreira de
Neves, Neuza Maria Alcantara
Matos, Sheila Maria Alvim de
D’innocenzo, Silvana
Silva, Rita De Cassia Ribeiro
Barreto, Maurício Lima
Costa, Ryan dos Santos
Pinto, Laise Cedraz
Figueiredo, Camila Alexandrina
dc.subject.mesh.en_US.fl_str_mv Overweight
topic Overweight
Excesso de peso
Variantes genéticas
Genes pró-inflamatórios
Overweight
Genetic variants
Proinflammatory genes
dc.subject.other.en_US.fl_str_mv Excesso de peso
Variantes genéticas
Genes pró-inflamatórios
dc.subject.en.en_US.fl_str_mv Overweight
Genetic variants
Proinflammatory genes
description Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB). Social Change, Asthma and Allergy in Latin America (SCAALA ).
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-12-22T13:07:06Z
dc.date.available.fl_str_mv 2022-12-22T13:07:06Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MELO, Ana Paula Castro et al. Variants in proinflammatory genes IL1RL1, IL1B and IRF4 are associated with overweight in a pediatric Brazilian population. Gene, v. 828, p. 1-10, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/56156
dc.identifier.issn.en_US.fl_str_mv 0378-1119
dc.identifier.doi.none.fl_str_mv 10.1016/j.gene.2022.146478
identifier_str_mv MELO, Ana Paula Castro et al. Variants in proinflammatory genes IL1RL1, IL1B and IRF4 are associated with overweight in a pediatric Brazilian population. Gene, v. 828, p. 1-10, 2022.
0378-1119
10.1016/j.gene.2022.146478
url https://www.arca.fiocruz.br/handle/icict/56156
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/56156/2/Melo%2c%20Ana%20Paula%20Castro%20%20-%20Variants%20in%20proinflammatory%20genes%20IL1RL1.pdf
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