Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/35980 |
Resumo: | National Research Ethics Committee (reference number: 120.616) and free informed consent was properly obtained from the parents or legal guardian of each child. |
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Silva, Milca de JesusSantana, Maria Borges Rabelo deTosta, Bruna R.Espinheira, Roberta PereiraNeves, Neuza Maria AlcantaraBarreto, Maurício LimaFigueiredo, Camila AlexandrinaCosta, Ryan dos Santos2019-09-27T18:59:41Z2019-09-27T18:59:41Z2019SILVA, Milca de Jesus et al. Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population. Allergy, Asthma & Clinical Immunology, v. 15, p. 1-12, 2019.1710-1484https://www.arca.fiocruz.br/handle/icict/3598010.1186/s13223-019-0340-7National Research Ethics Committee (reference number: 120.616) and free informed consent was properly obtained from the parents or legal guardian of each child.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Ciências da Biointeração. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Imunofarmacologia e Biologia Molecular. Departamento de Biorregulação. Salvador, BA, Brasil.Asthma is a complex disorder with multiple phenotypes which can influence its severity and response to treatment. The TH17 lymphocytes producing IL-17A and IL17-F cytokines, may have a role on asthma inflammation. The aim of our study was to evaluate the association between genetic variants in IL17 pathway genes with asthma and atopy markers. Materials and methods: Genotyping was performed using a commercial panel in 1245 participants of SCAALA cohort. The study included 91 SNVs in IL-17 pathway genes. Logistic regressions for asthma and atopy markers were performed using PLINK 1.9. In silico analyses were performed using rSNPbase, RegulomeDB, and Gtex portal for in silico gene expression. Results and discussion: The T allele of rs1974226 in IL17A was positively associated with asthma (OR: 1.37; 95% CI 1.02–1.82). Also, the T allele of rs279548 was positively associated with asthma (OR: 1.30; 95% CI 1.02–1.64), atopy (OR: 1.62; 95% CI 1.05–2.50) and increased expression of the IL17RC in lung and whole blood tissues. The others genetic variants in the IL17 pathways genes were associated with both protection and risk for asthma development as well as with IgE levels. Conclusion: The genetic variants in IL-17-related genes are associated with the atopic asthma phenotype and IgE production.engBMCAsmaAtopiaVariantesIL-17AsthmaAtopyVariantsIL-17 genesVariants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/35980/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSilva, J. M. Variants_in_the_IL17_.pdfSilva, J. M. Variants_in_the_IL17_.pdfapplication/pdf1261480https://www.arca.fiocruz.br/bitstream/icict/35980/2/Silva%2c%20J.%20M.%20Variants_in_the_IL17_.pdfc76565f612715004421e85c96914b33aMD52TEXTSilva, J. M. Variants_in_the_IL17_.pdf.txtSilva, J. M. Variants_in_the_IL17_.pdf.txtExtracted texttext/plain46987https://www.arca.fiocruz.br/bitstream/icict/35980/3/Silva%2c%20J.%20M.%20Variants_in_the_IL17_.pdf.txt635ece6339ff299352bcf1b8071acc30MD53icict/359802023-03-15 14:34:21.656oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:21Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population |
| title |
Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population |
| spellingShingle |
Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population Silva, Milca de Jesus Asma Atopia Variantes IL-17 Asthma Atopy Variants IL-17 genes |
| title_short |
Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population |
| title_full |
Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population |
| title_fullStr |
Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population |
| title_full_unstemmed |
Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population |
| title_sort |
Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population |
| author |
Silva, Milca de Jesus |
| author_facet |
Silva, Milca de Jesus Santana, Maria Borges Rabelo de Tosta, Bruna R. Espinheira, Roberta Pereira Neves, Neuza Maria Alcantara Barreto, Maurício Lima Figueiredo, Camila Alexandrina Costa, Ryan dos Santos |
| author_role |
author |
| author2 |
Santana, Maria Borges Rabelo de Tosta, Bruna R. Espinheira, Roberta Pereira Neves, Neuza Maria Alcantara Barreto, Maurício Lima Figueiredo, Camila Alexandrina Costa, Ryan dos Santos |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Milca de Jesus Santana, Maria Borges Rabelo de Tosta, Bruna R. Espinheira, Roberta Pereira Neves, Neuza Maria Alcantara Barreto, Maurício Lima Figueiredo, Camila Alexandrina Costa, Ryan dos Santos |
| dc.subject.other.pt_BR.fl_str_mv |
Asma Atopia Variantes IL-17 |
| topic |
Asma Atopia Variantes IL-17 Asthma Atopy Variants IL-17 genes |
| dc.subject.en.pt_BR.fl_str_mv |
Asthma Atopy Variants IL-17 genes |
| description |
National Research Ethics Committee (reference number: 120.616) and free informed consent was properly obtained from the parents or legal guardian of each child. |
| publishDate |
2019 |
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2019-09-27T18:59:41Z |
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2019-09-27T18:59:41Z |
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2019 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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SILVA, Milca de Jesus et al. Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population. Allergy, Asthma & Clinical Immunology, v. 15, p. 1-12, 2019. |
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https://www.arca.fiocruz.br/handle/icict/35980 |
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1710-1484 |
| dc.identifier.doi.none.fl_str_mv |
10.1186/s13223-019-0340-7 |
| identifier_str_mv |
SILVA, Milca de Jesus et al. Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population. Allergy, Asthma & Clinical Immunology, v. 15, p. 1-12, 2019. 1710-1484 10.1186/s13223-019-0340-7 |
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