Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals

Detalhes bibliográficos
Autor(a) principal: Gadelha, Sandra Rocha
Data de Publicação: 2008
Outros Autores: Alcantara, Luiz Carlos Júnior, Costa, Giselle Calasans de Souza, Acosta, Angelina Xavier, Rios, Domingos, Kashima, Simone G, Covas, Dimas Tadeu, Castro Filho, Bernardo Galvão
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/1891
Resumo: Laboratório Avançado de Saúde Pública. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, Brasil
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spelling Gadelha, Sandra RochaAlcantara, Luiz Carlos JúniorCosta, Giselle Calasans de SouzaAcosta, Angelina XavierRios, DomingosKashima, Simone GCovas, Dimas TadeuCastro Filho, Bernardo Galvão20082011-04-12T22:21:50Z2011-04-12T22:21:50Z2008GADELHA, S. R. et al. Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals. Journal of Medical Virology, v.80, n.12, p.2141-2146, 2008.0146-6615https://www.arca.fiocruz.br/handle/icict/189110.1002/jmv.21341engCorrelation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individualsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLaboratório Avançado de Saúde Pública. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, BrasilLaboratório Avançado de Saúde Pública. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, BrasilLaboratório Avançado de Saúde Pública. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, BrasilLaboratório Avançado de Saúde Pública. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, BrasilLaboratório de Genética Molecular, Departamento de Ciências Biológicas (DCB), Universidade Estadual do Sudoeste da Bahia (UESB), Bahia, BrasilHemocentro de Ribeirão Preto, São Paulo, BrasilHemocentro de Ribeirão Preto, São Paulo, BrasilLaboratório Avançado de Saúde Pública. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, BrasilHTLV-1 is the etiologic agent of ATL and HAM/TSP. The majority of HTLV-1-infected individuals remain asymptomatic, indicating that the infection alone is not sufficient to cause the diseases. It has been reported that cytokine gene polymorphisms, including polymorphisms at IL-6 and IL-10 gene, might be important. We analyzed SNP in the promoter region of the IL-6: -174, -572, -597, and -634 positions, and IL-10: -592 position to evaluate the role of these polymorphisms in the HAM/TSP pathogenesis in 133 HTLV-1 infected individuals and in 100 healthy individuals from Salvador, Bahia, Brazil. The -634C allele frequencies were higher among HAM/TSP patients (21.2%) than among oligosymptomatic (6.5%; P = 0.038) and asymptomatic (9.5%; P = 0.025) subjects. Similarly, the -174G allele frequencies were higher in HAM/TSP patients than in oligosymptomatic patients (P = 0.02). Moreover, the -634GC/-174GG genotype combination was identified at a higher frequency (38.5%) in the HAM/TSP patients than in subjects with other clinical status (8.7%; P = 0.016 for oligosymptomatic and 15.5%, P = 0.012 for asymptomatic patients). However, the multivariate logistic regression including the genotypes of the three studied loci showed that only -634 C IL-6 carriers remain as significant and independent TSP/HAM predictor (odds ratio [OR] = 5.31; 95% [CI] = 1.60-17.56; P = 0.006). We suggest that -634 G C in IL-6 could contribute to HAM/TSP development and that identification of the collective influence of several cytokine polymorphisms, their prevalence, and their interaction could help to better understand this disease.HTLV-1Interleukin-6Interleukin-10PolymorphismsBrazilian populationsInfecções por HTLV-IInterleucina-6Interleucina-10Paraparesia Espástica TropicalPolimorfismo de Um Único NucleotídeoRegiões Promotoras GenéticasDoenças da Medula Espinalinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCorrelation Between Polymorphisms at Interleukin-6.pdfCorrelation Between Polymorphisms at Interleukin-6.pdfapplication/pdf87640https://www.arca.fiocruz.br/bitstream/icict/1891/1/Correlation%20Between%20Polymorphisms%20at%20Interleukin-6.pdff65e1390029fb8f906878ac4509e4c9fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/1891/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTCorrelation Between Polymorphisms at Interleukin-6.pdf.txtCorrelation Between Polymorphisms at Interleukin-6.pdf.txtExtracted texttext/plain33185https://www.arca.fiocruz.br/bitstream/icict/1891/5/Correlation%20Between%20Polymorphisms%20at%20Interleukin-6.pdf.txte07a114c4fceeb08aaf0608f79290737MD55THUMBNAILCorrelation Between Polymorphisms at Interleukin-6.pdf.jpgCorrelation Between Polymorphisms at Interleukin-6.pdf.jpgGenerated Thumbnailimage/jpeg2501https://www.arca.fiocruz.br/bitstream/icict/1891/4/Correlation%20Between%20Polymorphisms%20at%20Interleukin-6.pdf.jpge376d5f11413f4274a5f0a6473c4c0bfMD54icict/18912023-03-15 14:33:15.798oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:15Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals
title Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals
spellingShingle Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals
Gadelha, Sandra Rocha
HTLV-1
Interleukin-6
Interleukin-10
Polymorphisms
Brazilian populations
Infecções por HTLV-I
Interleucina-6
Interleucina-10
Paraparesia Espástica Tropical
Polimorfismo de Um Único Nucleotídeo
Regiões Promotoras Genéticas
Doenças da Medula Espinal
title_short Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals
title_full Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals
title_fullStr Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals
title_full_unstemmed Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals
title_sort Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals
author Gadelha, Sandra Rocha
author_facet Gadelha, Sandra Rocha
Alcantara, Luiz Carlos Júnior
Costa, Giselle Calasans de Souza
Acosta, Angelina Xavier
Rios, Domingos
Kashima, Simone G
Covas, Dimas Tadeu
Castro Filho, Bernardo Galvão
author_role author
author2 Alcantara, Luiz Carlos Júnior
Costa, Giselle Calasans de Souza
Acosta, Angelina Xavier
Rios, Domingos
Kashima, Simone G
Covas, Dimas Tadeu
Castro Filho, Bernardo Galvão
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gadelha, Sandra Rocha
Alcantara, Luiz Carlos Júnior
Costa, Giselle Calasans de Souza
Acosta, Angelina Xavier
Rios, Domingos
Kashima, Simone G
Covas, Dimas Tadeu
Castro Filho, Bernardo Galvão
dc.subject.en.pt_BR.fl_str_mv HTLV-1
Interleukin-6
Interleukin-10
Polymorphisms
Brazilian populations
topic HTLV-1
Interleukin-6
Interleukin-10
Polymorphisms
Brazilian populations
Infecções por HTLV-I
Interleucina-6
Interleucina-10
Paraparesia Espástica Tropical
Polimorfismo de Um Único Nucleotídeo
Regiões Promotoras Genéticas
Doenças da Medula Espinal
dc.subject.decs.pt_BR.fl_str_mv Infecções por HTLV-I
Interleucina-6
Interleucina-10
Paraparesia Espástica Tropical
Polimorfismo de Um Único Nucleotídeo
Regiões Promotoras Genéticas
Doenças da Medula Espinal
description Laboratório Avançado de Saúde Pública. Centro de Pesquisas Gonçalo Moniz - FIOCRUZ, Bahia, Brasil
publishDate 2008
dc.date.none.fl_str_mv 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2011-04-12T22:21:50Z
dc.date.available.fl_str_mv 2011-04-12T22:21:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GADELHA, S. R. et al. Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals. Journal of Medical Virology, v.80, n.12, p.2141-2146, 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/1891
dc.identifier.issn.none.fl_str_mv 0146-6615
dc.identifier.doi.none.fl_str_mv 10.1002/jmv.21341
identifier_str_mv GADELHA, S. R. et al. Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals. Journal of Medical Virology, v.80, n.12, p.2141-2146, 2008.
0146-6615
10.1002/jmv.21341
url https://www.arca.fiocruz.br/handle/icict/1891
dc.language.iso.fl_str_mv eng
language eng
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instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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