Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals

Detalhes bibliográficos
Autor(a) principal: Gadelha, Sandra Rocha
Data de Publicação: 2008
Outros Autores: Alcântara, Luiz Carlos Júnior, Costa, Gisele Calazans, Acosta, Angelina Xavier, Rios, Domingos, Kashima, Simone, Covas, Dimas Tadeu, Castro, Bernardo Galvão
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13834
Resumo: Texto completo: acesso restrito. p. 2141-2146
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spelling Gadelha, Sandra RochaAlcântara, Luiz Carlos JúniorCosta, Gisele CalazansAcosta, Angelina XavierRios, DomingosKashima, SimoneCovas, Dimas TadeuCastro, Bernardo GalvãoGadelha, Sandra RochaAlcântara, Luiz Carlos JúniorCosta, Gisele CalazansAcosta, Angelina XavierRios, DomingosKashima, SimoneCovas, Dimas TadeuCastro, Bernardo Galvão2013-11-22T11:59:51Z20080146-6615http://repositorio.ufba.br/ri/handle/ri/13834v. 80, n. 12Texto completo: acesso restrito. p. 2141-2146HTLV-1 is the etiologic agent of ATL and HAM/TSP. The majority of HTLV-1-infected individuals remain asymptomatic, indicating that the infection alone is not sufficient to cause the diseases. It has been reported that cytokine gene polymorphisms, including polymorphisms at IL-6 and IL-10 gene, might be important. We analyzed SNP in the promoter region of the IL-6: −174, −572, −597, and −634 positions, and IL-10: −592 position to evaluate the role of these polymorphisms in the HAM/TSP pathogenesis in 133 HTLV-1 infected individuals and in 100 healthy individuals from Salvador, Bahia, Brazil. The −634C allele frequencies were higher among HAM/TSP patients (21.2%) than among oligosymptomatic (6.5%; P = 0.038) and asymptomatic (9.5%; P = 0.025) subjects. Similarly, the −174G allele frequencies were higher in HAM/TSP patients than in oligosymptomatic patients (P = 0.02). Moreover, the −634GC/−174GG genotype combination was identified at a higher frequency (38.5%) in the HAM/TSP patients than in subjects with other clinical status (8.7%; P = 0.016 for oligosymptomatic and 15.5%, P = 0.012 for asymptomatic patients). However, the multivariate logistic regression including the genotypes of the three studied loci showed that only −634 C IL-6 carriers remain as significant and independent TSP/HAM predictor (odds ratio [OR] = 5.31; 95% [CI] = 1.60–17.56; P = 0.006). We suggest that −634 G C in IL-6 could contribute to HAM/TSP development and that identification of the collective influence of several cytokine polymorphisms, their prevalence, and their interaction could help to better understand this disease.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-11-19T14:27:32Z No. of bitstreams: 1 10.1002-jmv.21341.pdf: 87640 bytes, checksum: f65e1390029fb8f906878ac4509e4c9f (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-22T11:59:51Z (GMT) No. of bitstreams: 1 10.1002-jmv.21341.pdf: 87640 bytes, checksum: f65e1390029fb8f906878ac4509e4c9f (MD5)Made available in DSpace on 2013-11-22T11:59:51Z (GMT). No. of bitstreams: 1 10.1002-jmv.21341.pdf: 87640 bytes, checksum: f65e1390029fb8f906878ac4509e4c9f (MD5) Previous issue date: 2008http://dx.doi.org/10.1002/jmv.21341reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHTLV-1Interleukin-6Interleukin-10PolymorphismsBrazilian populationsCorrelation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individualsJournal of Medical Virologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL10.1002-jmv.21341.pdf10.1002-jmv.21341.pdfapplication/pdf87640https://repositorio.ufba.br/bitstream/ri/13834/1/10.1002-jmv.21341.pdff65e1390029fb8f906878ac4509e4c9fMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/13834/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXT10.1002-jmv.21341.pdf.txt10.1002-jmv.21341.pdf.txtExtracted texttext/plain32908https://repositorio.ufba.br/bitstream/ri/13834/3/10.1002-jmv.21341.pdf.txtefb04394c5c8e57e635655306329c4e9MD53ri/138342022-07-05 14:02:58.39oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:58Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals
dc.title.alternative.pt_BR.fl_str_mv Journal of Medical Virology
title Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals
spellingShingle Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals
Gadelha, Sandra Rocha
HTLV-1
Interleukin-6
Interleukin-10
Polymorphisms
Brazilian populations
title_short Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals
title_full Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals
title_fullStr Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals
title_full_unstemmed Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals
title_sort Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals
author Gadelha, Sandra Rocha
author_facet Gadelha, Sandra Rocha
Alcântara, Luiz Carlos Júnior
Costa, Gisele Calazans
Acosta, Angelina Xavier
Rios, Domingos
Kashima, Simone
Covas, Dimas Tadeu
Castro, Bernardo Galvão
author_role author
author2 Alcântara, Luiz Carlos Júnior
Costa, Gisele Calazans
Acosta, Angelina Xavier
Rios, Domingos
Kashima, Simone
Covas, Dimas Tadeu
Castro, Bernardo Galvão
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gadelha, Sandra Rocha
Alcântara, Luiz Carlos Júnior
Costa, Gisele Calazans
Acosta, Angelina Xavier
Rios, Domingos
Kashima, Simone
Covas, Dimas Tadeu
Castro, Bernardo Galvão
Gadelha, Sandra Rocha
Alcântara, Luiz Carlos Júnior
Costa, Gisele Calazans
Acosta, Angelina Xavier
Rios, Domingos
Kashima, Simone
Covas, Dimas Tadeu
Castro, Bernardo Galvão
dc.subject.por.fl_str_mv HTLV-1
Interleukin-6
Interleukin-10
Polymorphisms
Brazilian populations
topic HTLV-1
Interleukin-6
Interleukin-10
Polymorphisms
Brazilian populations
description Texto completo: acesso restrito. p. 2141-2146
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2013-11-22T11:59:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13834
dc.identifier.issn.none.fl_str_mv 0146-6615
dc.identifier.number.pt_BR.fl_str_mv v. 80, n. 12
identifier_str_mv 0146-6615
v. 80, n. 12
url http://repositorio.ufba.br/ri/handle/ri/13834
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1002/jmv.21341
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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