Balance of IL-10 and Interferon-γ plasma levels in human visceral leishmaniasis: implications in the pathogenesis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2005 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/2749 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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Caldas, Arlene de Jesus MendesFavali, Cecilia Beatriz FiuzaAquino, Dorlene Maria Cardoso deVinhas, VeraWeyenbergh, Johan vanBrodskyn, Claudia IdaCosta, Jackson Mauricio LopesBarral Netto, ManoelBarral, Aldina Maria Prado2011-07-06T18:47:08Z2011-07-06T18:47:08Z2005CALDAS, A. et al. Balance of IL-10 and Interferon-γ plasma levels in human visceral leishmaniasis: implications in the pathogenesis. BMC Infectious Diseases, v.5, n.113, 2005.1471-2334https://www.arca.fiocruz.br/handle/icict/274910.1186/1471-2334-5-113engLeishmaniose Visceral HumanaImunorregulaçãoImunoprofilaxiaInterferon-yHuman Visceral LeishmaniasisImmunoregulationImmunoprophylaxisInterferon-yLeishmaniose VisceralInterferon gamaBalance of IL-10 and Interferon-γ plasma levels in human visceral leishmaniasis: implications in the pathogenesisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilDepartamento de Enfermagem. Universidade Federal do Maranhão. São Luís, MA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilDepartamento de Enfermagem. Universidade Federal do Maranhão. São Luís, MA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilInstituto de Investigação em Imunologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilInstituto de Investigação em Imunologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, BrasilInstituto de Investigação em Imunologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Medicina da Bahia. Salvador, BA, BrasilInstituto de Investigação em Imunologia. Salvador, BA, BrasilBackground: Leishmaniasis remains a serious public health problem in several parts of the developing world. Effective prophylactic measurements are hampered by imprecise comprehension of different aspects of the disease, including its immunoregulation. A better comprehension of immunoregulation in human VL may be useful both for designing and evaluating immunoprophylaxis. Methods: To explore immunoregulatory mechanisms, 20 visceral leishmaniasis (VL) patients were evaluated during active disease and at different periods up to one year after treatment determining their plasma cytokine levels, clinical parameters (palpable spleen and liver) and antibody levels. Results: Elevated plasma levels of IFN-γ and of IL-12 p40 were observed during active disease, significantly decreasing after treatment whereas in vitro Leishmania antigen-stimulated IFN-γ production by PBMC exhibited an inverse pattern being low during disease and increasing steadily thereafter. Absence of IFN-γ activity is a hallmark of VL. The main candidate for blunting IFN-γ activity is IL-10, a cytokine highly elevated in plasma with sharp decrease after treatment. Activity of IL-10 is inferred by high levels of anti-Leishmania specific IgG1 and IgG3. TGF-β had elevated total, but not of active, levels lessening the likelihood of being the IFN-γ counterpart. Spleen or liver size presented a steady decrease but return to normal values at only 120 days after treatment. Anti- Leishmania IgG (total and subclasses) levels and DTH or Leishmania-stimulated lymphocyte proliferation conversion to positive also present a slow decrease after treatment. IL-6 plasma levels were elevated in only a few patients. Conclusion: Taken together our results suggest that IFN-γ and IL-10 are the molecules most likely involved in determining fate of disease. After treatment, there is a long delay before the immune profile returns to normal what precludes using plasma cytokine levels as criteria of cure as simpler clinical evaluations, as a palpable spleen or liver, can be used.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCaldas_Favali_Aquino_etal.pdfCaldas_Favali_Aquino_etal.pdfapplication/pdf716910https://www.arca.fiocruz.br/bitstream/icict/2749/1/Caldas_Favali_Aquino_etal.pdf97412173b494bcb490cb197c3fb217c9MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/2749/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTCaldas_Favali_Aquino_etal.pdf.txtCaldas_Favali_Aquino_etal.pdf.txtExtracted texttext/plain38491https://www.arca.fiocruz.br/bitstream/icict/2749/5/Caldas_Favali_Aquino_etal.pdf.txtcd0a635853e72faafa27655827a681d4MD55THUMBNAILCaldas_Favali_Aquino_etal.pdf.jpgCaldas_Favali_Aquino_etal.pdf.jpgGenerated Thumbnailimage/jpeg2091https://www.arca.fiocruz.br/bitstream/icict/2749/4/Caldas_Favali_Aquino_etal.pdf.jpg1179ba97601e6615accd00bedf7880a1MD54icict/27492023-03-15 14:33:00.044oai:www.arca.fiocruz.br:icict/2749Tk9OLUVYQ0xVU0lWRSBESVNUUklCVVRJT04gTElDRU5TRQoKQnkgc2lnbmluZyBhbmQgc3VibWl0dGluZyB0aGlzIGxpY2Vuc2UsIHlvdSAodGhlIGF1dGhvcihzKSBvciBjb3B5cmlnaHQKb3duZXIpIGdyYW50cyB0byBEU3BhY2UgVW5pdmVyc2l0eSAoRFNVKSB0aGUgbm9uLWV4Y2x1c2l2ZSByaWdodCB0byByZXByb2R1Y2UsCnRyYW5zbGF0ZSAoYXMgZGVmaW5lZCBiZWxvdyksIGFuZC9vciBkaXN0cmlidXRlIHlvdXIgc3VibWlzc2lvbiAoaW5jbHVkaW5nCnRoZSBhYnN0cmFjdCkgd29ybGR3aWRlIGluIHByaW50IGFuZCBlbGVjdHJvbmljIGZvcm1hdCBhbmQgaW4gYW55IG1lZGl1bSwKaW5jbHVkaW5nIGJ1dCBub3QgbGltaXRlZCB0byBhdWRpbyBvciB2aWRlby4KCllvdSBhZ3JlZSB0aGF0IERTVSBtYXksIHdpdGhvdXQgY2hhbmdpbmcgdGhlIGNvbnRlbnQsIHRyYW5zbGF0ZSB0aGUKc3VibWlzc2lvbiB0byBhbnkgbWVkaXVtIG9yIGZvcm1hdCBmb3IgdGhlIHB1cnBvc2Ugb2YgcHJlc2VydmF0aW9uLgoKWW91IGFsc28gYWdyZWUgdGhhdCBEU1UgbWF5IGtlZXAgbW9yZSB0aGFuIG9uZSBjb3B5IG9mIHRoaXMgc3VibWlzc2lvbiBmb3IKcHVycG9zZXMgb2Ygc2VjdXJpdHksIGJhY2stdXAgYW5kIHByZXNlcnZhdGlvbi4KCllvdSByZXByZXNlbnQgdGhhdCB0aGUgc3VibWlzc2lvbiBpcyB5b3VyIG9yaWdpbmFsIHdvcmssIGFuZCB0aGF0IHlvdSBoYXZlCnRoZSByaWdodCB0byBncmFudCB0aGUgcmlnaHRzIGNvbnRhaW5lZCBpbiB0aGlzIGxpY2Vuc2UuIFlvdSBhbHNvIHJlcHJlc2VudAp0aGF0IHlvdXIgc3VibWlzc2lvbiBkb2VzIG5vdCwgdG8gdGhlIGJlc3Qgb2YgeW91ciBrbm93bGVkZ2UsIGluZnJpbmdlIHVwb24KYW55b25lJ3MgY29weXJpZ2h0LgoKSWYgdGhlIHN1Ym1pc3Npb24gY29udGFpbnMgbWF0ZXJpYWwgZm9yIHdoaWNoIHlvdSBkbyBub3QgaG9sZCBjb3B5cmlnaHQsCnlvdSByZXByZXNlbnQgdGhhdCB5b3UgaGF2ZSBvYnRhaW5lZCB0aGUgdW5yZXN0cmljdGVkIHBlcm1pc3Npb24gb2YgdGhlCmNvcHlyaWdodCBvd25lciB0byBncmFudCBEU1UgdGhlIHJpZ2h0cyByZXF1aXJlZCBieSB0aGlzIGxpY2Vuc2UsIGFuZCB0aGF0CnN1Y2ggdGhpcmQtcGFydHkgb3duZWQgbWF0ZXJpYWwgaXMgY2xlYXJseSBpZGVudGlmaWVkIGFuZCBhY2tub3dsZWRnZWQKd2l0aGluIHRoZSB0ZXh0IG9yIGNvbnRlbnQgb2YgdGhlIHN1Ym1pc3Npb24uCgpJRiBUSEUgU1VCTUlTU0lPTiBJUyBCQVNFRCBVUE9OIFdPUksgVEhBVCBIQVMgQkVFTiBTUE9OU09SRUQgT1IgU1VQUE9SVEVECkJZIEFOIEFHRU5DWSBPUiBPUkdBTklaQVRJT04gT1RIRVIgVEhBTiBEU1UsIFlPVSBSRVBSRVNFTlQgVEhBVCBZT1UgSEFWRQpGVUxGSUxMRUQgQU5ZIFJJR0hUIE9GIFJFVklFVyBPUiBPVEhFUiBPQkxJR0FUSU9OUyBSRVFVSVJFRCBCWSBTVUNICkNPTlRSQUNUIE9SIEFHUkVFTUVOVC4KCkRTVSB3aWxsIGNsZWFybHkgaWRlbnRpZnkgeW91ciBuYW1lKHMpIGFzIHRoZSBhdXRob3Iocykgb3Igb3duZXIocykgb2YgdGhlCnN1Ym1pc3Npb24sIGFuZCB3aWxsIG5vdCBtYWtlIGFueSBhbHRlcmF0aW9uLCBvdGhlciB0aGFuIGFzIGFsbG93ZWQgYnkgdGhpcwpsaWNlbnNlLCB0byB5b3VyIHN1Ym1pc3Npb24uCg==Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Balance of IL-10 and Interferon-γ plasma levels in human visceral leishmaniasis: implications in the pathogenesis |
| title |
Balance of IL-10 and Interferon-γ plasma levels in human visceral leishmaniasis: implications in the pathogenesis |
| spellingShingle |
Balance of IL-10 and Interferon-γ plasma levels in human visceral leishmaniasis: implications in the pathogenesis Caldas, Arlene de Jesus Mendes Leishmaniose Visceral Humana Imunorregulação Imunoprofilaxia Interferon-y Human Visceral Leishmaniasis Immunoregulation Immunoprophylaxis Interferon-y Leishmaniose Visceral Interferon gama |
| title_short |
Balance of IL-10 and Interferon-γ plasma levels in human visceral leishmaniasis: implications in the pathogenesis |
| title_full |
Balance of IL-10 and Interferon-γ plasma levels in human visceral leishmaniasis: implications in the pathogenesis |
| title_fullStr |
Balance of IL-10 and Interferon-γ plasma levels in human visceral leishmaniasis: implications in the pathogenesis |
| title_full_unstemmed |
Balance of IL-10 and Interferon-γ plasma levels in human visceral leishmaniasis: implications in the pathogenesis |
| title_sort |
Balance of IL-10 and Interferon-γ plasma levels in human visceral leishmaniasis: implications in the pathogenesis |
| author |
Caldas, Arlene de Jesus Mendes |
| author_facet |
Caldas, Arlene de Jesus Mendes Favali, Cecilia Beatriz Fiuza Aquino, Dorlene Maria Cardoso de Vinhas, Vera Weyenbergh, Johan van Brodskyn, Claudia Ida Costa, Jackson Mauricio Lopes Barral Netto, Manoel Barral, Aldina Maria Prado |
| author_role |
author |
| author2 |
Favali, Cecilia Beatriz Fiuza Aquino, Dorlene Maria Cardoso de Vinhas, Vera Weyenbergh, Johan van Brodskyn, Claudia Ida Costa, Jackson Mauricio Lopes Barral Netto, Manoel Barral, Aldina Maria Prado |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Caldas, Arlene de Jesus Mendes Favali, Cecilia Beatriz Fiuza Aquino, Dorlene Maria Cardoso de Vinhas, Vera Weyenbergh, Johan van Brodskyn, Claudia Ida Costa, Jackson Mauricio Lopes Barral Netto, Manoel Barral, Aldina Maria Prado |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose Visceral Humana Imunorregulação Imunoprofilaxia Interferon-y |
| topic |
Leishmaniose Visceral Humana Imunorregulação Imunoprofilaxia Interferon-y Human Visceral Leishmaniasis Immunoregulation Immunoprophylaxis Interferon-y Leishmaniose Visceral Interferon gama |
| dc.subject.en.pt_BR.fl_str_mv |
Human Visceral Leishmaniasis Immunoregulation Immunoprophylaxis Interferon-y |
| dc.subject.decs.pt_BR.fl_str_mv |
Leishmaniose Visceral Interferon gama |
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Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil |
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2005 |
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2005 |
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2011-07-06T18:47:08Z |
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2011-07-06T18:47:08Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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CALDAS, A. et al. Balance of IL-10 and Interferon-γ plasma levels in human visceral leishmaniasis: implications in the pathogenesis. BMC Infectious Diseases, v.5, n.113, 2005. |
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https://www.arca.fiocruz.br/handle/icict/2749 |
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1471-2334 |
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10.1186/1471-2334-5-113 |
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CALDAS, A. et al. Balance of IL-10 and Interferon-γ plasma levels in human visceral leishmaniasis: implications in the pathogenesis. BMC Infectious Diseases, v.5, n.113, 2005. 1471-2334 10.1186/1471-2334-5-113 |
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