Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma

Badaro, Roberto José da Silva; Falcoff, Ernesto; Badaró, Fernando Sérgio da Silva; Carvalho Filho, Edgar Marcelino; Sampaio, Diana da Silva Pedral; Barral, Aldina Maria Prado; Carvalho, Jose S; Barral Netto, Manoel; Brandely, Maud; Silva, Luciana; Bina, Jose Carlos; Teixeira, Rodolfo; Falcoff, Rebeca; Rocha, Heonir; Ho, John L; Johnson Junior, Warren D

Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma

Detalhes bibliográficos
Autor(a) principal:	Badaro, Roberto José da Silva
Data de Publicação:	1990
Outros Autores:	Falcoff, Ernesto, Badaró, Fernando Sérgio da Silva, Carvalho Filho, Edgar Marcelino, Sampaio, Diana da Silva Pedral, Barral, Aldina Maria Prado, Carvalho, Jose S, Barral Netto, Manoel, Brandely, Maud, Silva, Luciana, Bina, Jose Carlos, Teixeira, Rodolfo, Falcoff, Rebeca, Rocha, Heonir, Ho, John L, Johnson Junior, Warren D
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/23126
Resumo:	Múltipla - ver em Notas

Metadados do item

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spelling	Badaro, Roberto José da SilvaFalcoff, ErnestoBadaró, Fernando Sérgio da SilvaCarvalho Filho, Edgar MarcelinoSampaio, Diana da Silva PedralBarral, Aldina Maria PradoCarvalho, Jose SBarral Netto, ManoelBrandely, MaudSilva, LucianaBina, Jose CarlosTeixeira, RodolfoFalcoff, RebecaRocha, HeonirHo, John LJohnson Junior, Warren D2017-11-13T14:18:43Z2017-11-13T14:18:43Z1990BADARO, R. J. S. et al. Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma. New England Journal of Medicine, v. 322, n. 1, p. 16-21, 1990.0028-4793https://www.arca.fiocruz.br/handle/icict/2312610.1056/NEJM199001043220104engMassachusetts Medical SocietyLeishmaniose visceralInterferon gamaTratamentoAntimonioVisceral leishmaniasisinterferon gammaTreatmentAntimonyTreatment of visceral leishmaniasis with pentavalent antimony and interferon gammainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMúltipla - ver em NotasAcute visceral leishmaniasis is associated with an antigen-specific immunosuppression of mononuclear cells as evidenced by defective in vitro production of interferon gamma. We evaluated treatment with recombinant human interferon gamma in combination with conventional pentavalent antimony therapy in patients with visceral leishmaniasis. Six of eight patients with visceral leishmaniasis (mean duration, 17 months) that had been unresponsive to multiple courses of pentavalent antimony responded to treatment with recombinant human interferon gamma (100 to 400 micrograms per square meter of body-surface area per day) in addition to pentavalent antimony (20 mg per kilogram of body weight per day) for 10 to 40 days. The other two patients improved initially but then relapsed and required treatment with amphotericin B. Eight of nine additional patients with previously untreated severe visceral leishmaniasis were also successfully treated with the combination of interferon gamma and pentavalent antimony. The 14 patients who responded to this regimen had marked improvement in symptoms and in measures of anemia and leukopenia, as well as weight gain, a decrease in spleen size, and an absence or reduction of leishmanias in splenic aspirates. These patients had no recurrence of illness after a mean (+/- SE) follow-up of 8 +/- 1 months. Fever was the only major side effect of interferon gamma. We conclude that the combination of interferon gamma and pentavalent antimony is effective in treating seriously ill patients with refractory or previously untreated visceral leishmaniasis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/23126/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALBadaro RE Treatment of visceral....pdfBadaro RE Treatment of visceral....pdfapplication/pdf1091059https://www.arca.fiocruz.br/bitstream/icict/23126/2/Badaro%20RE%20Treatment%20of%20visceral....pdf874a7b12216807918bd0638e1f726371MD52TEXTBadaro RE Treatment of visceral....pdf.txtBadaro RE Treatment of visceral....pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv	Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma
title	Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma
spellingShingle	Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma Badaro, Roberto José da Silva Leishmaniose visceral Interferon gama Tratamento Antimonio Visceral leishmaniasis interferon gamma Treatment Antimony
title_short	Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma
title_full	Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma
title_fullStr	Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma
title_full_unstemmed	Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma
title_sort	Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma
author	Badaro, Roberto José da Silva
author_facet	Badaro, Roberto José da Silva Falcoff, Ernesto Badaró, Fernando Sérgio da Silva Carvalho Filho, Edgar Marcelino Sampaio, Diana da Silva Pedral Barral, Aldina Maria Prado Carvalho, Jose S Barral Netto, Manoel Brandely, Maud Silva, Luciana Bina, Jose Carlos Teixeira, Rodolfo Falcoff, Rebeca Rocha, Heonir Ho, John L Johnson Junior, Warren D
author_role	author
author2	Falcoff, Ernesto Badaró, Fernando Sérgio da Silva Carvalho Filho, Edgar Marcelino Sampaio, Diana da Silva Pedral Barral, Aldina Maria Prado Carvalho, Jose S Barral Netto, Manoel Brandely, Maud Silva, Luciana Bina, Jose Carlos Teixeira, Rodolfo Falcoff, Rebeca Rocha, Heonir Ho, John L Johnson Junior, Warren D
author2_role	author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Badaro, Roberto José da Silva Falcoff, Ernesto Badaró, Fernando Sérgio da Silva Carvalho Filho, Edgar Marcelino Sampaio, Diana da Silva Pedral Barral, Aldina Maria Prado Carvalho, Jose S Barral Netto, Manoel Brandely, Maud Silva, Luciana Bina, Jose Carlos Teixeira, Rodolfo Falcoff, Rebeca Rocha, Heonir Ho, John L Johnson Junior, Warren D
dc.subject.other.pt_BR.fl_str_mv	Leishmaniose visceral Interferon gama Tratamento Antimonio
topic	Leishmaniose visceral Interferon gama Tratamento Antimonio Visceral leishmaniasis interferon gamma Treatment Antimony
dc.subject.en.pt_BR.fl_str_mv	Visceral leishmaniasis interferon gamma Treatment Antimony
description	Múltipla - ver em Notas
publishDate	1990
dc.date.issued.fl_str_mv	1990
dc.date.accessioned.fl_str_mv	2017-11-13T14:18:43Z
dc.date.available.fl_str_mv	2017-11-13T14:18:43Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	BADARO, R. J. S. et al. Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma. New England Journal of Medicine, v. 322, n. 1, p. 16-21, 1990.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/23126
dc.identifier.issn.pt_BR.fl_str_mv	0028-4793
dc.identifier.doi.none.fl_str_mv	10.1056/NEJM199001043220104
identifier_str_mv	BADARO, R. J. S. et al. Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma. New England Journal of Medicine, v. 322, n. 1, p. 16-21, 1990. 0028-4793 10.1056/NEJM199001043220104
url	https://www.arca.fiocruz.br/handle/icict/23126
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Massachusetts Medical Society
publisher.none.fl_str_mv	Massachusetts Medical Society
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/23126/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/23126/2/Badaro%20RE%20Treatment%20of%20visceral....pdf https://www.arca.fiocruz.br/bitstream/icict/23126/3/Badaro%20RE%20Treatment%20of%20visceral....pdf.txt
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Treatment of visceral leishmaniasis with pentavalent antimony and interferon gamma

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