Species-specific escape of Plasmodium sporozoites from oocysts of avian, rodent, and human malarial parasites
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/19758 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil |
| id |
CRUZ_5a47e38a4240a7dfd27f63682f837f3d |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/19758 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Orfano, Alessandra da SilvaPimenta, Rafael NacifDuarte, Ana Paula MarquesVillegas, Luis Eduardo MartínezRodrigues, Nilton BarnabePinto, Luciana da ConceiçãoCampos, Keillen Monick MartinsBeltrán, Yudi Tatiana PinillaChaves, Bárbara AparecidaGuerra, Maria G. V. BarbosaMonteiro, Wuelton MarceloSmith, Ryan C.Molina‑Cruz, AlvaroLacerda, Marcus Vinicius Guimarães deSecundino, Nágila Francinete CostaJacobs‑Lorena, MarceloBarillas‑Mury, CarolinaPimenta, Paulo Filemon Paolucci2017-07-06T19:27:18Z2017-07-06T19:27:18Z2016ORFANO, Alessandra da Silva et al. Species-specific escape of Plasmodium sporozoites from oocysts of avian, rodent, and human malarial parasites. Malaria Journal, v. 15, art. 394, 20161475-2875https://www.arca.fiocruz.br/handle/icict/1975810.1186/s12936-016-1451-yengBiomed CentralOocistoPlasmodiumSporozoiteescapeOocystMosquito vectorPlasmodiumHuman Murine AvianSpecies-specific escape of Plasmodium sporozoites from oocysts of avian, rodent, and human malarial parasitesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil.Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brazil.Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brazil.Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brazil.Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brazil.Iowa State University. Department of Entomology. Ames, IA, USA/ Johns Hopkins Bloomberg School of Public Health. Department of Molecular Microbiology and Immunology. Baltimore, MD, USA.National Institutes of Health. Laboratory of Malaria and Vector Research. Rockville, MD, USA.Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brazil/Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil.Johns Hopkins Bloomberg School of Public Health. Department of Molecular Microbiology and Immunology. Baltimore, MD, USA.National Institutes of Health. Laboratory of Malaria and Vector Research. Rockville, MD, USA.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/Fundação de Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brazil.Background: Malaria is transmitted when an infected mosquito delivers Plasmodium sporozoites into a vertebrate host. There are many species of Plasmodium and, in general, the infection is host-specific. For example, Plasmodium gallinaceum is an avian parasite, while Plasmodium berghei infects mice. These two parasites have been extensively used as experimental models of malaria transmission. Plasmodium falciparum and Plasmodium vivax are the most important agents of human malaria, a life-threatening disease of global importance. To complete their life cycle, Plasmodium parasites must traverse the mosquito midgut and form an oocyst that will divide continuously. Mature oocysts release thousands of sporozoites into the mosquito haemolymph that must reach the salivary gland to infect a new vertebrate host. The current understanding of the biology of oocyst formation and sporozoite release is mostly based on experimental infections with P. berghei, and the conclusions are generalized to other Plasmodium species that infect humans without further morphological analyses. Results: Here, it is described the microanatomy of sporozoite escape from oocysts of four Plasmodium species: the two laboratory models, P. gallinaceum and P. berghei, and the two main species that cause malaria in humans, P. vivax and P. falciparum. It was found that sporozoites have species-specific mechanisms of escape from the oocyst. The two model species of Plasmodium had a common mechanism, in which the oocyst wall breaks down before sporozoites emerge. In contrast, P. vivax and P. falciparum sporozoites show a dynamic escape mechanism from the oocyst via polarized propulsion. Conclusions: This study demonstrated that Plasmodium species do not share a common mechanism of sporozoite escape, as previously thought, but show complex and species-specific mechanisms. In addition, the knowledge of this phenomenon in human Plasmodium can facilitate transmission-blocking studies and not those ones only based on the murine and avian models.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/19758/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALOrfano_ Alessandra_Species-specific_IRR_2016.pdfOrfano_ Alessandra_Species-specific_IRR_2016.pdfapplication/pdf7110861https://www.arca.fiocruz.br/bitstream/icict/19758/2/Orfano_%20Alessandra_Species-specific_IRR_2016.pdfd66d546952a582fae9e6b5fc6be65c1cMD52TEXTOrfano_ Alessandra_Species-specific_IRR_2016.pdf.txtOrfano_ Alessandra_Species-specific_IRR_2016.pdf.txtExtracted texttext/plain454https://www.arca.fiocruz.br/bitstream/icict/19758/3/Orfano_%20Alessandra_Species-specific_IRR_2016.pdf.txt67681d9174a26b2d30c87a7148600a40MD53icict/197582019-06-19 10:06:48.845oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:06:48Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Species-specific escape of Plasmodium sporozoites from oocysts of avian, rodent, and human malarial parasites |
| title |
Species-specific escape of Plasmodium sporozoites from oocysts of avian, rodent, and human malarial parasites |
| spellingShingle |
Species-specific escape of Plasmodium sporozoites from oocysts of avian, rodent, and human malarial parasites Orfano, Alessandra da Silva Oocisto Plasmodium Sporozoite escape Oocyst Mosquito vector Plasmodium Human Murine Avian |
| title_short |
Species-specific escape of Plasmodium sporozoites from oocysts of avian, rodent, and human malarial parasites |
| title_full |
Species-specific escape of Plasmodium sporozoites from oocysts of avian, rodent, and human malarial parasites |
| title_fullStr |
Species-specific escape of Plasmodium sporozoites from oocysts of avian, rodent, and human malarial parasites |
| title_full_unstemmed |
Species-specific escape of Plasmodium sporozoites from oocysts of avian, rodent, and human malarial parasites |
| title_sort |
Species-specific escape of Plasmodium sporozoites from oocysts of avian, rodent, and human malarial parasites |
| author |
Orfano, Alessandra da Silva |
| author_facet |
Orfano, Alessandra da Silva Pimenta, Rafael Nacif Duarte, Ana Paula Marques Villegas, Luis Eduardo Martínez Rodrigues, Nilton Barnabe Pinto, Luciana da Conceição Campos, Keillen Monick Martins Beltrán, Yudi Tatiana Pinilla Chaves, Bárbara Aparecida Guerra, Maria G. V. Barbosa Monteiro, Wuelton Marcelo Smith, Ryan C. Molina‑Cruz, Alvaro Lacerda, Marcus Vinicius Guimarães de Secundino, Nágila Francinete Costa Jacobs‑Lorena, Marcelo Barillas‑Mury, Carolina Pimenta, Paulo Filemon Paolucci |
| author_role |
author |
| author2 |
Pimenta, Rafael Nacif Duarte, Ana Paula Marques Villegas, Luis Eduardo Martínez Rodrigues, Nilton Barnabe Pinto, Luciana da Conceição Campos, Keillen Monick Martins Beltrán, Yudi Tatiana Pinilla Chaves, Bárbara Aparecida Guerra, Maria G. V. Barbosa Monteiro, Wuelton Marcelo Smith, Ryan C. Molina‑Cruz, Alvaro Lacerda, Marcus Vinicius Guimarães de Secundino, Nágila Francinete Costa Jacobs‑Lorena, Marcelo Barillas‑Mury, Carolina Pimenta, Paulo Filemon Paolucci |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Orfano, Alessandra da Silva Pimenta, Rafael Nacif Duarte, Ana Paula Marques Villegas, Luis Eduardo Martínez Rodrigues, Nilton Barnabe Pinto, Luciana da Conceição Campos, Keillen Monick Martins Beltrán, Yudi Tatiana Pinilla Chaves, Bárbara Aparecida Guerra, Maria G. V. Barbosa Monteiro, Wuelton Marcelo Smith, Ryan C. Molina‑Cruz, Alvaro Lacerda, Marcus Vinicius Guimarães de Secundino, Nágila Francinete Costa Jacobs‑Lorena, Marcelo Barillas‑Mury, Carolina Pimenta, Paulo Filemon Paolucci |
| dc.subject.other.pt_BR.fl_str_mv |
Oocisto Plasmodium |
| topic |
Oocisto Plasmodium Sporozoite escape Oocyst Mosquito vector Plasmodium Human Murine Avian |
| dc.subject.en.pt_BR.fl_str_mv |
Sporozoite escape Oocyst Mosquito vector Plasmodium Human Murine Avian |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil |
| publishDate |
2016 |
| dc.date.issued.fl_str_mv |
2016 |
| dc.date.accessioned.fl_str_mv |
2017-07-06T19:27:18Z |
| dc.date.available.fl_str_mv |
2017-07-06T19:27:18Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
ORFANO, Alessandra da Silva et al. Species-specific escape of Plasmodium sporozoites from oocysts of avian, rodent, and human malarial parasites. Malaria Journal, v. 15, art. 394, 2016 |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/19758 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1475-2875 |
| dc.identifier.doi.none.fl_str_mv |
10.1186/s12936-016-1451-y |
| identifier_str_mv |
ORFANO, Alessandra da Silva et al. Species-specific escape of Plasmodium sporozoites from oocysts of avian, rodent, and human malarial parasites. Malaria Journal, v. 15, art. 394, 2016 1475-2875 10.1186/s12936-016-1451-y |
| url |
https://www.arca.fiocruz.br/handle/icict/19758 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Biomed Central |
| publisher.none.fl_str_mv |
Biomed Central |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/19758/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/19758/2/Orfano_%20Alessandra_Species-specific_IRR_2016.pdf https://www.arca.fiocruz.br/bitstream/icict/19758/3/Orfano_%20Alessandra_Species-specific_IRR_2016.pdf.txt |
| bitstream.checksum.fl_str_mv |
9193a7c197bc67acd023525e72a03240 d66d546952a582fae9e6b5fc6be65c1c 67681d9174a26b2d30c87a7148600a40 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813009026111242240 |