Leishmania infantum lipophosphoglycan induced-Prostaglandin E2production in association with PPAR-γ expression via activation of Toll like receptors-1 and 2
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1038/s41598-017-14229-8 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/24884 |
Resumo: | Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Salvador, BA, Brasil / Universidade Federal do Oeste da Bahia. Centro de Ciências Biológicas e da Saúde. Barreiras, BA, Brasil. |
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Lima, Jonilson BerlinkSantos, Théo AraújoSouza, Milena LázaroCarneiro, Alan BritoIbraim, Izabela CoimbraSantos, Flávio Henrique JesusLuz, Nívea FariasPontes, Sara de MouraEntringer, Petter FrancoDescoteaux, AlbertBozza, Patrícia TorresSoares, Rodrigo PedroBorges, Valéria Matos2018-02-20T14:45:35Z2018-02-20T14:45:35Z2017LIMA, Jonilson Berlink; et al. Leishmania infantum lipophosphoglycan induced- Prostaglandin E2 production in association with PPAR-γ expression via activation of Toll like receptors-1 and 2. Scientifc Reports, v.7: 14321, 11p, Oct. 2017.2045-2322https://www.arca.fiocruz.br/handle/icict/2488410.1038/s41598-017-14229-82045-2322engNature Publishing GroupLeishmania infantumPPRAProstaglandinaReceptores Toll-LikeGlicoproteínas de Membrana Associadas ao LisossomoLeishmania infantumPPRA-y expressionProstaglandin E2Toll like receptors-1 and 2LipophosphoglycanLeishmania infantum lipophosphoglycan induced-Prostaglandin E2production in association with PPAR-γ expression via activation of Toll like receptors-1 and 2info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Gonçalo Muniz. Salvador, BA, Brasil / Universidade Federal do Oeste da Bahia. Centro de Ciências Biológicas e da Saúde. Barreiras, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Salvador, BA, Brasil / Universidade Federal do Oeste da Bahia. Centro de Ciências Biológicas e da Saúde. Barreiras, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Muniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Universidade Federal do Rio de Janeiro. NUPEM. Campus Macaé. macaé, RJ, Brasil.Institut National de la Recherche Scientifique. Institut Armand-Frappier. Laval, Canada.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Muniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Lipophosphoglycan (LPG) is a key virulence factor expressed on the surfaces of Leishmania promastigotes. Although LPG is known to activate macrophages, the underlying mechanisms resulting in the production of prostaglandin E2(PGE2) via signaling pathways remain unknown. Here, the inflammatory response arising from stimulation by Leishmania infantum LPG and/or its lipid and glycan motifs was evaluated with regard to PGE2induction. Intact LPG, but not its glycan and lipid moieties, induced a range of proinflammatory responses, including PGE2and nitric oxide (NO) release, increased lipid droplet formation, and iNOS and COX2 expression. LPG also induced ERK-1/2 and JNK phosphorylation in macrophages, in addition to the release of PGE2, MCP-1, IL-6, TNF-α and IL-12p70, but not IL-10. Pharmacological inhibition of ERK1/2 and PKC affected PGE2and cytokine production. Moreover, treatment with rosiglitazone, an agonist of peroxisome proliferator-activated receptor gamma (PPAR-γ), also modulated the release of PGE2and other proinflammatory mediators. Finally, we determined that LPG-induced PPAR-γ signaling occurred via TLR1/2. Taken together, these results reinforce the role played by L. infantum-derived LPG in the proinflammatory response seen in Leishmania infection.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/24884/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALalan_carneiro_etal_IOC_2017.pdfalan_carneiro_etal_IOC_2017.pdfapplication/pdf1888939https://www.arca.fiocruz.br/bitstream/icict/24884/2/alan_carneiro_etal_IOC_2017.pdfb9e4323376f30ec53fccc102bfc178bcMD52TEXTalan_carneiro_etal_IOC_2017.pdf.txtalan_carneiro_etal_IOC_2017.pdf.txtExtracted texttext/plain51037https://www.arca.fiocruz.br/bitstream/icict/24884/3/alan_carneiro_etal_IOC_2017.pdf.txt79aa764267e4d8273be8e18c1880b522MD53icict/248842018-08-15 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| dc.title.pt_BR.fl_str_mv |
Leishmania infantum lipophosphoglycan induced-Prostaglandin E2production in association with PPAR-γ expression via activation of Toll like receptors-1 and 2 |
| title |
Leishmania infantum lipophosphoglycan induced-Prostaglandin E2production in association with PPAR-γ expression via activation of Toll like receptors-1 and 2 |
| spellingShingle |
Leishmania infantum lipophosphoglycan induced-Prostaglandin E2production in association with PPAR-γ expression via activation of Toll like receptors-1 and 2 Lima, Jonilson Berlink Leishmania infantum PPRA Prostaglandina Receptores Toll-Like Glicoproteínas de Membrana Associadas ao Lisossomo Leishmania infantum PPRA-y expression Prostaglandin E2 Toll like receptors-1 and 2 Lipophosphoglycan |
| title_short |
Leishmania infantum lipophosphoglycan induced-Prostaglandin E2production in association with PPAR-γ expression via activation of Toll like receptors-1 and 2 |
| title_full |
Leishmania infantum lipophosphoglycan induced-Prostaglandin E2production in association with PPAR-γ expression via activation of Toll like receptors-1 and 2 |
| title_fullStr |
Leishmania infantum lipophosphoglycan induced-Prostaglandin E2production in association with PPAR-γ expression via activation of Toll like receptors-1 and 2 |
| title_full_unstemmed |
Leishmania infantum lipophosphoglycan induced-Prostaglandin E2production in association with PPAR-γ expression via activation of Toll like receptors-1 and 2 |
| title_sort |
Leishmania infantum lipophosphoglycan induced-Prostaglandin E2production in association with PPAR-γ expression via activation of Toll like receptors-1 and 2 |
| author |
Lima, Jonilson Berlink |
| author_facet |
Lima, Jonilson Berlink Santos, Théo Araújo Souza, Milena Lázaro Carneiro, Alan Brito Ibraim, Izabela Coimbra Santos, Flávio Henrique Jesus Luz, Nívea Farias Pontes, Sara de Moura Entringer, Petter Franco Descoteaux, Albert Bozza, Patrícia Torres Soares, Rodrigo Pedro Borges, Valéria Matos |
| author_role |
author |
| author2 |
Santos, Théo Araújo Souza, Milena Lázaro Carneiro, Alan Brito Ibraim, Izabela Coimbra Santos, Flávio Henrique Jesus Luz, Nívea Farias Pontes, Sara de Moura Entringer, Petter Franco Descoteaux, Albert Bozza, Patrícia Torres Soares, Rodrigo Pedro Borges, Valéria Matos |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Lima, Jonilson Berlink Santos, Théo Araújo Souza, Milena Lázaro Carneiro, Alan Brito Ibraim, Izabela Coimbra Santos, Flávio Henrique Jesus Luz, Nívea Farias Pontes, Sara de Moura Entringer, Petter Franco Descoteaux, Albert Bozza, Patrícia Torres Soares, Rodrigo Pedro Borges, Valéria Matos |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmania infantum PPRA Prostaglandina Receptores Toll-Like Glicoproteínas de Membrana Associadas ao Lisossomo |
| topic |
Leishmania infantum PPRA Prostaglandina Receptores Toll-Like Glicoproteínas de Membrana Associadas ao Lisossomo Leishmania infantum PPRA-y expression Prostaglandin E2 Toll like receptors-1 and 2 Lipophosphoglycan |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmania infantum PPRA-y expression Prostaglandin E2 Toll like receptors-1 and 2 Lipophosphoglycan |
| description |
Fundação Oswaldo Cruz. Instituto Gonçalo Muniz. Salvador, BA, Brasil / Universidade Federal do Oeste da Bahia. Centro de Ciências Biológicas e da Saúde. Barreiras, BA, Brasil. |
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2017 |
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2017 |
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2018-02-20T14:45:35Z |
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2018-02-20T14:45:35Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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LIMA, Jonilson Berlink; et al. Leishmania infantum lipophosphoglycan induced- Prostaglandin E2 production in association with PPAR-γ expression via activation of Toll like receptors-1 and 2. Scientifc Reports, v.7: 14321, 11p, Oct. 2017. |
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https://www.arca.fiocruz.br/handle/icict/24884 |
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2045-2322 |
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10.1038/s41598-017-14229-8 |
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2045-2322 |
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LIMA, Jonilson Berlink; et al. Leishmania infantum lipophosphoglycan induced- Prostaglandin E2 production in association with PPAR-γ expression via activation of Toll like receptors-1 and 2. Scientifc Reports, v.7: 14321, 11p, Oct. 2017. 2045-2322 10.1038/s41598-017-14229-8 |
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openAccess |
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Nature Publishing Group |
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Nature Publishing Group |
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