Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae

Mendes, Ana Luisa Gomes; Joaquim, Heloísa Di Matteo; Zamae, Mara Inês Stefanini; Assis, Ramon Meira; Peixoto, Jéssica Renata de Moura; Araújo, Margarida Maria Gomes de; Guedes, Antônio Carlos Martins; Oliveira, Edward José; Paschoal, Vanessa Peruhype Magalhães; Xavier, Marcelo Antônio Pascoal

Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae

Detalhes bibliográficos
Autor(a) principal:	Mendes, Ana Luisa Gomes
Data de Publicação:	2020
Outros Autores:	Joaquim, Heloísa Di Matteo, Zamae, Mara Inês Stefanini, Assis, Ramon Meira, Peixoto, Jéssica Renata de Moura, Araújo, Margarida Maria Gomes de, Guedes, Antônio Carlos Martins, Oliveira, Edward José, Paschoal, Vanessa Peruhype Magalhães, Xavier, Marcelo Antônio Pascoal
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/40553
Resumo:	Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Anatomia Patológica e Medicina Legal. Belo Horizonte, MG, Brasil.

Metadados do item

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spelling	Mendes, Ana Luisa GomesJoaquim, Heloísa Di MatteoZamae, Mara Inês StefaniniAssis, Ramon MeiraPeixoto, Jéssica Renata de MouraAraújo, Margarida Maria Gomes deGuedes, Antônio Carlos MartinsOliveira, Edward JoséPaschoal, Vanessa Peruhype MagalhãesXavier, Marcelo Antônio Pascoal2020-03-30T13:36:10Z2020-03-30T13:36:10Z2020MENDES, Ana Luisa Gomes et al. Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 115, p. 1-7, 2020.1678-8060https://www.arca.fiocruz.br/handle/icict/4055310.1590/0074-02760190324engFundação Oswaldo CruzExpression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium lepraeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Anatomia Patológica e Medicina Legal. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Anatomia Patológica e Medicina Legal. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Anatomia Patológica e Medicina Legal. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Anatomia Patológica e Medicina Legal. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Anatomia Patológica e Medicina Legal. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Anatomia Patológica e Medicina Legal. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Anatomia Patológica e Medicina Legal. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.BACKGROUND: Leprosy is an infectious-contagious disease caused by Mycobacterium leprae that remain endemic in 105 countries. This neglected disease has a wide range of clinical and histopathological manifestations that are related to the host inflammatory and immune responses. More recently, the inflammasome has assumed a relevant role in the inflammatory response against microbiological agents. However, the involvement of inflammasome in leprosy remains poorly understood. OBJECTIVES: The aim is to associate biomarkers of inflammasome with the different immunopathological forms of leprosy. METHODS: We performed an observational, cross-sectional, and comparative study of the immunophenotypic expression of inflammasome-associated proteins in immunopathological forms of leprosy of 99 skin lesion samples by immunohistochemistry. The intensity and percentage of NLRP3, Caspase-1, Caspases-4/5, interleukin-1β and interleukin-18 immunoreactivities in the inflammatory infiltrate of skin biopsies were evaluated. FINDINGS: Strong expression of NLRP3 and inflammatory Caspases-4/5 were observed in lepromatous leprosy (lepromatous pole). In addition, were observed low expression of caspase-1, interleukin-1β, and interleukin-18 in tuberculoid and lepromatous leprosy. The interpolar or borderline form showed immunophenotype predominantly similar to the lepromatous pole. MAIN CONCLUSIONS: Our results demonstrate that the NLRP3 inflammasome is inactive in leprosy, suggestingLeprosyInflammasomeNLRP3Caspaseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40553/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALExpression of NLRP3 inflammasome.pdfExpression of NLRP3 inflammasome.pdfapplication/pdf4380064https://www.arca.fiocruz.br/bitstream/icict/40553/2/Expression%20of%20NLRP3%20inflammasome.pdffbe913dc1a8856a2d183731ffda05b04MD52TEXTExpression of NLRP3 inflammasome.pdf.txtExpression of NLRP3 inflammasome.pdf.txtExtracted texttext/plain28595https://www.arca.fiocruz.br/bitstream/icict/40553/3/Expression%20of%20NLRP3%20inflammasome.pdf.txt7c030f3409b85bd66fc23130a070fc54MD53icict/405532020-03-31 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dc.title.pt_BR.fl_str_mv	Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae
title	Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae
spellingShingle	Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae Mendes, Ana Luisa Gomes Leprosy Inflammasome NLRP3 Caspase
title_short	Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae
title_full	Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae
title_fullStr	Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae
title_full_unstemmed	Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae
title_sort	Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae
author	Mendes, Ana Luisa Gomes
author_facet	Mendes, Ana Luisa Gomes Joaquim, Heloísa Di Matteo Zamae, Mara Inês Stefanini Assis, Ramon Meira Peixoto, Jéssica Renata de Moura Araújo, Margarida Maria Gomes de Guedes, Antônio Carlos Martins Oliveira, Edward José Paschoal, Vanessa Peruhype Magalhães Xavier, Marcelo Antônio Pascoal
author_role	author
author2	Joaquim, Heloísa Di Matteo Zamae, Mara Inês Stefanini Assis, Ramon Meira Peixoto, Jéssica Renata de Moura Araújo, Margarida Maria Gomes de Guedes, Antônio Carlos Martins Oliveira, Edward José Paschoal, Vanessa Peruhype Magalhães Xavier, Marcelo Antônio Pascoal
author2_role	author author author author author author author author author
dc.contributor.author.fl_str_mv	Mendes, Ana Luisa Gomes Joaquim, Heloísa Di Matteo Zamae, Mara Inês Stefanini Assis, Ramon Meira Peixoto, Jéssica Renata de Moura Araújo, Margarida Maria Gomes de Guedes, Antônio Carlos Martins Oliveira, Edward José Paschoal, Vanessa Peruhype Magalhães Xavier, Marcelo Antônio Pascoal
dc.subject.en.pt_BR.fl_str_mv	Leprosy Inflammasome NLRP3 Caspase
topic	Leprosy Inflammasome NLRP3 Caspase
description	Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Anatomia Patológica e Medicina Legal. Belo Horizonte, MG, Brasil.
publishDate	2020
dc.date.accessioned.fl_str_mv	2020-03-30T13:36:10Z
dc.date.available.fl_str_mv	2020-03-30T13:36:10Z
dc.date.issued.fl_str_mv	2020
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	MENDES, Ana Luisa Gomes et al. Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 115, p. 1-7, 2020.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/40553
dc.identifier.issn.pt_BR.fl_str_mv	1678-8060
dc.identifier.doi.none.fl_str_mv	10.1590/0074-02760190324
identifier_str_mv	MENDES, Ana Luisa Gomes et al. Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 115, p. 1-7, 2020. 1678-8060 10.1590/0074-02760190324
url	https://www.arca.fiocruz.br/handle/icict/40553
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Fundação Oswaldo Cruz
publisher.none.fl_str_mv	Fundação Oswaldo Cruz
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/40553/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/40553/2/Expression%20of%20NLRP3%20inflammasome.pdf https://www.arca.fiocruz.br/bitstream/icict/40553/3/Expression%20of%20NLRP3%20inflammasome.pdf.txt
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Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae

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