TST conversions and systemic interferon-gamma increase after methotrexate introduction in psoriasis patients
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/46570 |
Resumo: | Universidade Federal de Pernambuco. Hospital das Clínicas. Clínica de Dermatologia. Recife, PE, Brasil. / Universidade Federal de Pernambuco. Hospital das Clínicas. Departamento de Medicina Tropical. Recife, PE, Brasil. |
| id |
CRUZ_5ad958470983e4c67b112257ea8ab9c8 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/46570 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Medeiros, Vanessa Lucília Silveira deSantos, Fabiana Cristina FulcoMontenegro, Lílian Maria LapaSilva, Maria da ConceiçãoSouza, Valdênia Maria Oliveira deLima Neto, Reginaldo Gonçalvez deMoura, Líbia Cristina Rocha VilelaMagalhães, Vera2021-04-08T15:04:17Z2021-04-08T15:04:17Z2020MEDEIROS, V. L. S. de. et al. TST conversions and systemic interferon-gamma increase after methotrexate introduction in psoriasis patients. PLoS One, 15 (12), p. 1-13, 3 dez. 2020.1932-6203https://www.arca.fiocruz.br/handle/icict/4657010.1371/journal.pone.0242098engAdultC-Reactive Protein / metabolismFemaleHumansImmunosuppressive Agents / administration & dosageInterferon-gamma / bloodLatent Tuberculosis / complicationsLatent Tuberculosis / drug therapyLatent Tuberculosis / epidemiologyLatent Tuberculosis / microbiologyMaleMass ScreeningMethotrexate / administration & dosageMethotrexate / adverse effectsMiddle AgedPsoriasis / bloodPsoriasis / complicationsPsoriasis / drug therapyPsoriasis / epidemiologySeverity of Illness IndexTuberculin Test / adverse effectsTumor Necrosis Factor-alpha / bloodYoung AdultAdultoProteína C-Reativa / metabolismoFemininoHumanosImunossupressores / administração & dosagemInterferon gama / sangueTuberculose Latente / complicaçõesTuberculose Latente / tratamento farmacológicoTuberculose Latente / epidemiologiaTuberculose Latente / microbiologiaMasculinoProgramas de RastreamentoMetotrexato / administração & dosagemMetotrexato / efeitos adversosPessoa de Meia-IdadePsoríase / sanguePsoríase / complicaçõesPsoríase / tratamento farmacológicoPsoríase / epidemiologiaÍndice de Gravidade de DoençaTeste Tuberculínico / efeitos adversosFator de Necrose Tumoral alfa / sangueAdulto JovemTST conversions and systemic interferon-gamma increase after methotrexate introduction in psoriasis patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Pernambuco. Hospital das Clínicas. Clínica de Dermatologia. Recife, PE, Brasil. / Universidade Federal de Pernambuco. Hospital das Clínicas. Departamento de Medicina Tropical. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Laboratório de Imunoepidemiologia. Recife, PE, Brasil / Universidade Federal de Pernambuco. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Imunologia. Laboratório de Imunoepidemiologia. Recife, PE, Brasil / Universidade Federal de Pernambuco. Recife, PE, Brasil.Universidade Federal de Pernambuco. Hospital das Clínicas. Departamento de Medicina Tropical. Recife, PE, Brasil.Universidade Federal de Pernambuco. Hospital das Clínicas. Departamento de Medicina Tropical. Recife, PE, Brasil. / Universidade Federal de Pernambuco. Laboratório de Imunopatologia Keizo Asami-LIKA. Recife, PE, Brasil.Universidade Federal de Pernambuco. Hospital das Clínicas. Departamento de Medicina Tropical. Recife, PE, Brasil.Universidade Federal de Pernambuco. Hospital das Clínicas. Departamento de Medicina Tropical. Recife, PE, Brasil.Universidade Federal de Pernambuco. Hospital das Clínicas. Departamento de Medicina Tropical. Recife, PE, Brasil.Background: Tuberculosis screening in psoriasis patients is complex due to the immunological alterations associated with psoriasis, the presence of comorbidities, and the effect of immunosuppressive treatment. However, it is not established whether the results of screening tests are affected by these factors in psoriasis patients. Objectives: To determine whether there is a change in the results of the tuberculin skin test (TST) or the interferon-gamma release assay (IGRA) in psoriasis patients living in tuberculosis (TB)-endemic area after 12 weeks of methotrexate (MTX) treatment and to investigate the association of the test results with clinical and inflammatory markers. Methods: Forty-five patients were selected for a prospective single-arm self-controlled study and followed for at least 18 months. The TST, IGRA, Psoriasis Area and Severity Index (PASI), and inflammatory factors (erythrocyte sedimentation rate (ESR), C-reactive protein, interferon-gamma (IFN-γ), and tumor necrosis factor-alpha levels), were determined before and after 12 weeks of oral 15 mg per week MTX administration and compared. The associations between the IGRA and TST results were verified before and after treatment according to inflammatory factors and clinical characteristics (age, blood glucose, weight, body mass index, disease duration, and PASI). Results: We collected data on 25 patients who completed the full course of therapy and the follow-up. None of the patients developed TB. TST positivity was significantly elevated at week 12 (25% baseline vs 44% at week 12, P < 0.037). Three IGRAs followed the TST conversions. There was no difference between TST and IGRA pre- or posttreatment. Serum IFN-γ increased significantly in week 12 (15.95 pg/ml baseline vs 18.82 pg/ml at week 12, P < 0.005) and tended to be higher among TST-positive patients (P = 0.072). The baseline IGRA was associated with a higher ESR (P = 0.038). None of the test results were associated with clinical characteristics. Conclusions: In addition to the classic booster effect, TST conversions in patients using MTX can occur due to an increase in IFN-γ. However, it is not possible to exclude true TST conversions. Therefore, other diagnostic methods, like IGRA or chest tomography, should be used when the TST has intermediate results.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83085https://www.arca.fiocruz.br/bitstream/icict/46570/1/license.txt4194663c61da82c21746deb8d6361188MD51ORIGINALTST conversions and systemic interferon-gamma increase after methotrexate introduction in psoriasis patients.pdfTST conversions and systemic interferon-gamma increase after methotrexate introduction in psoriasis patients.pdfapplication/pdf601970https://www.arca.fiocruz.br/bitstream/icict/46570/2/TST%20conversions%20and%20systemic%20interferon-gamma%20increase%20after%20methotrexate%20introduction%20in%20psoriasis%20patients.pdf2d07ac7e3d3a43ee94144edd48e067e5MD52TEXTTST conversions and systemic interferon-gamma increase after methotrexate introduction in psoriasis patients.pdf.txtTST conversions and systemic interferon-gamma increase after methotrexate introduction in psoriasis patients.pdf.txtExtracted texttext/plain46087https://www.arca.fiocruz.br/bitstream/icict/46570/3/TST%20conversions%20and%20systemic%20interferon-gamma%20increase%20after%20methotrexate%20introduction%20in%20psoriasis%20patients.pdf.txt4e40d0235ac9c8d6d5c32876ae258ddbMD53icict/465702021-04-09 02:22:20.759oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-04-09T05:22:20Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
TST conversions and systemic interferon-gamma increase after methotrexate introduction in psoriasis patients |
| title |
TST conversions and systemic interferon-gamma increase after methotrexate introduction in psoriasis patients |
| spellingShingle |
TST conversions and systemic interferon-gamma increase after methotrexate introduction in psoriasis patients Medeiros, Vanessa Lucília Silveira de Adult C-Reactive Protein / metabolism Female Humans Immunosuppressive Agents / administration & dosage Interferon-gamma / blood Latent Tuberculosis / complications Latent Tuberculosis / drug therapy Latent Tuberculosis / epidemiology Latent Tuberculosis / microbiology Male Mass Screening Methotrexate / administration & dosage Methotrexate / adverse effects Middle Aged Psoriasis / blood Psoriasis / complications Psoriasis / drug therapy Psoriasis / epidemiology Severity of Illness Index Tuberculin Test / adverse effects Tumor Necrosis Factor-alpha / blood Young Adult Adulto Proteína C-Reativa / metabolismo Feminino Humanos Imunossupressores / administração & dosagem Interferon gama / sangue Tuberculose Latente / complicações Tuberculose Latente / tratamento farmacológico Tuberculose Latente / epidemiologia Tuberculose Latente / microbiologia Masculino Programas de Rastreamento Metotrexato / administração & dosagem Metotrexato / efeitos adversos Pessoa de Meia-Idade Psoríase / sangue Psoríase / complicações Psoríase / tratamento farmacológico Psoríase / epidemiologia Índice de Gravidade de Doença Teste Tuberculínico / efeitos adversos Fator de Necrose Tumoral alfa / sangue Adulto Jovem |
| title_short |
TST conversions and systemic interferon-gamma increase after methotrexate introduction in psoriasis patients |
| title_full |
TST conversions and systemic interferon-gamma increase after methotrexate introduction in psoriasis patients |
| title_fullStr |
TST conversions and systemic interferon-gamma increase after methotrexate introduction in psoriasis patients |
| title_full_unstemmed |
TST conversions and systemic interferon-gamma increase after methotrexate introduction in psoriasis patients |
| title_sort |
TST conversions and systemic interferon-gamma increase after methotrexate introduction in psoriasis patients |
| author |
Medeiros, Vanessa Lucília Silveira de |
| author_facet |
Medeiros, Vanessa Lucília Silveira de Santos, Fabiana Cristina Fulco Montenegro, Lílian Maria Lapa Silva, Maria da Conceição Souza, Valdênia Maria Oliveira de Lima Neto, Reginaldo Gonçalvez de Moura, Líbia Cristina Rocha Vilela Magalhães, Vera |
| author_role |
author |
| author2 |
Santos, Fabiana Cristina Fulco Montenegro, Lílian Maria Lapa Silva, Maria da Conceição Souza, Valdênia Maria Oliveira de Lima Neto, Reginaldo Gonçalvez de Moura, Líbia Cristina Rocha Vilela Magalhães, Vera |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Medeiros, Vanessa Lucília Silveira de Santos, Fabiana Cristina Fulco Montenegro, Lílian Maria Lapa Silva, Maria da Conceição Souza, Valdênia Maria Oliveira de Lima Neto, Reginaldo Gonçalvez de Moura, Líbia Cristina Rocha Vilela Magalhães, Vera |
| dc.subject.mesh.pt_BR.fl_str_mv |
Adult C-Reactive Protein / metabolism Female Humans Immunosuppressive Agents / administration & dosage Interferon-gamma / blood Latent Tuberculosis / complications Latent Tuberculosis / drug therapy Latent Tuberculosis / epidemiology Latent Tuberculosis / microbiology Male Mass Screening Methotrexate / administration & dosage Methotrexate / adverse effects Middle Aged Psoriasis / blood Psoriasis / complications Psoriasis / drug therapy Psoriasis / epidemiology Severity of Illness Index Tuberculin Test / adverse effects Tumor Necrosis Factor-alpha / blood Young Adult |
| topic |
Adult C-Reactive Protein / metabolism Female Humans Immunosuppressive Agents / administration & dosage Interferon-gamma / blood Latent Tuberculosis / complications Latent Tuberculosis / drug therapy Latent Tuberculosis / epidemiology Latent Tuberculosis / microbiology Male Mass Screening Methotrexate / administration & dosage Methotrexate / adverse effects Middle Aged Psoriasis / blood Psoriasis / complications Psoriasis / drug therapy Psoriasis / epidemiology Severity of Illness Index Tuberculin Test / adverse effects Tumor Necrosis Factor-alpha / blood Young Adult Adulto Proteína C-Reativa / metabolismo Feminino Humanos Imunossupressores / administração & dosagem Interferon gama / sangue Tuberculose Latente / complicações Tuberculose Latente / tratamento farmacológico Tuberculose Latente / epidemiologia Tuberculose Latente / microbiologia Masculino Programas de Rastreamento Metotrexato / administração & dosagem Metotrexato / efeitos adversos Pessoa de Meia-Idade Psoríase / sangue Psoríase / complicações Psoríase / tratamento farmacológico Psoríase / epidemiologia Índice de Gravidade de Doença Teste Tuberculínico / efeitos adversos Fator de Necrose Tumoral alfa / sangue Adulto Jovem |
| dc.subject.decs.pt_BR.fl_str_mv |
Adulto Proteína C-Reativa / metabolismo Feminino Humanos Imunossupressores / administração & dosagem Interferon gama / sangue Tuberculose Latente / complicações Tuberculose Latente / tratamento farmacológico Tuberculose Latente / epidemiologia Tuberculose Latente / microbiologia Masculino Programas de Rastreamento Metotrexato / administração & dosagem Metotrexato / efeitos adversos Pessoa de Meia-Idade Psoríase / sangue Psoríase / complicações Psoríase / tratamento farmacológico Psoríase / epidemiologia Índice de Gravidade de Doença Teste Tuberculínico / efeitos adversos Fator de Necrose Tumoral alfa / sangue Adulto Jovem |
| description |
Universidade Federal de Pernambuco. Hospital das Clínicas. Clínica de Dermatologia. Recife, PE, Brasil. / Universidade Federal de Pernambuco. Hospital das Clínicas. Departamento de Medicina Tropical. Recife, PE, Brasil. |
| publishDate |
2020 |
| dc.date.issued.fl_str_mv |
2020 |
| dc.date.accessioned.fl_str_mv |
2021-04-08T15:04:17Z |
| dc.date.available.fl_str_mv |
2021-04-08T15:04:17Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
MEDEIROS, V. L. S. de. et al. TST conversions and systemic interferon-gamma increase after methotrexate introduction in psoriasis patients. PLoS One, 15 (12), p. 1-13, 3 dez. 2020. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/46570 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1932-6203 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0242098 |
| identifier_str_mv |
MEDEIROS, V. L. S. de. et al. TST conversions and systemic interferon-gamma increase after methotrexate introduction in psoriasis patients. PLoS One, 15 (12), p. 1-13, 3 dez. 2020. 1932-6203 10.1371/journal.pone.0242098 |
| url |
https://www.arca.fiocruz.br/handle/icict/46570 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/46570/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/46570/2/TST%20conversions%20and%20systemic%20interferon-gamma%20increase%20after%20methotrexate%20introduction%20in%20psoriasis%20patients.pdf https://www.arca.fiocruz.br/bitstream/icict/46570/3/TST%20conversions%20and%20systemic%20interferon-gamma%20increase%20after%20methotrexate%20introduction%20in%20psoriasis%20patients.pdf.txt |
| bitstream.checksum.fl_str_mv |
4194663c61da82c21746deb8d6361188 2d07ac7e3d3a43ee94144edd48e067e5 4e40d0235ac9c8d6d5c32876ae258ddb |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813009284926013440 |