Thalidomide is Associated With Increased T Cell Activation and Inflammation in Antiretroviral-naive HIV-infected Individuals in a Randomised Clinical Trial of Efficacy and Safety
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25013 |
Resumo: | Universidade Federal de São Paulo. Laboratório de Retrovirologia. São Paulo, SP, Brasil / Oncohiv. Rio de Janeiro, RJ, Brasil. |
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Vergara, Tânia R. C.Samer, SadiaOliveira, Joanna R. SantosGiron, Leila B.Arif, Muhammad ShoaibFreitas, Maria Luciana SilvaCherman, Lia A.Treitsman, Mauro S.Chebabo, AlbertoSucupira, Maria Cecilia A.Cruz, Alda M. daDiaz, Ricardo Sobhie2018-03-01T13:12:45Z2018-03-01T13:12:45Z2017VERGARA, Tânia R. C. et al. Thalidomide is Associated With Increased T Cell Activation and Inflammation in Antiretroviral-naive HIV-infected Individuals in a Randomised Clinical Trial of Efficacy and Safety. EBiomedicine, v.23, p.59-67. 2017.2352-3964https://www.arca.fiocruz.br/handle/icict/2501310.1016/j.ebiom.2017.08.007engElsevierHIVTalidomidaInflamaçãoAgente de reversão de latênciaAtivação de células TThalidomideT cell activationInflammationLatency reversal agentHIVThalidomide is Associated With Increased T Cell Activation and Inflammation in Antiretroviral-naive HIV-infected Individuals in a Randomised Clinical Trial of Efficacy and Safetyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de São Paulo. Laboratório de Retrovirologia. São Paulo, SP, Brasil / Oncohiv. Rio de Janeiro, RJ, Brasil.Universidade Federal de São Paulo. Laboratório de Retrovirologia. São Paulo, SP, Brasil.Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro. Rio de Janeiro, Brasil.Universidade Federal de São Paulo. Laboratório de Retrovirologia. São Paulo, SP, Brasil.Universidade Federal de São Paulo. Laboratório de Retrovirologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.Secretaria Municipal de Saúde Antônio Ribeiro Neto. Rio de Janeiro, RJ, BrasilOncohiv. Rio de Janeiro, RJ, Brasil.Oncohiv. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Universidade Federal de São Paulo. Laboratório de Retrovirologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ. Brasil.Universidade Federal de São Paulo. Laboratório de Retrovirologia. São Paulo, SP, Brasil.Trial Design: Open-label, randomised, controlled, pilot proof-of-concept clinical trial. Methods: Participants: Antiretroviral naïve adult males with CD4 count ≥350 cells/mm3. Interventions: Patients were randomised to receive thalidomide 200 mg QD for 3 weeks (Thalidomide group) or not (Control group) and followed for 48 weeks. Objective: We hypothesized that short-term Thalidomide use would reduce HIV related inflammation and HIV replication among antiretroviral naïve HIV infected individuals. Outcome: Viral loads, CD4/CD8 counts, ultra-sensitive C-reactive protein (US-CRP), cell activation markers, and plasma lipopolysaccharide (LPS) were analyzed. Randomisation: Unrestricted randomisation. Blinding: No blinding was used. Results: Numbers randomised: Thirty recruited individuals were randomised to Thalidomide (16 patients) or Control (14 patients) groups. Recruitment: Patients were recruited from April 2011 to January 2013. Outcome: Viral loads remained stable in both groups. During thalidomide treatment, a decrease in CD4/CD8 ratio (p=0.04), a decrease in CD4 count (p=0.04), an increase in cell activation calculated by the percentage of CD38 +/HLA-DR+ CD8 cells (p b 0.05) and an increase in US-CRP (p b 0.01) were observed in the Thalidomide group, with all parameters returning to baseline levels after thalidomide interruption.We confirmed that thalidomide increased HIV replication in vitro of 6 of 7 samples from long-term antiretroviral suppressed individuals. Harms: No class 3/4 adverse events occurred. Conclusions: Short-termuse of thalidomide led to an intense transient increase in T cell activation and inflammation, with a decrease in the CD4+ cell count without changes to the CD8+ cell count. We confirmed that thalidomide acts in vitro as a latency reversal agent and speculate that the in vivo results obtained were due to an increase in HIV replication.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25013/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmarialuciana_freitas_etal_IOC_2017.pdfmarialuciana_freitas_etal_IOC_2017.pdfapplication/pdf824000https://www.arca.fiocruz.br/bitstream/icict/25013/2/marialuciana_freitas_etal_IOC_2017.pdf6d2f92294baaecd9a5780c433a4ba3d2MD52TEXTmarialuciana_freitas_etal_IOC_2017.pdf.txtmarialuciana_freitas_etal_IOC_2017.pdf.txtExtracted texttext/plain48656https://www.arca.fiocruz.br/bitstream/icict/25013/3/marialuciana_freitas_etal_IOC_2017.pdf.txt60ad1228538912466f4abcbc2164d606MD53icict/250132018-08-15 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| dc.title.pt_BR.fl_str_mv |
Thalidomide is Associated With Increased T Cell Activation and Inflammation in Antiretroviral-naive HIV-infected Individuals in a Randomised Clinical Trial of Efficacy and Safety |
| title |
Thalidomide is Associated With Increased T Cell Activation and Inflammation in Antiretroviral-naive HIV-infected Individuals in a Randomised Clinical Trial of Efficacy and Safety |
| spellingShingle |
Thalidomide is Associated With Increased T Cell Activation and Inflammation in Antiretroviral-naive HIV-infected Individuals in a Randomised Clinical Trial of Efficacy and Safety Vergara, Tânia R. C. HIV Talidomida Inflamação Agente de reversão de latência Ativação de células T Thalidomide T cell activation Inflammation Latency reversal agent HIV |
| title_short |
Thalidomide is Associated With Increased T Cell Activation and Inflammation in Antiretroviral-naive HIV-infected Individuals in a Randomised Clinical Trial of Efficacy and Safety |
| title_full |
Thalidomide is Associated With Increased T Cell Activation and Inflammation in Antiretroviral-naive HIV-infected Individuals in a Randomised Clinical Trial of Efficacy and Safety |
| title_fullStr |
Thalidomide is Associated With Increased T Cell Activation and Inflammation in Antiretroviral-naive HIV-infected Individuals in a Randomised Clinical Trial of Efficacy and Safety |
| title_full_unstemmed |
Thalidomide is Associated With Increased T Cell Activation and Inflammation in Antiretroviral-naive HIV-infected Individuals in a Randomised Clinical Trial of Efficacy and Safety |
| title_sort |
Thalidomide is Associated With Increased T Cell Activation and Inflammation in Antiretroviral-naive HIV-infected Individuals in a Randomised Clinical Trial of Efficacy and Safety |
| author |
Vergara, Tânia R. C. |
| author_facet |
Vergara, Tânia R. C. Samer, Sadia Oliveira, Joanna R. Santos Giron, Leila B. Arif, Muhammad Shoaib Freitas, Maria Luciana Silva Cherman, Lia A. Treitsman, Mauro S. Chebabo, Alberto Sucupira, Maria Cecilia A. Cruz, Alda M. da Diaz, Ricardo Sobhie |
| author_role |
author |
| author2 |
Samer, Sadia Oliveira, Joanna R. Santos Giron, Leila B. Arif, Muhammad Shoaib Freitas, Maria Luciana Silva Cherman, Lia A. Treitsman, Mauro S. Chebabo, Alberto Sucupira, Maria Cecilia A. Cruz, Alda M. da Diaz, Ricardo Sobhie |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Vergara, Tânia R. C. Samer, Sadia Oliveira, Joanna R. Santos Giron, Leila B. Arif, Muhammad Shoaib Freitas, Maria Luciana Silva Cherman, Lia A. Treitsman, Mauro S. Chebabo, Alberto Sucupira, Maria Cecilia A. Cruz, Alda M. da Diaz, Ricardo Sobhie |
| dc.subject.other.pt_BR.fl_str_mv |
HIV Talidomida Inflamação Agente de reversão de latência Ativação de células T |
| topic |
HIV Talidomida Inflamação Agente de reversão de latência Ativação de células T Thalidomide T cell activation Inflammation Latency reversal agent HIV |
| dc.subject.en.pt_BR.fl_str_mv |
Thalidomide T cell activation Inflammation Latency reversal agent HIV |
| description |
Universidade Federal de São Paulo. Laboratório de Retrovirologia. São Paulo, SP, Brasil / Oncohiv. Rio de Janeiro, RJ, Brasil. |
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2017 |
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2017 |
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2018-03-01T13:12:45Z |
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2018-03-01T13:12:45Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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VERGARA, Tânia R. C. et al. Thalidomide is Associated With Increased T Cell Activation and Inflammation in Antiretroviral-naive HIV-infected Individuals in a Randomised Clinical Trial of Efficacy and Safety. EBiomedicine, v.23, p.59-67. 2017. |
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https://www.arca.fiocruz.br/handle/icict/25013 |
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2352-3964 |
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10.1016/j.ebiom.2017.08.007 |
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VERGARA, Tânia R. C. et al. Thalidomide is Associated With Increased T Cell Activation and Inflammation in Antiretroviral-naive HIV-infected Individuals in a Randomised Clinical Trial of Efficacy and Safety. EBiomedicine, v.23, p.59-67. 2017. 2352-3964 10.1016/j.ebiom.2017.08.007 |
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Elsevier |
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