Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate

Kratz, Jadel Müller; Andrighetti-Fröhner, Carla Regina; Kolling, Deise Juliana; Leal, Paulo César; Santos, Cláudio César Cirne; Yunes, Rosendo Augusto; Nunes, Ricardo José; Trybala, Edward; Bergström, Tomas; Frugulhetti, Izabel C. P. P.; Barardi, Célia Regina Monte; Simões, Cláudia Maria Oliveira

Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate

Detalhes bibliográficos
Autor(a) principal:	Kratz, Jadel Müller
Data de Publicação:	2008
Outros Autores:	Andrighetti-Fröhner, Carla Regina, Kolling, Deise Juliana, Leal, Paulo César, Santos, Cláudio César Cirne, Yunes, Rosendo Augusto, Nunes, Ricardo José, Trybala, Edward, Bergström, Tomas, Frugulhetti, Izabel C. P. P., Barardi, Célia Regina Monte, Simões, Cláudia Maria Oliveira
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/28992
Resumo:	Universidade Federal de Santa Catarina. Departamento de Ciências Farmacêuticas. Laboratório de Virologia Aplicada, Florianópolis, SC, Brasil.

Metadados do item

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spelling	Kratz, Jadel MüllerAndrighetti-Fröhner, Carla ReginaKolling, Deise JulianaLeal, Paulo CésarSantos, Cláudio César CirneYunes, Rosendo AugustoNunes, Ricardo JoséTrybala, EdwardBergström, TomasFrugulhetti, Izabel C. P. P.Barardi, Célia Regina MonteSimões, Cláudia Maria Oliveira2018-09-22T20:58:54Z2018-09-22T20:58:54Z2008KRATZ, Jadel Müller; et al. Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate. Mem Inst Oswaldo Cruz , v.103, n.5, p. 437-442, Aug. 2008.0074-0276https://www.arca.fiocruz.br/handle/icict/289921678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.AntiviraisHIV-1Herpesvirus Humano 1Ácido GálicoantiviralHSV-1HIV-1gallic acidpentyl gallateAnti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallateinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Santa Catarina. Departamento de Ciências Farmacêuticas. Laboratório de Virologia Aplicada, Florianópolis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Ciências Farmacêuticas. Laboratório de Virologia Aplicada, Florianópolis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Ciências Farmacêuticas. Laboratório de Virologia Aplicada, Florianópolis, SC, Brasil / / Universidade Federal de Santa Catarina. Departamento de Química. Laboratório de Síntese e Estrutura-Atividade. Florianópolis, SC, Brasil / Universidade de Göteborg. Departamento de Virologia Clínica. Súecia..Universidade Federal de Santa Catarina. Departamento de Ciências Farmacêuticas. Laboratório de Virologia Aplicada, Florianópolis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Química. Laboratório de Síntese e Estrutura-Atividade. Florianópolis, SC, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil.Universidade Federal de Santa Catarina. Departamento de Química. Laboratório de Síntese e Estrutura-Atividade. Florianópolis, SC, BrasilUniversidade Federal de Santa Catarina. Departamento de Química. Laboratório de Síntese e Estrutura-Atividade. Florianópolis, SC, BrasilUniversidade de Goteborg. Departamento de Virologia ClÍnica. Suécia.Universidade de Goteborg. Departamento de Virologia ClÍnica. Suécia.Universidade Federal Fluminense. Laboratório de Virologia Molecular, Departamento de Biologia Celular e Molecular. Niterói, RJ, Brasil.niversidade Federal de Santa Catarina. Campus Universitário Trindade. Departamento de Microbiologia e Parasitologia. Laboratório de Virologia Aplicada. Florianópolis, SC, Brasil.Universidade Federal de Santa Catarina. Departamento de Ciências Farmacêuticas. Laboratório de Virologia Aplicada, Florianópolis, SC, Brasil.The synthetic n-alkyl esters of gallic acid (GA), also known as gallates, especially propyl, octyl and dodecyl gallates, are widely employed as antioxidants by food and pharmaceutical industries. The inhibitory effects of GA and 15 gallates on Herpes Simplex Virus type 1 (HSV-1) and Human Immunodeficiency Virus (HIV-1) replication were investigated here. After a preliminary screening of these compounds, GA and pentyl gallate (PG) seemed to be the most active compounds against HSV-1 replication and their mode of action was characterized through a set of assays, which attempted to localize the step of the viral multiplication cycle where impairment occurred. The detected anti-HSV-1 activity was mediated by the inhibition of virus attachment to and penetration into cells, and by virucidal properties. Furthermore, an anti-HIV-1 activity was also found, to different degrees. In summary, our results suggest that both compounds could be regarded as promising candidates for the development of topical anti-HSV-1 agents, and further studies concerning the anti-HIV-1 activity of this group of molecules are merited.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28992/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALclaudio_cirnesantos_etal_IOC_2008.pdfclaudio_cirnesantos_etal_IOC_2008.pdfapplication/pdf443828https://www.arca.fiocruz.br/bitstream/icict/28992/2/claudio_cirnesantos_etal_IOC_2008.pdfe62a4fa6db160d85b8c73c47cb997ec7MD52TEXTclaudio_cirnesantos_etal_IOC_2008.pdf.txtclaudio_cirnesantos_etal_IOC_2008.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv	Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate
title	Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate
spellingShingle	Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate Kratz, Jadel Müller Antivirais HIV-1 Herpesvirus Humano 1 Ácido Gálico antiviral HSV-1 HIV-1 gallic acid pentyl gallate
title_short	Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate
title_full	Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate
title_fullStr	Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate
title_full_unstemmed	Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate
title_sort	Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate
author	Kratz, Jadel Müller
author_facet	Kratz, Jadel Müller Andrighetti-Fröhner, Carla Regina Kolling, Deise Juliana Leal, Paulo César Santos, Cláudio César Cirne Yunes, Rosendo Augusto Nunes, Ricardo José Trybala, Edward Bergström, Tomas Frugulhetti, Izabel C. P. P. Barardi, Célia Regina Monte Simões, Cláudia Maria Oliveira
author_role	author
author2	Andrighetti-Fröhner, Carla Regina Kolling, Deise Juliana Leal, Paulo César Santos, Cláudio César Cirne Yunes, Rosendo Augusto Nunes, Ricardo José Trybala, Edward Bergström, Tomas Frugulhetti, Izabel C. P. P. Barardi, Célia Regina Monte Simões, Cláudia Maria Oliveira
author2_role	author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Kratz, Jadel Müller Andrighetti-Fröhner, Carla Regina Kolling, Deise Juliana Leal, Paulo César Santos, Cláudio César Cirne Yunes, Rosendo Augusto Nunes, Ricardo José Trybala, Edward Bergström, Tomas Frugulhetti, Izabel C. P. P. Barardi, Célia Regina Monte Simões, Cláudia Maria Oliveira
dc.subject.other.pt_BR.fl_str_mv	Antivirais HIV-1 Herpesvirus Humano 1 Ácido Gálico
topic	Antivirais HIV-1 Herpesvirus Humano 1 Ácido Gálico antiviral HSV-1 HIV-1 gallic acid pentyl gallate
dc.subject.en.pt_BR.fl_str_mv	antiviral HSV-1 HIV-1 gallic acid pentyl gallate
description	Universidade Federal de Santa Catarina. Departamento de Ciências Farmacêuticas. Laboratório de Virologia Aplicada, Florianópolis, SC, Brasil.
publishDate	2008
dc.date.issued.fl_str_mv	2008
dc.date.accessioned.fl_str_mv	2018-09-22T20:58:54Z
dc.date.available.fl_str_mv	2018-09-22T20:58:54Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	KRATZ, Jadel Müller; et al. Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate. Mem Inst Oswaldo Cruz , v.103, n.5, p. 437-442, Aug. 2008.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/28992
dc.identifier.issn.pt_BR.fl_str_mv	0074-0276
dc.identifier.eissn.none.fl_str_mv	1678-8060
identifier_str_mv	KRATZ, Jadel Müller; et al. Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate. Mem Inst Oswaldo Cruz , v.103, n.5, p. 437-442, Aug. 2008. 0074-0276 1678-8060
url	https://www.arca.fiocruz.br/handle/icict/28992
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
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Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate

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