Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Memórias do Instituto Oswaldo Cruz |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000500005 |
Resumo: | The synthetic n-alkyl esters of gallic acid (GA), also known as gallates, especially propyl, octyl and dodecyl gallates, are widely employed as antioxidants by food and pharmaceutical industries. The inhibitory effects of GA and 15 gallates on Herpes Simplex Virus type 1 (HSV-1) and Human Immunodeficiency Virus (HIV-1) replication were investigated here. After a preliminary screening of these compounds, GA and pentyl gallate (PG) seemed to be the most active compounds against HSV-1 replication and their mode of action was characterized through a set of assays, which attempted to localize the step of the viral multiplication cycle where impairment occurred. The detected anti-HSV-1 activity was mediated by the inhibition of virus attachment to and penetration into cells, and by virucidal properties. Furthermore, an anti-HIV-1 activity was also found, to different degrees. In summary, our results suggest that both compounds could be regarded as promising candidates for the development of topical anti-HSV-1 agents, and further studies concerning the anti-HIV-1 activity of this group of molecules are merited. |
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Memórias do Instituto Oswaldo Cruz |
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Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallateantiviralHSV-1HIV-1gallic acidpentyl gallateThe synthetic n-alkyl esters of gallic acid (GA), also known as gallates, especially propyl, octyl and dodecyl gallates, are widely employed as antioxidants by food and pharmaceutical industries. The inhibitory effects of GA and 15 gallates on Herpes Simplex Virus type 1 (HSV-1) and Human Immunodeficiency Virus (HIV-1) replication were investigated here. After a preliminary screening of these compounds, GA and pentyl gallate (PG) seemed to be the most active compounds against HSV-1 replication and their mode of action was characterized through a set of assays, which attempted to localize the step of the viral multiplication cycle where impairment occurred. The detected anti-HSV-1 activity was mediated by the inhibition of virus attachment to and penetration into cells, and by virucidal properties. Furthermore, an anti-HIV-1 activity was also found, to different degrees. In summary, our results suggest that both compounds could be regarded as promising candidates for the development of topical anti-HSV-1 agents, and further studies concerning the anti-HIV-1 activity of this group of molecules are merited.Instituto Oswaldo Cruz, Ministério da Saúde2008-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000500005Memórias do Instituto Oswaldo Cruz v.103 n.5 2008reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762008000500005info:eu-repo/semantics/openAccessKratz,Jadel MüllerAndrighetti-Fröhner,Carla ReginaKolling,Deise JulianaLeal,Paulo CésarCirne-Santos,Cláudio CésarYunes,Rosendo AugustoNunes,Ricardo JoséTrybala,EdwardBergström,TomasFrugulhetti,Izabel CPPBarardi,Célia Regina MonteSimões,Cláudia Maria Oliveiraeng2020-04-25T17:50:19Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:15:40.418Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
dc.title.none.fl_str_mv |
Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate |
title |
Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate |
spellingShingle |
Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate Kratz,Jadel Müller antiviral HSV-1 HIV-1 gallic acid pentyl gallate |
title_short |
Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate |
title_full |
Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate |
title_fullStr |
Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate |
title_full_unstemmed |
Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate |
title_sort |
Anti-HSV-1 and anti-HIV-1 activity of gallic acid and pentyl gallate |
author |
Kratz,Jadel Müller |
author_facet |
Kratz,Jadel Müller Andrighetti-Fröhner,Carla Regina Kolling,Deise Juliana Leal,Paulo César Cirne-Santos,Cláudio César Yunes,Rosendo Augusto Nunes,Ricardo José Trybala,Edward Bergström,Tomas Frugulhetti,Izabel CPP Barardi,Célia Regina Monte Simões,Cláudia Maria Oliveira |
author_role |
author |
author2 |
Andrighetti-Fröhner,Carla Regina Kolling,Deise Juliana Leal,Paulo César Cirne-Santos,Cláudio César Yunes,Rosendo Augusto Nunes,Ricardo José Trybala,Edward Bergström,Tomas Frugulhetti,Izabel CPP Barardi,Célia Regina Monte Simões,Cláudia Maria Oliveira |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Kratz,Jadel Müller Andrighetti-Fröhner,Carla Regina Kolling,Deise Juliana Leal,Paulo César Cirne-Santos,Cláudio César Yunes,Rosendo Augusto Nunes,Ricardo José Trybala,Edward Bergström,Tomas Frugulhetti,Izabel CPP Barardi,Célia Regina Monte Simões,Cláudia Maria Oliveira |
dc.subject.por.fl_str_mv |
antiviral HSV-1 HIV-1 gallic acid pentyl gallate |
topic |
antiviral HSV-1 HIV-1 gallic acid pentyl gallate |
dc.description.none.fl_txt_mv |
The synthetic n-alkyl esters of gallic acid (GA), also known as gallates, especially propyl, octyl and dodecyl gallates, are widely employed as antioxidants by food and pharmaceutical industries. The inhibitory effects of GA and 15 gallates on Herpes Simplex Virus type 1 (HSV-1) and Human Immunodeficiency Virus (HIV-1) replication were investigated here. After a preliminary screening of these compounds, GA and pentyl gallate (PG) seemed to be the most active compounds against HSV-1 replication and their mode of action was characterized through a set of assays, which attempted to localize the step of the viral multiplication cycle where impairment occurred. The detected anti-HSV-1 activity was mediated by the inhibition of virus attachment to and penetration into cells, and by virucidal properties. Furthermore, an anti-HIV-1 activity was also found, to different degrees. In summary, our results suggest that both compounds could be regarded as promising candidates for the development of topical anti-HSV-1 agents, and further studies concerning the anti-HIV-1 activity of this group of molecules are merited. |
description |
The synthetic n-alkyl esters of gallic acid (GA), also known as gallates, especially propyl, octyl and dodecyl gallates, are widely employed as antioxidants by food and pharmaceutical industries. The inhibitory effects of GA and 15 gallates on Herpes Simplex Virus type 1 (HSV-1) and Human Immunodeficiency Virus (HIV-1) replication were investigated here. After a preliminary screening of these compounds, GA and pentyl gallate (PG) seemed to be the most active compounds against HSV-1 replication and their mode of action was characterized through a set of assays, which attempted to localize the step of the viral multiplication cycle where impairment occurred. The detected anti-HSV-1 activity was mediated by the inhibition of virus attachment to and penetration into cells, and by virucidal properties. Furthermore, an anti-HIV-1 activity was also found, to different degrees. In summary, our results suggest that both compounds could be regarded as promising candidates for the development of topical anti-HSV-1 agents, and further studies concerning the anti-HIV-1 activity of this group of molecules are merited. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000500005 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000500005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0074-02762008000500005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.103 n.5 2008 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
reponame_str |
Memórias do Instituto Oswaldo Cruz |
collection |
Memórias do Instituto Oswaldo Cruz |
instname_str |
Fundação Oswaldo Cruz |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
repository.name.fl_str_mv |
Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
repository.mail.fl_str_mv |
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1669937703051853824 |