Plasma Cytokine Expression Is Associated with Cardiac Morbidity in Chagas Disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/9446 |
Resumo: | Universidade Federal de Minas Gerais. Faculdade de Medicina. Infectologia e Medicina Tropical. Belo Horizonte, MG, Brazil |
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Sousa, Giovane RodrigoGomes, Juliana Assis SilvaFares, Rafaelle Christine GomesDamasio, Marcos Paulo de SouzaChaves, Ana TherezaFerreira, Karine SilvestreNunes, Maria Carmo PereiraMedeiros, Nayara Ingrid deValente, Vanessa Alves AzevedoOliveira, Rodrigo Corrêa deRocha, Manoel Otávio da Costa2015-02-06T14:27:57Z2015-02-06T14:27:57Z2014SOUSA, Giovane Rodrigo et al. Plasma Cytokine Expression Is Associated with Cardiac Morbidity in Chagas Disease. PLoS ONE, v. 9, n. 3, p. e87082, 20141553-7366https://www.arca.fiocruz.br/handle/icict/944610.1371/journal.pone.0087082engPublic Library of SciencePlasma Cytokine Expression Is Associated with Cardiac Morbidity in Chagas Diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Faculdade de Medicina. Infectologia e Medicina Tropical. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Faculdade de Medicina. Infectologia e Medicina Tropical. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Morfologia. Belo Horizonte, Minas Gerais, BrazilFundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunologia Celular e Molecular. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Morfologia. Belo Horizonte, Minas Gerais, BrazilFundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunologia Celular e Molecular. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Morfologia. Belo Horizonte, Minas Gerais, BrazilUniversidade Federal de Minas Gerais. Faculdade de Medicina. Infectologia e Medicina Tropical. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunologia Celular e Molecular. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciencias Biologicas. Departamento de Morfologia. Belo Horizonte, Minas Gerais, BrazilFundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil/Instituto Nacional de Ciencia e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Faculdade de Medicina. Infectologia e Medicina Tropical. Belo Horizonte, MG, BrazilThe expression of immune response appears to be associated with morbidity in Chagas disease. However, the studies in this field have usually employed small samples of patients and statistical analyses that do not consider the wide dispersion of cytokine production observed in these patients. The aim of this study was to evaluate the plasma cytokine levels in welldefined clinical polar groups of chagasic patients divided into categories that better reflect the wide cytokine profile and its relationship with morbidity. Patients infected with Trypanosoma cruzi (T. cruzi) were grouped as indeterminate (IND) and cardiac (CARD) forms ranging from 23 to 69 years of age (mean of 45.6611.25). The IND group included 82 individuals, ranging from 24 to 66 years of age (mean of 39.6610.3). The CARD group included 94 patients ranging from 23 to 69 years of age (mean of 48612.52) presenting dilated cardiomyopathy. None of the patients have undergone chemotherapeutic treatment, nor had been previously treated for T. cruzi infection. Healthy non-chagasic individuals, ranging from 29 to 55 years of age (mean of 42.668.8) were included as a control group (NI). IND patients have a higher intensity of interleukin 10 (IL-10) expression when compared with individuals in the other groups. By contrast, inflammatory cytokine expression, such as interferon gamma (IFN-c), tumor necrosis factor alpha (TNF-a), interleukin 6 (IL-6), and interleukin 1 beta (IL-1b), proved to be the highest in the CARD group. Correlation analysis showed that higher IL-10 expression was associated with better cardiac function, as determined by left ventricular ejection fraction and left ventricular diastolic diameter values. Altogether, these findings reinforce the concept that a fine balance between regulatory and inflammatory cytokines represents a key element in the establishment of distinct forms of chronic Chagas disease.Chagas diseaseChronic cardiomyopathyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9446/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINAL2014_048.pdf2014_048.pdfapplication/pdf2077033https://www.arca.fiocruz.br/bitstream/icict/9446/2/2014_048.pdf5c9786393949bf065beeeb0aad05f1bdMD52TEXT2014_048.pdf.txt2014_048.pdf.txtExtracted texttext/plain39003https://www.arca.fiocruz.br/bitstream/icict/9446/3/2014_048.pdf.txt9a15d88f255ec246d5cd0072a6b6703bMD53icict/94462019-06-19 10:07:33.628oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:07:33Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Plasma Cytokine Expression Is Associated with Cardiac Morbidity in Chagas Disease |
| title |
Plasma Cytokine Expression Is Associated with Cardiac Morbidity in Chagas Disease |
| spellingShingle |
Plasma Cytokine Expression Is Associated with Cardiac Morbidity in Chagas Disease Sousa, Giovane Rodrigo Chagas disease Chronic cardiomyopathy |
| title_short |
Plasma Cytokine Expression Is Associated with Cardiac Morbidity in Chagas Disease |
| title_full |
Plasma Cytokine Expression Is Associated with Cardiac Morbidity in Chagas Disease |
| title_fullStr |
Plasma Cytokine Expression Is Associated with Cardiac Morbidity in Chagas Disease |
| title_full_unstemmed |
Plasma Cytokine Expression Is Associated with Cardiac Morbidity in Chagas Disease |
| title_sort |
Plasma Cytokine Expression Is Associated with Cardiac Morbidity in Chagas Disease |
| author |
Sousa, Giovane Rodrigo |
| author_facet |
Sousa, Giovane Rodrigo Gomes, Juliana Assis Silva Fares, Rafaelle Christine Gomes Damasio, Marcos Paulo de Souza Chaves, Ana Thereza Ferreira, Karine Silvestre Nunes, Maria Carmo Pereira Medeiros, Nayara Ingrid de Valente, Vanessa Alves Azevedo Oliveira, Rodrigo Corrêa de Rocha, Manoel Otávio da Costa |
| author_role |
author |
| author2 |
Gomes, Juliana Assis Silva Fares, Rafaelle Christine Gomes Damasio, Marcos Paulo de Souza Chaves, Ana Thereza Ferreira, Karine Silvestre Nunes, Maria Carmo Pereira Medeiros, Nayara Ingrid de Valente, Vanessa Alves Azevedo Oliveira, Rodrigo Corrêa de Rocha, Manoel Otávio da Costa |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Sousa, Giovane Rodrigo Gomes, Juliana Assis Silva Fares, Rafaelle Christine Gomes Damasio, Marcos Paulo de Souza Chaves, Ana Thereza Ferreira, Karine Silvestre Nunes, Maria Carmo Pereira Medeiros, Nayara Ingrid de Valente, Vanessa Alves Azevedo Oliveira, Rodrigo Corrêa de Rocha, Manoel Otávio da Costa |
| dc.subject.en.pt_BR.fl_str_mv |
Chagas disease Chronic cardiomyopathy |
| topic |
Chagas disease Chronic cardiomyopathy |
| description |
Universidade Federal de Minas Gerais. Faculdade de Medicina. Infectologia e Medicina Tropical. Belo Horizonte, MG, Brazil |
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2014 |
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2014 |
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2015-02-06T14:27:57Z |
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2015-02-06T14:27:57Z |
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SOUSA, Giovane Rodrigo et al. Plasma Cytokine Expression Is Associated with Cardiac Morbidity in Chagas Disease. PLoS ONE, v. 9, n. 3, p. e87082, 2014 |
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10.1371/journal.pone.0087082 |
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SOUSA, Giovane Rodrigo et al. Plasma Cytokine Expression Is Associated with Cardiac Morbidity in Chagas Disease. PLoS ONE, v. 9, n. 3, p. e87082, 2014 1553-7366 10.1371/journal.pone.0087082 |
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