Chagas disease: morbidity profile in an endemic area of Northeastern Brazil

Detalhes bibliográficos
Autor(a) principal: Andrade,Cléber de Mesquita
Data de Publicação: 2015
Outros Autores: Câmara,Antônia Cláudia Jácome da, Nunes,Daniela Ferreira, Guedes,Paulo Marcos da Matta, Pereira,Wogelsanger Oliveira, Chiari,Egler, Diniz,Rosiane Viana Zuza, Galvão,Lúcia Maria da Cunha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000600706
Resumo: Abstract: INTRODUCTION : This study evaluated the clinical forms and manifestation severities of Chagas disease among serologically reactive individuals from Western Rio Grande do Norte (Northeastern Brazil). METHODS : This cross-sectional study included 186 adults who were evaluated using electrocardiography, echocardiography, chest radiography, and contrast radiography of the esophagus and colon. A clinical-epidemiological questionnaire was also used. RESULTS : The indeterminate, cardiac, digestive, and cardiodigestive clinical forms of Chagas disease were diagnosed in 51.6% (96/186), 32.2% (60/186), 8.1% (15/186) and 8.1% (15/186) of the participants, respectively. Heart failure (functional classes I-IV) was detected in 7.5% (14/186) of the participants, and 36.4% (24/66), 30.3% (20/66), 15.2% (10/66), 13.6% (9/66), and 4.5% (3/66) of the patients were at stage A, B1, B2, C, and D, respectively. Dilated cardiomyopathy and electrocardiographic changes were detected in 10.2% (19/186) and 48.1% (91/186) of the participants, respectively. Apical aneurysm was diagnosed in 10.8% (20/186) of the participants, and other changes in the segmental myocardial contractility of the left ventricle were diagnosed in 33.9% (63/186) of the participants. Megaesophagus (groups I-IV) was observed in 7% (13/186) of the participants, megacolon (grades 1-3) was detected in12.9% (24/186) of the participants, and both organs were affected in 29.2% (7/24) of the megacolon cases. CONCLUSIONS : We detected various clinical forms of Chagas disease (including the digestive form). Our findings indicate that clinical symptoms alone may not be sufficient to exclude or confirm cardiac and/or digestive damage, and the number of patients with symptomatic clinical forms may be underestimated.
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spelling Chagas disease: morbidity profile in an endemic area of Northeastern BrazilTrypanosoma cruziChagas diseaseChagasic cardiomyopathyMegaesophagus. Megacolon.Abstract: INTRODUCTION : This study evaluated the clinical forms and manifestation severities of Chagas disease among serologically reactive individuals from Western Rio Grande do Norte (Northeastern Brazil). METHODS : This cross-sectional study included 186 adults who were evaluated using electrocardiography, echocardiography, chest radiography, and contrast radiography of the esophagus and colon. A clinical-epidemiological questionnaire was also used. RESULTS : The indeterminate, cardiac, digestive, and cardiodigestive clinical forms of Chagas disease were diagnosed in 51.6% (96/186), 32.2% (60/186), 8.1% (15/186) and 8.1% (15/186) of the participants, respectively. Heart failure (functional classes I-IV) was detected in 7.5% (14/186) of the participants, and 36.4% (24/66), 30.3% (20/66), 15.2% (10/66), 13.6% (9/66), and 4.5% (3/66) of the patients were at stage A, B1, B2, C, and D, respectively. Dilated cardiomyopathy and electrocardiographic changes were detected in 10.2% (19/186) and 48.1% (91/186) of the participants, respectively. Apical aneurysm was diagnosed in 10.8% (20/186) of the participants, and other changes in the segmental myocardial contractility of the left ventricle were diagnosed in 33.9% (63/186) of the participants. Megaesophagus (groups I-IV) was observed in 7% (13/186) of the participants, megacolon (grades 1-3) was detected in12.9% (24/186) of the participants, and both organs were affected in 29.2% (7/24) of the megacolon cases. CONCLUSIONS : We detected various clinical forms of Chagas disease (including the digestive form). Our findings indicate that clinical symptoms alone may not be sufficient to exclude or confirm cardiac and/or digestive damage, and the number of patients with symptomatic clinical forms may be underestimated.Sociedade Brasileira de Medicina Tropical - SBMT2015-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000600706Revista da Sociedade Brasileira de Medicina Tropical v.48 n.6 2015reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/0037-8682-0235-2015info:eu-repo/semantics/openAccessAndrade,Cléber de MesquitaCâmara,Antônia Cláudia Jácome daNunes,Daniela FerreiraGuedes,Paulo Marcos da MattaPereira,Wogelsanger OliveiraChiari,EglerDiniz,Rosiane Viana ZuzaGalvão,Lúcia Maria da Cunhaeng2015-12-08T00:00:00Zoai:scielo:S0037-86822015000600706Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2015-12-08T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false
dc.title.none.fl_str_mv Chagas disease: morbidity profile in an endemic area of Northeastern Brazil
title Chagas disease: morbidity profile in an endemic area of Northeastern Brazil
spellingShingle Chagas disease: morbidity profile in an endemic area of Northeastern Brazil
Andrade,Cléber de Mesquita
Trypanosoma cruzi
Chagas disease
Chagasic cardiomyopathy
Megaesophagus. Megacolon.
title_short Chagas disease: morbidity profile in an endemic area of Northeastern Brazil
title_full Chagas disease: morbidity profile in an endemic area of Northeastern Brazil
title_fullStr Chagas disease: morbidity profile in an endemic area of Northeastern Brazil
title_full_unstemmed Chagas disease: morbidity profile in an endemic area of Northeastern Brazil
title_sort Chagas disease: morbidity profile in an endemic area of Northeastern Brazil
author Andrade,Cléber de Mesquita
author_facet Andrade,Cléber de Mesquita
Câmara,Antônia Cláudia Jácome da
Nunes,Daniela Ferreira
Guedes,Paulo Marcos da Matta
Pereira,Wogelsanger Oliveira
Chiari,Egler
Diniz,Rosiane Viana Zuza
Galvão,Lúcia Maria da Cunha
author_role author
author2 Câmara,Antônia Cláudia Jácome da
Nunes,Daniela Ferreira
Guedes,Paulo Marcos da Matta
Pereira,Wogelsanger Oliveira
Chiari,Egler
Diniz,Rosiane Viana Zuza
Galvão,Lúcia Maria da Cunha
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade,Cléber de Mesquita
Câmara,Antônia Cláudia Jácome da
Nunes,Daniela Ferreira
Guedes,Paulo Marcos da Matta
Pereira,Wogelsanger Oliveira
Chiari,Egler
Diniz,Rosiane Viana Zuza
Galvão,Lúcia Maria da Cunha
dc.subject.por.fl_str_mv Trypanosoma cruzi
Chagas disease
Chagasic cardiomyopathy
Megaesophagus. Megacolon.
topic Trypanosoma cruzi
Chagas disease
Chagasic cardiomyopathy
Megaesophagus. Megacolon.
description Abstract: INTRODUCTION : This study evaluated the clinical forms and manifestation severities of Chagas disease among serologically reactive individuals from Western Rio Grande do Norte (Northeastern Brazil). METHODS : This cross-sectional study included 186 adults who were evaluated using electrocardiography, echocardiography, chest radiography, and contrast radiography of the esophagus and colon. A clinical-epidemiological questionnaire was also used. RESULTS : The indeterminate, cardiac, digestive, and cardiodigestive clinical forms of Chagas disease were diagnosed in 51.6% (96/186), 32.2% (60/186), 8.1% (15/186) and 8.1% (15/186) of the participants, respectively. Heart failure (functional classes I-IV) was detected in 7.5% (14/186) of the participants, and 36.4% (24/66), 30.3% (20/66), 15.2% (10/66), 13.6% (9/66), and 4.5% (3/66) of the patients were at stage A, B1, B2, C, and D, respectively. Dilated cardiomyopathy and electrocardiographic changes were detected in 10.2% (19/186) and 48.1% (91/186) of the participants, respectively. Apical aneurysm was diagnosed in 10.8% (20/186) of the participants, and other changes in the segmental myocardial contractility of the left ventricle were diagnosed in 33.9% (63/186) of the participants. Megaesophagus (groups I-IV) was observed in 7% (13/186) of the participants, megacolon (grades 1-3) was detected in12.9% (24/186) of the participants, and both organs were affected in 29.2% (7/24) of the megacolon cases. CONCLUSIONS : We detected various clinical forms of Chagas disease (including the digestive form). Our findings indicate that clinical symptoms alone may not be sufficient to exclude or confirm cardiac and/or digestive damage, and the number of patients with symptomatic clinical forms may be underestimated.
publishDate 2015
dc.date.none.fl_str_mv 2015-12-01
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000600706
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1590/0037-8682-0235-2015
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
dc.source.none.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical v.48 n.6 2015
reponame:Revista da Sociedade Brasileira de Medicina Tropical
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reponame_str Revista da Sociedade Brasileira de Medicina Tropical
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repository.name.fl_str_mv Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)
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